Nelson, MD
Carl V. Nelson, Derwood, MD US
Patent application number | Description | Published |
---|---|---|
20110006895 | Expendable Tamper Evident Security Seal - An expendable tamper evident seal system for monitoring a mechanism to which physical access is required in order to open or close an access-way, comprising: an embedding material moldable into a shape conforming to the mechanism and adapted to be applied to the mechanism; circuit components randomly embedded in the embedding material so as to be arranged in positions and orientations corresponding to the shape, whereby physical access to the mechanism that alters the shape of the embedding material correspondingly alters the positions and orientations of the circuit components in the material; and an electronic interrogation device (EID) including components that induce in the circuit components an electromagnetic spectral response indicative of the position of the EID relative to the positions and orientations of the circuit components in the material, and measure the spectral response. | 01-13-2011 |
Daniel C. Nelson, Rockville, MD US
Patent application number | Description | Published |
---|---|---|
20160038572 | Endolysins Active Against Staphylococcus Bacteria, Pharmaceutical Compositions, and Methods Relating Thereto - The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including isolated endolysin polypeptides from bacteriophage GRCS. | 02-11-2016 |
Daniel Craig Nelson, Rockville, MD US
Patent application number | Description | Published |
---|---|---|
20090092555 | Octameric Protein For Use In Bionanotechnology Applications - The present invention relates to purified multimeric proteins, comprising PlyCB monomers or functional fragments or variants thereof, which self-assemble into a ring like structure. The present invention also encompasses such multimeric proteins that comprise an integrin-binding sequence. The present invention further discloses contrast reagents, implant coatings, bone implants, and complexes for use in bionanotechnology applications, each of which comprise such multimeric proteins. | 04-09-2009 |
Donald Douglas Nelson, Montgomery Village, MD US
Patent application number | Description | Published |
---|---|---|
20090209978 | Systems and Methods For Real-Time Winding Analysis For Knot Detection - Embodiments of systems, methods, and computer-readable media for real-time winding analysis for knot detection are disclosed. For example, one embodiment of the present invention includes a method having the steps of receiving a first wrapping signal indicating a first wrapping of the simulated thread around a second tool to create a first loop. The method further includes determining a first wrapping direction based at least in part on the first wrapping signal; receiving a first tightening signal indicating a pulling of a first end of the simulated thread through the first loop; determining a first half-hitch based at least in part on the first winding direction and the first tightening signal; and outputting the first half-hitch. In another embodiment, a computer-readable media includes code for a carrying out such a method. | 08-20-2009 |
20110218774 | Systems and Methods for Simulations Utilizing a Virtual Coupling - Embodiments include storing values of a first plurality of nodes in memory based on tracking the position of a plurality of points of a physical object and maintaining a second plurality of nodes in memory, each node of the second plurality of nodes corresponding to a node of the first plurality. The values of the second plurality of nodes can be used to model interactions with other objects and to render a view of a simulated object. The simulation can access data identifying a simulation boundary and selectively update values of the second plurality of nodes using the first plurality of nodes while ensuring that the simulation boundary is not violated. A value of the second plurality of nodes can be set to be different from the value of the corresponding one of the first plurality of nodes if using the first node's value would violate the boundary. | 09-08-2011 |
George Nelson, Thurmont, MD US
Patent application number | Description | Published |
---|---|---|
20100297660 | SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH RENAL DISEASE - Methods for determining the genetic predisposition of a human subject to developing renal disease, such as focal segmental glomerulosclerosis (FSGS) or end-stage kidney disease are provided herein. These methods include methods for detecting renal disease, or determining the risk of developing renal disease in a human subject, such as a subject of African ancestry. The methods utilize the detection of one or more haplotype blocks comprising at least two tag single nucleotide polymorphisms (SNPs) in a non-coding region of a MYH9 gene or detecting the presence of at least one tag SNP in a non-coding region of a MYH9 gene. An array for detecting a genetic predisposition to renal disease using probes complementary to the tag SNPs in the non-coding region of the MYH9 gene are also disclosed. | 11-25-2010 |
John M. Nelson, Bethesda, MD US
Patent application number | Description | Published |
---|---|---|
20110184954 | DATABASE AND INDEX ORGANIZATION FOR ENHANCED DOCUMENT RETRIEVAL - A customized, specialty-oriented database and index. of a subject matter area and methods for constructing and using such a database are provided. Selection and indexing of articles is done by experts in the topic with which the database is concerned. As a result, articles are indexed in a manner that allows facile, rapid retrieval of highly relevant articles with few or no false positives with much reduced database maintenance cost through frugal limitation of number of documents in the database, number of terms in a Master Index, and number of codes assigned to each document. A thesaurus allows indexing and search in accordance with terminology familiar to different anticipated groups of users (e.g. doctors, patients, nurses, technicians, and the like). Key articles collections and rapid access to documents therein are also provided. Additional classifications may be applied to articles or documents and searched as an additional search criterion such as a potential use. The context of key word(s) included in the search query can be specified from the hierarchical list of key words without requiring additional classification of articles/documents. Search results may also be filtered and/or sorted based on components included in the articles/documents. | 07-28-2011 |
20110314025 | DATABASE AND INDEX ORGANIZATION FOR ENHANCED DOCUMENT RETRIEVAL - A customized, specialty-oriented database and index. of a subject matter area and methods for constructing and using such a database are provided. Selection and indexing of articles is done by experts in the topic with which the database is concerned. As a result, articles are indexed in a manner that allows facile, rapid retrieval of highly relevant articles with few or no false positives with much reduced database maintenance cost through frugal limitation of number of documents in the database, number of terms in a Master Index, and number of codes assigned to each document. A thesaurus allows indexing and search in accordance with terminology familiar to different anticipated groups of users (e.g. doctors, patients, nurses, technicians, and the like). Key articles collections and rapid access to documents therein are also provided. | 12-22-2011 |
John M. Nelson, Chevy Chase, MD US
Patent application number | Description | Published |
---|---|---|
20130268538 | Database and Index Organization for Enhanced Document Retrieval - A customized, topical database and methods for constructing and using such a database are provided. Selection and indexing of articles is done by experts in the topic with which the database is concerned. As a result, articles are indexed in a manner that allows facile, rapid retrieval of highly relevant articles with few or no false positives. | 10-10-2013 |
20150186364 | Database and Index Organization for Enhanced Document Retrieval - A customized, specialty-oriented database and index. of a subject matter area and methods for constructing and using such a database are provided. Selection and indexing of articles is done by experts in the specialty with which the database is concerned. A thesaurus allows indexing and search in accordance with terminology familiar to different anticipated groups of users (e.g. doctors, patients, nurses, technicians, and the like) by translating search terms to a standard and limited list of topics; a limited number of which are assigned to each document/article and allowing the topics most likely to be relevant to be found. The search can be conducted based on the most relevant topic found or sequential searches can be performed based on topics most relevant to individual search terms or combined search terms and the search results combined on the basis of common topic classifications to leverage the benefits of document classification. | 07-02-2015 |
John Marshall Nelson, Bethesda, MD US
Patent application number | Description | Published |
---|---|---|
20090319524 | DATABASE AND INDEX ORGANIZATION FOR ENHANCED DOCUMENT RETRIEVAL - A customized, specialty-oriented database and index, of a subject matter area and methods for constructing and using such a database are provided. Selection and indexing of articles is done by experts in the topic with which the database is concerned. As a result, articles are indexed in a manner that allows facile, rapid retrieval of highly relevant articles with few or no false positives with much reduced database maintenance cost through frugal limitation of number of documents in the database, number of terms in a Master Index, and number of codes assigned to each document. A thesaurus allows indexing and search in accordance with terminology familiar to different anticipated groups of users (e.g. doctors, patients, nurses, technicians, and the like). Key articles collections and rapid access to documents therein are also provided. | 12-24-2009 |
Karen Nelson, Sandy Spring, MD US
Kevin Dale Nelson, Havre De Grace, MD US
Patent application number | Description | Published |
---|---|---|
20100230884 | Work-piece piercing claw jaws for vise - An exemplary embodiment providing one or more improvements includes removable faces for jaws in machine vise which are able to grip a work-piece with great stability, accuracy, and reproducibility. Embodiments include multiple gripping features so the gripping surface easily can be renewed by demounting and reversing a worn face to a new face. Embodiments include the ability to of the claw jaws to be mounted on any fixed or movable vise station to use the entire clamping range of the machine vise. Embodiments are disclosed which are used with round or curved as well as flat work-pieces. Embodiments also include flat surfaced claw jaws which may be used to grip a work-piece for secondary machining to remove indentations from the work-piece. | 09-16-2010 |
20120292844 | Work-piece piercing claw jaws for vise - An exemplary embodiment providing one or more improvements includes removable faces for jaws in machine vise which are able to grip a work-piece with great stability, accuracy, and reproducibility. Embodiments include multiple gripping features so the gripping surface easily can be renewed by demounting and reversing a worn face to a new face. Embodiments include the ability to of the claw jaws to be mounted on any fixed or moveable vise station to use the entire clamping range of the machine vise. Embodiments are disclosed which are used with round or curved as well as flat work-pieces. Embodiments also include flat surfaced claw jaws which may be used to grip a work-piece for secondary machining to remove indentations from the work-piece. | 11-22-2012 |
Linda Jo Nelson, Elkridge, MD US
Patent application number | Description | Published |
---|---|---|
20110296711 | Overboot - This invention provides an overboot consists of an upper portion made of fabric and a lower portion, or sole, which is made of a rugged flexible material such as rubber or thermoelastomer. The upper portion has a front, a back, an inside, an outside, and an interior. The upper portion has an opening to allow a foot of a user wearing a shoe or ski boot to enter the interior. In one embodiment, the opening of the upper portion may have a means of closure. The rear of the overboot opens in order to ease the insertion of the foot of the user. The rear opening may consist of either one or two vertical slits. | 12-08-2011 |
Natalie F. Nelson, Baltimore, MD US
Patent application number | Description | Published |
---|---|---|
20100252553 | MULTI-POCKETED FOLDING ORGANIZER - A multi-pocketed decorative fabric organizer that resembles a folding file and serves as a workspace when opened and then folds up in seconds keeping all the items and materials stored in it intact, and provides a portable and compact organizer for various purposes. The organizer consists of a hard surface that folds out to a writing or working space consisting of conveniently located plastic storage pockets and an exterior of decorative fabrics. | 10-07-2010 |
20150027832 | MULTI-POCKETED FOLDING ORGANIZER - A multi-pocketed decorative fabric organizer that resembles a folding file and serves as a workspace when opened and then folds up in seconds keeping all the items and materials stored in it intact, and provides a portable and compact organizer for various purposes. The organizer consists of a hard surface that folds out to a writing or working space consisting of conveniently located plastic storage pockets and an exterior of decorative fabrics. | 01-29-2015 |
Peter F. Nelson, Potomac, MD US
Patent application number | Description | Published |
---|---|---|
20140203642 | Multiple Outlet Sequenced Power Strip - A multiple outlet sequenced power strip with only a specific number of outlets capable of running at any one time which is comprised of at least: a housing, input and output outlets, and a form of variable motor; thus allowing for the possible use of multiple high power devices on one wall socket and subsequently breaker. | 07-24-2014 |
Thomas Nelson, Rockville, MD US
Patent application number | Description | Published |
---|---|---|
20090030055 | PKC activation as a means for enhancing sAPPALPHA secretion and improving cognition using bryostatin type compounds - The present invention relates to compositions and methods to modulate α-secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in diseased individuals, particularly Alzheimer's Disease patients, and treatment thereof through increased sAPP production. Macrocyclic lactones (i.e. bryostatin class and neristatin class) are compounds preferred for use with the present composition. The present invention also provides methods for increasing the generation of non-amyloidogenic soluble APP comprising the activation of protein kinase C (PKC) by administering an effective amount of PKC activator(s). | 01-29-2009 |
Wiliam G. Nelson, Towson, MD US
Patent application number | Description | Published |
---|---|---|
20150252438 | AGENTS FOR REVERSING EPIGENETIC SILENCING OF GENES - The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated genomic DNA. Also provided are methods for reactivating silenced genes having CpG island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administering an agent that modulates methyl-binding domain (MBD) protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. Additionally, compounds identified by the present invention useful for treatment and prevention of diseases, such as cancer and sickle cell anemia, are provided. | 09-10-2015 |
William G. Nelson, Towson, MD US
Patent application number | Description | Published |
---|---|---|
20090197263 | Compare-MS: Method Rapid, Sensitive and Accurate Detection of DNA Methylation - The present invention provides methods and kits useful for enriching, identifying and quantifying methylated DNA3 particularly hypermethylated CpG islands by digesting a sample with a methylation-sensitive restriction endonuclease and capturing methylated restriction fragments with a methyl-binding capture reagent. The methods of the invention may be used in the detection of cancer, particularly detection of prostate cancer. | 08-06-2009 |
20100093768 | Agents for Reversing Epigenetic Silencing of Genes - The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated genomic DNA. Also provided are methods for reactivating silenced genes having CpG island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administering an agent that modulates methyl-binding domain (MBD) protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. Additionally, compounds identified by the present invention useful for treatment and prevention of diseases, such as cancer and sickle cell anemia, are provided. | 04-15-2010 |
20140038183 | 5-HYDROXYMETHYLCYTOSINE IN HUMAN CANCER - The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for diagnosing or predicting cancer in a patient. In one embodiment, a method for identifying a patient as having cancer comprises the steps of (a) providing a formalin-fixed, paraffin-embedded or fresh frozen sample of patient tissue; (b) steaming the sample in antigen retrieval buffer; (c) incubating the sample in hydrochloric acid (HCl); (d) incubating the sample with an affinity reagent specific for 5hmC under conditions to form a complex between the affinity reagent and 5-hydroxymethylcytosine (5hmC) present in the sample; (e) detecting the complexes formed between 5hmC and the affinity reagent with secondary detection reagents; (f) quantifying 5hmC levels; and (g) identifying the patient as having cancer if the 5hmC levels in the sample are reduced as compared to a control. | 02-06-2014 |
20140274767 | DNA METHYLATION MARKERS FOR METASTATIC PROSTATE CANCER - The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide. | 09-18-2014 |