Patent application number | Description | Published |
20100311094 | Allosteric Modulation Of Ship Polypeptides And Uses Thereof - This invention provides a method for identifying allosteric modulators of a SHIP polypeptide, wherein said SHIP polypeptide is contacted with a test compound, and wherein said SHIP polypeptide comprises an allosteric site selected from the group consisting of a SHIP C2 domain and a SHIP PH domain. | 12-09-2010 |
20100323990 | SHIP 1 MODULATOR PRODRUGS - The present invention provides the use of prodrugs of pelorol and homopelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions. | 12-23-2010 |
20110171645 | METHODS OF DIAGNOSING ACUTE CARDIAC ALLOGRAFT REJECTION - The present invention relates to methods of diagnosing acute rejection of a cardiac allograft using genomic expression profiling, proteomic expression profiling, metabolite profiling, or alloreactive T-cell genomic expression profiling, | 07-14-2011 |
20110189680 | Methods of Diagnosing Rejection of a Kidney Allograft Using Genomic or Proteomic Expression Profiling - A method of determining the acute allograft rejection status of a subject, the method comprising the steps of: determining the nucleic acid expression profile of one or more than one nucleic acid markers, or one or more than one proteomic markers in a biological sample from the subject; comparing the expression profile of the one or more than one nucleic acid markers to a control profile; and determining whether the expression level of the one or more than one nucleic acid markers is increased relative to the control profile, wherein the increase of the one or more than one nucleic acid markers is indicative of the acute rejection status of the subject. | 08-04-2011 |
20110263539 | SHIP 1 MODULATOR COMPOUNDS - The present invention provides the use of pelorol analogs of Formula, (I) and pharmaceutical compositions thereof as modulators of SHIP 1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions. | 10-27-2011 |
20120129925 | SHIP 1 MODULATORS - The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof. | 05-24-2012 |
Patent application number | Description | Published |
20100277253 | RF SIGNAL COMBINER/SPLITTER AND RELATED METHODS - A radio frequency (RF) signal combiner/splitter may include a printed circuit board (PCB) having first and second opposing major surfaces, and openings therethrough. The RF signal combiner/splitter may further include a ferromagnetic body. The ferromagnetic body may include a first portion spaced from the first major surface of the PCB, a second portion spaced from the second major surface of the PCB, and interconnecting portions coupling the first and second portions and extending through respective openings in the PCB. The PCB may include conductive traces cooperating with the ferromagnetic body to define circuitry for combining/splitting RF signals. For example, the PCB may further comprise additional conductive traces cooperating with the ferromagnetic body to define impedance matching circuitry coupled to the circuitry for combining/splitting RF signals. | 11-04-2010 |
20110260823 | TRANSMISSION LINE IMPEDANCE TRANSFORMER AND RELATED METHODS - A transmission line impedance transformer may include a printed circuit board (PCB) having a dielectric layer and an electrically conductive layer thereon defining a medial interconnection portion, and first and second lateral loop portions extending laterally outwardly from opposing first and second sides of the medial interconnection portion. The PCB also may have first ferrite body receiving openings therein adjacent the first lateral loop portion and second ferrite body receiving openings therein adjacent the second lateral loop portion. The transmission line impedance transformer may also include a first ferromagnetic body extending through the first ferrite body receiving openings to surround the first lateral loop portion, and a second ferromagnetic body extending through the second ferrite body receiving openings to surround the second lateral loop portion. | 10-27-2011 |
20130005281 | RF COMMUNICATIONS DEVICE WITH INVERSE FUNCTION FOR COUPLER THEREIN AND RELATED METHODS - A radio frequency (RF) communications device may include a power amplifier, an antenna, a tunable coupler between the power amplifier and the antenna, a processor, and an exciter module coupled between the processor and the power amplifier and generating an RF signal based upon a baseband signal. The processor may be configured to set the tunable coupler to a desired tuning and thereby defining a transfer function for the tunable coupler, and to generate an inverse transfer function of the transfer function of the tunable coupler. The processor may be configured to perform digital filtering upstream of the power amplifier based upon the inverse transfer function. | 01-03-2013 |
20130175628 | ELECTRONIC DEVICE INCLUDING ELECTRICALLY CONDUCTIVE BODY FOR ESD PROTECTION AND RELATED METHODS - An electronic device may include a transistor device including a transistor package and transistor terminals extending outwardly therefrom. The electronic device may also include an electrically conductive body removably coupled to and shorting together the transistor terminals for electrostatic discharge (ESD) protection. | 07-11-2013 |
20130203367 | ELECTRONIC DEVICE WITH ADJUSTABLE FILTER AND ASSOCIATED METHODS - An electronic device includes an adjustable filter with a first filter element, and a second filter element coupled to the first filter element. The second filter element includes a field effect transistor (FET) including a source terminal, a drain terminal, and a gate terminal. The source terminal and the gate terminal are coupled to a reference voltage. A control circuit is coupled to the drain terminal and is configured to apply a control voltage thereto to vary a capacitance between the source and drain terminals to adjust the adjustable filter. | 08-08-2013 |
20140080432 | ELECTRONIC DEVICE WITH ADJUSTABLE FILTER AND ASSOCIATED METHODS - An electronic device includes an adjustable filter with a first filter element, and a second filter element coupled to the first filter element. The second filter element includes a field effect transistor (FET) including a source terminal, a drain terminal, and a gate terminal. The source terminal and the gate terminal are coupled to a reference voltage. A control circuit is coupled to the drain terminal and is configured to apply a control voltage thereto to vary a capacitance between the source and drain terminals to adjust the adjustable filter. | 03-20-2014 |
Patent application number | Description | Published |
20090285878 | Compositions and methods for stabilizing liposomal drug formulations - The present invention is directed to liposomal compositions comprising a camptothecin, which are optimized to reduce camptothecin degradation and/or precipitation of camptothecin degradation products in the external medium. The invention further provides improved methods of formulating liposomal camptothecins, kits comprising liposome-encapsulated camptothecins, and methods of using the same to treat a variety of diseases and disorders, including cancer. | 11-19-2009 |
20110097720 | SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS - The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject. | 04-28-2011 |
20110117125 | COMPOSITIONS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS - The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art. | 05-19-2011 |
20120225434 | SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS - The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject. | 09-06-2012 |
20140295449 | SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS - The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject. | 10-02-2014 |
Patent application number | Description | Published |
20100235065 | METHOD FOR OPERATING A VEHICLE BRAKE SYSTEM - A method that compensates for temperature-related effects in a vehicle brake system. According to one embodiment, the method determines the temperature of a brake pad, calculates a temperature-based modifier, and then uses the temperature-based modifier to adjust one or more brake command signals provided to the vehicle brake system so that they are compensated for temperature-related changes in the coefficient of friction (μ) of the brake pad and rotor. The method may be used with brake-by-wire systems such as electrohydraulic braking (EHB) systems and electromechanical braking (EMB) systems. | 09-16-2010 |
20100280724 | METHODS AND SYSTEMS FOR CALIBRATING BRAKING SYSTEMS AND CONTROLLING BRAKING IN VEHICLES - A method for controlling braking in a vehicle having a brake pedal includes the steps of obtaining a first measure of braking intent based on movement of the brake pedal, obtaining a second measure of braking intent based on a force applied to the brake pedal, controlling the braking based on the first measure provided that a transition parameter is less than a first predetermined value, controlling the braking based on the second measure provided that the transition parameter is greater than a second predetermined value, and controlling the braking based on the first measure and the second measure provided that the transition parameter is greater than the first predetermined value and less than the second predetermined value. | 11-04-2010 |
20110015845 | METHODS AND SYSTEMS FOR CONTROLLING BRAKING OF A VEHICLE WHEN THE VEHICLE IS STATIONARY - A method for controlling braking of a vehicle includes the steps of calculating a first pressure based on a driver request, and providing pressure that does not exceed a predetermined pressure threshold if the vehicle is stationary and the first pressure is less than the predetermined pressure threshold. | 01-20-2011 |
20110049974 | METHODS AND SYSTEMS FOR BRAKING DIFFERENT AXLES OF A VEHICLE USING A DECELERATION VALUE - A method for controlling braking of a vehicle having a first axle and a second axle includes the steps of obtaining a deceleration value pertaining to an input from a driver of the vehicle, braking the first axle with a first pressure, braking the second axle with a second pressure that is substantially equal to the first pressure if the deceleration value has not exceeded a predetermined threshold, and braking the second axle with a third pressure that is greater than the first pressure if the deceleration value has exceeded the predetermined threshold. | 03-03-2011 |
20110130935 | METHODS AND SYSTEMS FOR BRAKE PEDAL TUNING AND BRAKING CONTROL IN VEHICLES - A method for calibrating a braking system of a vehicle having a brake pedal includes the steps of measuring, via a sensor, a speed of the vehicle, generating, via a processor, an optimized mapping relating a movement of the brake pedal and a deceleration of the vehicle based at least in part upon the speed of the vehicle, and calibrating, via the processor, a relationship between an engagement of the brake pedal and the deceleration of the vehicle using the optimized mapping. | 06-02-2011 |
20120133202 | DYNAMIC REGENERATIVE BRAKING TORQUE CONTROL - Methods, systems, and program products for adjusting regenerative braking torque in a vehicle having wheels and a regenerative braking system providing the regenerative braking torque are provided. A deceleration of the vehicle is determined. A wheel slip of the wheels is determined. The regenerative braking torque is adjusted for the regenerative braking system using the deceleration and the wheel slip. | 05-31-2012 |
20140081545 | METHODS AND SYSTEMS FOR CONTROLLING BRAKING OF A VEHICLE WHEN THE VEHICLE IS STATIONARY - A method for controlling braking of a vehicle includes the steps of calculating a first pressure based on a driver request, and providing pressure that does not exceed a predetermined pressure threshold if the vehicle is stationary and the first pressure is less than the predetermined pressure threshold. | 03-20-2014 |
20140103722 | ELECTRICAL SYSTEM AND METHOD FOR A HYBRID-ELECTRIC VEHICLE - An electrical system includes a battery for providing electrical power to a starter mechanism and an auxiliary load of a hybrid-electric vehicle. An electric double-layer capacitor (“EDLC”) is electrically connectable to the battery and the auxiliary load. A separation switch is electrically connected between the battery and the EDLC for electrically separating the battery from the EDLC and the auxiliary load. The separation switch is opened in response to the voltage across the battery being less than the voltage across the EDLC. | 04-17-2014 |
Patent application number | Description | Published |
20080247189 | Imaging device illumination system - An imaging device illumination system comprises first and second elongate light guides configured to emit light toward an object to be imaged, each of the first and second light guides having an input window at one end thereof for receiving light from a light source and an end face at an opposite end thereof, wherein the input window of the first light guide is disposed proximate to the end face of the second light guide. | 10-09-2008 |
20110181924 | IMAGE CAPTURE MODULE SUPPORT - In one embodiment, an apparatus includes a transparent platen supported over an inside of a tub, an elongated member situated in the tub in a horizontal plane, a plurality of biasing members operatively connected to the elongated member, and a plurality of gap-maintaining members operable to connect to an image capture module and operatively connected to the platen. The elongated member is movable within a tub in a vertical plane, to movably support an image capture module in a horizontal plane. The biasing members are operable to urge the elongated member towards the platen. The gap-maintaining members are operable to maintain a constant distance between platen and an image capture module. | 07-28-2011 |
20120281257 | IMAGING DEVICE ASSEMBLY - An imaging device assembly that includes a first imaging module frame, a second imaging module frame, and at least one first attachment member including a base positioned within an interior of the first imaging module frame and at least one protrusion extending from the base through a first wall portion of the first imaging module frame to be exposed external to the first imaging module frame, wherein the at least one protrusion is releasably connected to a top portion of the second imaging module frame. | 11-08-2012 |
20140340722 | SCANNER PLATEN - A scanner is disclosed. The scanner has a platen with at least one edge of the platen uncovered. | 11-20-2014 |