| Patent application number | Description | Published |
|---|
| 20080273128 | Programmable mask and method of fabricating biomolecule array using the same - The present invention relates to a programmable mask used in a photolithography process for fabricating a biomolecule array and a method of fabricating a biomolecule array using the same and, more particularly, to a programmable mask which can increase a contrast ratio of transmittance versus shielding of light incident to a liquid crystal which constitutes each pixel by irradiating parallel ultraviolet (“UV”) light generated from an external parallel light exposure device to a certain cell and using a vertically aligned liquid crystal panel or an LC panel having no spacer, and a method of fabricating a biomolecule array using the same. | 11-06-2008 |
| 20090120865 | DISPOSABLE MULTI-LAYERED FILTRATION DEVICE FOR THE SEPARATION OF BLOOD PLASMA - Provided is a disposable multi-layered filtration device for the separation of blood plasma which can be applied to a biochip and appropriate for disposal uses. The filtration device for the separation of blood plasma includes: an upper substrate including a blood inlet; an intermediate substrate including a filtering unit for extracting blood plasma from blood flowing through the blood inlet; and a lower substrate including an air outlet, wherein the upper substrate, the intermediate substrate, and the lower substrate are stacked and adhered. | 05-14-2009 |
| 20090152187 | FILTER CHIP AND METHOD OF MANUFACTURING THE SAME - There are provided a filter chip in which a filter is mounted on a microfluidic device as a hybrid form, and a method of manufacturing the filter chip. The method includes: forming a bottom structure where a groove for stably mounting a filter is formed; mounting the filter on the groove; forming a top structure forming a fluid inlet for injecting a fluid into the filter; and covering the top structure on a top area of the groove to attach to the bottom structure, wherein the groove and the filter have a shape becoming narrow from the fluid inlet to a fluid outlet in such a way that the fluid receives a rapid change of a capillary force while passing through the filter. Accordingly, blood plasma is capable of being separated at a higher speed by increasing the capillary force of the fluid outlet, thereby obtaining the blood plasma as large amount as possible. | 06-18-2009 |
| 20090152326 | ULTRASONIC WELDING-BASED MICROFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE SAME - A method of manufacturing an ultrasonic welding-based microfluidic device, the method including: forming a bottom board having two welding stoppers formed right and left and having a certain height and a certain interval; forming a top board having two energy directors formed with an interval greater than the interval between the two welding stoppers; putting the top board on the bottom board to locate the energy directors at the outside of welding stoppers, respectively; and welding the top board to the bottom board by using ultrasonic welding, wherein a channel is formed between the two welding stoppers without additional energy directors. Accordingly, it is possible to prevent a phenomenon that a fluid irregularly flows due to an uneven surface formed on a side of the channel while the energy directors are melted. | 06-18-2009 |
| 20100135856 | NANOPARTICLE FOR DETECTING BIOMATERIALS AND BIOSENSOR BY USING THE NANOPARTICLE - Provided are a nanoparticle for detecting biomaterials and a biosensor by using the nanoparticle. The nanoparticle includes a metal nanostructure around which an electric field is induced by localized surface plasmon resonance when light is irradiated onto a surface of the metal nanostructure, a spacer covering the surface of the metal nanostructure, and capture molecules specifically reacting with fluorophore-labeled target molecules, and immobilized on a surface of the spacer. | 06-03-2010 |
| 20100135965 | METHOD OF CHONDROGENIC DIFFERENTIATION FROM MESENCHYMAL STEM CELL, AND COMPOSITION COMPRISING CHONDROGENIC CELL DIFFERENTIATED USING THE METHOD TO TREAT DISEASE CAUSED BY CARTILAGE DAMAGE - Provided are a method of chondrogenic differentiation from mesenchymal stem cells and a composition comprising chondrogenic cells differentiated using the method to treat diseases caused by cartilage damage. In the method, a centrifugal force is applied to human mesenchymal stem cells to be differentiated into chondrogenic cells. The chondrogenic differentiation may be achieved at moderate cost without using expensive cytokines or growth factors by periodically applying only a centrifugal force. According to the method of chondrogenic differentiation from mesenchymal stem cells in the present embodiment, chondrogenic cells may be also differentiated from human mesenchymal stem cells. | 06-03-2010 |
| 20100142678 | MINIMALLY INVASIVE PARTICLE BEAM CANCER THERAPY APPARATUS - A minimally invasive particle beam cancer therapy apparatus that can be inserted into the body and deliver a particle beam onto a cancer cell generated in the body. The minimally invasive particle beam cancer therapy apparatus may include: a particle beam delivery system delivering a particle beam onto a diseased part formed inside a therapy subject, the particle beam delivery system being partially inserted into the therapy subject when delivering the particle beam; a medical apparatus body shaped like a pipe having a predetermined length and physically connected to the particle beam delivery system, the medical apparatus being partially inserted into the therapy subject in a longitudinal direction along with the particle beam delivery system being partially inserted into the therapy subject to help the insertion of the particle beam delivery system into the therapy subject; and a control system controlling a driving operation of the particle beam delivery system. | 06-10-2010 |
| 20100143194 | MICROFLUIDIC DEVICE - Provided is a microfluidic device. The microfluidic device includes a sample storage chamber storing sample fluid therein, a detection chamber connected to the sample storage chamber and detecting a specific material of the sample fluid, a cleaning liquid storage chamber connected to the detection chamber and storing cleaning liquid therein, a plurality of fluid passages interconnecting the chambers, and a micropump transferring the cleaning liquid. The microfluidic device precisely inspects a sample fluid although a small amount of the sample fluid flows. | 06-10-2010 |
| 20100157300 | LIQUID SAMPLE ANALYSIS CHIP READING SYSTEM, AND ANALYSIS METHOD AND UBIQUITOUS READING SYSTEM USING THE SAME - Provided is a liquid sample analysis chip reading system. The reading system includes an analysis chip, a light emitting part, a plurality of light wave-guides, and a light receiving part. The analysis chip includes a plurality of detecting parts. The light emitting part includes three light sources emitting light having wavelengths (or colors) different from each other. The plurality of light wave-guides irradiate the light emitted from the light emitting part onto the plurality of corresponding detecting parts, respectively. The light receiving part includes a plurality of light receiving devices for receiving the light having a specific color reflected from each of the plurality of corresponding detecting parts of the analysis chip. The three light sources are discontinuously controlled to emit light onto the plurality of light wave-guides. | 06-24-2010 |
| 20100159573 | MICROFLUIDIC DILUTION DEVICE - Provided is a microfluidic dilution device that uses capillary force to dilute first and second fluids in a predetermined ratio. The microfluidic dilution device includes a channel plate, a cover plate, fluid chambers, and a confluence chamber. The fluid chambers are filled with first and second fluids in a predetermined ratio. First and second fluids flowing to the confluence chamber are diluted in a predetermined ratio. | 06-24-2010 |
| 20100159574 | MICROFLUIDIC DEVICE AND MICROFLUIDIC ANALYSIS EQUIPMENT - Provided are a microfluidic device and a microfluidic analysis equipment. The microfluidic device includes guides disposed along both edges, a lower plate including a flow path defined between the guides, and a movable upper plate moved along the guides on the lower plate and having a length less than that the flow path. A fluid flow can be simply accurately controlled by adjusting a position of the movable upper plate. As a result, the fluid can sufficiently react in the detection part and the reaction part. Therefore, effective reaction and detection can be realized using only a small amount of fluid, thereby improving sensitivity. In addition, due to the improved sensitivity, a washing process for removing materials that are not consumed in the reaction can be omitted. Also, the movable upper plate can be manually moved using a user's finger. | 06-24-2010 |
| 20100159576 | BIOCHIP AND BIOMATERIAL DETECTION APPARATUS - Provided are a biochip and a biomaterial detection apparatus. The biochip includes a substrate, a metal layer, and a dielectric layer. The substrate includes a surface having a plurality of acute parts which are formed by first and second inclined planes. The metal layer is formed on at least one of the first and second inclined planes. The dielectric layer is formed on the metal layer, and capture molecules specifically binding to target molecules which are marked with a fluorescent substance are immobilized to a surface of the dielectric layer. | 06-24-2010 |
| 20100159580 | CELL CULTURE COMPARTMENT UNIT AND ARRAY INCLUDING THE SAME - Provided are a cell culture compartment unit and an array including the same. The cell culture compartment unit includes: a cell culture region and a bio material emission region including a cell culture fluid, which are separated with a porous membrane therebetween; a piezoelectric device on the porous membrane of the cell culture region; a thin layer for cell attachment being on the piezoelectric device and having at least one surface on which cells are attachable; and a first power supply applying a first electric field to the piezoelectric device. | 06-24-2010 |
| 20100159600 | METHOD OF CONTROLLING FLUID FLOW IN MICROFLUIDIC DEVICE AND MICROFLUIDIC ANALYSIS APPARATUS - Provided are methods of controlling a fluid flow in a microfluidic device and a microfluidic analysis apparatus. According to the method, an inclination of the microfluidic device with respect to a horizontal direction can be adjusted to simply and accurately control a fluid flow in the microfluidic device. Thus, a fluid conveyance can be completely controlled, and an inspection can be performed using only a small amount of sample. In addition, the method of controlling the fluid flow in the microfluidic device can be manually performed by a user. Thus, since a power is not required, the method of controlling the fluid flow in the microfluidic device can be economical and simple. The microfluidic analysis apparatus includes an inclination operation unit for causing an inclination change of a receiving part of the microfluidic device with respect to a horizontal plane and an inclination control part for controlling an operation of the inclination operation unit to simply and accurately control the fluid flow, thereby to accurately analyze the fluid. | 06-24-2010 |
| 20100227419 | LAB-ON-A-CHIP AND METHOD OF DRIVING THE SAME - Provided is a lab-on-a-chip. The lab-on-a-chip includes a first region where a lower substrate and an upper substrate are bonded to each other, a second region where the lower and upper substrates are not bonded, and a gap adjusting member disposed at an end of the second region that is opposite to a boundary between the first and second regions, the gap adjusting member being configured to adjust a gap between the first and second substrates to control a capillary force. | 09-09-2010 |
| 20100267127 | POLYMERASE CHAIN REACTION APPARATUS - Provided is a polymerase chain reaction (PCR) apparatus. A PCR is performed using the module assembly-type PCR apparatus. The module assembly-type PCR apparatus includes a first module, a second module, and a third module. A sample is provided to the first module. The second module provides different temperature ranges to the first module to generate thermal convection. The third module controls an operation of the second module. The first module is separably coupled to the second module. The second module is electrically separably coupled to the third module. | 10-21-2010 |
| 20100267570 | PS-SPCL SEARCHING APPARATUS AND METHOD USING SURFACE PLASMON RESONANCE - A Positional Scanning—Synthetic Peptide Combinatorial Library (PS-SPC) searching apparatus and method using Surface Plasmon Resonance (SPR) are provided. The method includes spotting and fixing each of a plurality of peptide pools to a top of one thin metal film, inputting specific materials to the top of the thin metal film, applying a TM-mode light to a bottom of the thin metal film and exciting SPR for the thin metal film, and detecting a TM mode reflected light reflected from the thin metal film and displaying the detected light as a two-dimensional image. | 10-21-2010 |
| 20100279396 | MICRO-SCALED ANIMAL CELL INCUBATOR AND PRODUCTION METHOD THEREOF - There is provided a cell culture technology for culturing an animal cell in a separate microstructure. The micro-scaled animal cell incubator includes a lower glass substrate having fine hot wires processed with a metal and formed in an upper surface thereof; a first PDMS film attached onto the lower glass substrate to form two or more liquid and solid storage spaces in a position corresponding to the fine hot wires of the lower glass substrate and gas flow channels coupled respectively to the liquid and solid storage spaces to allow generated gases to flow therethrough; a gas-permeable PDMS thin film attached onto the gas flow channels of the PDMS film to pass the generated gases therethrough; a second PDMS film attached onto the PDMS thin film and having a culture medium storage space for storing a culture medium; and an upper glass substrate attached onto the second PDMS film and having fine hot wires formed in a lower surface thereof, the fine hot wires being covered by the PDMS film. The micro-scaled animal cell incubator may be useful to control a temperature of a culture medium to a suitable temperature level, as well as to self-supply gases required for the animal cell culture in a microstructure. | 11-04-2010 |
| 20100304501 | BIO LAB-ON-A-CHIP AND METHOD OF FABRICATING AND OPERATING THE SAME - Disclosed is a bio lab-on-a-chip. The bio lab-on-a-chip is provided on a piezoelectric thin film on a substrate, and includes a sensing unit to sense a bio signal and a fluidic control unit which controls a transfer of a microfluid adjacent to the sensing unit. Provided is also a method of fabricating the bio lab-on-a-chip. The method includes the steps of forming a piezoelectric thin film, forming a sensing unit to sense a bio signal of a microfluid on the piezoelectric thin film, and forming a fluidic control unit located adjacent to the sensing unit. | 12-02-2010 |
| 20110011827 | METHOD OF MANUFACTURING HOLLOW MICRONEEDLE STRUCTURES - Provided is a method of manufacturing a hollow microneedle structure. The method includes forming an injection mold having a through hole, filling the injection mold with a photoresist formed of a viscous material, and extruding the photoresist from the injection mold through the through hole, solidifying the extruded photoresist to form a needle-type photoresist structure, forming a seed layer on the surface of the photoresist structure, forming a metal plated layer on the seed layer, inclining an end tip of the photoresist structure having the metal plated layer, and removing the photoresist from the metal plated layer to form a hollow. Thus, the hollow microneedle structure can be manufactured to have such diameter, length, hardness, and inclination angle as to minimize pain. The hollow microneedle structure can be combined with an apparatus for detecting a biomaterial or injecting cosmetic substances or medicines, and variously applied. | 01-20-2011 |
| 20110049401 | MAGNETIC MICROVALVE USING METAL BALL AND METHOD OF MANUFACTURING THE SAME - There is provided a magnetic microvalve using a metal ball and a method of manufacturing the same. A magnetic microvalve using a metal ball according to an aspect of the invention may include: an upper substrate having a microchannel serving as a passage through which a fluid moves, a fluid inlet through which the fluid flows into the microchannel, and a fluid outlet through which the fluid, having passed through the microchannel, flows out of the microchannel; a lower substrate having a trench locally provided therein; a PDMS/metal ball combination having a metal ball and PDMS surrounding the metal ball so that the metal ball is located in a central portion thereof, the PDMS/metal ball combination being inserted into the trench provided in the lower substrate; and a magnet located above the microchannel, provided in the upper substrate, and generating magnetic force. | 03-03-2011 |
| 20110082056 | ARRAY APPARATUS FOR DIVIDING SINGLE CELL - An array apparatus for dividing a single cell includes: a fluid channel having one or more spaces for separating a single cell included in a fluid; an air valve channel positioned at an upper portion of an entrance and exit of the spaces formed in the fluid channel and controlling a fluid flow in the fluid channel; a pressure channel positioned at upper portions of the spaces formed in the fluid channel and dividing the single cell separated from the spaces; and a cell trapping structure installed in the interior of the spaces formed in the fluid channel and separating a single cell included in the fluid flowing along the fluid channel. | 04-07-2011 |
| 20110101237 | CARBON ION GENERATING DEVICE AND TUMOR TREATMENT APPARATUS USING THE SAME - Provided are a carbon ion generating device and a tumor treatment apparatus using the same. The carbon ion generating device includes a carbon nanostructure, a carbon emitting structure, an ionizing structure, and an accelerator. The carbon emitting structure is configured to induce an emission of carbon atoms from one end of the carbon nanostructure. The ionizing structure is configured to ionize the emitted carbon atoms. The accelerator is configured to accelerate the ionized carbon atoms. | 05-05-2011 |
| 20110101244 | TARGET MATERIALS FOR GENERATING PROTONS AND TREATMENT APPARATUSES INCLUDING THE SAME - Provided is a treatment apparatus including a target material for generating protons. The treatment apparatus includes a cylindrical bore member having an inner space to receive a patient; a proton generating target material provided to an inner surface of the bore member; and a laser adapted to supply a laser beam to the proton generating target material so that protons are generated from the proton generating target material and projected to a tumor site of the patient. The proton generating target material includes a supporting film and a hydrogenated amorphous silicon (a-Si:H) film provided on the supporting film. | 05-05-2011 |
| 20110147619 | TREATMENT APPARATUSES AND METHODS USING PROTON - A treatment apparatus using proton includes a proton generation unit and a magnet. The proton generation unit projects proton into a tumor site of a patient, and the magnet forms a magnetic field around the patient. The proton conducts a spiral motion due to collision with atom of the tumor site and Lorenz force generated by the magnetic field. | 06-23-2011 |
