Patent application number | Description | Published |
20130022612 | METHODS AND COMPOSITIONS FOR MALARIA PROPHYLAXIS - A composition for preventing malaria infection including a steric inhibitor of circumsporozoite protein cleavage. A pharmaceutical composition for preventing malaria infection including a steric inhibitor and a pharmaceutical carrier. A method of malaria infection prophylaxis including the step of administering an effective amount of the composition of the present invention. A method of malaria prophylaxis by sterically inhibiting circumsporozoite protein processing or by directly inhibiting a protease of a sporozoite from binding to its target. Methods of preventing sporozoite cell invasion or preventing circumsporozoite processing through steric or direct inhibition. | 01-24-2013 |
20130045216 | Method for Treating Amyloid Disease - Disclosed herein are methods for treating amyloid disease in humans by clearing amyloid peptides from one or more bodily fluids such as, e.g., blood, of a patient. In particular, the methods are based on the administration of compounds capable of binding to amyloid-beta (Aβ) or on dialysis of blood or plasma exchange in order to remove Aβ peptides from the blood circulation, and/or brain or other affected organs. | 02-21-2013 |
20130079385 | USP47 Inhibtors and Methods to Induce Apoptosis - The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain embodiments, the invention relates to methods and kits to screen for related agents that induce apoptosis. Additionally, the invention relates to assays for screening compounds capable of acting as USP47 inhibitors. | 03-28-2013 |
20130090255 | Biological Markers of Chronic Wound Tissue and Methods of Using for Criteria in Surgical Debridement - The present invention relates to methods for identifying tissue sites in a chronic wound that are suitable for debridement and whether debridement procedure has been successful using particular biological markers of the cells within the tissue sites of the chronic wounds. | 04-11-2013 |
20130121067 | HIGH SPEED LOW POWER MAGNETIC DEVICES BASED ON CURRENT INDUCED SPIN-MOMENTUM TRANSFER - A high speed, low power method to control and switch the magnetization direction and/or helicity of a magnetic region in a magnetic device for memory cells using spin polarized electrical current. The magnetic device comprises a reference magnetic layer with a fixed magnetic helicity and/or magnetization direction and a free magnetic layer with a changeable magnetic helicity and/or magnetization direction. The fixed magnetic layer and the free magnetic layer are preferably separated by a non-magnetic layer. The fixed and free magnetic layers may have magnetization directions at a substantially non-zero angle relative to the layer normal. A current can be applied to the device to induce a torque that alters the magnetic state of the device so that it can act as a magnetic memory for writing information. The resistance, which depends on the magnetic state of the device, is measured to read out the information stored in the device. | 05-16-2013 |
20130123306 | Inhibition of Mitogen-activated Protein Kinases in Cardiovascular Disease - The present invention relates to methods for inhibiting subacute thrombosis and/or intimal hyperplasia following an interventional vascular procedure by contacting a blood vessel or a synthetic material with a mitogen-activated protein kinase (MAPK) pathway inhibitor. The present invention further relates to vascular devices comprising a MAPK pathway inhibitor. | 05-16-2013 |
20130137754 | TUMOR THERAPY WITH REPLICATION COMPETENT SINDBIS VIRAL VECTORS - Disclosed herein are methods for treating a mammal harboring a solid tumor which expresses higher levels of High Affinity Laminin Receptors (LAMR) than normal cells of the same lineage comprising systematically administering to a mammal in need of such treatment a therapeutically effective amount of a Replication Competent (RC) Sindbis virus vector, wherein said vector encodes a suicide gene. | 05-30-2013 |
20130143632 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR GENERATING A PUZZLE GAME USING VARIOUS EXEMPLARY PROPERTIES OF THE VISUAL WORLD - Exemplary systems, methods and computer-accessible mediums can be provided for generating and playing a game or a puzzle. For example, it is possible to determine at least one game symbol corresponding to a portion of a gestalt figure for each location in a grid. Further, it is possible to provide, to a player, at least one hint or other information about a location of each symbol in the grid. A guess and/or a response as to a content of the location of each symbol can be received from the player. | 06-06-2013 |
20130144183 | System and Method for Guidance of Anesthesia, Analgesia and Amnesia - Method for determining anesthesia dosage includes following steps. First Interventional Agent (“FIA”) is administered to Patient at a first rate to achieve First Predetermined Plane of Anesthesia (“FPPA”). Brain waves of Patient are analyzed to formulate First Set of Data (“FSD”) corresponding to a self-norm during administration of FIA. First transfer function corresponding to patient biochemical reactions to FIA is computed from FSD. Rate of administration of FIA to Patient is altered by a selected amount after achievement of FPPA for first time required for Patient to deviate from FPPA by predetermined degree. An altered amount of FIA required to cause the predetermined deviation is determined as difference between amount of FIA that would have been delivered to Patient during first time at the first rate and an amount delivered to Patient during the first time at the altered rate. Patient is administered the altered amount of FIA. | 06-06-2013 |
20130146057 | System and Method for Circuits to Allow CPAP to Provide Zero Pressure - A system comprises a respiratory delivery arrangement adapted to cover at least one respiratory orifice of a patient. The system also comprises a first conduit having a first end and a second end, the second end connected to the respiratory delivery arrangement. A positive pressure is provided to the respiratory orifice via the first conduit and a second conduit having a third end and a fourth end, the fourth end connected to the respiratory delivery arrangement. An exhaled gas is extracted from the respiratory orifice by one or both of a valve configured to redirect flow through the respiratory delivery arrangement and a venturi opening. | 06-13-2013 |
20130147597 | Song Selection Based upon Axial Pen Pressure - Methods, systems, and apparatuses, including computer programs encoded on computer readable media, for determining, using a pressure sensor, pressure data comprising a pressure indication and a time indication. A first mood is determined based upon the pressure data and one or more songs are selected based upon the determined first mood. A playlist is modified based upon the selected one or more songs, wherein the modified playlist comprises the selected one or more songs and the modified playlist is played. Song data, based upon the modified playlist, is wirelessly transmitted to a remote device. | 06-13-2013 |
20130150283 | SHORT PEPTIDES USEFUL FOR TREATMENT OF ISCHEMIA/REPERFUSION INJURY AND OTHER TISSUE DAMAGE CONDITIONS ASSOCIATED WITH NITRIC OXIDE AND ITS REACTIVE SPECIES - This invention discloses isolated short peptides comprising the amino acid sequence Cys-Glu-Phe-His (CEFH; SEQ ID NOS: 1 and 15) and analogs thereof as well as compositions comprising CEFH peptides and analogs thereof. The CEFH peptides disclosed herein are effective in mediating the denitration of 3-nitrotyrosines (3-NT) in cellular proteins thereby preventing tissue damage associated with excess nitric oxide (NO) and its reactive species. The CEFH peptides disclosed herein are useful in the treatment of ischemia/reperfusion (I/R) injury and other disorders. | 06-13-2013 |
20130156783 | IMMUNOTHERAPY TARGETING OF THE SHARED ABNORMAL CONFORMATIONAL STATE OF AMYLOIDOGENIC PEPTIDES/PROTEINS - The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease. | 06-20-2013 |
20130164884 | ASSEMBLY OF QUASICRYSTALLINE PHOTONIC HETEROSTRUCTURES - A method and system for assembling a quasicrystalline heterostructure. A plurality of particles is provided with desirable predetermined character. The particles are suspended in a medium, and holographic optical traps are used to position the particles in a way to achieve an arrangement which provides a desired property. | 06-27-2013 |
20130166226 | APPARATUS, SYSTEM, METHOD AND COMPUTER-READABLE MEDIUM FOR ISOLATING CHEMICAL EXCHANGE SATURATION TRANSFER CONTRAST FROM MAGNETIZATION TRANSFER ASYMMETRY UNDER TWO-FREQUENCY RF IRRADIATION - Apparatus, system, method and computer-readable medium for isolating chemical exchange saturation transfer contrast from magnetization transfer asymmetry under two-frequency RF irradiation. A two-pool model for magnetization transfer (MT) can be established fully based on Provotorov's theory of saturation, and then extended to the situation of simultaneous two-frequency RF irradiation. Numerical simulations and experimental results demonstrate that two-frequency RF irradiation can make MT effects independent of irradiation frequency over a wide range, and thus can suppress MT asymmetry. Exemplary embodiments can be provided to isolate chemical exchange saturation transfer (CEST) contrast from MT asymmetry contrast by using the two-frequency RF irradiation technique. A further embodiment can isolate a narrow-frequency spectrum MT mechanism from a broad-frequency spectrum MT mechanism. | 06-27-2013 |
20130171136 | Methods of Treating Giant Cell Arteritis With Anti-TNF Alpha Antibodies - Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided. | 07-04-2013 |
20130172275 | INHIBITING BINDING OF FGF23 TO THE BINARY FGFR-KLOTHO COMPLEX FOR THE TREATMENT OF HYPOPHOSPHATEMIA - The present invention is directed to a method of treating hypophosphatemia in a subject. This method involves selecting a subject with hypophosphatemia associated with elevated or normal FGF23 and administering to the selected subject an inhibitor of FGF23-Klotho-FGF receptor complex formation under conditions effective to treat the hypophosphatemia. The present invention is also directed to a method of screening for compounds suitable for treatment of hypophosphatemia associated with elevated or normal FGF23. This method involves providing FGF23, FGFR-Klotho complex, and one or more candidate compounds. The FGF23, the FGFR-Klotho complex, and the candidate compounds are combined under conditions effective for the FGF23 and the binary FGFR-Klotho complex to form a ternary complex if present by themselves. This method also involves identifying the candidate compounds, which prevent formation of the complex as being potentially suitable in treating hypophosphatemic conditions associated with elevated or normal FGF23. A method of screening the specificity of compounds which prevent formation of the FGF23-Klotho-FGFR complex is also disclosed. | 07-04-2013 |
20130183298 | Methods of Treating Hepatitis With Anti-TNF alpha Antibodies - Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided. | 07-18-2013 |
20130184211 | INHIBITING BINDING OF FGF23 TO THE BINARY FGFR-KLOTHO COMPLEX FOR THE TREATMENT OF HYPOPHOSPHATEMIA - The present invention is directed to a method of treating hypophosphatemia in a subject. This method involves selecting a subject with hypophosphatemia associated with elevated or normal FGF23 and administering to the selected subject an inhibitor of FGF23-Klotho-FGF receptor complex formation under conditions effective to treat the hypophosphatemia. The present invention is also directed to a method of screening for compounds suitable for treatment of hypophosphatemia associated with elevated or normal FGF23. This method involves providing FGF23, FGFR-Klotho complex, and one or more candidate compounds. The FGF23, the FGFR-Klotho complex, and the candidate compounds are combined under conditions effective for the FGF23 and the binary FGFR-Klotho complex to form a ternary complex if present by themselves. This method also involves identifying the candidate compounds, which prevent formation of the complex as being potentially suitable in treating hypophosphatemic conditions associated with elevated or normal FGF23. A method of screening the specificity of compounds which prevent formation of the FGF23-Klotho-FGFR complex is also disclosed. | 07-18-2013 |
20130185014 | SYSTEMS, PROCESSES AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING A BI-DIRECTIONAL SCAN PATH FOR PEAK CAPTURE POWER REDUCTION IN LAUCH-OFF-SHIFT TESTING - Exemplary systems, methods and computer-readable mediums can assign, from the circuit, at least two scan cells as at least two interface registers, and generate at least one bidirectional scan path between the at least two interface registers of the at least one portion of the circuit. The at least two interface registers can be disposed in neighboring positions, and the assigning can include a partitioning procedure that can iteratively merge the scan cells of the at least one portion of the circuit into a plurality of regions. | 07-18-2013 |
20130194646 | OPTICAL CONVEYORS - Optical conveyors providing motive force to objects. The optical conveyors are one-sided and are able to exert forces on illuminated objects that are directed opposite to the direction of the light's propagation. | 08-01-2013 |