Patent application number | Description | Published |
20090144841 | Polymorphisms in the human gene for the multidrug resistance-associated protein 1 (MRP-1) and their use in diagnostic and therapeutic applications - The present invention relates to a polymorphic MRP-1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit. | 06-04-2009 |
20120190017 | POLYMORPHISMS IN THE HUMAN GENE FOR THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (MRP-1) AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - The present invention relates to a polymorphic MRP-1 polynucleotide, genes or vectors comprising the polynucleotides and a host cell genetically engineered with the polynucleotide or gene. Also provided are methods for producing molecular variant polypeptides, cells capable of expressing a molecular variant polypeptide and to a polypeptide encoded by the polynucleotide or the gene or obtainable by the method or cells produced herein. Also provided is an antibody to the polypeptide, a transgenic animal, and to a solid support comprising one or a plurality of the provided polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also provided. In addition, the invention relates to methods for producing of a pharmaceutical composition, diagnosing a disease and, detection of the polynucleotide. Furthermore, provided herein are uses of the polynucleotides, genes, vectors, polypeptides or antibodies herein. | 07-26-2012 |
20130309665 | POLYMORPHISMS IN THE HUMAN GENE FOR THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (MRP-1) AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - The present invention relates to a polymorphic MRP-1 polynucleotide, genes or vectors comprising the polynucleotides and a host cell genetically engineered with the polynucleotide or gene. Also provided are methods for producing molecular variant polypeptides, cells capable of expressing a molecular variant polypeptide and a polypeptide encoded by the polynucleotide or the gene or obtainable by the method or cells produced herein. Also provided is an antibody to the polypeptide, a transgenic animal, and a solid support comprising one or a plurality of the provided polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also provided. In addition, the invention relates to methods for producing a pharmaceutical composition, diagnosing a disease and detection of the polynucleotide. Furthermore, provided herein are uses of the polynucleotides, genes, vectors, polypeptides or antibodies herein. | 11-21-2013 |
20150018229 | POLYMORPHISMS IN THE HUMAN GENE FOR THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (MRP-1) AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - The present invention relates to a polymorphic MRP-1 polynucleotide, genes or vectors comprising the polynucleotides and a host cell genetically engineered with the polynucleotide or gene. Also provided are methods for producing molecular variant polypeptides, cells capable of expressing a molecular variant polypeptide and a polypeptide encoded by the polynucleotide or the gene or obtainable by the method or cells produced herein. Also provided is an antibody to the polypeptide, a transgenic animal, and a solid support comprising one or a plurality of the provided polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also provided. In addition, the invention relates to methods for producing a pharmaceutical composition, diagnosing a disease and detection of the polynucleotide. Furthermore, provided herein are uses of the polynucleotides, genes, vectors, polypeptides or antibodies herein. | 01-15-2015 |
Patent application number | Description | Published |
20080315863 | Apparatus For the Measurement of a Streaming Potential of a Liquid Containing Solid Matter - Disclosed is an apparatus for measuring a streaming potential of a liquid containing solid matter. Said apparatus comprises a first electrode device relative to the direction of flow, said first electrode device being provided with a first rod-shaped electrode, as well as a second electrode device encompassing a second rod-shaped electrode, and a filter device located between the electrode devices. In order to improve the reproducibility and stability of the test results, the first electrode is embedded in a wall of a duct of the first electrode device so as to protrude into the duct by a maximum of half the diameter thereof perpendicular to the direction of flow. | 12-25-2008 |
20090217743 | DEVICE AND PROCESS FOR DETERMINING AN ORGANIC AND INORGANIC FRACTION OF A SAMPLE - A device is displayed for determining an organic and inorganic fraction of a sample, which comprises a suspension medium, particularly water, and also solids. A preferably tightly sealable treatment chamber is provided, which comprises a sampling device, a filter unit, which is constructed and attached to the sampling device such that the suspension medium can be removed from the sample through the filter unit, a suction device for removing the suspension medium, a heat energy source for supplying heat energy to the sample, a temperature measuring unit for recording the temperature of the sample, a weighing unit for weighing the sample and a control and data evaluation unit, for controlling the energy source and for receiving and storing output signals from the temperature measuring unit and also the weighing unit. All parts of the device are constructed so that a sample can be analysed within the treatment chamber, without having to remove it in the interim. This represents a considerable time saving. | 09-03-2009 |
20110209700 | INHALATION THERAPY DEVICE COMPRISING A VALVE - The inhalation therapy device according to the invention comprises a nebulizer chamber which accommodates an aerosol generator that emits aerosol into the nebulizer chamber. A valve that has a valve seat, a resilient valve member and a valve member positioning means is arranged at an opening of the nebulizer chamber. The valve member positioning means can be moved out of a first position and into a second position so as to position the valve member on the valve seat in such a manner that in the first position, the valve member, in a flow-free state, is positioned on the valve seat in a pre-tensioned manner and in a second position, is spaced apart from the valve seat. | 09-01-2011 |
20140291888 | INHALATION THERAPY DEVICE WITH A NOZZLE NEBULISER - The invention relates to an inhalation therapy device with a nozzle nebuliser, in particular with a nozzle nebuliser having a nozzle element which is easy to clean and is thereby simple and reliable to handle so that the nozzle is not damaged and the geometry of the nozzle is not affected during cleaning. The aerosol generator comprises a nozzle element, said nozzle consisting of at least a first part and a second part, said first part of the nozzle element being made of a more resilient material than said second part of the nozzle element, and said first part of the nozzle element being attached to said second part of the nozzle element. Owing to the resilient material, the nozzle can deform during cleaning and can return to the original shape without altering its initial geometry. | 10-02-2014 |