Mizusawa, Tokyo
Hidehiro Mizusawa, Tokyo JP
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20100234282 | SYSTEM FOR DELIVERING NUCLEIC ACIDS FOR SUPPRESSING TARGET GENE EXPRESSION BY UTILIZING ENDOGENOUS CHYLOMICRON - The object of present invention is to provide a system that can deliver in vivo nucleic acids such as an siRNA for suppressing a target gene expression in vivo more safely and efficiently, and to provide an expression-suppressing agent and a pharmaceutical composition utilizing the system. An introduction substance into chylomiclon, particularly nucleic acids to which an alpha-tocopherol is bound for suppressing a target gene expression, can be delivered more safely and efficiently into hepatic cells in vivo by administering the nucleic aids under the condition where the production of chylomicron is induced in the body. Alternatively, alpha-tocopherol-bound nucleic acids are mixed with extracted chylomiclon, and then they are administered. Consequently, a target gene expression is suppressed, thereby a disease caused by an elevated expression of the target gene can be treated more safely and efficiently. | 09-16-2010 |
20130116306 | SYSTEM FOR DELIVERING NUCLEIC ACIDS FOR SUPPRESSING TARGET GENE EXPRESSION BY UTILIZING ENDOGENOUS CHYLOMICRON - The object of present invention is to provide a system that can deliver in vivo nucleic acids such as an siRNA for suppressing a target gene expression in vivo more safely and efficiently, and to provide an expression-suppressing agent and a pharmaceutical composition utilizing the system. An introduction substance into chylomiclon, particularly nucleic acids to which an alpha-tocopherol is bound for suppressing a target gene expression, can be delivered more safely and efficiently into hepatic cells in vivo by administering the nucleic aids under the condition where the production of chylomicron is induced in the body. Alternatively, alpha-tocopherol-bound nucleic acids are mixed with extracted chylomiclon, and then they are administered. Consequently, a target gene expression is suppressed, thereby a disease caused by an elevated expression of the target gene can be treated more safely and efficiently. | 05-09-2013 |
20140302603 | CHIMERIC DOUBLE-STRANDED NUCLEIC ACID - A method of reducing the level of a transcription product in a cell comprising contacting with the cell a composition comprising a double-stranded nucleic acid complex comprising a first nucleic acid strand annealed to a second nucleic acid strand, wherein: (i) the first nucleic acid strand hybridizes to the transcription product and comprises (a) a region consisting of at least 4 consecutive nucleotides that are recognized by RNase H when the strand is hybridized to the transcription product, (b) one or more nucleotide analogs located on 5′ terminal side of the region, (c) one or more nucleotide analogs located on 3′ terminal side of the region and (d) a total number of nucleotides and nucleotide analogs ranging from 8 to 35 nucleotides and (ii) the second nucleic acid strand comprises (a) nucleotides and optionally nucleotide analogs and (b) at least 4 consecutive RNA nucleotides. | 10-09-2014 |
20150320350 | BRAIN FUNCTION EVALUATION SYSTEM AND BRAIN FUNCTION EVALUATION METHOD - In order to evaluate a motor-function disorder accompanying a brain disease by a non-conventional new method, a brain function evaluation system | 11-12-2015 |
Hiroshi Mizusawa, Tokyo JP
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20110064452 | Image forming apparatus, image forming method, and process cartridge - An image forming apparatus including multiple image bearing members that bear respective electrostatic latent images, provided in tandem; multiple developing devices that develop the respective electrostatic latent images with toner to form respective toner images; an intermediate transfer member onto which the multiple toner images are transferred to form a composite toner image; multiple first lubricant applicators that apply a lubricant to the respective image bearing members; and a second lubricant applicator that applies a lubricant to the intermediate transfer member, provided upstream from the extreme upstream image bearing member. In this image forming apparatus, the amount of lubricant applied from the extreme upstream first lubricant applicator to the extreme upstream image bearing member is smaller than that applied from each of the other lubricant applicators to the respective image bearing members. | 03-17-2011 |
20110206432 | Image forming apparatus - An image forming apparatus includes a plurality of image forming units that are arranged in parallel so as to be opposed to an intermediate transfer belt or a transfer carriage belt. A black image forming unit that forms a black toner image is arranged at a downstream end or upstream end in the running direction of the intermediate transfer belt or the transfer carriage belt with respect to the other image forming units. The black image forming unit is configured so that its lubricant supplying unit contains a larger amount of lubricant. | 08-25-2011 |
20110274474 | Lubricant applicator, process cartridge, transfer unit, and image forming apparatus - A lubricant applicator includes a solid lubricant, a lubricant applying member to apply the solid lubricant to a target object, a biasing member to bias the solid lubricant toward the lubricant applying member, and a regulating member to regulate the solid lubricant, which is biased toward the lubricant applying member by the biasing member, to prevent the lubricant from separating from the lubricant applying member by more than a predetermined distance. The regulating member is switchable between a regulating state for regulating the solid lubricant not to separate from the lubricant applying member by more than the predetermined distance and a non-regulating state. | 11-10-2011 |
20130163998 | IMAGE FORMING APPARATUS, DETACHABLE UNIT, AND PLURAL DETACHABLE UNITS - Disclosed is an image forming apparatus that is to be detachably attached by a detachable unit, wherein the detachable unit includes a unit side connector that fits a main body side connector disposed in a main body of the image forming apparatus by an attaching operation for attaching the detachable unit to the main body of the image forming apparatus, wherein one of the detachable unit and the main body of the image forming apparatus includes a concave portion extended in an attaching direction in which the detachable unit is attached to the main body of the image forming apparatus, and wherein the other one of the detachable unit and the main body of the image forming apparatus includes a convex portion disposed at a position corresponding to the concave portion. | 06-27-2013 |
20150346638 | POWDER CONVEYING DEVICE, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS - A powder conveying device, including: a powder conveying path including a curved portion; and a conveying screw, wherein the conveying screw is disposed in the powder conveying path, and includes: a rotation axis portion having flexibility; and a blade portion, where the blade portion is helically formed on an outer periphery of the rotation axis portion, and is configured to convey a powder, wherein the conveying screw includes a conveying screw curved portion located in the curved portion of the powder conveying path, and wherein at least a surface of the blade portion of the conveying screw curved portion includes a slipping layer containing a silicon-containing compound. | 12-03-2015 |
Keigo Mizusawa, Tokyo JP
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20160067359 | COMPOSITION HAVING DYE AND CONJUGATE OF POLYETHYLENEGLYCOL AND ADDITIVE AND CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING HAVING THE SAME - The present invention provides contrast agents for photoacoustic imaging which exhibit high degrees of accumulation in tumor and low degrees of retention in the blood and can be administered into the blood. The contrast agents for photoacoustic imaging include a conjugate of a dye and a polyethyleneglycol represented by Formula (1), (5), (6), or (7) and an additive represented by Formula (301). | 03-10-2016 |
Ken-Ichi Mizusawa, Tokyo JP
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20080206680 | Composition for forming anti-reflective coating for use in lithography - There is provided a composition for forming anti-reflective coating for anti-reflective coating that has a good absorption of light at a wavelength utilized for manufacturing a semiconductor device, that exerts a high protection effect against light reflection, that has a high dry etching rate compared with the photoresist layer. Concretely, the composition for forming anti-reflective coating contains a triazine trione compound, oligomer compound or polymer compound having hydroxyalkyl structure as substituent on nitrogen atom. | 08-28-2008 |
Kouji Mizusawa, Tokyo JP
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20120198250 | PORTABLE TERMINAL EQUIPMENT, A POWER SUPPLY SYSTEM, AND A POWER SUPPLY METHOD AND A POWER SUPPLY PROGRAM FOR PORTABLE TERMINAL EQUIPMENT - A portable terminal equipment capable of operating for a long time is provided. The portable terminal equipment includes: a plurality of circuits separated galvanically and a power supply switching switch which switches power supply to the plurality of circuits between power supply from a USB (Universal Serial Bus) and power supply from a battery for each of respective circuits included in the plurality of circuits. | 08-02-2012 |
Masayuki Mizusawa, Tokyo JP
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20080212173 | Illumination Optical Apparatus and Optical Apparatus - There are provided an illumination optical apparatus and an optical apparatus using this illumination optical apparatus that are capable of efficiently collecting light emitted from a light-emitting section for illumination with less illumination nonuniformity, without having to employ a complicated structure. There are provided a light-emitting sections; a lens system for converting a diverging beam emitted from the light-emitting section into a beam of collimated light; an afocal optical system for adjusting the cross-sectional area of a beam of collimated light obtained by the lens array; a fly-eye lens for forming a plurality of light-source images from the collimated light whose cross-sectional area is adjusted by the afocal optical system; and a Koehler illumination optical system that uses the plurality of light-source images formed by the fly-eye lens as a light source. | 09-04-2008 |
20080252965 | EPI-ILLUMINATION OPTICAL SYSTEM FOR MICROSCOPES - The invention relates to an epi-illumination optical system for microscopes which relies upon a Köhler illumination system using a collective lens array, having simplified adjustment function capable of adjusting the image position of a light source to the back focal position of each microscope objective lens in operable association with microscope objective lens replacement. The invention provides an epi-illumination optical system for microscopes, with an objective lens serving as a condenser lens, which comprises a light source, a collimate lens, and a lens array. The epi-illumination optical system further comprises a projection optical system adapted to project an image of light source formed by collective lens array. The projection optical system comprises a partial optical system movable in an optical axis direction, so that the imaging position for the image array of light source is adjustable to the back focal position of the objective lens | 10-16-2008 |
Naomi Mizusawa, Tokyo JP
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20080227165 | Process for producing conjugated fatty acid and food/drink produced by the process - A conjugated fatty acid such as the cis-9, trans-11 isomer of conjugated linoleic acid having high bioactivities is selectively and efficiently produced by conjugating an unsaturated fatty acid having at least two double bonds with the use of viral cells, dead cells or a cell extract of at least one bacterium selected from the group consisting of | 09-18-2008 |
Shigeru Mizusawa, Tokyo JP
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20130163186 | CONNECTION UNIT AND ELECTRONIC APPARATUS - Disclosed herein is a connection unit, including: a connector unit having a connection connector to which a connector portion of a personal digital assistance is connected; an apparatus insertion opening into which the personal digital assistance is inserted; a cover which is pivoted between a closing position where the apparatus insertion opening is closed and an opening position where the apparatus insertion opening is opened, and which receives and holds the personal digital assistance connected to the connection connector in a state in which at least a part of the apparatus insertion opening is opened; and an adjusting mechanism having a manipulation portion, and adjusting a pivot position of the cover by a manipulation carried out for the manipulation portion. | 06-27-2013 |
Susumu Mizusawa, Tokyo JP
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20080292751 | Lactic Acid Bacteria Fermented Substance and Fermented Milk Food Product Containing the Same - An object of the invention is to provide a lactic acid bacteria fermentation product, which has been obtained by culturing lactic acid bacteria on a medium containing an extract of at least one food material selected from the group consisting of rice bran, persimmon leaves, | 11-27-2008 |
20090252709 | NOVEL BACTERIUM BELONGING TO THE GENUS BIFIDOBACTERIUM AND UTILIZATION OF THE SAME - It is intended to provide | 10-08-2009 |
20100015281 | FERMENTED FOOD CONTAINING BIFIDOBACTERIUM BACTERIA AND METHOD FOR PRODUCING THE SAME - Provided is a fermented food containing an extract of at least one plant material selected from the group consisting of turmeric, | 01-21-2010 |
Takashi Mizusawa, Tokyo JP
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20150260994 | OPTICAL DEVICE, HEAD MOUNTED DISPLAY, ASSEMBLING METHOD FOR THE SAME, HOLOGRAPHIC DIFFRACTION GRATING, DISPLAY DEVICE, AND ALIGNMENT DEVICE - In some embodiments, a head mounted display is provided, comprising a light guide, at least first and second diffraction gratings, alignment marks A | 09-17-2015 |
Yoshinori Mizusawa, Tokyo JP
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20130260586 | CONNECTOR - A connector comprises a housing extending in a front-rear direction and a sealing member attached in the housing. The housing has a rear wall located at a rear end portion of the housing and an enclosed portion extending from the rear wall in the front-rear direction. When the housing is formed by a molding process, a metal mold is used to form a plurality of seal stoppers around the enclosed portion. Each of the seal stoppers protrudes from the enclosed portion in a direction perpendicular to the front-rear direction. The housing has a plurality of holes which are formed when the metal mold is removed from the housing. Each of the holes pierces the rear wall in the front-rear direction. The holes face the respective seal stoppers in the front-rear direction. The sealing member is attached to the enclosed portion so as to be located between the rear wall and the seal stoppers in the front-rear direction. The front sides of the holes are covered by the sealing member. | 10-03-2013 |
20130288543 | CONNECTOR - A connector comprises a housing, a power contact attached to the housing, and a fixing member fixing the power contact to the housing. The connector is mateable along a front-rear direction with a mating connector located at a mating side. The housing has a rear wall, a contact-holding hole and an abutment portion, wherein the contact-holding hole pierces the rear wall in the front-rear direction, and the abutment portion is located toward the mating side with respect to the contact-holding hole. The power contact has a held portion, a fixed portion and an abutting portion, wherein the held portion is inserted in the contact-holding hole from the mating side to be held by the contact-holding hole, the fixed portion is formed to be located far from the mating side with respect to the held portion, and the abutting portion is formed to be located toward the mating side with respect to the held portion so that the abutting portion is brought into abutment with the abutment portion when the held portion is inserted in the contact-holding hole. The fixing member is attached to the held portion so that a part of the housing is sandwiched between the abutting portion and the fixing member in the front-rear direction. | 10-31-2013 |