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Navia, US

Jose L. Navia, Shaker Heights, OH US

Patent application numberDescriptionPublished
20090093873VASCULAR GRAFT AND METHOD OF USE - A vascular graft includes an elongated main body portion, a first sewing ring, a second sewing ring, and a third sewing ring. The elongated main body portion includes a first end defining a first opening, a second end defining a second opening, and an aperture defined by a perimeter. The first sewing ring is securely attached to the perimeter of the aperture. The second sewing ring is securely attached to the first end of the main body portion adjacent the first opening. The third sewing ring is securely attached to the second end of the main body portion adjacent the second opening.04-09-2009
20090177262APPARATUS AND METHOD FOR TREATING CARDIOVASCULAR DISEASES - A method is provided for treating a cardiovascular disease, such as pulmonary arterial hypertension, an arrhythmia, or heart failure. One step of the method includes providing an apparatus. The apparatus includes an expandable support member having oppositely disposed proximal and distal end portions and a main body portion extending between the end portions. The proximal end portion includes a plurality of wing members extending from the main body portion. At least a portion of the expandable support member is treated with at least one therapeutic agent for eluting into a blood vessel. The expandable support member is inserted into the pulmonary vasculature and then advanced to a bifurcation in the pulmonary vasculature. The bifurcation includes the intersection of a first pulmonary vessel, a second pulmonary vessel, and a third pulmonary vessel. The expandable support member is secured at the bifurcation to treat pulmonary arterial hypertension, for example.07-09-2009
20110004299APPARATUS AND METHOD FOR REPLACING A DISEASED CARDIAC VALVE - An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the main body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.01-06-2011

Patent applications by Jose L. Navia, Shaker Heights, OH US

Jose Luis Navia, Shaker Heights, OH US

Patent application numberDescriptionPublished
20090132036APPARATUS AND METHOD FOR TREATING A REGURGITANT HEART VALVE - An apparatus is provided for treating regurgitation of blood flow through a diseased heart valve. The apparatus includes an annular support member and at least one posterior leaflet support member. The annular support member has an anterior end portion, a posterior end portion, and oppositely disposed first and second intermediate portions extending between the end portions. The at least one posterior leaflet support member is securely connected to the annular support member and is dimensioned to extend across a portion of a free edge of a posterior valve leaflet. The posterior leaflet support member comprises an arcuate center portion integrally formed with and extending between first and second end portions. The arcuate center portion has a concave shape relative to the anterior end portion. At least one of the first and second end portions is securely attached to the posterior end portion.05-21-2009
20090299387METHOD AND APPARATUS FOR FLUIDLY ISOLATING A PORTION OF A BODY LUMEN WALL FROM FLOW THROUGH THE BODY LUMEN - An apparatus for fluidly isolating a portion of a blood vessel wall from bloodflow at an anastomosis site within a blood vessel is described. An insertion catheter has longitudinally spaced proximal and distal catheter ends and an operative lumen extending therebetween, and is configured for insertion into the blood vessel at an insertion location spaced apart from the anastomosis site. An isolation device is attached to the distal catheter end, and includes a concave working surface bounded by an isolation rim and a bloodflow surface opposite the working surface. The isolation rim is configured to contact at least a portion of the blood vessel longitudinally aligned with, and radially spaced from, the anastomosis site. The bloodflow surface is in contact with bloodflow past the anastomosis site within the blood vessel when the isolation device engages the blood vessel wall. A retention means is attached to the isolation device and in fluid communication with the operative lumen. The retention means is configured to exert force on the blood vessel wall to at least partially engage the blood vessel wall with the isolation device. A method of fluidly isolating a portion of a blood vessel wall from bloodflow at an anastomosis site within a blood vessel is also provided.12-03-2009
20100036401VASCULAR GRAFT AND METHOD OF USE - A vascular graft includes an elongated main body portion having a distal end portion defining a first opening and a second proximal end portion defining a second opening. The vascular graft also includes a first sewing ring having a base portion securely attached to the first distal end portion of the elongated body portion, and a second sewing ring having a base portion securely attached to the first distal end portion at a location proximal to the first sewing ring. The first and second base portions form a channel for receiving an end portion of a blood vessel.02-11-2010
20100312333APPARATUS AND METHOD FOR REPLACING A DISEASED CARDIAC VALVE - An apparatus is provided for replacing a native cardiac valve. The native cardiac valve has at least one leaflet and is surrounded by a native cardiac valve annulus having superior and inferior aspects. The apparatus comprises a barbell-shaped, expandable anchoring member including first, second, and main body portions extending between the end portions. The main body portion includes a channel defined by inner and outer surfaces. Each of the first and second end portions has a diameter greater than the diameter of the main body portion. The first and second end portions are sized to respectively contact the superior and inferior aspects of the native cardiac valve annulus when the expandable anchoring member is in an expanded configuration. The apparatus also includes an expandable support member operably disposed within the main body portion of the expandable anchoring member, and a prosthetic cardiac valve secured within the expandable support member.12-09-2010
20110153009APPARATUS AND METHODS FOR REPAIR OF A CARDIAC VALVE - An apparatus for repairing a cardiac valve includes an annuloplasty ring having an expandable support member with oppositely disposed proximal and distal end portions and a main body portion between the end portions. The proximal end portion includes a plurality of wing members extending from the main body portion. Each of the wing members includes at least one hook member for embedding into a cardiac wall and a valve annulus to secure the annuloplasty ring therein. The apparatus also includes an energy delivery mechanism for selectively contracting the annuloplasty ring to restrict the valve annulus and correct valvular insufficiency. The energy delivery mechanism includes a detachable electrical lead having distal and proximal end portions. The distal end portion has a securing member for operably attaching the distal end portion to a portion of the expandable support member. The proximal end portion is operably connected to an energy delivery source.06-23-2011

Patent applications by Jose Luis Navia, Shaker Heights, OH US

Juan L. Navia, Doylestown, PA US

Patent application numberDescriptionPublished
20090053680COMPOSITIONS AND METHODS FOR INDUCING SATIETY AND REDUCING CALORIC INTAKE - A method is provided for determining the eating restraint behavior of an individual and communicating a recommendation to the individual based on the eating restraint behavior for compositions to consume that effective for the diagnosed eating restraint behavior. Such compositions effective for low rigid restraint eaters include soluble fiber and a multivalent cation.02-26-2009
20090104326SWEETENER COMPOSITIONS - A solid sweetening composition having erythritol and a secondary sweetener in a single solid matrix, a method of making the solid sweetening composition and methods of sweetening a comestible.04-23-2009

Manuel Navia, Lexington, MA US

Patent application numberDescriptionPublished
20090143351SUBSTITUTED AZETIDINONES - Compounds are provided which have the structure06-04-2009
20100144698SUBSTITUTED AZETIDINONES - Compounds are provided which have the structure06-10-2010

Patent applications by Manuel Navia, Lexington, MA US

Manuel A. Navia, Lexington, MA US

Patent application numberDescriptionPublished
20090264410THERAPEUTIC COMPOUNDS AND USES THEREOF - Compounds of formula (I) are described herein10-22-2009

Patent applications by Manuel A. Navia, Lexington, MA US

Manuel A. Navia, Boston, MA US

Patent application numberDescriptionPublished
20080214800SIRT INHIBITORS THAT BIND TO NAD - Methods of treating sirtuin related disorders and compounds useful in treating sirtuin related disorders are described.09-04-2008
20110152232SULFONAMIDE COMPOUNDS AND USES THEREOF - Compounds that modulate GHS-R are described, for examples compounds formula (I)06-23-2011

Patent applications by Manuel A. Navia, Boston, MA US