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Mukaidani
Chise Mukaidani, Higashihiroshima JP
| Patent application number | Description | Published |
|---|---|---|
| 20090313710 | Nonalcoholic Steatohepatitis Model Animal and Fatty Liver Model Animal - Disclosed is a nonhuman animal showing the symptoms of human nonalcoholic steatohepatitis which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal and then transplanting human hepatocytes that are propagated in the body of the chimeric nonhuman animal into an immunodeficient hepatopathic nonhuman animal of the same species as the immunodeficient hepatopathic nonhuman animal described above, as well as a nonhuman animal showing the symptoms of human fatty liver which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal. | 12-17-2009 |
Chise Mukaidani, Higashihiroshima-Shi JP
| Patent application number | Description | Published |
|---|---|---|
| 20090060882 | Method Of Treating Mouse Carrying Human Hepatocytes - Human adult hepatocytes are transplanted into an immunodeficient hepatopathy mouse and then human growth hormone is administered to the mouse to thereby elevate twice or more the replacement ratio by the human adult hepatocytes having been transplanted. Further, human growth hormone is administered to an immunodeficient hepatopathy mouse carrying human young hepatocytes transplanted thereinto so as to improve fatty liver of the mouse in which about 70% or more of the hepatocytes have been replaced by the human hepatocytes. | 03-05-2009 |
Chise Mukaidani, Hiroshima JP
| Patent application number | Description | Published |
|---|---|---|
| 20090047655 | Method Of Screening Candidate Drug - It is intended to provide a method of screening a candidate drug mainly metabolized by a drug metabolizing enzyme, CYP2D6, CYP2C9 or CYP2C19 with the use of a chimeric mouse carrying human hepatocytes transplanted thereinto, whereby it is determined whether or not the candidate drug is metabolized in a subject deficient in CYP2D6, CYP2C9 or CYP2C19. It is also intended to provide a method of determining whether or not a candidate drug induces or inhibits the activity of any of drug metabolizing enzymes, CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 with the use of a chimeric mouse carrying human hepatocytes transplanted thereinto. | 02-19-2009 |
Toshiaki Mukaidani, Osaka JP
| Patent application number | Description | Published |
|---|---|---|
| 20090188276 | REFRIGERATION SYSTEM - A refrigeration system includes a refrigerant circuit including a chilling expansion valve, a chilling heat exchanger, a compressor ( | 07-30-2009 |