Neupert
Christine Neupert, Zuerich CH
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20110207214 | NOVEL TOOLS FOR THE PRODUCTION OF GLYCOSYLATED PROTEINS IN HOST CELLS - The invention improves glycoprotein production and protein glycosylation engineering in eukaryotes, specifically the production of human-like complex or hybrid glycosylated proteins in lower eukaryotes such as yeasts. The invention provides glycosylation modified eukaryotic host cells capable of producing glycosylation optimized proteins useful as immunoglobulins and other therapeutic proteins, and provides cells capable of producing glycoproteins having glycan structures similar to glycoproteins produced in human cell. The invention further provides proteins with human-like glycan structures and novel compositions thereof producible by these cells. | 08-25-2011 |
Hannes Neupert, Tanna DE
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20130314205 | MODULAR VEHICLE SYSTEM, ELECTRIC VEHICLE AND MODULE FOR CONNECTING TO AN ELECTRIC VEHICLE - The invention relates to a modular vehicle system, having an electric vehicle ( | 11-28-2013 |
Joerg Neupert, Korntal-Muenchingen DE
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20100230370 | Crane control with active heave compensation - The present invention represents a procedure for compensating the heave movement of offshore cranes. The dynamic model of the compensation actuator (hydraulically operated winch) and the load hanging on a rope are derived. Based on this model, a path-tracking control unit is developed. To compensate the movement of the ship/watercraft caused by waves, the heave movement is defined as a time-varying disturbance and is analyzed with respect to uncoupling conditions. With a model expansion, these conditions are satisfied, and an inversion-based uncoupling control law is formulated. To stabilize the system, an observer is used for reconstructing the unknown state by means of a force measurement. Furthermore, the compensation efficiency can be improved by predicting the heave movement. There is proposed a prediction method in which no ship/watercraft models or properties are required. The simulation and measurement results validate the heave compensation method. | 09-16-2010 |
20110006025 | CRANE FOR HANDLING A LOAD HANGING ON A LOAD CABLE - The present invention relates to a crane for handling a load hanging on a load cable, comprising a slewing gear for rotating the crane, a luffing gear for luffing up the boom, and a hoisting gear for lowering or lifting the load hanging on the load cable, with a control unit for calculating the actuation of slewing gear, luffing gear and/or hoisting gear, wherein the calculation of the actuation commands for actuating slewing gear, luffing gear and/or hoisting gear is effected on the basis of a desired movement of the load indicated in Cartesian coordinates. | 01-13-2011 |
Jorg Neupert, Korntal-Munchingen DE
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20090008351 | Crane control, crane and method - The present invention shows a crane control of a crane which includes at least one cable for lifting a load, wherein at least one sensor unit is provided for determining a cable angle relative to the direction of gravitational force. Furthermore, there is shown a crane control for driving the positioners of a crane which includes at least one first and one second strand of cables for lifting the load, with a load oscillation damping for damping spherical pendular oscillations of the load, wherein first and second sensor units are provided, which are associated to the first and second strands of cables, in order to determine the respective cable angles and/or cable angular velocities, and the load oscillation damping includes a control in which the cable angles and/or cable angular velocities determined by the first and second sensor units are considered. Furthermore, a corresponding crane and a method are shown. | 01-08-2009 |
Juliane Neupert, Postdam DE
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20110207117 | GENERATION OF PRODUCTION STRAINS THAT EFFICIENTLY EXPRESS NUCLEAR TRANSGENES - The present invention relates to a method of generating eukaryotic cells suitable for the expression of transgenes in said cells comprising (a) introducing a nucleic acid encoding a selectable marker responsive to a selecting agent into the nucleus of cells, wherein the level of expression of said selectable marker is proportional to the level of phenotypic responsiveness to said selecting agent; (b) selecting, among the cells obtained in step (a), for cells with a detectable expression of said selectable marker; (c) optionally propagating the cells selected for in step (b); (d) mutagenizing the cells selected for in step (b) or propagated in step (c) or allowing for the appearance of spontaneous mutations in the cells selected for in step (b) or propagated in step (c); and (e) selecting for cells displaying an increased expression of said selectable marker compared to the expression obtained in step (b). The present invention furthermore relates to a eukaryotic cell produced by the method of the present invention, a method of producing a compound of interest in a cell produced with the method of the present invention comprising (a) introducing a nucleic acid encoding (i) the compound of interest which is a protein or an RNA; or (ii) a protein necessary to synthesize said compound of interest; and optionally a selectable marker responsive to a selecting agent into said cell; (b) expressing said protein in the cell; and (c) isolating the compound of interest produced; and a kit comprising (a) a cell obtainable by the method of the invention and optionally a vector optimized for protein expression in said cell; or (b) the cell of the invention. | 08-25-2011 |
Klaus Neupert, Pocking DE
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20130119830 | FLUID-COOLED ELECTRIC MACHINE - A fluid-cooled electric machine includes a fluid circuit and an integrated pump element which executes a pumping action to conduct fluid through the fluid circuit as a result of a rotational movement of the electric machine. The electric machine includes a stator and a rotor arranged to demarcate with the stator a conical air gap which is flooded with fluid. | 05-16-2013 |
Stephan Neupert, Stuttgart DE
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20120244449 | CONTAINER ARRANGEMENT FOR A FUEL CELL SYSTEM, AND METHOD FOR INTRODUCING AN ION EXCHANGE MODULE IN A COOLANT CONTAINER - A container arrangement ( | 09-27-2012 |
Walter Neupert, Germering DE
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20100209436 | METHOD FOR TREATING DISEASES RELATED TO MITOCHONDRIAL DYSFUNCTION - The present invention relates to means and methods for therapeutic intervention of mitochondrial disorders or diseases, in particular to a method for the treatment, prevention and/or amelioration of a disorder or disease correlated with mitochondrial dysfunction, a mitochondrial disorder or disease or a disorder or disease characterized by an altered OPA1 processing. Thereby, a pharmaceutically active amount of a compound capable of modulating the activity of an oligomeric complex comprising Afg3I1 and/or Afg3I2 or (a) variant(s) thereof is administered to a patient in need of medical intervention. The present invention also relates to the use of an oligomeric complex comprising Afg3I1 and/or Afg3I2 or (a) variant(s) thereof for the preparation of a pharmaceutical composition for the mentioned therapeutic intervention. The present invention further relates to a method of screening for a compound capable of modulating the activity of an oligomeric complex comprising Afg3I1 and/or Afg3I2 or (a) variant(s) thereof comprising the use of OPA1. | 08-19-2010 |
Werner Neupert, Rheinfelden DE
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20100010232 | Aryl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives - The present invention relates to the use of acyl derivatives of curcumin, desmethoxy curcumin and bisdesmethoxy curcumin and of curcuminisoxazolide as components of animal feed or feed additives for the improvement of animal performance and the new acyl derivatives per se as well as the corresponding animal feed or feed additives containing them. | 01-14-2010 |