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| 20090111110 | Method of diagnosing adolescent idiopathic scoliosis and related syndromes causing spinal deformities and method for screening for a compound useful in the treatment of any of these diseases - A method for diagnosing an increased risk for a disease characterized by a dysfunctional melatonin-signaling pathway in an animal comprising detecting the presence or absence of at least one impairment in melatonin-signaling pathway in at least one of the animal's cells, wherein the presence of at least one impairment in melatonin-signaling pathway indicates that the animal possesses an increased risk of developing said disease. and a method of screening for a compound useful in the treatment of a disease characterized by a dysfunctional melatonin-signaling pathway, said method comprising the steps of contacting a candidate compound with at least one cell expressing at least one melatonin-signaling pathway impairment, wherein the candidate compound is selected if said melatonin-signaling pathway impairment is reduced in the presence of the candidate compound as compared to that in the absence thereof. | 04-30-2009 |
| 20100028882 | METHODS FOR DIAGNOSING OSTEOARTHRITIS - Methods are disclosed for assessing risk of developing osteoarthritis. Said methods comprise determining the cellular localizations, blood or synovial fluid concentrations, sumoylation states and post-translational modifications of pituitary homeobox transcription factor 1 (pitx-1) repressor proteins, identifying mutations in genes which encode said proteins and identifying any mutations or post-translational modifications causing the nuclear accumulation or retention of said proteins. Said proteins include prohibitin (PHB-I), prohibitone (PHB-2) and B cell lymphoma-6 transcriptional repressor interacting co-repressor (BCoR). | 02-04-2010 |
| 20100029567 | METHOD OF CORRECTING IMBALANCE BETWEEN BONE RESORPTION AND BONE FORMATION AND KITS AND COMPOSITIONS THEREFOR - Compounds, methods, uses, compositions, kits and packages for the treatment of imbalance between bone resorption and bone formation, based on uses of 4-phenyl-2 propionamidotetralin (4-P-PDOT) and analogs, derivatives, prodrugs, precursors thereof, and salts thereof, are described. | 02-04-2010 |
| 20100055707 | METHODS OF SCREENING FOR COMPOUNDS FOR USE AS MODULATORS OF LEFT-RIGHT ASYMMETRY IN SCOLIOTIC SUBJECTS AND FOR MONITORING EFFICACY OF AN ORTHOPAEDIC DEVICE - A method of screening for a compound for treating or preventing adolescent idiopathic scoliosis (AIS), said method comprising: (a) contacting a test compound with a paraspinal skin fibroblast or a paraspinal muscle cell sample from the right and/or left side of the spine of a subject; and (b) determining at least one of Nodal, Notch1, Pitx2, Lefty1 and Lefty2's expression and/or activity in the cell sample; wherein the test compound is selected as potentially useful in treating or preventing AIS if at least one of Nodal, Notch1, Pitx2, Lefty1 and Lefty2's expression and/or activity in the cell sample is different in the presence of the test compound as compared to in the absence thereof. | 03-04-2010 |
| 20100075333 | METHOD OF DETERMINING THE RISK OF SCOLIOSIS - A method for determining the risk for developing a scoliosis comprising monitoring osteopontin (OPN) expression in a sample from a subject over time; wherein an OPN expression that increases in the subject sample over time is indicative that the subject is at risk for developing a scoliosis. | 03-25-2010 |
| 20100173296 | METHODS OF STRATIFYING ADOLESCENT IDIOPATHIC SCOLIOSIS, ISOLATED NUCLEIC ACID MOLECULES FOR USE IN SAME AND KITS USING SAME - A method of stratifying a subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting Paired-like homeodomain transcription factor 1 (Pitxi) expression in the cell sample; whereby the results of the detecting step enables the stratification of the subject having AIS as belonging to an AIS subclass. | 07-08-2010 |
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| 20080260160 | Opt-in process and nameserver system for IETF DNSSEC - The process of signing and then publishing a DNS zone according to the IETF DNSSEC protocols is improved by the present invention, in order to facilitate the DNSSEC deployment until most of the DNS zones are signed. The prior art situation is that a second-level domain, e.g. example.com, often faces an unwanted status of “DNSSEC island of security,” and a challenging task of “trust anchor key” out-of-band distribution. The invention somehow fixes such broken DNSSEC chains of trust, e.g. it fills the gap between a DNSSEC island of security and its signed grandparent or ancestor. The invention is deemed useful for the introduction of DNS root nameservice substitution for DNSSEC support purposes, and allows opt-in while NSEC | 10-23-2008 |
| 20090210696 | Method of bootstrapping an authenticated data session configuration - An inventive method is disclosed for bootstrapping a trusted client public key at the server side in a client-server model of e-commerce or distributed computer applications. Generally, the invention integrates security technique elements and user procedural elements in such a way that no vulnerability arises due to the decoupling of elements. It is thus aimed at high security application areas. The readily available support of X.509 client security certificates in web browsers is advantageous for easy deployment at the client side. However, serious usability flaws deter the use of client certificates despite their potential for high security client authentication. The invention circumvents this contradiction at the client registration phase, and extends the benefits of simplified reliance on client public-private key pair to production use of the circumvention. Many variations of the inventive idea are disclosed, including the use of a dummy client security certificate that addresses the interoperability pitfalls of the X.509 technology while the trust in the client public key rests on other elements of the inventive method. | 08-20-2009 |
| 20090310777 | Trust Anchor Key Cryptogram and Cryptoperiod Management Method - In the field of public key cryptography, e.g. a public key infrastructure, the distribution of trust anchor keys to end-user systems is difficult when the time comes to change the public key, either because a compromise of the private key counterpart is suspected, or as a cryptoperiod policy enforcement. With the present invention, the central organization (from which the trust anchor key originates) is given the opportunity to distribute at once a number of trust anchor keys, in advance of their respective intended period of use, and without exposing the individual public keys to brute force attacks before their actual period of use. At a later time, the central organization distributes unlocking information that enables the use of a public key distributed according to the present invention. The preferred embodiment makes use of an hidden selection of a cryptographic function among a function family. | 12-17-2009 |
