Patent application number | Description | Published |
20110036787 | PARTICLE SEPARATION - Apparatus for increasing a concentration of large particles in a mixture which includes the large particles and smaller particles, including a flow chamber, a filtrate accepting chamber, a filtering component separating the flow chamber from the filtrate accepting chamber, the filtering component including a plurality of pores passing therethrough, characterized by further including means for generating a flow of the fluid in the flow chamber, with a flow component in a direction parallel to a surface of the filtering component sufficient to substantially prevent particles from adhering to the filtering component and clogging the pores. A method of increasing a concentration of large particles in a mixture which includes the large particles and smaller particles, including providing a flow chamber and a filtrate accepting chamber separated by a filtering component, the filtering component including a plurality of pores passing therethrough, and placing a fluid with the mixture in the flow chamber, characterized by causing the fluid with the mixture to flow in the flow chamber, with a flow component parallel to a surface of the filtering component sufficient to substantially prevent particles from adhering to the filtering component and clogging the pores, thereby increasing the concentration of the larger particles relative to the concentration of the smaller particles in the mixture. Related apparatus and methods are also described. | 02-17-2011 |
20110275543 | DEVICE FOR STUDYING INDIVIDUAL CELLS - A device for studying individual cells including a picowell array (such as an array of microwells, dimples, depressions, tubes or enclosures) and a fluid reservoir in fluid communication with the picowells through channels is disclosed. Preferably, the device has a moveable lid that in one rest location allows loading of cells in the picowell array. Preferably the channels of the device are capillary channels. | 11-10-2011 |
Patent application number | Description | Published |
20090105095 | Device for Studying Individual Cells - A device for studying individual cells including a picowell array (such as an array of microwells, dimples, depressions, tubes or enclosures) and a fluid reservoir in fluid communication with the picowells through channels is disclosed. Preferably, the device has a moveable lid that in one rest location allows loading of cells in the picowell array. Preferably the channels of the device are capillary channels. | 04-23-2009 |
20090111141 | Method and Device for Studying Floating, Living Cells - Disclosed is a method of studying floating living cell by confining the cells floating in an aqueous medium in picowells located on a bottom surface of a top wall of a chamber. Disclosed is also a picowell-bearing device for the study of cells comprising a chamber having at least one picowell on a bottom surface of the chamber. Also disclosed is a picowell-bearing device for the study of cells comprising a chamber having at least one picowell on an internal surface and at least one moveable wall, a force applicator configured to removeably apply a substantially uniformly distributed force around the periphery of the moveable wall in a direction to retain the moveable wall secured to the chamber. | 04-30-2009 |
20100247386 | PICO LITER WELL HOLDING DEVICE AND METHOD OF MAKING THE SAME - Described herein are embossing methods for forming pico liter well arrays (and other structures), arrangements of such pico liter well arrays, for example, in arrays of pico liter well areas, and methods of forming templates for such embossing. Also described as wells with a refractive index similar to that of an aqueous medium used for supporting cells in the wells. | 09-30-2010 |
20100274500 | METHOD AND SYSTEM FOR MEASURING MEMBRANE POTENTIAL BASED ON FLUORESCENCE POLARIZATION - A method of determining a membrane potential is disclosed. The method comprises (a) determining a difference in fluorescence polarization of a charged fluorescent probe being distributed across the membrane; and (b) determining a potential of the membrane, wherein the potential is proportional to the difference in the fluorescent polarization. | 10-28-2010 |
20110014688 | PICO LITER WELL HOLDING DEVICE AND METHOD OF MAKING THE SAME - The present invention broadly comprises a holding device for studying cells comprising at least one cavity adapted to receive cells in a medium consisting essentially of water, the cavity having a substrate and a generally inert wall, wherein the substrate includes a surface for receiving the medium, and wherein the surface includes a multiplicity of pico liter wells and is characterized in that the substrate is substantially translucent and has a refractive index equal to the refractive index of the medium. The invention further comprises a method of making the holding device comprising providing a carrier plate, applying an adhesive layer to the carrier plate, depositing a curable substrate on the adhesive layer, applying a second layer of adhesive to the substrate, attaching a wall structure to the second layer of adhesive, forming a multiplicity of pico liter wells in the substrate, curing the substrate, and removing the template. | 01-20-2011 |
20110034348 | DEVICE FOR THE STUDY OF LIVING CELLS - A cell study device, comprising, a base layer, a planar conduit defining layer, including a conduit cut out of the layer; and a planar cover layer which defines a capillary flow channel in said conduit layer, said conduit layer and said cover layer acting as side walls for said capillary flow channel, wherein said layers are formed of materials that do not interfere with cell behavior over a period of at least 5 hours when loaded with aqueous solution. | 02-10-2011 |
20110189721 | INTERACTIVE TRANSPARENT INDIVIDUAL CELLS BIOCHIP PROCESSOR - An Interactive Transparent Individual Cells Biochip Processor (ITICBP) device is described, which is useful for assessing a single, individual living cell at identifiable location or assessing group of cells each at identifiable location. | 08-04-2011 |
Patent application number | Description | Published |
20080241874 | Method and device for manipulating individual small objects - A method for individually moving small objects, such as cells, from one location to another as well as a device for implementing the method is disclosed. A small object such as a cell is isolated at some initial location and moved to some destination location by the movement of the small object through a succession of intermediate locations until the small object arrives at the destination location. Also disclosed are methods of manipulating cells made possible by the method and device of the present invention. | 10-02-2008 |
20130071914 | METHOD FOR STUDYING FLOATING, LIVING CELLS - Disclosed is a method of studying floating living cell by confining the cells floating in an aqueous medium in picowells located on a bottom surface of a top wall of a chamber. Disclosed is also a picowell-bearing device for the study of cells comprising a chamber having at least one picowell on a bottom surface of the chamber. Also disclosed is a picowell-bearing device for the study of cells comprising a chamber having at least one picowell on an internal surface and at least one moveable wall, a force applicator configured to removeably apply a substantially uniformly distributed force around the periphery of the moveable wall in a direction to retain the moveable wall secured to the chamber. | 03-21-2013 |
20130344473 | ARRESTING OBJECTS - A method and system for arresting objects in an array of chambers including, applying a solution to at least one chamber in an array of chambers, in a manner that does not connect two chambers, such that at least one object in the solution is arrested in said at least one chamber, the chambers having a volume of 0.5 microliters-3 microliters. | 12-26-2013 |