Patent application number | Description | Published |
20100222286 | RECEPTOR MODULATORS EXHIBITING NEUROPROTECTIVE AND MEMORY ENHANCING ACTIVITIES - The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in preventing and treating central nervous system disorders by inhibiting over-activation of NMDA and/or MC receptors. In one aspect, the present invention provides methods of treating and/or preventing neurodegenerative diseases and neuropathological disorders, methods of providing neuroprotection under stress conditions such as a stroke, methods of enhancing the brain's cognitive functions and methods of treating depression, anxiety and cachexia induced by a chronic disease in mammals and humans. | 09-02-2010 |
20110144168 | OXAZOLIDINE DERIVATIVES AS NMDA ANTAGONISTS - The present invention provides therapeutically active oxazolidine derivatives and compositions as NMDA antagonists, which are useful in preventing and treating central nervous system disorders by inhibiting over-activation of NMDA receptors. In one aspect, the present invention provides methods of treating and/or preventing neurodegenerative diseases and neuropathological disorders, methods of providing neuroprotection under stress conditions such as a stroke, and methods of enhancing the brain's cognitive functions in mammals and humans. For example, the compounds can prevent glutamate-induced neuro-toxicity by inhibiting the activities of the NMDA receptor in the presence of toxic doses of NMDA. In addition, the compounds can potentiate the calcium current in the presence of low dose of NMDA. | 06-16-2011 |
20110288169 | TRITERPENOID COMPOUNDS AND METHODS OF USE THEREOF - The present invention provides therapeutically active compounds and compositions as receptor antagonists and methods of use thereof. In one aspect, the compounds are useful in modulating pain, inflammation and acute phase reactions by inhibiting the PGE2 receptors including PGE2 EP1, EP2 and EP4 receptors. | 11-24-2011 |
20120270821 | CDK5 Inhibitors and Therapeutic Uses Thereof - Natural occurring inhibitors of cyclin-dependent protein kinase 5 (Cdk5), isolated from the root of | 10-25-2012 |
20130012462 | RECEPTOR MODULATORS EXHIBITING NEUROPROTECTIVE AND MEMORY ENHANCING ACTIVITIES - The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in preventing and treating central nervous system disorders by inhibiting over-activation of NMDA and/or MC receptors. In one aspect, the present invention provides methods of treating and/or preventing neurodegenerative diseases and neuropathological disorders, methods of providing neuroprotection under stress conditions such as a stroke, methods of enhancing the brain's cognitive functions and methods of treating depression, anxiety and cachexia induced by a chronic disease in mammals and humans. | 01-10-2013 |
20130079293 | NEURO-PROTECTIVE EFFECTS OF ADELOSTEMMA GRACILLIMUM AND ITS ISOLATED COMPOUNDS - Isolated compounds from | 03-28-2013 |
20130137762 | COMPOSITION FOR TREATING NEURODEGENERATIVE DISEASE OR NEUROPATHOLOGICAL CONDITION - This invention relates to extracts and refined fractions of a traditional Chinese medicinal herb, | 05-30-2013 |
20150119348 | CDK5 Inhibitors and Therapeutic Uses Thereof - Natural occurring inhibitors of cyclin-dependent protein kinase 5 (Cdk5), isolated from the root of | 04-30-2015 |