Mundlos
Stefan Mundlos, Berlin DE
Patent application number | Description | Published |
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20080260830 | Growth Factor Mutants With Improved Biological Activitiy - The invention relates to novel biosynthetic growth factor mutants which exhibit improved biological activity. | 10-23-2008 |
20120144511 | MUTEINS OF THE PYRROLINE-5-CARBOXYLATE REDUCTASE 1 - The invention relates to muteins of the pyrroline-5-carboxylate reductase 1 (PYCR1), to nucleic acid molecules comprising a nucleotide sequence encoding such muteins, to methods of determining in a subject a predisposition of having an age related disorder associated with PYCR1, to methods of identifying a compound capable of modifying the expression of PYCR1 and methods of treating a subject having an age-related disorder associated with PYCR1. The invention further relates to a genetically modified animal and a method of modifying the expression of the PYCR1 gene in an animal. | 06-07-2012 |
Stefan Mundlos, Kleinmachnow DE
Patent application number | Description | Published |
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20120058944 | BONE MORPHOGENETIC PROTEIN 2 (BMP2) VARIANTS WITH REDUCED BMP ANTAGONIST SENSITIVITY - The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof. | 03-08-2012 |
Stefan Mundlos, Singapore SG
Patent application number | Description | Published |
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20150240285 | MUTEINS OF THE PYRROLINE-5-CARBOXYLATE REDUCTASE 1 - The invention relates to muteins of the pyrroline-5-carboxylate reductase 1 (PYCR1), to nucleic acid molecules comprising a nucleotide sequence encoding such muteins, to methods of determining in a subject a predisposition of having an age related disorder associated with PYCR1, to methods of identifying a compound capable of modifying the expression of PYCR1, and methods of treating a subject having an age-related disorder associated with PYCR1. The invention further relates to a genetically modified animal and a method of modifying the expression of the PYCR1 gene in an animal. | 08-27-2015 |