Patent application number | Description | Published |
20090181393 | Methods for the identification, assessment, and treatment of patients with proteasome inhibition therapy - The present invention is directed to the identification of markers that can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to treatment. In particular, the present invention is directed to the use of certain combinations of markers, wherein the expression of the markers correlates with responsiveness or non-responsiveness to a therapeutic regimen comprising proteasome inhibition. Thus, by examining the expression levels of individual markers and those comprising a marker set, it is possible to determine whether a therapeutic agent, or combination of agents, will be most likely to reduce the growth rate of tumors in a clinical setting. | 07-16-2009 |
20130013334 | METHODS FOR THE IDENTIFICATION, ASSESSMENT, AND TREATMENT OF PATIENTS WITH CANCER THERAPY - The present invention is directed to the identification of predictive markers that can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to treatment. In particular, the present invention is directed to the use of certain individual and/or combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen. Thus, by examining the expression levels of individual predictive markers and/or predictive markers comprising a marker set, it is possible to determine whether a therapeutic agent, or combination of agents, will be most likely to reduce the growth rate of tumors in a clinical setting. | 01-10-2013 |
Patent application number | Description | Published |
20140143757 | DYNAMIC COMPONENT PERFORMANCE MONITORING - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for dynamic graph performance monitoring. One of the methods includes receiving input data by the data processing system, the input data provided by an application executing on the data processing system. The method includes determining a characteristic of the input data. The method includes identifying, by the application, a dynamic component from multiple available dynamic components based on the determined characteristic, the multiple available dynamic components being stored in a data storage system. The method includes processing the input data using the identified dynamic component. The method also includes determining one or more performance metrics associated with the processing. | 05-22-2014 |
20140143760 | DYNAMIC GRAPH PERFORMANCE MONITORING - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for dynamic graph performance monitoring. One of the methods includes receiving multiple units of work that each include one or more work elements. The method includes determining a characteristic of the first unit of work. The method includes identifying, by a component of the first dataflow graph, a second dataflow graph from multiple available dataflow graphs based on the determined characteristic, the multiple available dataflow graphs being stored in a data storage system. The method includes processing the first unit of work using the second dataflow graph. The method includes determining one or more performance metrics associated with the processing. | 05-22-2014 |
Patent application number | Description | Published |
20090304641 | Methods and Compositions for Regulating Gene Expression - In certain embodiments, the disclosure relates to compositions and methods relating to a translation-based gene regulation system that functions in mammalian cells. In certain specific embodiments, the disclosure relates to methods of regulating gene expression via modulating translational termination. | 12-10-2009 |
20110061120 | SELF-CLEAVING RIBOZYMES AND USES THEREOF - In certain embodiments, the disclosure relates to compositions and methods relating to a ribozyme-based gene regulation system that functions in mammalian cells. In certain specific embodiments, the disclosure relates to schistosome self-cleaving RNA mutant motifs. | 03-10-2011 |
20120121552 | METHODS FOR PURIFYING HEMATOPOIETIC STEM CELLS - Described herein are methods for purifying hematopoietic stem cells. Also described herein are methods for purifying EPCR+ cells. The invention also provides substantially pure isolated hematopoietic stems cells, including EPCR+ hematopoietic stem cells. | 05-17-2012 |
20140044684 | Methods And Compositions For Regulating Gene Expression - In certain embodiments, the disclosure relates to compositions and methods relating to a translation-based gene regulation system that functions in mammalian cells. In certain specific embodiments, the disclosure relates to methods of regulating gene expression via modulating translation termination. | 02-13-2014 |
20150056174 | SELF-CLEAVING RIBOZYMES AND USES THEREOF - In certain embodiments, the disclosure relates to compositions and methods relating to a ribozyme-based gene regulation system that functions in mammalian cells. In certain specific embodiments, the disclosure relates to schistosome self-cleaving RNA mutant motifs. | 02-26-2015 |
Patent application number | Description | Published |
20100105136 | CHIMERIC T-CELL RECEPTORS AND T-CELLS TARGETING EGFRVIII ON TUMORS - Chimeric T-cell receptor proteins have been produced in cells by the construction of nucleic acids and vectors, and the transfection of the vectors into cells. The chimeric proteins comprise, as an extracellular binding portion, a single chain antibody portion that binds to EGFRvIII, a transmembrane portion derived from human CD8α or CD28, and an intracellular signaling portion derived from human CD3ζ. The invention includes nucleic acids, vectors and cells associated with the production of the chimeric membrane protein, as well as methods to treat rumors bearing EGFRvIII, a mutant epidermal growth factor receptor. | 04-29-2010 |
20140302025 | VEGF-BINDING PROTEIN FOR BLOCKADE OF ANGIOGENESIS - Provided are chimeric VEGF-binding proteins and nucleic acids (e.g., a vector) encoding chimeric VEGF-binding proteins, methods and host cells for producing these proteins and nucleic acids, and pharmaceutical compositions containing these proteins and nucleic acids. Also provided are methods of treating an angiogenic disease or disorder that include administering at least one of the chimeric VEGF-binding proteins or at least one of the nucleic acids (e.g., a vector) encoding a chimeric VEGF-bind ing protein. | 10-09-2014 |