Patent application number | Description | Published |
20090258027 | Methods of modulating immune function - The invention relates to methods for modulating the immune function through targeting of CLIP molecules as well as gamma delta T cells. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmune disease, transplant and cell graft rejection, cancer, bacterial infection, HIV infection, and AIDS, as well as novel methods of diagnosis and of introducing a treatment regimen into a subject. | 10-15-2009 |
20090258064 | COMPOSITIONS OF UCP INHIBITORS, FAS ANTIBODY, A FATTY ACID METABOLISM INHIBITOR AND/OR A GLUCOSE METABOLISM INHIBITOR - Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and/or Fas antibody or other inhibitor, or combination thereof, and a therapeutically acceptable amount of a fatty acid metabolism inhibitor and/or a therapeutically acceptable amount of a glucose metabolism inhibitor, optionally in combination with one or more chemotherpeutic agents. In preferred embodiments, the invention combines an antibody against UCP and/or Fas antigen with an oxirane carboxylic acid, represented by etomoxir, and/or with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers. | 10-15-2009 |
20100034839 | METHODS FOR TREATING VIRAL DISORDERS - The invention relates to topical formulations of CLIP inhibitors as well as methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with viral infection, such as HIV infection, and AIDS. | 02-11-2010 |
20100166782 | CLIP INHIBITORS AND METHODS OF MODULATING IMMUNE FUNCTION - The invention relates to methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmune disease, allergic disease transplant and cell graft rejection, cancer, bacterial infection, HIV infection, and AIDS. | 07-01-2010 |
20100166789 | PROTEINS FOR USE IN DIAGNOSING AND TREATING INFECTION AND DISEASE - The present invention describes compositions of thymus derived peptides and uses therefore in diagnostic methods and for the treatment of diseases associated with reduced T helper cell counts, diseases such as infection, e.g., HIV infection and other viral infections, parasitic, and bacterial infection, AIDS, ARC, multiple sclerosis, chronic fatigue syndrome, rheumatoid arthritis, Alzheimer's disease, asthma, allergy, dermatitis, type 1 diabetes mellitus, colitis, inflammatory bowel disease/irritable bowel syndrome, Crohn's disease, Psoriasis, Chronic obstructive pulmonary disease, Systemic lupus erythematosus, transplant rejection and cancer. | 07-01-2010 |
20110015262 | Systems and methods for treating human inflammatory and proliferative diseases, with a combination of compounds, or a bifunctional compound, that provides fatty acid metabolism and glycolysis inhibition - Methods and compositions for treating inflammatory and proliferative diseases, enabling treatment of MDR tumor cells by using combination of compounds, or a bifunctional compound, that inhibits both fatty acid metabolism and glycolysis. In particular, the invention combines or links a glycolysis inhibitor that is, or that is derived from, hypoglycin A (also referred to as hypoglycine A) and a fatty acid metabolism inhibitor. Preferably, the invention provides bifunctional compounds that link a moiety having the functionality of an oxirane carboxylic acid compound to a moiety having the functionality a hypoglycin A derivative. In specific embodiments, the invention provides a bifunctional compound that links a moiety having the functionality of etomoxir to a moiety having the functionality of hypoglycin A. | 01-20-2011 |
20110118175 | COMPETITIVE INHIBITORS OF INVARIANT CHAIN EXPRESSION AND/OR ECTOPIC CLIP BINDING - The invention relates to methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmune disease, cancer, Alzheimer's disease, allergic disease, transplant and cell graft rejection, HIV infection and other viral, bacterial, and parasitic infection, and AIDS. Methods are also provided for preparing a peptide having the property of being able to displace CLIP by feeding one or more peptide sequences into software that predicts MHC Class II binding regions in an antigen sequence and related products. | 05-19-2011 |
20120128724 | SYSTEMS AND METHODS FOR TREATING HUMAN INFLAMMATORY AND PROLIFERATIVE DISEASES AND WOUNDS, WITH FATTY ACID METABOLISM INHIBITORS AND/OR GLYCOLYTIC INHIBITORS - Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherapeutic agents. In preferred embodiments, the invention combines an oxirane carboxylic acid, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and/or an antibody against UCP and/or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers. | 05-24-2012 |
Patent application number | Description | Published |
20130226276 | METHODS AND APPARATUS FOR LUMINAL STENTING - A stent delivery system, a core assembly, and methods of operating the same are provided. The delivery system can comprise a catheter and the core assembly. The core assembly can comprise a constraining member, protruding member, a core member, and a stent extending along the core member. The tubular constraining member can be spaced apart from the core member and define a capture area. The protruding member can be disposed along the core member at least partially distal of the capture area. The stent can have a first portion disposed within the capture area and a second portion, distal to the first portion, extending across or over an outer surface of the protruding member so that the protruding member and the constraining member cooperate to inhibit expansion of the first portion of the stent. | 08-29-2013 |
20130226278 | METHODS AND APPARATUS FOR LUMINAL STENTING - A stent delivery system, a core assembly, and methods of operating the same are provided. The delivery system can comprise a catheter and the core assembly. The core assembly can comprise a constraining member, protruding member, a core member, and a stent extending along the core member. The tubular constraining member can be spaced apart from the core member and define a capture area. The protruding member can be disposed along the core member at least partially distal of the capture area. The stent can have a first portion disposed within the capture area and a second portion, distal to the first portion, extending across or over an outer surface of the protruding member so that the protruding member and the constraining member cooperate to inhibit expansion of the first portion of the stent. | 08-29-2013 |
20130304185 | METHODS AND APPARATUS FOR LUMINAL STENTING - A stent delivery system, a core assembly, and methods of operating the same are provided. The delivery system can comprise a catheter and the core assembly. The core assembly can comprise a constraining member, sleeve, a core member, and a stent extending along the core member. The tubular constraining member can be spaced apart from the core member and define a capture area. The sleeve can be disposed along the core member at least partially distal of the capture area. The stent can have a first portion disposed within the capture area and a second portion, distal to the first portion, extending across or over an outer surface of the sleeve so that the sleeve and the constraining member cooperate to inhibit expansion of the first portion of the stent. | 11-14-2013 |
20140031918 | LUMINAL STENTING - A stent delivery system, a core assembly, and methods of operating the same are provided. The delivery system can comprise a catheter and the core assembly. The core assembly can comprise a constraining member, protruding member, a core member, and a stent extending along the core member. The tubular constraining member can be spaced apart from the core member and define a capture area. The protruding member can be disposed along the core member at least partially distal of the capture area. The stent can have a first portion disposed within the capture area and a second portion, distal to the first portion, extending across or over an outer surface of the protruding member so that the protruding member and the constraining member cooperate to inhibit expansion of the first portion of the stent. | 01-30-2014 |
20140172067 | LUMINAL STENTING - A stent delivery system can include a core member, first and second restraints, and a stent engagement component. The core member can have a distal segment. The first and second restraints can be coupled to the core member distal segment and axially spaced apart from each other to provide an axial gap. The first and second restraints can each have an outer profile that tapers radially inwardly in directions away from the gap. The stent engagement component can be at least partially disposed in the axial gap between the first and second restraints such that the component is slidably and rotatably coupled to the core member distal segment. | 06-19-2014 |
20150066129 | DELIVERY OF MEDICAL DEVICES - A stent delivery system can include a core member, a stent engagement member, and a stent. The core member can have a distal segment. The stent engagement member can have a generally tubular body positioned about the core member distal segment and can be rotatably coupled to the core member. The engagement member can include an inner layer that has a first durometer and an outer layer that has a second durometer less than the first durometer. The stent can extend along the core member distal segment such that an inner surface of the stent is engaged by the engagement member outer layer for facilitating rotation of the stent relative to the core member. | 03-05-2015 |
20150066131 | DELIVERY OF MEDICAL DEVICES - A stent delivery system can include a core member, a stent, and a stent engagement member. The engagement member can be positioned along a distal segment of the core member and be coupled to the core member. The engagement member can have an outer surface. The stent can extending along the core member distal segment such that the outer surface of the engagement member engages an inner surface of the stent along at least a portion of only a distal half of the stent for transmitting an axial force from the core member to only the stent distal half of the stent. | 03-05-2015 |
20150245932 | VASCULAR REMODELING DEVICE - A vascular remodeling device has a plurality of sections, sized for deployment in a blood vessel, that is radially expandable from a collapsed state to an expanded state. Each section has a plurality of interconnected struts that define a waist, a proximal face, and a distal face. Each face comprises (i) a plurality of distal strut portions extending proximally from a distal side of the face, (ii) a plurality of proximal strut portions extending distally from a proximal side of the face, and (iii) a plurality of sub-struts, wherein, from each proximal strut portion, two of the sub-struts each extend to a different one of the distal strut portions. | 09-03-2015 |
20150297383 | LUMINAL STENTING - A stent delivery system can include a core member, first and second restraints, and a stent engagement component. The core member can have a distal segment. The first and second restraints can be coupled to the core member distal segment and axially spaced apart from each other to provide an axial gap. The first and second restraints can each have an outer profile that tapers radially inwardly in directions away from the gap. The stent engagement component can be at least partially disposed in the axial gap between the first and second restraints such that the component is slidably and rotatably coupled to the core member distal segment. | 10-22-2015 |
20160022458 | LUMINAL STENTING - A stent delivery system, a core assembly, and methods of operating the same are provided. The delivery system can comprise a catheter and the core assembly. The core assembly can comprise a constraining member, protruding member, a core member, and a stent extending along the core member. The tubular constraining member can be spaced apart from the core member and define a capture area. The protruding member can be disposed along the core member at least partially distal of the capture area. The stent can have a first portion disposed within the capture area and a second portion, distal to the first portion, extending across or over an outer surface of the protruding member so that the protruding member and the constraining member cooperate to inhibit expansion of the first portion of the stent. | 01-28-2016 |
Patent application number | Description | Published |
20120245674 | VASCULAR REMODELING DEVICE - A vascular remodeling device is provided. The device includes an anchor portion, sized for deployment in a blood vessel, that is radially expandable from a collapsed state to an expanded state. The device also includes a distal portion that is sized for deployment in a blood vessel. The distal portion is radially expandable from a collapsed state to an expanded state and, in some embodiments, has a distal face that is sufficiently occlusive in the distal-to-proximal direction to perform a therapeutic blocking function at an aneurysm. Some embodiments have an intermediate portion that connects a distal end of the anchor portion and a proximal end of the distal portion, and in some embodiments, the anchor portion and distal portion are able to pivot relative to each other at or near the intermediate portion. | 09-27-2012 |
20120245675 | VASCULAR REMODELING DEVICE - A vascular remodeling device is provided. The device has an anchor portion, sized for deployment in a blood vessel, that is radially expandable from a collapsed state to an expanded state. The device also includes a distal portion sized for deployment in a blood vessel. The distal portion is radially expandable from a collapsed state to an expanded state and has a distal face that is sufficiently occlusive in the distal-to-proximal direction to perform a therapeutic blocking function in an aneurysm neck. The device also has an intermediate portion that interconnects a distal end of the anchor portion and a proximal end of the distal portion. In some embodiments, the anchor portion and/or distal portion has a plurality of interconnected struts. | 09-27-2012 |
20130268053 | VASCULAR REMODELING DEVICE - A vascular remodeling device has a plurality of sections, sized for deployment in a blood vessel, that is radially expandable from a collapsed state to an expanded state. Each section has a plurality of interconnected struts that define a waist, a proximal face, and a distal face. Each face comprises (i) a plurality of distal strut portions extending proximally from a distal side of the face, (ii) a plurality of proximal strut portions extending distally from a proximal side of the face, and (iii) a plurality of sub-struts, wherein, from each proximal strut portion, two of the sub-struts each extend to a different one of the distal strut portions. | 10-10-2013 |
20150196345 | CRYOGENIC BALLOON ABLATION SYSTEM - A cryogenic ablation catheter includes a catheter shaft, a balloon and a connector respectively at the catheter shaft proximal and distal ends, a refrigerant delivery tube assembly including a refrigerant delivery tube rotatable within the catheter shaft lumen, and a refrigerant delivery element with an outlet located inside the balloon which directs refrigerant outwardly against the balloon at different rotary positions as it rotates. A cryogenic balloon ablation system includes the cryogenic ablation catheter, a catheter coupler mating with the connector, a motor including a rotatable hollow motor shaft, and a delivery line fluidly coupled to a cryogenic gas source for supplying cryogenic gas to the refrigerant delivery tube. At least one of the refrigerant delivery tube and the delivery line passes at least partway through the hollow motor shaft. The coupling tip of the connector and the refrigerant delivery tube rotate with the motor shaft. | 07-16-2015 |
Patent application number | Description | Published |
20150100793 | Method of Improving FPGA Security Using Authorization Codes - A method for securely programming a population of authorized FPGAs includes defining the population of authorized FPGAs, generating an encrypted configuration bitstream for the population of authorized FPGAs, generating an individual Authorization Code for each FPGA in the population of authorized FPGAs, feeding the individual Authorization Codes into the FPGAs in the population of FPGAs, feeding the encrypted configuration bitstream into all of the FPGAs in the population of FPGAs, and in each FPGA using the Authorization Code to decrypt the encrypted configuration bitstream to program the FPGA. | 04-09-2015 |
20150242615 | METHODS FOR CONTROLLING THE USE OF INTELLECTUAL PROPERTY IN INDIVIDUAL INTEGRATED CIRCUIT DEVICES - A method for controlling the use of intellectual property (IP) in an individual integrated circuit includes loading data including the IP into the individual integrated circuit, loading an IP license certificate into the individual integrated circuit, the certificate including identification of the IP authorized for the individual integrated circuit, determining inside the individual integrated circuit whether the IP is authorized for the individual integrated circuit, enabling operation of the individual integrated circuit if the IP circuit is authorized for use in the individual integrated circuit, and imposing a penalty on operation of the individual integrated circuit if the IP is not authorized for use in the individual integrated circuit. | 08-27-2015 |
20150242620 | METHODS FOR CONTROLLING THE USE OF INTELLECTUAL PROPERTY IN INDIVIDUAL INTEGRATED CIRCUIT DEVICES - A method for controlling the use of intellectual property (IP) in an individual integrated circuit includes loading data including the IP into the individual integrated circuit, loading an IP license certificate into the individual integrated circuit, the certificate including identification of the IP authorized for the individual integrated circuit, determining inside the individual integrated circuit whether the IP is authorized for the individual integrated circuit, enabling operation of the individual integrated circuit if the IP circuit is authorized for use in the individual integrated circuit, and imposing a penalty on operation of the individual integrated circuit if the IP is not authorized for use in the individual integrated circuit. | 08-27-2015 |
20150370247 | IDENTIFYING INTEGRATED CIRCUIT ORIGIN USING TOOLING SIGNATURE - A method for determining if an individual integrated circuit was manufactured using an individual instance of tooling includes collecting from the individual integrated circuit first data representing at least one attribute that varies as a function of the tooling used to manufacture the individual integrated circuit and second data identifying the integrated circuit as having been manufactured using the individual instance of tooling. The first data is compared to a signature of the individual instance of tooling identified by the second data. The signature is derived from the at least one attribute measured from a population of integrated circuits that were manufactured using the individual instance of tooling. The individual integrated circuit is identified as having been manufactured using the individual instance of tooling identified in the second data collected from the individual integrated circuit if the first data correlates to the signature by a predetermined threshold. | 12-24-2015 |
Patent application number | Description | Published |
20110197668 | APPARATUS FOR ADJUSTING FOOT STRUCTURES, FOR DESIGN OF A FOOT ORTHOTIC, AND METHODS OF USE - An apparatus comprised of a plurality of engagement structures independently movable along a longitudinal axis to initially engage a mid-foot region of a foot is described. A center structure or a first set of engagement structures engage the foot in a mid-foot region, and one or more peripheral engagement structures engage the plantar surface in regions surrounding the mid-foot region independent from the structure(s) engaging the mid-foot region. Positional information about the engagement structures is obtained, and a surface map from the positional information is constructed, to determine a profile or contour for an orthotic device in which the foot is in a restored bone state. | 08-18-2011 |
20120071856 | Medical Device and Method for Treatment of a Sinus Opening - A medical device and method for the treatment of a sinus opening includes a handle, a guide catheter, a guide wire, a balloon catheter, a guide wire movement mechanism and a balloon catheter movement mechanism. The handle has proximal and distal ends and a longitudinal axis along the length of the handle. The guide catheter is attached to the distal end of the handle and has a catheter lumen. The guide wire and balloon catheter are both disposed at least partially in the handle and catheter lumen. The guide wire movement mechanism and the balloon catheter movement mechanism are both operatively disposed on the handle. In addition, the guide wire movement mechanism is configured for advancement and retraction of the guide wire through the handle and catheter lumen by user operation of the guide wire movement mechanism. Moreover, the guide wire movement mechanism includes an integrated guide wire locking and rotation mechanism configured for rotation of the guide wire and for securely locking and unlocking the guide wire to the guide wire movement mechanism. Furthermore, the balloon catheter movement mechanism is configured for advancement and retraction of the balloon catheter through the handle and catheter lumen by user operation of the balloon catheter movement mechanism. | 03-22-2012 |
20140074141 | INFLATOR FOR DILATION OF ANATOMICAL PASSAGEWAY - A dilation catheter system is provided to dilate the ostium of a paranasal sinus or some other anatomical passageway (e.g., within the ear, nose, or throat, etc.). The system may include a dilation catheter, a dilator, a guide catheter, and an inflator. The dilation catheter may be positioned between the dilator and the inflator. The guide catheter is configured to guide the dilator into the affected passageway. The inflator may then be actuated to transfer fluid from the inflator, through the dilation catheter, and into the dilator. The transfer of fluid may inflate the dilator to an expanded state to open or dilate the affected passageway. The inflator may include a body, a plunger assembly, and locking features that selectively secure the position of the plunger assembly relative to the body by moving along a path that is transverse to a longitudinal axis defined by the plunger assembly. | 03-13-2014 |
20140316443 | METHOD AND APPARATUS FOR PASSING SUTURE - A device is disclosed that can pierce and hold tissue and then pass suture through tissue. The device can have a shuttle that can removably attach to a suture and jaws that can be rotatably opened and closed with respect to each other. A method for using the device to repeatedly pass the suture through the tissue without removing the suture or device from the target site is also disclosed. | 10-23-2014 |
20140360033 | APPARATUS FOR ADJUSTING FOOT STRUCTURES, FOR DESIGN OF A FOOT ORTHOTIC, AND METHODS OF USE - An apparatus comprised of a plurality of engagement structures independently movable along a longitudinal axis to initially engage a mid-foot region of a foot is described. A center structure or a first set of engagement structures engage the foot in a mid-foot region, and one or more peripheral engagement structures engage the plantar surface in regions surrounding the mid-foot region independent from the structure(s) engaging the mid-foot region. Positional information about the engagement structures is obtained, and a surface map from the positional information is constructed, to determine a profile or contour for an orthotic device in which the foot is in a restored bone state. | 12-11-2014 |
Patent application number | Description | Published |
20090327117 | Apparatus and Method for Trade Aggregation of Trade Allocations and Settlements - A post-trade aggregation system includes an allocation middleware interface, which interacts with an order management system to allocate and settle trades. The order management system receives a trade order on behalf of a customer and either apportions the trade into a plurality of smaller orders and communicates them to a plurality of order destinations directly (e.g. via the FIX protocol), or sends large orders to an order staging and optimization interface which then apportions the larger orders into a plurality of smaller orders and communicates the orders to a plurality of order destinations. The post-trade aggregation system contains an allocation middleware interface which receives the individual trade executions from the plurality of order destination and compresses them into a single average-priced block. The allocation middleware interface then sends the single average-priced block to be cleared by a designated clearing agent and allocates the single average-priced block into one or more custodian accounts. In further aspects, a method and apparatus are also provided. | 12-31-2009 |
20100332375 | Apparatus and Method for Trade Aggregation of Trade Allocations and Settlements - A post-trade aggregation system includes an allocation middleware interface, which interacts with an order management system to allocate and settle trades. The order management system receives a trade order on behalf of a customer and either apportions the trade into a plurality of smaller orders and communicates them to a plurality of order destinations directly (e.g. via the FIX protocol), or sends large orders to an order staging and optimization interface which then apportions the larger orders into a plurality of smaller orders and communicates the orders to a plurality of order destinations. The post-trade aggregation system contains an allocation middleware interface which receives the individual trade executions from the plurality of order destination and compresses them into a single average-priced block. The allocation middleware interface then sends the single average-priced block to be cleared by a designated clearing agent and allocates the single average-priced block into one or more custodian accounts. In further aspects, a method and apparatus are also provided. | 12-30-2010 |
20130144773 | APPARATUS AND METHOD FOR TRADE AGGREGATION OF TRADE ALLOCATIONS AND SETTLEMENTS - A post-trade aggregation system for financial instrument trading systems, wherein a trader manages a plurality of trade orders to be executed by one or more executing brokers on behalf of customers via a data interface system. The plurality of trade orders includes at least one wrap block order and at least one institutional block order. The plurality of trade orders are merged into a single merged block order, apportioned into a plurality of smaller electronic trade orders, and transmitted to a plurality of order destinations. One or more computer systems are in electronic communication with the data interface system and with a clearing system, and configured to compress individual executions from the plurality of order destinations corresponding to the plurality of smaller electronic trade orders into a single net marked-up step-out for wrap orders and a single average-priced block for institutional orders. | 06-06-2013 |
20150178839 | APPARATUS AND METHOD FOR TRADE AGGREGATION OF TRADE ALLOCATIONS AND SETTLEMENTS - A post-trade aggregation system includes an allocation middleware interface, which interacts with data interface to allocate and settle trades. An order management system receives a trade order on behalf of a customer and causes apportionment of the trade into a plurality of smaller orders to be transmitted to a plurality of order destinations directly (e.g. via the FIX protocol). The post-trade aggregation system includes an allocation middleware interface which receives the individual trade executions from the plurality of order destination and compresses them into a single average-priced block. The allocation middleware interface then transmits the single average-priced block to be cleared by a designated clearing agent and allocates the single average-priced block into one or more custodian accounts. | 06-25-2015 |