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| 20110046114 | ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN - The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): | 02-24-2011 |
| 20110077400 | PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES - Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form. | 03-31-2011 |
| 20110160220 | CRYSTALLINE FORM OF 6-[(4S)-2-METHYL-4-(2-NAPHTHYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-7-YL]PYRIDA- ZIN-3-AMINE - The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form. | 06-30-2011 |
| 20110237527 | SGLT-2 INHIBITORS, METHODS OF MAKING THEM, AND USES THEREOF - The present invention relates to compounds which are inhibitors of sodium dependent glucose co-transporter-2 (SGLT-2). These compounds are used in the treatment of various disorders, including diabetes, impaired glucose tolerance, insulin resistance, retinopathy, nephropathy, neuropathy, cataracts, hyperglycemia, hyperinsulinemia, hyperchlolesterolemia, elevated blood level of free fatty acids or glycerol, hyperlipidemia, hypertriglyceridemia, obesity, wound healing, tissue ischemia, atherosclerosis, and hypertension. These compounds and compositions are also useful for treating and preventing kidney stones, hyperuricemia, gout, and hyponatremia. Methods of making these compounds are also described in the present invention. | 09-29-2011 |
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| 20090019437 | Application management and execution system and method thereof - The invention discloses an application management and execution system and a method thereof. The application management and execution system comprises a virtual machine monitor for managing at least one virtual machine; the at least one virtual machine for processing at least one application, and storing, separately and respectively, application data used by each application and platform data required by the virtual machine for processing the application in one or more storage disk (persistent storage), and reading the application data and the platform data from the one or more storage devices respectively. The at least one application executing on the virtual machine may share the platform data in the one or more storage devices. When the virtual machine executes the at least one application, it may modify the application data in the storage devices. | 01-15-2009 |
| 20090094150 | Method and client system for implementing online secure payment - The invention discloses a method for implementing an online secure payment, which comprises steps of: transmitting to a dedicated operating system a secure payment request page for goods which is generated in a general operating system; and completing a payment operation in the secure payment request page of the dedicated operating system, after switching from the general operating system to the dedicated operating system. The invention further comprises a client system for implementing an online secure payment. In the invention, the general operating system for general operations is distinguished from the dedicated operating system for secure payment operations, and the security for the network payment is further enhanced by configuring the firewall and monitoring processes in the dedicated operating system. Furthermore, it is not necessary to make any modification on the existed network transaction system when the technical solution of the present invention is applied, the cost may be reduced and the technical solution of the present invention is facilitated to be deployed and spread. | 04-09-2009 |
| 20090150678 | Computer and method for sending security information for authentication - The present invention provides a computer and a method of sending security information for authentication, which relate to transmission of data information in computers. The present invention solves the vulnerability of information when a user conducts network transaction activities by a terminal. The computer of the present invention comprises: a virtual system platform; a first guest operating system installed on the virtual system platform, which is for installing a service application module, wherein the service application module generates a security information input interface when it is being executed; a second guest operating system installed on the virtual system platform; the second guest operating system comprises: a dynamic password generation module for generating security information, the security information is input into the security information input interface and is sent to a network server for authentication. The security of network activities conducted by users can be enhanced. | 06-11-2009 |
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| 20110188033 | MOLECULE DETECTION USING RAMAN LIGHT DETECTION - An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule. | 08-04-2011 |
| 20110188034 | SURFACE ENHANCED RAMAN SPECTROSCOPY EMPLOYING VIBRATING NANORODS - A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector. | 08-04-2011 |
| 20110188035 | VIBRATING TIP SURFACE ENHANCED RAMAN SPECTROSCOPY - A vibrating tip surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a nano-needle configured to vibrate. The apparatus includes the nano-needle with a substantially sharp tip at a free end opposite an end attached to a substrate. The tip is configured to adsorb an analyte. The apparatus further includes a vibration source configured to provide an alternating current (AC) electric field that induces a vibration of the free end and the tip of the nano-needle. Vibration of the nano-needle under the influence of the AC electric field facilitates detection of a Raman scattering signal from the analyte adsorbed on the nano-needle tip. The system further includes a synchronous detector configured to be gated cooperatively with the vibration of the nano-needle. The method includes inducing the vibration, illuminating the vibrating tip to produce a Raman signal, and detecting the Raman signal using the detector. | 08-04-2011 |
| 20110267606 | SURFACE-ENHANCED RAMAN SPECTROSCOPY DEVICE AND A MOLD FOR CREATING AND A METHOD FOR MAKING THE SAME - A surface-enhanced Raman spectroscopy device includes a substrate, and an ultraviolet cured resist disposed on the substrate. The ultraviolet cured resist has a pattern of cone-shaped protrusions, where each cone-shaped protrusion has a tip with a radius of curvature equal to or less than 10 nm. The ultraviolet cured resist is formed of a predetermined ratio of a photoinitiator, a cross-linking agent, and a siloxane based backbone chain. A Raman signal-enhancing material is disposed on each of the cone-shaped protrusions. | 11-03-2011 |
| 20110267607 | ENHANCING SIGNALS IN SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) - An integrated device for enhancing signals in Surface Enhanced Raman Spectroscopy (SERS). The integrated device comprising an array of nanostructures comprising a material, wherein the material is configured to allow light to pass through. The integrated device also comprising SERS active nanoparticles disposed on at least portion of the array of nanostructures and a mirror integrated below a base of the array of nanostructures. The mirror is configured to reflect light passing through the material into the array of nanostructures. | 11-03-2011 |
| 20110267608 | TUNABLE APPARATUS FOR PERFORMING SERS - A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable layer and a plurality of SERS-active nanoparticles disposed at one or more locations on the deformable layer, wherein the one or more locations are configured to be illuminated with light of a pump wavelength to cause Raman excitation light to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles. In addition, a morphology of the deformable layer is configured to be controllably varied to modify an intensity of the Raman scattered light produced from the molecules. | 11-03-2011 |
| 20110267609 | APPARATUS FOR PERFORMING SERS - An apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a reflective layer positioned above the substrate, a plurality of tapered nanowires disposed above the reflective layer, each of the plurality of tapered nanowires having a tapered end directed away from the reflective layer. | 11-03-2011 |
| 20110267610 | COMPACT SENSOR SYSTEM - A compact sensor system comprising: an analysis cell configured for photon-matter interaction, where photons are received from a light source; and an integrated-optical spectral analyzer configured for identifying a set of frequencies, the integrated-optical spectral analyzer comprising: a waveguide coupled with the analysis cell, the waveguide configured for propagating a set of frequencies through the waveguide; one or more ring resonators coupled with the waveguide, the one or more ring resonators comprising a predetermined bandwidth and configured for capturing the set of frequencies corresponding to frequencies within the predetermined bandwidth; and one or more frequency detectors coupled with the one or more tunable ring resonators, the one or more frequency detectors configured for generating electrical signals that identify each of the set of frequencies. | 11-03-2011 |
| 20110317160 | BROAD BAND STRUCTURES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY - Broad band structures for surface enhanced Raman spectroscopy are disclosed herein. Each embodiment of the structure is made up of a metal layer, and a dielectric layer established on at least a portion of the metal layer. The dielectric layer has a controlled thickness that varies from at least one portion of the dielectric layer to at least another portion of the dielectric layer. Nanostructures are established on the dielectric layer at least at the portion and the other portion, the nanostructures thus being configured to exhibit variable plasmon resonances. | 12-29-2011 |
| 20120013902 | MULTI-WAVELENGTH RAMAN LIGHT DETECTION FOR DETECTING A SPECIES - An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species. | 01-19-2012 |
| 20120026493 | GRATING FOR MULTIPLE DISCRETE WAVELENGTHS OF RAMAN SCATTERING - Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer. | 02-02-2012 |
