Natale
Alessandra Natale, Cambridge, Cambridgeshire GB
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20150355096 | DROPLET-BASED SEQUENCING METHOD - Disclosed is a method for determining the sequence of nucleotide bases in a polynucleotide analyte. It is characterised by analyte characterised by the steps of: a. generating a stream of droplets at least some of which comprise both ( | 12-10-2015 |
Alessandra Natale, Cambridgeshire GB
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20160040223 | SINGLE NUCLEOTIDE DETECTION METHOD - A method for determining the sequence of nucleotide bases in a polynucleotide analyte is provided. It is characterised by the steps of (1) generating a stream of single nucleotide bases from the analyte; (2) producing captured molecules by reacting each single nucleotide base with a capture system; (3) amplifying at least part of the captured molecule to produce a plurality of amplicons characteristic of the single nucleotide base; (4) labelling the amplicons with a corresponding probe having a characteristic detectable element and (5) detecting a property characteristic of the detectable element. | 02-11-2016 |
20160040224 | SINGLE NUCLEOTIDE DETECTION METHOD - A method for determining the sequence of nucleotide bases in a polynucleotide analyte is provided. It is characterised by the steps of (1) generating a stream of single nucleotide bases from the analyte by pyrophosphorolysis; (2) producing captured molecules by reacting each single nucleotide base with a capture system labelled with detectable elements in an undetectable state; (3) releasing the detectable elements from each captured molecule in a detectable state and (4) detecting the detectable elements so released and determining the sequence of nucleotide bases therefrom. The method can be used advantageously in sequencers involving the use of microdroplets. | 02-11-2016 |
Alessandra Natale, Cambridge GB
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20150056618 | METHOD AND APPARATUS - A method for mapping the number and location of restriction enzymes sites for a given restriction enzyme in a target nucleic acid comprises the steps of (1) translocating a target nucleic acid having detectable elements characteristic of the presence of the restriction enzyme sites therein through an analysing device comprising a nanopore and a detection window and (2) causing the detectable elements to be detected as they pass though the detection window. Typically the detectable elements are formed by attaching to the restriction enzyme sites a restriction enzyme to which one or more marker moieties have been added. The data or signal obtained from the detection is suitably in the form of a distribution profile of the detectable elements, and therefore the restriction enzyme sites along the length of the target nucleic acid and can be used to create a reference set of like distribution profiles against which new distributions can be compared. When the target nucleic acid is for example double stranded human DNA such comparisons enable valuable insights to be drawn about an individual's identity or his or her susceptibility to certain health conditions. | 02-26-2015 |
20150232925 | SEQUENCING METHOD - Disclosed is a method for determining the sequence of nucleotide bases in a polynucleotide analyte characterised by the steps of: | 08-20-2015 |
20150247192 | SEQUENCING METHOD - Disclosed is a method for sequencing a polynucleotide analyte comprising:•a. generating a stream of droplets containing a single nucleotide wherein the order of single nucleotides in the droplet stream corresponds to the sequence of nucleotides in the analyte;•b. introducing into each droplet a plurality of biological probe types each type comprising a different label in an undetectable state and being adapted to capture a different single nucleotide;•c. causing the single nucleotide contained in the droplet to bind to its complementary probe and•d. causing the label to be released from the probe that has bound the nucleotide in a detectable state. The probe is a dumbbell shaped probe comprising fluorescent donor and quencher labels and a single nucleotide gap. After gap repair by a polymerase and a ligase, a restriction enzyme recognition site is cleaved by a restriction enzyme, followed by exonuclease digestion to release the labels. | 09-03-2015 |
20150275293 | BIOLOGICAL PROBES AND THE USE THEREOF - Disclosed is a biological probe characterised in that it comprises a single-stranded nucleotide region the ends of which are attached to two different oligonucleotide regions wherein at least one of the oligonucleotide regions comprises detectable elements having a characteristic detection property and wherein the detectable elements are so arranged on the oligonucleotide region that the detectable property is less detectable than when the same number detectable elements are bound to a corresponding number of single nucleotides. The biological probe is especially useful for capturing single nucleotides or single-stranded nucleotides to create a used probe which can be degraded by means of a restriction enzyme and an exonuclease to generate single nucleotides carrying a detectable element in a form which can be detected. Typically the detectable elements are fluorophores and the corresponding characteristic fluorescence is rendered undetectable in the probe by for example the use of multiple adjacent fluorophores or mixtures of fluorophores and quenchers attached thereto. Preferably the single stranded nucleotide region is comprised of a single nucleotide whose associated nucleotide base is one of the characteristic of the nucleotides bases found in DNA or RNA. | 10-01-2015 |
Andrea Natale, Austin, TX US
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20150087955 | MULTI-WAVELENGTH PHOTOACOUSTIC CHARACTERIZATION AND THERMOGRAPHIC IMAGING - The present disclosure relates to a method comprising imaging a tissue with multi-wavelength photoacoustic imaging, to provide a visualization, characterization and/or thermographic imaging of the tissue. | 03-26-2015 |
Angela Natale, Seattle, WA US
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20100186519 | APPARATUS FOR TESTING FUSELAGE PANELS - Gripping claws and pairs of arched angular profiles are arranged along the perimeter of a cylindrical surface segment so as to grip the edges of a fuselage panel, closing the opening of a pressurizable chamber. | 07-29-2010 |
Anthony Natale, New Preston, CT US
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20110166598 | DEVICES AND METHODS FOR TONGUE STABILIZATION - Tongue-stabilization devices and methods, such as, for example, for treatment and/or reduction of symptoms of obstructive sleep apnea (OSA). | 07-07-2011 |
20120197361 | APPARATUS AND METHODS FOR TREATMENT OF OBSTRUCTIVE SLEEP APNEA UTILIZING CRYOLYSIS OF ADIPOSE TISSUES - Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis. | 08-02-2012 |
20120283826 | SYSTEMS AND METHODS FOR MASTOPEXY - A mastopexy implant for maintaining the breast in an elevated and aesthetically pleasing position includes a lower pole support comprising end portions which may be affixed to the chest wall or to a previously installed upper suspension strut. The implant is loaded in an insertion device. The insertion device is inserted through a small incision and into a subcutaneous pocket created in an inferior half of the breast. The lower pole support may have various constructs and in one embodiment includes a unitary conformable mesh having a plurality of arm or band members which are attached across the breast parenchyma and to the chest wall. | 11-08-2012 |
20130072852 | SYSTEMS AND METHODS FOR TREATING PATHOGENIC INFECTION - An internal anatomic target that is infected by pathogenic microorganisms is treated using an applicator configured for delivering a therapeutic solution thereto and an UV light-emitting device transmits UV light thereon. | 03-21-2013 |
20130274549 | ENDOSCOPES ENHANCED WITH PATHOGENIC TREATMENT - Various endoscopes are integrated with an applicator configured for delivering a therapeutic solution to an internal anatomic target that may be infected by pathogenic microorganisms and a UV light-emitting device transmitting UV light thereto. | 10-17-2013 |
20140222146 | SYSTEMS AND METHODS FOR MASTOPEXY - A mastopexy implant for maintaining the breast in an elevated and aesthetically pleasing position includes a lower pole support comprising end portions which may be affixed to the chest wall or to a previously installed upper suspension strut. The implant is loaded in an insertion device. The insertion device is inserted through a small incision and into a subcutaneous pocket created in an inferior half of the breast. The lower pole support may have various constructs and in one embodiment includes a unitary conformable mesh having a plurality of arm or band members which are attached across the breast parenchyma and to the chest wall. | 08-07-2014 |
20150272776 | APPARATUS AND METHODS FOR TREATMENT OF OBSTRUCTIVE SLEEP APNEA UTILIZING CRYOLYSIS OF ADIPOSE TISSUES - Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis. | 10-01-2015 |
20150351891 | SYSTEMS AND METHODS FOR MASTOPEXY - A mastopexy implant for maintaining the breast in an elevated and aesthetically pleasing position includes a lower pole support comprising end portions which may be affixed to the chest wall or to a previously installed upper suspension strut. The implant is loaded in an insertion device. The insertion device is inserted through a small incision and into a subcutaneous pocket created in an inferior half of the breast. The lower pole support may have various constructs and in one embodiment includes a unitary conformable mesh having a plurality of arm or band members which are attached across the breast parenchyma and to the chest wall. | 12-10-2015 |
Anthony Natale, New York, NY US
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20130090685 | METHODS AND SYSTEMS FOR TISSUE FASTENING - Fastening devices are provided that are designed to effectively close tissue as well as instruments for applying the inventive fastening devices. The devices are useful for closing tissue such as mucosa in the oral cavity, oropharynx, hypopharynx, laryngeal surfaces, oronasopharynx, or other mucosal tissues. In particular, uvulopalatopharyngoplasty (UPPP), uvulopalatal flap (UPF) technique, and tonsillectomy can be assisted using the inventive system. Embodiments also provide methods of using the fastening devices and/or instruments, and kits including the fastening devices. | 04-11-2013 |
Craig Natale, Lancaster, PA US
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20160073810 | Compartmentalized cup - A stackable compartmentalized drinking cup which is similar to separate cups with joined sides is disclosed. The separate compartments are joined in the top portion of the cup, and are apart at the bottom portion. The side of each cup section facing another cup section may be planar or may be twisted along the length of at least the bottom portion of the cup so that at least part of the cup is spiral. The cups are stackable as the joined sides can fit over and slide down the sides of a similarly constructed cup when so placed so that only the upper portion of the inner cup protrudes from the outer cup. Thermally responsive paints or dyes may further distinguish the compartments. | 03-17-2016 |
Cynthia B. Natale, Mansfield, TX US
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20140162537 | MEDIA BLAST NOZZLE WITH NON-METALLIC THREADS - A media blast includes a nozzle body manufactured of a first material with a set of internal threads manufactured of a second material different than the first material. A media blast nozzle for a spray gun, the media blast nozzle includes a nozzle body manufactured of a first material, the nozzle body defines an axis; and an insert with a set of internal threads manufactured of a second material different than the first material, the insert located at least partially within the nozzle body. | 06-12-2014 |
Dillon Natale, Sherborn, MA US
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20150348452 | BALLOON-BASED, HIGH ALTITUDE, LONG RANGE NOTIFICATON SYSTEM - A balloon-based long range notification apparatus comprises an elevating object capable of lifting up in air. A tether is coupled to a portion of the elevating object on one end thereof and to an object on another end thereof for anchoring the elevating object. A means for holding a display article to the tether is provided. The display article has means thereon for providing a visual indication. | 12-03-2015 |
Fabio Natale, Tribiano (mi) IT
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20080217373 | Magnetic Repulsion Coupling for Transmission of a Rotational Movement from a Driving Member to a Driven Member - Coupling for transmission of a rotational movement from a driving member to a driven member, comprising permanent magnets which are integral with the driving member and permanent magnets which are integral with the driven member, said permanent magnets having a matching polarity (N-N;S-S) and lying in respective radial planes parallel to the axis of rotation and situated opposite each other so that each pair of oppositely facing magnets produces a corresponding magnetic repulsion force. The magnet transmission force transmits the rotational movement from the driving member to the driven member. | 09-11-2008 |
20090026035 | Hybrid Apparatus for Transmitting Motive Power to a Driven Shaft - Apparatus for transmitting motive power from a combustion engine or from an electric generator/motor to a driven shaft coupled to a rotating device, includes a main shaft having a first end connected to the combustion engine by a first engaging/disengaging device and a second end connected to the driven shaft by a second engaging/disengaging device, said shaft having, mounted thereon, a first electromagnetic clutch, the rotor of which is adapted to selectively receive motive power from a secondary shaft which is connected to the motor/generator, the main shaft being provided with a pulley carrying a drive belt which is wound onto a second pulley mounted idle on said secondary shaft and adapted to transmit motive power to the generator/motor via a third engaging/disengaging device. | 01-29-2009 |
Fabio Natale, San Giuliano Milanese IT
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20110253077 | Reversible Double-Acting Electromagnetic Device For Transmitting The Movement To/From A Driven/Driving Member - A double-acting electromagnetic device for transmitting movement to/from a driven/driving member in a vehicle and including a shaft that rotates about a longitudinal axis of rotation and that has, mounted relative thereto a first rotor of a first coupling including a pair of concentric annular electromagnets mounted on a fixed support, a coaxial bell member, a coaxial cup member, a first bearing, a first armature connected to the coaxial bell member, a second armature concentric with the first armature and connected to the coaxial cup member which is mounted idle with respect to the shaft via the first bearing and which has a first pulley formed on a side surface, wherein the support for the electromagnets is attached to a fixed structure part which has a load-bearing function, and wherein the bell member includes an outer annular edge extending in an axial direction towards the electromagnets and mounted axially over the first rotor. | 10-20-2011 |
Joseph Natale, Yardley, PA US
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20080269673 | Cellular-Enabled Medical Monitoring and Infusion System - Described is a medical infusion device that is configured to send and receive data on a real-time basis through the use of circuitry that enables the connection of the device to a cellular network. In one embodiment, a medical infusion device is provided that includes a housing having a drug reservoir, a first processing system and a drive mechanism adapted to receive and execute instructions from the first processing system. The drive mechanism is in mechanical cooperation with the drug reservoir for controlling expulsion of the drug from the reservoir. Medical infusion device also includes an input device for receiving external instructions and configured to transmit the external instructions to the first processing system, a display for receiving and displaying information from the first processing system, and a second processing system in communication with the first processing system for controlling communication between the first processing system and a remote processing system via a cellular network. | 10-30-2008 |
Mario Natale, Jaegersburg DE
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20100040312 | GUIDE RAIL OF A LINEAR GUIDE - A guide rail of a linear guide, on guide surfaces on which a guide carriage is longitudinally displaceable. A material measure is arranged at a distance, preferably in parallel, to the guide rail and is fastened to the guide rail by means of a mount. The guide rail has a groove or a hole arranged outside the guide surface. The mount can be detachably fastened by means of expanding elements that engage with the groove or into the hole. | 02-18-2010 |
20100111454 | LUBRICATING DEVICE FOR A LINEAR ROLLING BEARING - A lubricating device for a linear rolling bearing which has a guide rail and a carriage that is longitudinally moveable on the guide rail and supported on the guide rail by rolling bodies. The rolling bodies are guided in longitudinal grooves along the guide rail, and the lubricating device is fastened to the carriage and lubricate the longitudinal grooves and/or the rolling bodies. The lubricating device also has lubricant supply ducts, which supply a lubricant to the longitudinal grooves and clear outlet openings in the region of the longitudinal grooves for transferring the lubricant to the longitudinal grooves. The lubricant supply ducts are covered by at least one absorbent repository element along the courses thereof in coverage areas. The repository element is designed and/or arranged to absorb lubricant in the coverage areas and to conduct it to the longitudinal grooves in parallel with the lubricant supply channels. | 05-06-2010 |
Massimo Natale, Pavone Canavese IT
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20130196924 | BIOMARKERS FOR DIAGNOSING AND DETECTING THE PROGRESSION OF NEURODEGENERATIVE DISORDERS, IN PARTICULAR OF AMYOTROPHIC LATERAL SCLEROSIS - The present invention relates to biomarkers, to their use and to a method for diagnosing in vitro or detecting the progression of a neurodegenerative disease in an individual, in particular for Amyotrophic Lateral Sclerosis (ALS). The method comprises the steps of isolating a biological sample from the individual; quantifying the level of one or more polypeptides in the biological sample according to the invention; comparing the obtained level with a reference level. | 08-01-2013 |
Michael Natale, Kerrville, TX US
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20140270400 | EXPEDITED INTERNATIONAL FLIGHT ONLINE CHECK-IN - A user may check-in to an international flight and receive an electronic boarding pass using captured travel document information. If the travel document information has not been captured, the travel document information may be captured from a travel document by one of visual image capture or wireless communication. Visual image capture includes capturing an image of the travel document, performing optical character recognition (OCR) on the image of the travel document to extract text; and storing the extracted text on a computer-readable medium. Wireless communication includes receiving travel document information from a wireless communication device included in the travel document. The captured travel document information is compared to a list of registered passengers to determine if the passenger associated with the travel document is registered for the international flight. If the passenger is determined to be registered for the first international flight an electronic boarding pass is generated. | 09-18-2014 |
Nicholas R. Natale, Webster, NY US
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20150335272 | BLOOD SUGAR CONCENTRATION (BSC) TESTING AND MONITORING SYSTEM AND METHOD - Disclosed and depicted is a system and method for reliably testing, monitoring and predicting blood sugar concentration (e.g., glucose) for a user. | 11-26-2015 |
Nicholas R. Natale, Missoula, MT US
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20130065935 | Novel Inhibitors of the Amino Acid Transporters ASCT1 and ASCT2 - The invention features compounds and methods relating to novel hydroxy-proline analog inhibitors of the ASCT1 and ASCT2 neutral amino acid transporters. These analogs are potent and selective inhibitors of ASCT2 and ASCT1-mediated amino acid transport as evidenced by significantly reduced glutamine or alanine transport-associated currents or radiolabeled substrate (amino acid) uptake in | 03-14-2013 |
20150056138 | Radiolabeled Inhibitors of the Amino Acid Transporters ASCT1 and ASCT2 - The invention features compounds and methods relating to hydroxy-proline analog inhibitors of the ASCT1 and ASCT2 neutral amino acid transporters useful for diagnostic purposes. These analogs are potent and selective inhibitors of ASCT2 and ASCT1-mediated amino acid transport as evidenced by significantly reduced glutamine or alanine transport-associated currents or radiolabeled substrate (amino acid) uptake in | 02-26-2015 |
20150368213 | Novel Inhibitors of System Xc- - The present invention is directed to novel inhibitors of system X | 12-24-2015 |
Nick Natale, Webster, NY US
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20120196500 | GAME CALL APPARATUS - Disclosed in this specification is a game call that emits a call for attracting wild game by rotating from an upright position to an inverted position. The game call includes an amplifier having a conic structure with a narrow circular aperture and a wide circular aperture. The narrow circular aperture is connected to the cylindrical top end such that it is within a perimeter defined by the narrow circular aperture. | 08-02-2012 |
Ron B. Natale, Santa Monica, CA US
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20080318230 | GENE EXPRESSION MARKERS FOR RESPONSE TO EGFR INHIBITOR DRUGS - The present invention concerns prognostic markers associated with cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed samples of cancer tissue, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor. | 12-25-2008 |
Sandra Joyce Natale, Chicago Heights, IL US
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20090012789 | Method and process for performing category-based analysis, evaluation, and prescriptive practice creation upon stenographically written and voice-written text files - System and method for electronically identifying and analyzing the type and frequency of errors and mismatches in a stenographically or voice written text against a stored master file and dynamically creating personalized user feedback, drills, and practice based on identified errors and mismatches from within the context of the stored master file. The system provides the user with a plurality of methods to enter a text file for error identification and analysis including both realtime and non-realtime input. The text input is then compared to a stored master file through a word-by-word iterative process which produces a comparison of writing input and stored master wherein errors and mismatches are identified and grouped in a plurality of pre-defined and user-selected categories, each of which is color-coded to facilitate pattern recognition of type and frequency of errors and mismatches in the submitted writing. | 01-08-2009 |
Terry Alan Natale, Hudson, OH US
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20150108148 | SYSTEMS FOR CORROSION PROTECTION OF STORAGE TANK SOIL SIDE BOTTOMS - A method and apparatus for the corrosion protection of tank soil side bottoms is achieved by providing equipment to an existing storage tank as by installing a chime delivery system about the perimeter of the storage tank bottom plate, and introducing an appropriate amount of a corrosion inhibitor into the chime delivery system, whereby the corrosion inhibitor is readily admitted into the spaces between the substrate and the tank bottom plate. The system avoids any refurbishment of the tank and allows for easy introduction and replenishment of inhibitor without interruption of tank operations. The system also does not require any renovation of the tank, and does not require any replacement of the tank bottom plate panels. | 04-23-2015 |
20150307256 | STORAGE TANK BOTTOM CORROSION PROTECTION SYSTEM - A system for protecting storage tank soil side bottoms against corrosion includes a pipe system comprising non-perforated inlet pipes and perforated pipes connected thereto. A sleeve container having solid VCI compounds therein is inserted into the perforated pipes. The sleeves are permeable to vapors emitted by the solid VCI compounds and flow through the pipe to a perforation where they are admitted into an area beneath a storage tank so that they can contact the tank bottom (soil side) and protect the same from corrosion. Alternatively, solid SCI compounds can be used in combination with VCI compounds. The corrosion protection system is designed to be used with aboveground storage tanks. This includes, but is not limited to, single bottom tanks: newly installed or existing tanks undergoing bottom replacement or installation of double bottoms. These tanks are located on substrates such as the compacted soil/sand or hard substrates such as concrete, bitumen mixtures and asphalt where channels can be cut into the substrate for installation of the pipe system. | 10-29-2015 |
William Roy Natale, Austin, TX US
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20100229230 | SYSTEM AND METHOD FOR SECURING COMPUTER SYSTEM AGAINST UNAUTHORIZED ACCESS - The present invention described secures a computer account against unauthorized access caused as a result of identity-theft, and insider-espionage using artificial intelligence and behavioral modeling methods. The present invention has the ability to detect intruders or impersonators by observing “suspicious” activity under a computer account. When it sees such suspicious behavior, it uses artificial intelligence to authenticate the suspect by interrogation. The present invention asks the suspect questions that only the legitimate computer account owner can verify correctly. If the suspect fails the interrogation, that proves that he/she is an impersonator and therefore further access to the computer account is denied immediately. On the other hand if the suspect passes, access to the computer account is restored. The present invention uses a Programmable Artificial Intelligence Engine (PAIE) to interact with computer users in human natural language. The PAIE can also be programmed to suit other applications where natural language interaction with humans is helpful. | 09-09-2010 |