Patent application number | Description | Published |
20100105743 | Pharmaceutical compositions and methods for stabilizing the same - Pharmaceutical compositions, and a method of stabilizing pharmaceutical compositions having clevidipine, or any pharmaceutically acceptable salt thereof, as the active ingredient is described. The method includes the slowing down or inhibiting of the oxidation pathway of clevidipine. This can be accomplished by reducing the amount the pharmaceutical composition is exposed to oxygen and/or light during the manufacturing and storing processes. According to this method, oxygen must be removed or replaced, or light must be sufficiently blocked such that light energy cannot reach the active ingredient of the composition, or is reduced to a level that the light-induced oxidation reaction converting clevidipine to H324/78 is minimized, such that the total detectable level of H324/78 in a given composition sample does not exceed about 0.2% on a weight-by-weight basis, or the ratio of clevidipine to H324/78 is equal to or greater than about 450 to 1 on a weight-to-weight basis. | 04-29-2010 |
20100113534 | Pharmaceutical Compositions And Methods For Producing Low Impurity Concentrations Of The Same - A composition having clevidipine as an active ingredient is described. The composition includes clevidipine as an active ingredient and an amount of the impurity H168/79 that is no greater than about 1.5%, or where the ratio between clevidipine and H168/79 is equal or above 60 to 1. | 05-06-2010 |
20120149770 | Antimicrobial Preservation of Propofol Emulsions - The invention provides intravenous formulations of propofol in an oil-in-water emulsion, having a combination of preservatives. | 06-14-2012 |
20120322835 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR PRODUCING LOW IMPURITY CONCENTRATIONS OF THE SAME - A composition having clevidipine as an active ingredient is described. The composition includes clevidipine as an active ingredient and an amount of the impurity H168/79 that is no greater than about 1.5%, or where the ratio between clevidipine and H168/79 is equal or above 60 to 1. | 12-20-2012 |
20120322836 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR STABILIZING THE SAME - Pharmaceutical compositions, and a method of stabilizing pharmaceutical compositions having clevidipine, or any pharmaceutically acceptable salt thereof, as the active ingredient is described. The method includes the slowing down or inhibiting of the oxidation pathway of clevidipine. This can be accomplished by reducing the amount the pharmaceutical composition is exposed to oxygen and/or light during the manufacturing and storing processes. According to this method, oxygen must be removed or replaced, or light must be sufficiently blocked such that light energy cannot reach the active ingredient of the composition, or is reduced to a level that the light-induced oxidation reaction converting clevidipine to H324/78 is minimized, such that the total detectable level of H324/78 in a given composition sample does not exceed about 0.2% on a weight-by-weight basis, or the ratio of clevidipine to H324/78 is equal to or greater than about 450 to 1 on a weight-to-weight basis. | 12-20-2012 |
20140005233 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR PRODUCING LOW IMPURITY CONCENTRATIONS OF THE SAME | 01-02-2014 |
Patent application number | Description | Published |
20080226591 | Compounds for the Treatment of Hepatitis C - The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. | 09-18-2008 |
20080226592 | Compounds for the Treatment of Hepatitis C - The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. | 09-18-2008 |
20080227769 | Compounds for the Treatment of Hepatitis C - The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. | 09-18-2008 |
20090162318 | Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors - The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. | 06-25-2009 |
20090280083 | Compounds for the Treatment of Hepatitis C - The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. | 11-12-2009 |
20100080772 | Hepatitis C Virus Inhibitors - The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection. | 04-01-2010 |
20110207749 | Glycine Chroman-6-Sulfonamides for Use as Inhibitors of Diacylglycerol Lipase - The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity. | 08-25-2011 |
20110207772 | Glycine Chroman-6-Sulfonamides for Use as Inhibitors of Diacylglycerol Lipase - The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity. | 08-25-2011 |
20110311480 | Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors - The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. | 12-22-2011 |
20130171098 | Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors - The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. | 07-04-2013 |
20140045816 | Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors - The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. | 02-13-2014 |
20140186299 | Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors - The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. | 07-03-2014 |
Patent application number | Description | Published |
20100052106 | PACKAGE DEVICE HAVING CRACK ARREST FEATURE AND METHOD OF FORMING - A package device has a package substrate, a semiconductor die on the package substrate, and a molding compound on the package substrate and over the semiconductor die. The semiconductor die has a last passivation layer, an active circuit region in an internal portion of the die, an edge seal region along a periphery of the die, and a structure over the edge seal region extending above the last passivation layer, covered by the molding compound, and comprising a polymer material. The structure may extend at least five microns above the last passivation layer. The structure stops cracks in the molding compound from reaching the active circuit region. The cracks, if not stopped, can reach wire bonds in the active region and cause them to fail. | 03-04-2010 |
20140001655 | POWER TRANSISTOR WITH HEAT DISSIPATION AND METHOD THEREFOR | 01-02-2014 |
20140327124 | POWER TRANSISTOR WITH HEAT DISSIPATION AND METHOD THEREFORE - A device comprising a substrate, an integrated circuit (IC) die attached to the substrate on one side, a plurality of contact pads on an active side of the IC die, a plurality of thermally and electrically conductive legs, each of the legs attached to a respective one of the contact pads, and an encapsulating material formed around the substrate, the IC die, and a portion of the legs. A contact end of each of the legs is exposed, and one of the contact ends conducts a signal from a transistor in the IC die. | 11-06-2014 |
20140346663 | SEMICONDUCTOR STRUCTURE WITH SACRIFICIAL ANODE AND METHOD FOR FORMING - A packaged semiconductor device is made by forming a conductive pad on an external surface of an integrated circuit device, forming a passivation layer over the conductive pad, removing a portion of the passivation layer over a bond area on the conductive pad, forming a sacrificial anode around a majority of a periphery surrounding the bond area, forming a conductive bond in the bond area, and forming an encapsulating material around the conductive bond and an exposed portion of the sacrificial anode. | 11-27-2014 |
20150084168 | PACKAGE ENCAPSULANT RELIEF FEATURE - A microelectronic device package including a package substrate, microelectronic component disposed on a first surface of a first portion of the substrate, and encapsulant material surrounding the microelectronic electronic component. An exposed surface of the first portion of the substrate is exposed through an opening in a first major surface of the encapsulant material. The exposed surface of the first portion has an edge. Encapsulant material is adjacent to the edge at the first major surface. The exposed surface is opposite the first surface. A stress relief feature located in one of the first major surface or a second major surface of the encapsulant material. The second major surface is opposite the first major surface. The stress relief feature reduces an amount of the encapsulant material and is 1 mm or less of a plane of the edge of the exposed surface. The plane is generally perpendicular to the exposed surface. | 03-26-2015 |
Patent application number | Description | Published |
20110276682 | System and Method for Determining Application Dependency Paths in a Data Center - A method and a system are disclosed for determining application dependency paths in a data center. The method and the system captures application traffic volume data on the servers with switches and monitoring agents; generates an application traffic matrix of all the components of the applications based on the application traffic volume data; estimates the number of the applications in the data center from the traffic matrix with a Rank Estimation via Singular Value Decomposition or Power Factorization Residue Errors process; and decomposes the traffic matrix into a first matrix and a second matrix with a non-negative matrix factorization process using the estimated number of applications. The first matrix represents a set of the components belonging to each of the applications and the second matrix represents the amount of traffic generated by each application over time. Any noise in the first and second matrices is removed with a concurrent volumes ratios based correlation process. | 11-10-2011 |
20120191843 | SYSTEMS AND METHODS FOR APPLICATION DEPENDENCY DISCOVERY - Systems and methods for discovering a set of applications that run on a network are disclosed. In accordance with one method, aggregate traffic volumes are determined for pairs of nodes on the network over a plurality of time intervals. The method further includes building a traffic matrix denoting each of the pairs of nodes and denoting respective aggregate traffic volume histories of each of the pairs of nodes that are based on the determined traffic volumes. In addition, the traffic matrix is formulated as a combination of bases vectors that model the set of applications. The bases vectors are determined by applying a covariance matrix adaptation evolutionary strategy based on the traffic matrix. An indication of the set of applications based on the bases vectors is output. | 07-26-2012 |
20130219223 | Method for Metric Ranking in Invariant Networks of Distributed Systems - A method for metric ranking in invariant networks includes, given an invariant network and a set of broken invariants, two ranking processes are used to determine and rank the anomaly scores of each monitoring metrics in large-scale systems. Operators can follow the rank to investigate the root-cause in problem investigation. In a first ranking process, given a node/metric, the method determines multiple scores by integrating information from immediate neighbors to decide the anomaly score for metric ranking. In a second ranking process, given a node/metric, an iteration process is used to recursively integrate the information from immediate neighbors at each round to determine its anomaly score for metric ranking. | 08-22-2013 |
20140047279 | Fault Localization in Distributed Systems Using Invariant Relationships - A computer implemented method for temporal ranking in invariant networks includes considering an invariant network and a set of broken invariants in the invariant network, assuming, for each time point inside a window W, that each metric with broken invariants is affected by a fault at that time point, computing an expected pattern for each invariant of a metric with assumed fault, said pattern indicative of time points at which an invariant will be broken given that its associated metric was affected by a fault at time t, comparing the expected pattern with the pattern observed over the time window W; and determining a temporal score based on a match from the prior comparing | 02-13-2014 |
20140108314 | INTEGRATED APPROACH TO MODEL TIME SERIES DYNAMICS IN COMPLEX PHYSICAL SYSTEMS - A system and method for analysis of complex systems which includes determining model parameters based on time series data, further including profiling a plurality of types of data properties to discover complex data properties and dependencies; classifying the data dependencies into predetermined categories for analysis; and generating a plurality of models based on the discovered properties and dependencies. The system and method may analyze, using a processor, the generated models based on a fitness score determined for each model to generate a status report for each model; integrate the status reports for each model to determine an anomaly score for the generated models; and generate an alarm when the anomaly score exceeds a predefined threshold. | 04-17-2014 |
20140108324 | DATA ANALYTIC ENGINE TOWARDS THE SELF-MANAGEMENT OF COMPLEX PHYSICAL SYSTEMS - Systems and method for modeling system dynamics, including extracting features representative of a temporal evolution of a dynamical system, further including deriving one or more vector trajectories by performing sliding window segmentation of one or more time series; applying a linear test to determine whether the one or more vector trajectories are linear or nonlinear; and performing linear or nonlinear subspace decomposition on the vector trajectory based on the linear test. The system and method may generate a system evolution model from the extracted features of the dynamical system and determine a fitness score of the system evolution model. | 04-17-2014 |