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Morgan, Jr., US
A. Charles Morgan, Jr., Scottsdale, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20090274710 | TRANS-MEMBRANE-ANTIBODY INDUCED INHIBITION OF APOPTOSIS - Cell suicide (apoptosis) is associated with pathogenesis, for example, it is the major cause for the loss of neurons in Alzheimer's disease. Caspase-3 is critically involved in the pathway of apoptosis. Superantibody (SAT)-trans-membrane technology has been used to produce antibodies against the caspase enzyme in an effort to inhibit apoptosis in living cells. The advantage of using trans-membrane antibodies as apoptosis inhibitors is their specific target recognition in the cell and their lower toxicity compared to conventional apoptosis inhibitors. It is shown that a MTS-transport-peptide modified monoclonal anti-caspase-3 antibody reduces actinomycin D-induced apoptosis and cleavage of spectrin in living cells. These results indicate that antibodies conjugated to a membrane transporter peptide have a therapeutic potential to inhibit apoptosis in a variety of diseases. | 11-05-2009 |
Alton C. Morgan, Jr., Scottsdale, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20090208418 | SUPERANTIBODY SYNTHESIS AND USE IN DETECTION, PREVENTION AND TREATMENT OF DISEASE - Superantibodies having enhanced autophilic, catalytic, and/or membrane-penetrating properties are prepared by affinity-based conjugation of a photoactivatable organic molecule to a target immunoglobulin. The photoactivatable organic molecule bears a chromophoric aromatic hydrocarbon moiety, which has affinity for the immunoglobulin. Upon photolysis, the organic molecule is covalently linked to the immunoglobulin. A preferred organic molecule is a peptide and a preferred aromatic hydrocarbon moiety is a tryptophan residue. The photoactivatable organic molecule need not bear a purine, pyrimidine or azido group to effect binding to the immunoglobulin and/or photoactivation. The superantibodies can enhance the potency and expand the targeting range of target antibodies. Autophilic superantibodies can promote apoptosis of target cells and/or enhance therapeutic efficacies in the treatment of patients with diseases or disorders responsive to antibody therapy. Exemplary of such diseases are atherosclerosis and cardiovascular disease. Membrane-penetrating superantibodies can prevent apoptosis by binding to intracellular anti-caspase signal proteins. Compositions containing the superantibodies, as well as methods of making and using them, are disclosed. | 08-20-2009 |
| 20100017898 | THERAPEUTIC APPLICATIONS OF NONCOVALENT DIMERIZING ANTIBODIES - Compositions and methods for providing antibodies having noncovalent, self-binding properties are disclosed. Such autophilic antibodies can bind cellular receptors to promote apoptosis of target cells and enhance therapeutic efficacies in the treatment of patients with debilitating or life-threatening diseases. Representative diseases targeted by the autophilic antibodies are lymphomas, breast cancers, colon cancers, and melanomas. Autoimmune disorders, Alzheimer's disease, and other neuro-degenerative conditions, as well as graft or transplant rejection, are among other treatable conditions. | 01-21-2010 |
Alton Charles Morgan, Jr., Scottsdale, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20090317379 | AUTOPHILIC ANTIBODIES AND METHOD OF MAKING THE SAME - Antibodies having noncovalent, autophilic properties are disclosed. The autophilic antibodies are derived from antibodies conjugated with an autophilic peptide. Such autophilic antibodies can promote apoptosis of target cells and enhance therapeutic efficacies in the treatment of patients with diseases or disorders responsive to antibody therapy. Compositions containing the antibodies, and methods of making and using the antibodies are also disclosed. | 12-24-2009 |
Christopher C. Morgan, Jr., Plymouth, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20100130318 | Anti-Slip Sheaves for Continuously Variable Transmissions - A sheave for use in a continuously variable transmission comprises a truncated, substantially conical portion having an inner radius, an outer radius and a contact surface extending between the inner radius and the outer radius. The contact surface of the sheave may include a plurality of concentric step features such that the contact surface is graduated between the inner radius and the outer radius. Each step feature may include a rise portion and a pitch portion. The rise portion of each step feature and the pitch portion of each step feature may extend in a circumferential direction on the contact surface. | 05-27-2010 |
Christopher Carleton Morgan, Jr., Plymouth, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20100130327 | Multi-Drive Fluid Pump - A multi-drive pump may include a pump housing, an inlet port, an outlet port, a primary pump gear, a secondary pump gear, a first internal mechanical drive mechanism coupled to the primary pump gear and a second internal mechanical drive mechanism and an internal electro-magnetic drive mechanism coupled to the secondary pump gear. The pump housing may define an internal volume fluidly coupled to the inlet port and the outlet port. The primary pump gear and the secondary pump gear may be positioned in the pump housing and coupled to one another. Rotation of the primary pump gear and the secondary pump gear draws fluid into the inlet port and expels fluid from the outlet port. The primary pump gear may be rotated by the first internal mechanical drive mechanism and the secondary pump gear may be rotated by the second internal mechanical drive mechanism and the internal electro-magnetic drive mechanism. | 05-27-2010 |
David J. Morgan, Jr., Los Altos, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100105767 | COMPOUNDS, COMPOSITIONS AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. | 04-29-2010 |
H. William Morgan, Jr., Centre Hall, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100044379 | Vessel lock down system - A pressure vessel includes a lid being rotatable into an unlocked position by a first actuator and then raised vertically above its housing by a second actuator secured along the housing. A pressure safety latch is provided to both vent the vessel before the Hd is moved into its unlocked position and release the lid for unlocking rotatable movement. | 02-25-2010 |
| 20100193427 | FILTRATION ELEMENT HAVING A VARIABLE DENSITY SIDEWALL - A filter made of specifically arranged filaments. The filter has an upstream side where fluid enters and a downstream side where fluid exits. The filaments are greatest in diameter near the upstream side wherein the filaments continuously and gradually decrease in thickness toward the downstream side. The pores or spaces between the filaments are largest near the upstream side and decrease gradually toward the downstream side. This allows various size particles to become entrained in the filter in an evenly distributed manner. | 08-05-2010 |
Noel E. Morgan, Jr., North Olmsted, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20090102083 | Method and System for Wavelength Specific Thermal Irradiation and Treatment - A system for direct injection of selected, narrow bandwidth thermal-infrared (IR) radiation or energy into articles for a wide range of processing purposes is provided. The irradiation wavelengths are selected according to the specific absorption band characteristics of the target entity to create the desired efficiency of thermal transfer. The applications of the invention may include heating, raising or maintaining the temperature of articles, or stimulating a target item in a range of different industrial, medical, consumer, or commercial circumstances. The system is especially applicable to operations that require or benefit from the ability to irradiate at specifically selected mid-infrared wavelengths or to pulse or inject the radiation. The system is particularly advantageous when functioning at higher speeds and in a non-contact environment with the target. | 04-23-2009 |
| 20110002675 | DIGITAL HEAT INJECTION BY WAY OF SURFACE EMITTING SEMI-CONDUCTOR DEVICES - A method and system are provided for digitally injecting heat into a wide range of products by way of incorporation of a special class of semi-conductor lasers, e.g. surface emitting devices. This technique relates to a more specific, economical, and advantageous way of practicing the art of directly injecting narrowband radiant energy that desirously matches the absorption specification of a particular material at a specified wavelength. | 01-06-2011 |
| 20110006462 | METHOD AND SYSTEM FOR MOLDLESS BOTTLE MANUFACTURING - A method and/or system for forming a plastic bottle from a preform without the use of a mold or a complete mold are provided. The technique includes selectively injecting heat into the preform using narrowband irradiation devices emitting irradiation in a narrow wavelength band matching desired absorptive characteristics of selective portions of the preform according to a predetermined heat signature to achieve a three-dimensional heat profile in the preform. The heat profile corresponds to a desired shape of a finished bottle and facilitates self-limiting stretching of the selected portions of the preform to achieve the desired shape. Using the technique, air is selectively injected into the preform to form in free air the finished bottle having the desired shape. | 01-13-2011 |
William G. Morgan, Jr., Sanford, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20100313435 | METHOD AND SYSTEM FOR ADJUSTING A TURBOMACHINE GLAND SEAL - A method of determining an alignment of a floating seal for a turbo machine, including establishing a reference surface on a rotor of the turbomachine that is essentially perpendicular to an instantaneous centerline of the rotor, establishing a control surface that radially aligns a floating seal member that surrounds the rotor, providing an inflatable member arranged between a stationary portion of the turbomachine and a surface of the floating seal, inflating the inflatable member such that the inflatable member urges the floating seal firmly against the control surface, measuring an axial distance between the floating seal and the reference surface at a plurality of locations, determining a parallelism between the facing surfaces of the floating seal and the rotor based upon the plurality of measured axial distances, comparing the determined parallelism with a predetermined threshold, and adjusting an orientation of the control surface based upon the comparison. | 12-16-2010 |