Nelson, PA
Amanda Nelson, Hummelstown, PA US
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20090311213 | METHODS AND COMPOSITIONS FOR TREATMENT OF RETINOID-RESPONSIVE CONDITIONS - Methods and composition for treating a retinoid-responsive condition in a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a substance selected from the group consisting of: neutrophil gelatinase-associated lipocalin (NGAL), an NGAL analog, an NGAL stimulator and an analog of an NGAL stimulator, to a subject having a retinoid-responsive condition. Retinoid-responsive conditions illustratively include acne, rosacea, psoriasis, promyelocytic leukemia and neuroblastoma. | 12-17-2009 |
20130022685 | Topical Compositions and Methods of Detection and Treatment - A topical composition includes a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein. The hydrophobic particles are derived from the same or different hydrophobic material and each hydrophobic particle has a melting point below the melting point of the respective hydrophobic material. The hydrophobic particles comprise a mean particle size of less than about 10 nm, and the nanoemulsion further includes one or more pharmaceutically active agents. | 01-24-2013 |
Carl D. Nelson, Beaver, PA US
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20090045892 | CIRCUIT BREAKER WITH ARTICULATING CONTROL CABINET - A circuit breaker is provided having three horizontal circuit breakers coupled together with a base housing. Each of the horizontal circuit breakers comprising a tank secured in the housing, first and second current transformers extending from the tank and exit and entrance insulators extending from the first and second current transformers. The housing is mountable on a support frame. To facilitate shipping and field assembly, the circuit breaker includes an control panel moveably coupled to the housing. | 02-19-2009 |
Clara E. Nelson, Pittsburgh, PA US
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20090062533 | NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS - Described are naphthols useful in the manufacture of novel indeno-fused photochromic naphthopyran materials. | 03-05-2009 |
David E. Nelson, Hershey, PA US
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20120197002 | METHOD OF THERMOFORMING COPOLYESTERS - A method of preventing bubble formation during or after thermoforming polyester sheet comprising heating the polyester sheet to about 100-165° F. for at least about 1 hour prior to thermoforming the sheet. | 08-02-2012 |
David M. Nelson, Allentown, PA US
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20110024664 | NEEDLELESS ACCESS PORT VALVES - Needleless access port valves are generally discussed herein with particular discussions extended to needleless access port valves incorporating a piston comprising slit along an upper piston section for accommodating fluid flow. The slit opens when the piston is compressed by a medical implement, such as a syringe tip, to permit fluid communication between the inlet and the outlet of the vale housing. The slit may be cut using high frequency cutting machine or a multi-axis robot arm and a cutting blade. | 02-03-2011 |
David Scott Nelson, Easton, PA US
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20120055592 | Method of Metal Processing Using Cryogenic Cooling - Described herein are a method, an apparatus, and a system for metal processing that improves one or more properties of a sintered metal part by controlling the process conditions of the cooling zone of a continuous furnace using one or more cryogenic fluids. In one aspect, there is provided a method comprising: providing a furnace wherein the metal part is passed therethough on a conveyor belt and comprises a hot zone and a cooling zone wherein the cooling zone has a first temperature; and introducing a cryogenic fluid into the cooling zone where the cryogenic fluid reduces the temperature of the cooling zone to a second temperature, wherein at least a portion of the cryogenic fluid provides a vapor within the cooling zone and cools the metal parts passing therethrough at an accelerated cooling rate. | 03-08-2012 |
Donald W. Nelson, Murrysville, PA US
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20100064458 | SCRATCH AND DISPOSE APPARATUS - An apparatus for scratching and disposing a scratch-off coating that conceals information on a paper is provided. The apparatus includes a panel, one or more scratch tools, a brush and a debris unit. The panel includes a base and a plurality of walls. The plurality of walls is configured along a periphery of the base to form an enclosed area therebetween for accommodating the paper. The paper is accommodated within the enclosed area, and the scratch-off coating is scratched using the one or more scratch tools. The one or more scratch tools are capable of being contained within the panel. Scratching the scratch-off coating forms debris. The debris formed is swept using a brush. The brush is capable of being contained within the panel. The swept debris is received and contained in the debris unit that is coupled to a first wall of the plurality of walls. | 03-18-2010 |
Greg Nelson, Bethlehem, PA US
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20140276892 | DRIVER ASSEMBLY WITH GUIDEWIRE CONTROL MECHANISM - An implant driver assembly includes an assembly for advancing a threaded implant over a wire. The assembly may include a driver tool with a proximal end, a distal end and a first engagement surface that has a first thread. The driver tool may also include a first wire passage. The assembly may further include a wire locking mechanism with a second engagement surface having a second thread. The second thread is engaged with the first thread to rotatably couple the wire locking mechanism with the driver tool. The wire locking mechanism may further include a second wire passage. The second wire passage may be substantially coaxially aligned with the first wire passage. | 09-18-2014 |
Gregory Nelson, Center Valley, PA US
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20150066089 | ROD PERSUADER, SYSTEM AND METHOD - A spinal rod persuader, system and method can include an outer tube, an inner tube, and a locking element. A first actuation mechanism can be movable in a linear fashion along a longitudinal axis direction to cause the locking element to move in a linear fashion over the inner tube and to lock the inner tube onto a pedicle screw. A second actuation mechanism can be rotated to cause the outer tube to move in a longitudinal axis direction with respect to the inner tube to push the spinal rod into a final position with respect to the pedicle screw while the pedicle screw is locked to the inner tube. A slot and/or tab structure can be provided in the outer tube such that actuation of the slot/tab will allow disassembly of the inner tube, outer tube and locking element with respect to each other. | 03-05-2015 |
James R. Nelson, Annville, PA US
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20110036823 | SYSTEM AND METHOD FOR SNOW AND ICE REMOVAL - A system and method for removing frozen precipitation that has accumulated on a surface of a road vehicle is disclosed. The system includes a heating array attached to the surface and a power source. When energized by the power source, the heating array generates heat that melts the frozen precipitation from the surface. | 02-17-2011 |
20110259866 | SYSTEM FOR SNOW AND ICE REMOVAL - A system for removing frozen precipitation that has accumulated on a surface of a road vehicle is disclosed. In an embodiment, the system includes a hydrophobic and/or low friction sheet attached to an upper surface of the road vehicle. The system may further include a heating array attached to the surface and a power source. | 10-27-2011 |
20140217079 | SYSTEM FOR SNOW AND ICE REMOVAL - A system for removing frozen precipitation that has accumulated on an upper exterior surface of a road vehicle. In an embodiment, the system includes a hydrophobic and/or low friction sheet attached to an upper exterior surface of the road vehicle. The system may further include a heating array attached to the surface and a power source. | 08-07-2014 |
Jeremy Richard Nelson, Upper Black Eddy, PA US
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20150177608 | AUTO STEREOSCOPIC PROJECTOR SCREEN - A projector system using a screen comprised of either a plurality of miniature, reflective, and concave or convex curved surfaces that are arranged in a pattern to create a screen surface for front projection, or a plurality of miniature, transparent, and curved convex or concave lenses that are arranged in a pattern to create a screen surface for rear projection, and a projector system with the pixel capacity to control the color and brightness focused onto many different subsections of each curved surface. Each curved lens or curved mirror surface is small enough so that when viewed from the viewing area, the lit and unlit areas seen within each individual curved surface blend together so that only the average brightness and color of each curved surface can be seen by a viewer. By controlling the subsections of each curved surface with focused light from a high resolution projector, the system can control the image the viewer sees in their left eye separately from their right eye and the viewer can see stereographic images without the need to wear filtering glasses. With inclusion of an external head tracking system, the left/right images for each subsection can be switched as needed when one or multiple viewers move their head or seating position within the viewing area. | 06-25-2015 |
Joel B. Nelson, Pittsburgh, PA US
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20150050647 | Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse - The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a rapid relapse, of his cancer. It is based, at least in part, on the results of a comprehensive genome analysis on 241 prostate cancer samples (104 prostate cancer, 85 matched bloods, 49 matched benign prostate tissues adjacent to cancer, and 3 cell lines) which indicate that (i) genome copy number variation (CNV) occurred in both cancer and non-cancer tissues, and (ii) CNV predicts prostate cancer progression. | 02-19-2015 |
Joel Byron Nelson, Pittsburgh, PA US
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20130079241 | Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse - The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a rapid relapse, of his cancer. It is based, at least in part, on the results of a comprehensive genome analysis on 241 prostate cancer samples (104 prostate cancer, 85 matched bloods, 49 matched benign prostate tissues adjacent to cancer, and 3 cell lines) which indicate that (i) genome copy number variation (CNV) occurred in both cancer and non-cancer tissues, and (ii) CNV predicts prostate cancer progression. | 03-28-2013 |
20140371235 | SMALL MOLECULES TARGETING ANDROGEN RECEPTOR NUCLEAR LOCALIZATION AND/OR LEVEL IN PROSTATE CANCER - A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: | 12-18-2014 |
John S. Nelson, Harrisburg, PA US
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20140130943 | Method of Making High Strength Steel Crane Rail - A method of making a high strength head-hardened crane rail and the crane rail produced by the method. The method comprises the steps of providing a steel rail having a composition comprising, in weight percent: C, 0.79-1.00%; Mn, 0.40-1.00; Si, 0.30-1.00; Cr, 0.20-1.00; V, 0.05-0.35; Ti, 0.01-0.035; N, 0.002 to 0.0150; and the remainder being predominantly iron. The steel rail is cooled from a temperature between about 700 and 800° C. at a cooling rate having an upper cooling rate boundary plot defined by an upper line connecting xy-coordinates (0 s, 800° C.), (40 s, 700° C.), and (140 s, 600° C.) and a lower cooling rate boundary plot defined by a lower line connecting xy-coordinates (0 s, 700° C.), (40 s, 600° C.), and (140 s, 500° C.). | 05-15-2014 |
Joseph Nelson, Greensburg, PA US
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20110027021 | CUTTING INSERT WITH INTERNAL COOLANT DELIVERY AND CUTTING ASSEMBLY USING THE SAME - A metalcutting insert that is useful in chipforming and material removal from a workpiece The metalcutting insert includes a metalcutting insert body, which includes a cutting edge having at least one discrete cutting location. The metalcutting insert body further contains a distinct interior coolant passage communicating with the discrete cutting location. The distinct interior coolant passage has a coolant passage inlet defining a coolant passage inlet cross-sectional area, a coolant passage discharge defining a coolant passage discharge cross-sectional area, and an axial coolant passage length. The distinct interior coolant passage defines a coolant flow cross-sectional area along the axial coolant passage length thereof. The coolant passage inlet cross-sectional area is substantially the same as the coolant passage discharge cross-sectional area. The geometry of the coolant flow area changes along the axial coolant passage length. | 02-03-2011 |
Joseph V. Nelson, Greensburg, PA US
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20100172704 | CUTTING INSERT WITH COOLANT DELIVERY AND METHOD OF MAKING THE CUTTING INSERT - An assembly of components for forming upon consolidation of the components a cutting insert for use in chipforming and material removal from a workpiece wherein the cutting insert receives coolant from a coolant source. The assembly comprises a cavity member that presents opposite first and second rake surfaces and a flank surface. The cavity member further presents a first cutting edge at the juncture of the first rake surface and the flank surface. The cavity member further has a first depression in the first rake surface that is generally adjacent to the first cutting edge. The cavity member has a first cavity channel in communication with the first depression. The assembly also has a first core member that has a first core channel and a first flange wherein when the components are assembled, the first core channel is adjacent to the first cavity channel and the first flange is adjacent to the first depression. The assembly also has a second core member which has a second flange containing a fifth notch and the second core member further containing a fifth notch channel opening into the fifth notch. When the components are assembled, the fifth notch is adjacent to the second rake surface and the fifth notch channel is adjacent to the first cavity channel. Upon consolidation of the components, the cavity member, the first core member and the second core member join together so that the first depression and the first flange define a first fluid spray chamber, and the first cavity channel and the first core channel and the fifth notch channel join together to form a fifth internal fluid passageway, which provides fluid communication from the fifth notch adjacent to the second rake surface to the first fluid spray chamber adjacent to the first rake surface. | 07-08-2010 |
20110020072 | SHIM FOR A CUTTING INSERT AND CUTTING INSERT-SHIM ASSEMBLY WITH INTERNAL COOLANT DELIVERY - A cutting insert-shim assembly that has a cutting insert with a bottom surface and a plurality of interior coolant passages wherein each interior coolant passage has a coolant inlet in the bottom surface of the cutting insert. The shim has a first side surface and a second side surface and contains a cavity, which communicates with the coolant conduit. The cavity defines a first opening in the first side surface and a second opening in the second side surface. When the shim is in a first condition, the first side surface contacts the bottom surface of the cutting insert and the first opening provides a first level of coolant communication to the interior coolant passages in the cutting insert. When the shim is in a second condition, the second side surface contacts the bottom surface of the cutting insert and the second opening provides a second level of coolant communication to the interior coolant passages in the cutting insert. | 01-27-2011 |
Kevin G. Nelson, West Pittston, PA US
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20100136223 | METHODS AND COMPOSITIONS FOR DIELECTRIC MATERIALS - The present invention comprises methods and compositions of dielectric materials. The dielectric materials of the present invention comprise materials having a dielectric constant of more than 1.0 and less than 1.9 and/or a dissipation factor of less than 0.0009. Other characteristics include the ability to withstand a wide range of temperatures, from both high temperatures of approximately +260° C. to low temperatures of approximately −200° C., operate in wide range of atmospheric conditions and pressures (e.g., a high atmosphere, low vacuum condition such as that found in the outer-space as well as conditions similar to those found at sea level or below sea level). The dielectric materials of the present invention may be used in the manufacture of composite structures that can be used alone or in combination with other materials, and can be used in electronic components or devices such as RF interconnects. | 06-03-2010 |
20110149528 | METHODS AND COMPOSITIONS FOR DIELECTRIC MATERIALS - The present invention comprises methods and compositions of dielectric materials. The dielectric materials of the present invention comprise materials having a dielectric constant of more than 1.0 and less than 1.9 and/or a dissipation factor of less than 0.0009. Other characteristics include the ability to withstand a wide range of temperatures, from both high temperatures of approximately +260° C. to low temperatures of approximately −200° C., operate in wide range of atmospheric conditions and pressures (e.g., a high atmosphere, low vacuum condition such as that found in the outer-space as well as conditions similar to those found at sea level or below sea level). The dielectric materials of the present invention may be used in the manufacture of composite structures that can be used alone or in combination with other materials, and can be used in electronic components or devices such as RF interconnects. | 06-23-2011 |
Mathew Nelson, Harrison City, PA US
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20120147358 | SWIR targeted agile Raman (STAR) system for on-the-move detection of emplace explosives - The present disclosure provides for a system and method for detecting explosives and other materials in a sample scene. First interacted photons are produced from a target area wherein the first interacted photons are generated via solar radiation. The first interacted photons are assessed to thereby generate a SWIR hyperspectral image. The SWIR hyperspectral image is analyzed to identify an area of interest likely of comprising an explosive material. The area of interest is illuminated using laser light illumination to generate second interacted photons from the area of interest. These second interacted photons are assessed to determine whether it not an explosive material is present in the area of interest. The system and method may be configured in standoff, OTM, static and UGV configurations. | 06-14-2012 |
Matthew Nelson, Pittsburgh, PA US
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20120150028 | System and Method of Chemical Imaging Using Puled Laser Excitation and Time-Gated Detection to Determine Tissue Margins During Surgery - System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed. | 06-14-2012 |
Matthew P. Nelson, Harrison City, PA US
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20080197287 | SYSTEM AND METHOD FOR SUPER RESOLUTION OF A SAMPLE IN A FIBER ARRAY SPECTRAL TRANSLATOR SYSTEM - The disclosure relates generally to methods and apparatus for obtaining a super resolution image of a sample using a fiber array spectral translator system. In one embodiment includes collecting photons from a sample at a first end of a fiber array spectral translator; delivering the photons from a second end of the fiber array spectral translator into a multiple detector rows of a photon detector; interpolating between the multiple detector rows to thereby form interpolated rows; and arranging an output of the multiple detector rows and the interpolated rows so as to obtain a super resolution image of the sample. | 08-21-2008 |
20080198365 | TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTION - A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack. | 08-21-2008 |
20090128802 | Time and Space Resolved Standoff Hyperspectral IED Explosives LIDAR Detector - A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack. | 05-21-2009 |
20090152454 | METHOD AND APPARATUS FOR AUTOMATED SPECTRAL CALIBRATION - The disclosure generally relates to a method and apparatus for automated spectral calibration of a spectroscopy device. In one embodiment, the disclosure relates to a method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum. | 06-18-2009 |
20090303471 | Chemical imaging explosives (CHIMED) optical sensor - A system and method of detecting explosive compounds located on a sample. The sample is irradiated with animal-safe ultra-violet radiation generating a fluorescence data set. A fluorescence database is searched based on the fluorescence data set in order to identify a known fluorescence data set. If the searching of the fluorescence database identifies a known fluorescence data set, an area of interest in the sample is identified based on the known fluorescence data set identified in the fluorescence database searching. The area of interest is irradiated with substantially monochromatic radiation to generate a Raman data set of the area of interest. A Raman database is searched based on the Raman data set in order to identify a known Raman data set. An explosive compound in the area of interest is identified based on the known Raman data set identified by searching the Raman database. | 12-10-2009 |
20100148073 | System and Method for Structured Illumination and Collection for Improved Optical Confocality of Raman Fiber Array Spectral Translator Imaging and Interactive Raman Probing - The disclosure relates generally to methods and apparatus for using telescope optics and a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample. | 06-17-2010 |
20120120393 | TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTOR - A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack. | 05-17-2012 |
Pamela H. Nelson, Downingtown, PA US
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20080213829 | Materials and methods to increase peptide chain expression - DNA sequences that increase peptide chain expression when operably linked to a gene encoding the peptide chain and methods of generating a peptide chain expression host cell using the foregoing are disclosed. Peptide chain expression host cells are also disclosed. | 09-04-2008 |
Paul Nelson, Elverson, PA US
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20100218311 | Playard Top Rail and Latch Mechanism - A juvenile product includes a frame with a rail, the rail including first and second rail sections, a latch assembly coupling the first and second rail sections and configured to reside in a latched state for an in-use orientation of the rail, and an elastic bias element coupled to the first rail section or the second rail section and configured to be under tension in or near the in-use orientation such that the elastic bias element drives the rail away from the in-use orientation when the rail is near the in-use orientation with the latch assembly not in the latched state. | 09-02-2010 |
Toby Nelson, Pittsburgh, PA US
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20080299669 | Methods and devices for analytical sensing of biogenic amines - Disclosed herein are chromogenic response polymers and methods and devices that utilize the disclosed polymers which are suitable for use in detecting the presence of and identity of biogenic amines. | 12-04-2008 |