Inventors list |
Assignees list |
Classification tree browser |
Top 100 Inventors |
Top 100 Assignees |
Morgan, MA
Adam Morgan, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110300132 | 4-AMINOQUINAZOLINE PRODRUGS - This invention relates to prodrugs of 4-aminoquinazoline compounds, and to pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering inhibitors of the EGFR and HER2. | 12-08-2011 |
Adam Morgan, Ashland, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120058085 | Deuterium Modified Benzimidazoles - This invention relates to derivatives of | 03-08-2012 |
Adam J. Morgan, Ashland, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110053964 | 4-AMINOQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF - This invention relates to novel 4-aminoquinazolines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering inhibitors of the EGFR and HER-2. | 03-03-2011 |
Barry Morgan, Franklin, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090062147 | Methods for synthesis of encoded libraries - The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag. | 03-05-2009 |
| 20090156624 | Methionine aminopeptidase-2 inhibitors and methods of use thereof - The present invention provides methods of parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention. | 06-18-2009 |
| 20090253638 | Somatostatin Antagonists - The invention features somatostatin antagonists having a D-amino acid at the second residue. | 10-08-2009 |
| 20090270341 | PRODUCT COMPRISING A TRANSDUCTION INHIBITOR OF HETEROTRIMERIC G PROTEIN SIGNALS COMBINED WITH ANOTHER ANTI-CANCER AGENT FOR THERAPEUTIC USE IN THE TREATMENT OF CANCER - A composition for treating cancer comprising an anti-tumorally effective amount of a product comprising at least one transduction inhibitor of heterotrimeric G protein signals and at least one other anti-cancer agent selected from the group consisting of prenyltransferase inhibitors, taxol and its analogues, gemcitabine and camptothecin and its analogues, administered simultaneously, separately or spread over a period of time and a pharmaceutical carrier. | 10-29-2009 |
| 20110136697 | METHODS FOR SYNTHESIS OF ENCODED LIBRARIES - The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag. | 06-09-2011 |
| 20110251089 | METHODS FOR SYNTHESIS OF ENCODED LIBRARIES - The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag. | 10-13-2011 |
| 20120071329 | METHODS FOR IDENTIFYING COMPOUNDS OF INTEREST USING ENCODED LIBRARIES - The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag. | 03-22-2012 |
Barry A. Morgan, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100069391 | Novel sEH Inhibitors and Their Use - The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. | 03-18-2010 |
Bruce A. Morgan, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080286261 | Methods of modulating hair growth - The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided. | 11-20-2008 |
| 20090232778 | Methods and Compositions for Hair Growth - Methods and compositions for identifying and isolating dermal papilla cells are described. DP cells can be identified based on corin expression. Isolated DP cells can be used, e.g., to modulate hair growth. | 09-17-2009 |
Bryan C. Morgan, Leominster, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090172432 | Power management in electronic systems - In one embodiment, an electronic apparatus comprises at least one processor and a computer readable medium coupled to the processor and comprising logic instructions encoded in the computer readable medium, wherein the instructions, when executed in a processing system, cause the processing system to perform operations comprising initializing a direct memory access profiler in an electronic system, wherein the direct memory access is coupled to a policy manager in the electronic system, measuring at least one memory consumption characteristic of the electronic system, communicating the at least one memory consumption characteristic to a policy manager of the electronic system, and using the at least one memory consumption characteristic to adjust a power state of the electronic system. | 07-02-2009 |
Charles R. Morgan, Manchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080301634 | METHOD AND APPARATUS FOR STREAM BASED MARKUP LANGUAGE POST-PROCESSING - Systems, methods and apparatus operate to receiving a markup processing program containing a set of markup processing instructions. Each markup processing instruction includes an operation defining a processing operation to be matched to a markup language representation and a corresponding action to be performed upon matching the operation to the markup language representation. The system receives the markup language representation containing encoded items representative of markup language constructs and executes the markup processing program in conjunction with the markup language representation to dynamically control generation of an output control signal indicating how the markup language representation is to be processed for generation of output based on the markup language representation. The markup processing program is applied in real-time to streaming XML data and represents logic instructions that carry out application of post processing such as XPATH expression evaluation, schema validation or other post processing on the stream of XML data. | 12-04-2008 |
| 20080320382 | METHOD AND APPARATUS FOR STREAM BASED MARKUP LANGUAGE POST-PROCESSING - Systems, methods and apparatus operate to receiving a markup processing program containing a set of markup processing instructions. Each markup processing instruction includes an operation defining a processing operation to be matched to a markup language representation and a corresponding action to be performed upon matching the operation to the markup language representation. The system receives the markup language representation containing encoded items representative of markup language constructs and executes the markup processing program in conjunction with the markup language representation to dynamically control generation of an output control signal indicating how the markup language representation is to be processed for generation of output based on the markup language representation. The markup processing program is applied in real-time to streaming XML data and represents logic instructions that carry out application of post processing such as XPATH expression evaluation, schema validation or other post processing on the stream of XML data. | 12-25-2008 |
Charles R. Morgan, Topsfield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090150891 | RESPONSIVE TASK SCHEDULING IN COOPERATIVE MULTI-TASKING ENVIRONMENTS - Task scheduling in cooperative multi-tasking environments is accomplished by a task scheduler that evaluates the relative priority of an executing task and tasks in a queue waiting to be executed. The task scheduler may issue a suspend request to lower priority tasks so that high priority tasks can be executed. Tasks are written or compiled with checks located at opportune locations for suspending and resuming the given task. The tasks under a suspend request continue operation until they reach a check, at which point the task will suspend operation depending on specific criteria. By allowing both the task and the task scheduler to assist in determining the precise timing of the suspension, the multi-tasking environment becomes highly efficient and responsive. | 06-11-2009 |
Dan Morgan, Salem, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090182353 | THERMAL SUTURE WELDING APPARATUS AND METHOD - A method of suture welding is disclosed which includes: receiving suture segments between first and second jaw members, the first and second jaw members being in an open state. closing the first and second jaw members to captively hold and position the suture segments between the first and second jaw members; selectively applying an elongated joiner element to the suture segments where the joiner element has a selectively operative heating element facing the suture segments; and applying energy to the heating element to weld the suture segments-to-be-welded, whereby the heating element has a temperature above a predetermined threshold adapted to at least partially melt the suture segments. | 07-16-2009 |
| 20090191174 | BLOOD PROCESSING DEVICE AND ASSOCIATED SYSTEMS AND METHODS - The present invention is directed to an environmentally closed cell processing device, for the aseptic processing of blood cells. The device includes a continuous flow centrifuge, fluid reservoirs and fluid handling systems. Blood cells are processed by the present device, to remove their immunodominant antigens. Seroconverted cells and methods of treating subjects with these cells are also described. | 07-30-2009 |
Dane Morgan, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100330426 | Electrode Active Material and Method of Making The Same - The invention provides an electrochemical cell which includes a first electrode and a second electrode which is a counter electrode to said first electrode, and an electrolyte material interposed there between. The first electrode includes an alkali metal phosphorous compound doped with an element having a valence state greater than that of the alkali metal. | 12-30-2010 |
Daniel E. Morgan, Salem, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120136378 | SUB-CORTICAL SUTURE CUTTER - An arthroscopic suture cutting device according to embodiments of the invention includes an outer tube; an inner rod including an outer surface and an aperture, a distalmost edge of a second distal opening located distally of a distalmost edge of a first distal opening, the inner rod can receive a suture extending through both distal openings; in a loading position, the inner rod extends distally of the outer tube to receive the suture; in an intermediate position, the distal openings are closer to the outer tube, such that the suture is permitted to slide through the aperture without release; and in a cut position, the distalmost edges of the distal openings are within the outer tube. Moving from intermediate position to cut position draws the suture between outer tube and inner rod, urging the inner rod radially toward the second distal opening, cutting the suture between the outer tube and the distalmost edge of the second distal opening. | 05-31-2012 |
David S. Morgan, Clinton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090274505 | Braille Writer - Mechanical braille writer. The braille writer includes a chassis supporting a plurality of finger operated keys with each key mechanically interconnected with an embossing mechanism so that depression of a key causes a corresponding one of a plurality of pins in the embossing mechanism to extend outwardly from the embossing mechanism to create a raised dot on paper adjacent to the embossing mechanism. The embossing mechanism comprises a block adapted for slidingly guiding the plurality of pins for paper contact. It is preferred that each one of the plurality of pins is straight and identical to the other pins. | 11-05-2009 |
Eleanor D. Morgan, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100015293 | MULTI-COMPONENT PACKAGING SYSTEM AND APPARATUS - A multi-component packaging system includes a lower containing assembly, an upper containing assembly, and a cover. The lower containing assembly defines an interior cavity that is adapted to receive a first food component. The upper containing assembly defines an interior that is adapted to receive a second food component. The upper containing assembly is adapted for engagement with the lower containing assembly. The cover is engaged with at least one of the lower containing assembly and the upper containing assembly. The cover includes a passage portion that defines a plurality of apertures. Anti-foam compositions for use in the multi-component packaging system and a multi-component packaging system containing the anti-foam compositions disposed on one or more interior surfaces of the packaging system are also disclosed. | 01-21-2010 |
Frederick Morgan, Canton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080204268 | METHODS AND APPARATUS FOR CONVEYING INFORMATION VIA COLOR OF LIGHT - Methods and apparatus for conveying information. One or more information signals representing scalar or numeric information that is not associated with color is/are received from a data base, a network, the World Wide Web, or a software program. The information signal(s) is/are converted into one or more illumination control signals representing at least color information, and a color of illumination generated by one or more LED-based light sources is controlled in response to the illumination control signal(s) so as to convey the scalar or numeric information via at least the color of the generated illumination. | 08-28-2008 |
| 20090050908 | Solid state lighting component - An LED component according to the present invention comprising an array of LED chips mounted on a submount with the LED chips capable of emitting light in response to an electrical signal. The array can comprise LED chips emitting at two colors of light wherein the LED component emits light comprising the combination of the two colors of light. A single lens is included over the array of LED chips. The LED chip array can emit light of greater than 800 lumens with a drive current of less than 150 milli-Amps. The LED chip component can also operate at temperatures less than 3000 degrees K. In one embodiment, the LED array is in a substantially circular pattern on the submount. | 02-26-2009 |
| 20100127634 | METHODS AND APPARATUS FOR CONVEYING INFORMATION VIA COLOR OF LIGHT - Methods and apparatus for conveying information. One or more information signals representing scalar or numeric information that is not associated with color is/are received from a data base, a network, the World Wide Web, or a software program. The information signal(s) is/are converted into one or more illumination control signals representing at least color information, and a color of illumination generated by one or more LED-based light sources is controlled in response to the illumination control signal(s) so as to convey the scalar or numeric information via at least the color of the generated illumination. | 05-27-2010 |
| 20110151507 | Solar Biofactory, Photobioreactors, Passive Thermal Regulation Systems and Methods for Producing Products - The invention described herein relates to photobioreactors, methods, assembly and use of such apparatus for culturing light-capturing organisms in a cost-effective manner. Various embodiments provide for a passive thermal regulation system employing selected microorganisms in a photobioreactor apparatus and methods for biological production of various fuel and chemical products from these organisms. Additional embodiments provide a solar biofactory system capable of culturing light capturing organisms to an areal productivity of 3.3 g/m2/hr. Further embodiments are directed to a photobioreactor capable of culturing light capturing organisms to an OD | 06-23-2011 |
Frederick M. Morgan, Quincy, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080215391 | UNIVERSAL LIGHTING NETWORK METHODS AND SYSTEMS - Methods and apparatus relating to the collection of data regarding a plurality of customers in a retail or entertainment environment. Data may be collected via at least one sensor coupled to at least one lighting fixture in the retail or entertainment environment. In one exemplary implementation, data may be collected by one or more lighting fixtures, and data may be communicated via light generated by any one or more fixtures without perceivably affecting a quality of light generated by the one or more fixtures. A map may be generated based on the collected data to display traffic patterns and/or dwell times of the plurality of customers in the retail or entertainment environment, and such a map may be displayed, for example, via a graphical user interface. | 09-04-2008 |
| 20100148689 | SYSTEMS AND METHODS FOR CALIBRATING LIGHT OUTPUT BY LIGHT-EMITTING DIODES - A system and method for calibrating light output from an LED is provided. The system includes a support on which an LED is positioned, a photosensor to measure the light output from the LED, and means for calibrating and adjusting the light output of the LED. Calibration is accomplished by measuring the light output from the LED, comparing such output against a reference value, and adjusting the measured output against the reference value. | 06-17-2010 |
| 20100171145 | LED PACKAGE METHODS AND SYSTEMS - Methods and systems are provided for LED modules that include an LED die integrated in an LED package with a submount that includes an electronic component for controlling the light emitted by the LED die. The electronic component integrated in the s submount may include drive hardware, a network interface, memory, a processor, a switch-mode power supply, a power facility, or another type of electronic component. | 07-08-2010 |
Frederick M. Morgan, Canton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100207534 | INTEGRATED LED-BASED LUMINARE FOR GENERAL LIGHTING - Lighting apparatus and methods employing LED light sources are described. The LED light sources are integrated with other components in the form of a luminaire or other general purpose lighting structure. Some of the lighting structures are formed as Parabolic Aluminum Reflector (PAR) luminaires, allowing them to be inserted into conventional sockets. The lighting structures display beneficial operating characteristics, such as efficient operation, high thermal dissipation, high output, and good color mixing. | 08-19-2010 |
| 20110217692 | Photobioreactors, Solar Energy Gathering Systems, And Thermal Control Methods - The present invention provides photobioreactors, solar energy gathering systems, and methods for thermal control of a culture medium containing a prototrophic organism in a photobioreactor, that allow temperature control in a cost effective manner, reducing the energy required for temperature control of a culture medium containing phototrophic microorganisms in a photobioreactor. | 09-08-2011 |
Jeffrey Morgan, Sharon, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090018033 | Cell Aggregation and Encapsulation Device and Method - The invention is a cell aggregation device comprising a hydrogel substrate having at least one, preferably a plurality, of cell-repellant compartments recessed into the uppermost surface. Each compartment is composed of an upper cell suspension seeding chamber having an open uppermost portion and a bottom portion, and one, or more than one, lower cell aggregation recess connected to the bottom portion of the upper cell suspension seeding chamber by a port. The diameter of the port may be fully contiguous with the walls of the chambers and walls of the recesses, or the diameter of the port may be more narrow than the walls of the chamber but fully contiguous with the walls of the recesses or more narrow than both the walls of the chamber and the walls of the recesses. The upper cell suspension seeding chambers are formed and positioned to funnel the cells into the lower cell aggregation recesses through gravitational force. The aggregation recesses are formed and positioned to promote cellular aggregation by coalescing cells into a finite region of minimum gravitational energy, increasing intercellular contact and minimizing or preventing cell adherence to the substrate. A device for encapsulating aggregates of live cells is provided. The device comprises (i) a biocompatible, bio-sustainable substrate having a cell-encapsulating face composed of one or more biocompatible, bio-sustainable, spaced-apart, cell-encapsulating compartments extending therefrom and (ii) a coating layer composed of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and the cell-encapsulating compartments. A method for making the device is also provided. | 01-15-2009 |
Jeffrey R. Morgan, Sharon, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090104095 | NOVEL COMPOSITIONS AND RELATED METHODS, COATINGS, AND ARTICLES - Novel compositions, as well as related methods, coatings, and articles, are disclosed. | 04-23-2009 |
| 20090104473 | NOVEL COMPOSITIONS AND RELATED METHODS, COATINGS, AND ARTICLES - Novel compositions, as well as related methods, coatings, and articles, are disclosed. | 04-23-2009 |
| 20090105384 | NOVEL COMPOSITIONS AND RELATED METHODS, COATINGS, AND ARTICLES - Novel compositions, as well as related methods, coatings, and articles, are disclosed. | 04-23-2009 |
| 20110212481 | ASSAYS AND METHODS FOR FUSING CELL AGGREGATES TO FORM PROTO-TISSUES - Provided are assays and methods for creating proto-tissues from aggregates of cells. The invention concerns assays and methods useful in tissue engineering and reconstruction techniques, specifically in the formation of macrotissues from microtissues using microtissue pre-culture time as a controlling parameter. | 09-01-2011 |
John Morgan, Marblehead, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100052697 | REPAIRING DEFECTS - Methods and systems for defect repair are disclosed. The methods include: (a) identifying a defect causing an absence of an electrical connection between a first circuit element and a second circuit element, the first and second circuit elements being positioned in or on a substrate and the defect being positioned in the substrate; (b) removing a portion of the substrate to expose the defect, and depositing a conductive material to electrically connect the first and second circuit elements; and (c) verifying that the defect caused the absence of an electrical connection between the first and second circuit elements. | 03-04-2010 |
| 20120085906 | CROSS-SECTION SYSTEMS AND METHODS - A first instrument ( | 04-12-2012 |
Jonathan A. Morgan, Groton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090067417 | Method and apparatus for supporting SIP/IMS-based femtocells - A femtocell is integrated into a core network so as to securely and efficiently deliver one or more mobile services to an end user on an existing mobile device over a broadband connection. This integration can be into a basic Internet Protocol (IP)-based network, or an IMS-based network. In an illustrated embodiment, a femtocell is integrated to a SIP- or IMS-based network using a “convergence” server. The convergence server preferably is a SIP-based fixed mobile convergence (FMC) application server that provides an all-IP approach to core network integration for femtocells. The convergence server provides a number of high level functions including secure access of an end user mobile device into the core network through the femtocell (which involves authenticating the femtocell as well as a specific end user mobile device), single number voice and messaging services (by updating an end user's location to be the femtocell), mobility (to support handover between the femtocell and macro cell networks), delivery of supplementary services (such as call waiting, call hold, caller ID, three-way calling, and the like) on the femtocell network, and the delivery of new and advanced services (such as home landline routing, mobile TV, multimedia downloads and the like). | 03-12-2009 |
Michael D. Morgan, Billerica, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100310846 | CEMENTITIOUS FOAMS AND FOAM SLURRIES - Lightweight cementitious foams of the invention have excellent dynamic and dimensional stability due to use of foaming system comprising polycarboxylate surfactant foam generating agent, foam stabilizer (e.g., PVOH), and shrinkage reducing admixture to inhibit plastic shrinkage and micro-cracking of cement. The foaming system can be used in conventional cement mortars or concretes as well as with exemplary cementitious slurry systems of the invention, which include an expansive agent, a cross-linking agent for the foam stabilizer. Microfibers can be used in the foam, slurry, or both, to prevent micro-cracking. Cementitious foams can be made without use of autoclave or lightweight aggregates to achieve enhanced compressive strength and thermal insulation properties that compare favorably with conventional foams and insulation materials at comparable densities. | 12-09-2010 |
Oliver Morgan, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110099462 | Content Integrity Management System - A method and system are provided for efficiently verifying the integrity of file-based video audio and other essence in a content production system. The method involves creating a sequence of hash codes for the editable units of the essence, which are stored as metadata apart from the content (either in a separate file or in a separate portion of the same file), and are correlated to the content by a time label (which may be an offset or a timecode number). Upon retrieval from storage, the hash codes are generated for the retrieved essence and compared to the stored hash codes to verify that the content has not been modified. | 04-28-2011 |
Peter Morgan, Natick, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120131566 | EFFICIENT VIRTUAL APPLICATION UPDATE - Efficient virtual application updating is enabled. An old version of a virtual application can be compared to a new version of the virtual application and updated as a function thereof. A file unchanged from the old version to the new version can be hard linked from the new version to the old version. For a changed file, matching portions of the file can be copied from the old version to the new version, and remaining un-matching portions can be acquired from another source. | 05-24-2012 |
Peter A. Morgan, Allston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100287313 | APPLICATION VIRTUALIZATION - A virtual application packaged for a specific executing environment may be executed on a processing device having an executing environment different from the specific executing environment. A reference, included in extracted installer metadata, to one or more key paths of a hierarchically-structured data store may be modified according to a set of rules related to the executing environment detected in the processing device. The modified extracted installer metadata may be provided to an installer for installing the virtual application. During execution of the virtual application, a request to read, write, or modify the hierarchically-structured data store may be intercepted and changed, such that a first key path included in the request may be mapped to a second key path, based on the detected executing environment. Similarly, a response to the request, which may include the second key path, may be intercepted and modified, to the first key path. | 11-11-2010 |
Richard D. Morgan, Middleton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090036320 | Rational Design of Binding Proteins That Recognize Desired Specific Sequences - Methods and compositions are provided for creating a binding protein that recognizes a rationally chosen recognition sequence in which a first amino acid has been substituted for a second amino acid using site-directed mutagenesis of a member protein of a set of proteins at an identified position or positions correlated with recognition of a chosen specified target module in the recognition sequence. A system is provided for automating the storage and manipulation of the correlations between positions and types of amino acid residues in the binding protein with specific modules at specified positions in the target recognition sequence and for designing and creating proteins with novel specificities. | 02-05-2009 |
| 20100159534 | Recombinant Type II Restriction Endonuclease, NmeAIII, and a Process for Producing the Same - A protein is described that has an amino acid sequence characterized by at least 90% sequence identity with SEQ ID NO: 24, the protein being capable of recognizing a sequence consisting of 5′-GCCGAG-3′ within the double-stranded DNA and cleaving the substrate predominantly at 21/19 nucleotides from the recognition site. A method is also described that utilizes the protein for creating a DNA tag for use as a unique identifier for paired end sequencing of DNA or serial analysis of gene expression. | 06-24-2010 |
| 20100304462 | Synthetic Binding Proteins - Methods and compositions are provided for creating a binding protein that recognizes a rationally chosen recognition sequence in which a first amino acid has been substituted for a second amino acid using site-directed mutagenesis of a member protein of a set of proteins at an identified position or positions correlated with recognition of a chosen specified target module in the recognition sequence. A system is provided for automating the storage and manipulation of the correlations between positions and types of amino acid residues in the binding protein with specific modules at specified positions in the target recognition sequence and for designing and creating proteins with novel specificities. | 12-02-2010 |
| 20100330551 | Novel Restriction Endonucleases, DNA Encoding These Endonucleases and Methods for Identifying New Endonucleases with the Same or Varied Specificity - Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases or isoschizomers. The sequence similarity analyses includes selecting a positive sequence match from any sequence producing an expectation value of less than or equal to e-02. | 12-30-2010 |
Ricky James Morgan, Chestnut Hill, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120091550 | SPECTROSCOPY AND SPECTRAL IMAGING METHODS AND APPARATUS - The invention pertains to a new type of standing wave filter in which the detector is located within the cavity, rather than outside the cavity and methods of manufacturing such a filter. | 04-19-2012 |
Thomas T. Morgan, Pepperell, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100247436 | In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles - Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors. | 09-30-2010 |
| 20110129413 | Bioconjugation of Calcium Phosphosilicate Nanoparticles For Selective Targeting of Cells In Vivo - Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents are protected from interaction with the environment at normal physiological pH. However, once the CPNPs have been taken up, at intracellular pH, the CPNPs dissolve releasing the agent. Thus, chemotherapeutic or imaging agents are delivered to specific cells and permit the treatment and/or imaging of those cells. Use of the bioconjugated CPNPs both limits the amount of systemic exposure to the agent and delivers a higher concentration of the agent to the cell. The methods and principals of bioconjugating CPNPs are taught by examples of bioconjugation of targeting molecules for breast cancer, pancreatic cancer, and leukemia. | 06-02-2011 |
Vincent J. Morgan, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080206711 | Integrated Dental Abutment Block - An integrated abutment block has an abutment with an internal portion imbedded in the block and a depending post. | 08-28-2008 |