Patent application number | Description | Published |
20090093530 | (2R)-2-[4-Sulfonyl) Aminophenyl] Propanamides and Pharmaceutical Compositions Containing Them - The present invention relates to novel (2R)-2-phenylpropanamides bearing a 4-sulfonylamino substituent on the 4 position of the phenyl group and to pharmaceutical compositions containing them, which are used as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells, and which are useful in the treatment of various ELR+CXC chemokine-mediated disorders. In particular, the compounds of the invention are useful in the treatment and control of specific CXCR2 dependent pathologies such as BOS, COPD, angiogenesis and melanoma. | 04-09-2009 |
20090124664 | (R)-Arylalkylamino Derivatives and Pharmaceutical Compositions Containing Them - The present invention relates to selected (R)-arylalkylamino derivatives of formula (I), in which R, R1 and Ar are as defined in the claims. These compounds show a surprising potent inhibitory effect on C5a induced human PMN chemotaxis. The compounds of the invention absolutely lack of CXCL8 inhibitory activity. Said compounds are useful in the treatment of pathologies depending on the chemotactic activation of neutrophils and monocytes induced by the fraction C5a of the complement. In particular, the compounds of the invention are useful in the treatment of sepsis, psoriasis, rheumatoid arthritis, ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of injury caused by ischemia and reperfusion. | 05-14-2009 |
20100152256 | (2R)-2-[(4-sulfonyl) aminophenyl] propanamides and pharmaceutical compositions containing them - The present invention relates to novel (2R)-2-phenylpropanamides bearing a 4-sulfonylamino substituent on the 4 position of the phenyl group and to pharmaceutical compositions containing them, which are used as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells, and which are useful in the treatment of various ELR+CXC chemokine-mediated disorders. In particular, the compounds of the invention are useful in the treatment and control of specific CXCR2 dependent pathologies such as BOS, COPD, angiogenesis and melanoma. | 06-17-2010 |
20100249198 | (R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The present invention relates to a novel class of (R)-4-(heteroaryl)phenylpropionic derivatives of formula (I), useful in the inhibition of the chemotactic activation induced by the fraction C5a of complement. Said compounds are useful in the treatment of pathologies depending on the chemotactic activation of neutrophils and monocytes induced by the fraction C5a of the complement. In particular, the compounds of the invention are useful in the treatment of autoimmune hemolytic anemia (AIHA), psoriasis, bullous pemphigoid, rheumatoid arthritis, ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of injury caused by ischemia and reperfusion. | 09-30-2010 |
20100267726 | 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. In particular, 2(ortho)-substituted arylacetic acids or their derivatives, such as amides and sulfonamides, lack cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion. | 10-21-2010 |
20110195967 | 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from their activation. In particular, 2(ortho)-substituted arylacetic acids or their derivatives, such as amides and sulfonamides, lack cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion. | 08-11-2011 |
20140031398 | TRPM8 RECEPTOR ANTAGONISTS - Compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (hereinafter referred to as TRPM8), having formula: | 01-30-2014 |
20140371276 | TRPM8 ANTAGONISTS - The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I). Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exhacerbated respiratory disorders and urological disorders. | 12-18-2014 |
Patent application number | Description | Published |
20110155547 | MEDIUM VOLTAGE CIRCUIT BREAKER - A Medium Voltage circuit breaker which comprises a pole assembly having, for each phase, an interruption chamber housing a first fixed contact and a second movable contact reciprocally couplable/uncouplable between an open and close position; the Medium Voltage circuit breaker further comprises an actuator to actuate the opening and closing operation of said circuit breaker and an insulating base frame supporting said pole assembly and said actuator. | 06-30-2011 |
20110155555 | MEDIUM VOLTAGE CIRCUIT BREAKER - A Medium Voltage circuit breaker which comprises a pole assembly having, for each phase, a first fixed contact and a second movable contact reciprocally couplable/uncouplable between an open and close position. The circuit breaker further comprises an actuator to actuate the opening and closing operation of said circuit breaker, and a kinematic chain operatively connecting said actuator to said movable contact. The kinematic chain comprises a sliding element operatively connected to said actuator, said sliding element having a first sliding surface operatively coupled to said movable contact and being movable between a first, open, position and a second, closed, position. | 06-30-2011 |
20120320487 | Medium Voltage Circuit Breaker - A Medium Voltage circuit breaker which comprises an insulating base frame supporting: a pole assembly having, for each phase, an interruption unit housing a fixed contact and a movable contact reciprocally couplable/uncouplable between an open and a closed position; an actuator to actuate the opening and closing operation of said circuit breaker; and, a control and diagnostic unit comprising a control box having a casing housing a plurality of accessory devices of said circuit breaker. | 12-20-2012 |
20150087177 | ELECTRICAL ADAPTER, AND RELATED SWITCHGEAR PANEL - An electrical adapter is disclosed for connecting a connection contact of a circuit breaker with an associated contact piece of an electrical circuit along which the circuit breaker has to be inserted, including a hollow tubular element having a first end portion and a second end portion configured to be electrically connected to a connection contact and a contact piece, respectively, an inner cavity of the hollow tubular element having, at the first end portion, a first frusto-conical shape. A first connector having a hollow deformable body and configured to be accommodated inside the first end portion. A locking body configured to be securely placed along the inner cavity of the hollow tubular element. A second connector including a first connection portion configured to be accommodated inside the first end portion of the hollow tubular element. | 03-26-2015 |