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Mosquera
Linda Allan Mosquera, Andover, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090070693 | Technique for individualizing content - Techniques which permit content developers with no programming skills to develop multi-versioned individualized content. The techniques include GUIs which permit the content developers to insert tags into the content without knowledge of tag syntax or of the syntax of rules for specifying conditional insertion. There are two GUIs, one for tags which specify positions at which personal information of a recipient is to be inserted into the content, and one for inserting tags for content that is specific to a particular version of the content. Once the GUI for the version tags specifies a version, ordinary editing operations on the content result in the production of the version tags. The GUIS further permit the content developer to specify generation of displays which show content which is shared by all of the versions, a particular version of the content, and a particular recipient's version. | 03-12-2009 |
Luis Mosquera, Oviedo, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20100184148 | IN VITRO GERMINAL CENTERS - The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days. | 07-22-2010 |
| 20110250620 | METHODS OF EVALUATING AN IMMUNE RESPONSE TO AN ANTIGEN - The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days. | 10-13-2011 |
| 20110269176 | METHODS FOR ASSAYING RESPONSES TO VACCINES - The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days. | 11-03-2011 |
Luis A. Mosquera, Miami, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20090092602 | USE OF ANTI-TISSUE FACTOR ANTIBODIES FOR TREATING THROMBOSES - Disclosed is a method for preventing or treating thrombosis in a mammal such as a primate and particularly a human patient. A preferred method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to human tissue factor (TF). Additional methods and kits are provided. | 04-09-2009 |
| 20090252726 | ANTIBODIES FOR INHIBITING BLOOD COAGULATION AND METHODS OF USE THEREOF - The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:FVIIa complex, effectively preventing factor X or FIX binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site. Also provided are humanized antibodies and fragments thereof that bind to the TF. | 10-08-2009 |
Luis D. Mosquera, Foster City, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120123889 | SYSTEM AND METHOD FOR STREAMLINED ACQUISITION, DOWNLOAD AND OPENING OF DIGITAL CONTENT - A system and method for the purchase, downloading and opening of digital content, which is accomplished with one or two gestures, e.g., button or taps. Digital content items are displayed on the user's local device along with a button, i.e., a “Buy” button that can be selected to purchase a particular item of content. The user taps, clicks, or selects the “Buy” button to initiate the purchase, downloading and opening of the content. The instruction to purchase the content is transmitted to the remote server, which completes the purchase transaction and begins the download of the purchased content. Included with the downloaded content, preferably as parameters or metadata, is an indication of which reader application is required to open and read the digital content. When the download to the user's local device is completed, it uses these parameters to automatically launch the appropriate reader and automatically open the purchased, downloaded content, without any action required by the user. | 05-17-2012 |
Michael Mosquera, Forked River, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100196292 | Hydrophylic silicone elastomers in cosmetics - The invention is directed to the use of a number of hydrophilic silicone elastomers in various cosmetic and personal care products where they serve various functions such as emulsifiers, film forming agents, viscosity stabilizers, conditioning agents and protective barrier forming agents. Emulsions and personal care products based upon same are also described. | 08-05-2010 |