Molloy, GB
Anthony Molloy, Edgbaston GB
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20080223410 | Cleaning a Plurality of Supply Lines - The fluid supply apparatus includes a plurality of supply lines ( | 09-18-2008 |
Billy J. Molloy, Stockport GB
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20130252342 | Detection And Quantification Of Vitamin D Metabolites Using An Alkylamine To Form Stable Adducts For Mass Spectrometric Analysis - The invention describes a method of determining the amount of an analyte in a sample wherein the analyte comprises one or more vitamin D metabolites; comprising the steps of; contacting the analyte with an alkylamine to form an alkylamine adduct; subjecting the adduct to a MS technique to determine the amount of the adduct; and calculating the amount of the analyte equivalent to the amount of the adduct. | 09-26-2013 |
Billy J. Molloy, Bramhall GB
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20130126721 | Measurement Of 25-Hydroxyvitamin D3 And C3 EP1-25-Hydroxyvitamin D3 - The invention describes a method of quantification of an analyte selected from the group consisting of 25-hydroxyvitamin D3 and C3-epi-25-hydroxyvitamin D3 in a specimen containing the analyte; comprising the steps of subjecting the specimen to UPLC reverse-phase separation; and; detecting the protonated precursor pseudo-molecular ion of the analyte using a mass spectrometry technique to determine the amount of the analyte. | 05-23-2013 |
Christopher Molloy, Watford GB
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20150265557 | COMPOUNDS FOR THE TREATMENT AND PREVENTION OF RETROVIRAL INFECTIONS - The present invention provides compounds and pharmaceutical compositions for use in treating or preventing retroviral infections, in particular HIV infections and/or diseases associated with an HIV infection. | 09-24-2015 |
Christopher Molloy, Hertfordshire GB
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20100190726 | Novel Phyllanthus Extract - A method is described for producing an extract of | 07-29-2010 |
Christopher Molloy, Watford Hertfordshire GB
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20140038168 | NOVEL DRUG TARGET SITE WITHIN GP120 OF HIV - The present invention relates to a method of designing an inhibitor of the binding of HIV (human immunodeficiency virus) glycoprotein (gp)120 to a CD4-receptor or to the integrin alpha4 beta7 (a4b7). The inhibitor interacts with at least two amino acid residues comprised in six motifs within the 3-dimensional structure of gp120. Also provided are compounds, pharmaceutical compositions thereof and uses thereof in the development of an inhibitor of the binding of a HIV gp120 to a CD4-receptor or an integrin alpha4 beta7 (a4b7). The inhibitors are useful for the prevention or treatment of an HIV infection and/or diseases associated with an HIV infection. | 02-06-2014 |
Christopher Richard Molloy, Watford GB
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20150228041 | CLINICAL TRIAL RECRUITMENT PLATFORM DRIVEN BY MOLECULAR PROFILE - Disclosed are platforms, systems, media, and methods for enabling a clinical trial administrator to identify individuals potentially eligible for a clinical trial based at least in part on an individual molecular phenotype, review profiles of identified individuals, and make clinical trial enrollment offers to identified individuals. Also disclosed are platforms, systems, media, and methods for enabling a patient to review and accept or decline clinical trial enrollment offers and identify relevant individuals, clinical trials, and therapies based at least in part on an individual molecular phenotype. | 08-13-2015 |
Matthew Molloy, Wallsend GB
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20080223410 | Cleaning a Plurality of Supply Lines - The fluid supply apparatus includes a plurality of supply lines ( | 09-18-2008 |
Michael G. Molloy, Caxton GB
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20090184921 | Input Through Sensing of User-Applied Forces - Methods and devices for providing a user input to a device through sensing of user-applied forces are described. A user applies forces to a rigid body as if to deform it and these applied forces are detected by force sensors in or on the rigid body. The resultant force on the rigid body is determined from the sensor data and this resultant force is used to identify a user input. In an embodiment, the user input may be a user input to a software program running on the device. In an embodiment the rigid body is the rigid case of a computing device which includes a display and which is running the software program. | 07-23-2009 |
20140327637 | INPUT THROUGH SENSING OF USER-APPLIED FORCES - Methods and devices for providing a user input to a device through sensing of user-applied forces are described. A user applies forces to a rigid body as if to deform it and these applied forces are detected by force sensors in or on the rigid body. The resultant force on the rigid body is determined from the sensor data and this resultant force is used to identify a user input. In an embodiment, the user input may be a user input to a software program running on the device. In an embodiment the rigid body is the rigid case of a computing device which includes a display and which is running the software program. | 11-06-2014 |
Michael J. Molloy, Stevenage GB
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20130243764 | ANTIGEN-BINDING PROTEINS WITH INCREASED FCRN BINDING - The present invention provides antigen binding proteins which bind specifically to TNF-alpha. For example novel variants of anti-TNF antibodies such as adalimumab which show increased binding to the FcRn receptor or increased half life compared to adalimumab. Also provided are compositions comprising the antigen binding proteins and uses of such compositions in treatment of disorders and disease. | 09-19-2013 |
Michael Peter Molloy, London GB
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20160063630 | DYNAMICALLY UPDATING PREDICTION SYSTEM - Methods and systems are provided for dynamically updating a projected cash flow for an investment using a gesture-based graphical user interface. The method comprises displaying in the graphical user interface a graphical representation of the projected cash flow for an investment and performance metrics for the investment based on the projected cash flow; receiving gesture input from a user via the graphical user interface; updating the projected cash flow based on the gesture input; updating the performance metrics based on the updated projected cash flow; updating the graphical user interface to reflect the updates to the projected cash flow and the performance metrics. | 03-03-2016 |
Peter Molloy, Abingdon Oxfordshire GB
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20160137715 | T CELL RECEPTORS - The present invention relates to T cell receptors (TCRs) which bind the HLA-A2 restricted FMNKFIYEI (158-166) peptide epitope derived from α Fetoprotein (AFP). Certain preferred TCRs of the invention demonstrate excellent binding characteristics and specificity profiles for this AFP epitope. T cell receptors of the invention may comprise at least one TCR alpha chain variable domain and/or at least one TCR beta chain variable domain, the alpha chain variable domain which may comprise an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1-112 of SEQ ID No: 2, and/or the beta chain variable domain which may comprise an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1-112 of SEQ ID No: 3. | 05-19-2016 |
Peter Eamon Molloy, Abingdon GB
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20130058908 | HIGH AFFINITY NY-ESO T CELL RECEPTORS - The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a K | 03-07-2013 |
20130295063 | HIGH AFFINITY HIV T CELL RECEPTORS - The present invention provides TCRs having high affinity. The TCR binds to SLYNTVATL (SEQ ID NO:16)-HLA-A*0201 with a K | 11-07-2013 |
20150231202 | HIGH AFFINITY NY-ESO T CELL RECEPTORS - The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a K | 08-20-2015 |
Peter Eamon Molloy, Oxfordshire GB
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20090214551 | High Affinity Hiv T Cell Receptors - The present invention provides TCRs having an affinity (K | 08-27-2009 |
20100113300 | T CELL RECEPTOR DISPLAY - A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed. | 05-06-2010 |
20110014169 | HIGH AFFINITY NY-ESO T CELL RECEPTORS - The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a K | 01-20-2011 |
20110038842 | High affinity ny-eso t cell receptor - The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a K | 02-17-2011 |
20110262414 | HIGH AFFINITY NY-ESO T CELL RECEPTORS - The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a K | 10-27-2011 |
20140349855 | T CELL RECEPTOR DISPLAY - A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed. | 11-27-2014 |
20140371085 | T CELL RECEPTOR DISPLAY - A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed. | 12-18-2014 |
Roisin Molloy, Belfast GB
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20160116339 | HAND-HELD MEDICAL-DATA CAPTURE-DEVICE INTEROPERATION WITH ELECTRONIC MEDICAL RECORD SYSTEMS - In one implementation, an apparatus estimates body core temperature from an infrared measurement of an external source point using a cubic relationship between the body core temperature and the measurement of an external source point is described, estimates temperature from a digital infrared sensor and determines vital signs from a solid-state image transducer, or determines vital signs from a solid-state image transducer and estimates body core temperature from an infrared measurement of an external source point using a cubic relationship between the body core temperature and the measurement of an external source point; after which the estimated an/or determined information is transmitted to an external database. | 04-28-2016 |
Sean Molloy, Buckinghamshirre GB
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20100121386 | Progressive Reduction Instrument for Reduction of a Vertebral Rod and Method of Use - An instrument and method for reducing a vertebral rod into an anchor attached to a vertebral member. The instrument may include a gripper and an attached reduction member that includes a handle and shaft. The gripper is configured to attach to an anchor and may include an asymmetrical shape to accommodate the anatomy of a patient and a funneled capturing space to facilitate reduction of the vertebral rod. The reduction member may be configured to apply a reduction force to the vertebral rod at the various axial and lateral medial positions within the capturing space. The reduction member may also provide for course and fine movement of the shaft during the movement of the vertebral rod. | 05-13-2010 |
Steve Molloy, Cambridge GB
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20130310036 | SELECTING BETWEEN RADIO ACCESS TECHNOLOGIES - A mobile terminal comprising: transceiver apparatus for accessing a wireless network using an earlier and a later generation radio access technology, to establish a voice channel and packet data channel; and an inter radio access technology selector configured to monitor a condition for disabling the earlier generation access, being a condition other than coverage under the earlier generation technology falling below an acceptable lower level. The selector makes inter radio access technology decisions dynamically from the mobile terminal by updating registration with the network to indicate that the earlier generation technology is no longer supported. The selector thereby prevents the mobile terminal being subject to decisions from the network that would otherwise impose transfer to the earlier generation. At least some of the decisions made from the mobile terminal thus disable the earlier generation access whilst in presence of at least the lower level of coverage under the earlier generation. | 11-21-2013 |