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Michelson, CA

Gary Karlin Michelson, Los Angeles, CA US

Patent application numberDescriptionPublished
20110190773SURGICAL RONGEUR - An improved rongeur for cutting bone or cartilage comprising two shaft members capable of reciprocating motion relative to each other wherein one shaft member terminates in a foot plate and the other shaft member comprises a combined cutting element and storage member is disclosed. The combined cutting element and storage member has a cutting edge at its distal end and a storage chamber proximate the cutting edge for collecting and storing cut pieces of bone or cartilage in an amount greater than the maximum bone or cartilage capable of being cut in a single full cut. The combined cutting element and storage member is truly disposable, rather than merely replaceable and requires the use of no tools or special assembly. The rongeur may be manually activated or activated by a solenoid and powered by a battery.08-04-2011

Gary Karlin Michelson, Venice, CA US

Patent application numberDescriptionPublished
20080255564Bone cutting device - Apparatus and a method of inserting spinal implants is disclosed in which an intervertebral space is first distracted, a hollow sleeve having teeth at one end is then driven into the vertebrae adjacent that disc space. A drill is then passed through the hollow sleeve removing disc and bone in preparation for receiving the spinal implant which is then inserted through the sleeve.10-16-2008
20080287955Distractor for use in spinal surgery and method of use thereof - Apparatus and a method of inserting spinal implants is disclosed in which an intervertebral space is first distracted, a hollow sleeve having teeth at one end is then driven into the vertebrae adjacent that disc space. A drill is then passed through the hollow sleeve removing disc and bone in preparation for receiving the spinal implant which is then inserted through the sleeve.11-20-2008
20090088857Implant for the delivery of electrical current to promote bone growth between adjacent bone masses - An electrical bone growth promotion apparatus for the delivery of electrical current to an implant surgically implanted between adjacent bone masses to promote bone growth to areas adjacent to the implant is disclosed. The apparatus of the present invention comprises a self contained implant having a surgically implantable, renewable power supply and related control circuitry for delivering electrical current directly to the implant and thus directly to the area in which the promotion of bone growth is desired. The desired areas of bone growth promotion may be controlled by conducting negative charge only to the desired location of bone growth promotion.04-02-2009
20100217394Frusto-conical spinal implant - The present invention is directed to a variety of interbody spinal fusion implants having at least a partially frusto-conical configuration. The spinal fusion implants of the present invention may be relatively solid or hollow and may have surface roughenings to promote bone ingrowth and stability. The spinal fusion implants of the present invention may have wells extending into the material of the implant from the surface for the purpose of holding fusion promoting materials and to provide for areas of bone ingrowth fixation. A variety of surface irregularities may be employed to increase implant stability and implant surface area, and/or for the purpose of advancing the spinal fusion implant into the fusion site.08-26-2010
20110004310Lordotic interbody spinal fusion implants - The present application is directed to interbody spinal fusion implants having a structural configuration that provides for the maintaining and creating of the normal anatomic angular relationship of two adjacent vertebrae of the spine to maintain and create spinal lordosis. The spinal fusion implants are sized to fit within the disc space created by the removal of disc material between two adjacent vertebrae and conform wholly or in part to the disc space created. The spinal fusion implants of the present invention have upper and lower surfaces that form a support structure for bearing against the end plates of the adjacent vertebrae. The upper and lower surfaces are disposed in a converging angular relationship to each other such that the implants have an overall “wedged-shape” in an elevational side view. The angular relationship of the upper and lower surfaces places and maintains the vertebrae adjacent to those surfaces in an angular relationship to each other, creating and maintaining the desired lordosis.01-06-2011
20110054529THREADED INTERBODY SPINAL FUSION IMPLANT - The present invention is directed to a variety of interbody spinal fusion implants having at least a partially frusto-conical configuration. An external thread is employed to increase implant stability and implant surface area, and for the purpose of advancing the spinal fusion implant into the fusion site. The spinal fusion implants of the present invention may be relatively solid or hollow and may have surface roughenings to promote bone ingrowth and stability. The spinal fusion implants of the present invention may have wells extending into the material of the implant from the surface for the purpose of holding fusion promoting materials and to provide for areas of bone ingrowth fixation.03-03-2011
20110137420EXPANDABLE PUSH-IN ORTHOPEDIC IMPLANT - A push-in orthopedic implant having an expandable height. The implant includes an upper member, a lower member, and a blocker pivotally attached to one of the upper and lower members. The blocker is attached proximate one of the proximal and distal ends of the one of the upper and lower members, and is adapted to pivot into cooperative engagement with another of the one of the upper and lower members. The blocker is adapted to hold at least a portion of the upper and lower members apart so as to maintain an increased height of the implant and resist the collapse of the implant to a collapsed implant height when the implant is in a final deployed position.06-09-2011
20110196501INTERBODY SPINAL IMPLANT INDUCTIVELY COUPLED TO AN EXTERNAL POWER SUPPLY - An electrical bone growth promotion apparatus for the delivery of electrical current to an implant surgically implanted between adjacent bone masses to promote bone growth to areas adjacent to the implant is disclosed. The apparatus of the present invention comprises a self contained implant having a surgically implantable, renewable power supply and related control circuitry for delivering electrical current directly to the implant and thus directly to the area in which the promotion of bone growth is desired. The desired areas of bone growth promotion may be controlled by conducting negative charge only to the desired location of bone growth promotion.08-11-2011
20110224795SPINAL FUSION IMPLANT - The present invention is directed to a variety of interbody spinal fusion implants for insertion across the surgically corrected height of a disc space between two adjacent vertebral bodies of a human spine. The spinal fusion implants of the present invention have opposed upper and lower portions with openings extending through the implant to provide for bone growth from vertebral body to vertebral body. The upper and lower portions of the spinal fusion implants of the present invention have bone engaging projections to engage the implants to the adjacent vertebral bodies.09-15-2011
20110270318DEVICE AND METHOD FOR RESILIENTLY LOCKING A SCREW TO A PLATE - A spinal fixation device for stabilizing one or more segments of the human spine and for preventing the dislodgement of intervertebral spinal fusion implants, which remains permanently fixated once applied.11-03-2011

Patent applications by Gary Karlin Michelson, Venice, CA US

Glenn Michelson, San Francisco, CA US

Patent application numberDescriptionPublished
20110008371METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OX- O-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID FOR TREATMENT OF ANTECEDENT HEMATOLOGIC DISORDERS - Methods of treating, preventing or managing antecedent hematologic disorders, such as myelodysplastic syndrome, including chronic myelomonocytic leukemia are disclosed. The methods encompass the administration of SNS-595. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with cytarabine. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.01-13-2011

Glenn C. Michelson, Emeryville, CA US

Patent application numberDescriptionPublished
20090215793Methods for treating drug resistant cancer - A method for treating drug-resistant cancer, includes: administering to a patient in need thereof, a compound of formula I, a tautomer of the compound, a salt of the compound, a salt of the tautomer, a mixture thereof, or a pharmaceutical composition comprising the compound, the tautomer, the salt of the compound, the salt of the tautomer, or the mixture, wherein the patient is a cancer patient with drug-resistant cancer, wherein the compound of Formula I is as defined in the application.08-27-2009

Lillian Michelson, Los Angeles, CA US

Patent application numberDescriptionPublished
20090066206METHOD AND APPARATUS OF CATCHING OBJECTS FALLING BEHIND AN ARTICLE OF FURNISHING - A method comprising cutting a cradle to a desired length, positioning the cradle at a position between an article of furnishing and a wall and reachable without moving the article of furnishing, removing adhesive backing from the cradle, and affixing the cradle to the article of furnishing and the wall. An apparatus comprising a generally rectangular sheet having two lateral edges and two longitudinal edges and dimensions generally conforming to a gap between an article of furnishing and a wall, and a plurality of adhesive strips put on one surface of the sheet along the two longitudinal edges of the sheet.03-12-2009

Manfred G. Michelson, Calabasas, CA US

Patent application numberDescriptionPublished
20110097074High speed motion picture film processor - A high speed motion picture film processor has a developer tank having a positive pressure relative to an ambient air pressure outside of the tank. A gas make-up system adds nitrogen inside of the developer tank while a system of seals minimizes leakage. Two seals are used along a periphery of the developer tank; one is below a sprocket level while the other is above the sprocket level. These two barriers can utilize a liquid reservoir that is filled by operation of the processor with excess liquid returning to the developer tank and they are constructed so as to allow movement. A film entrance sealing device and a film exit sealing device, each with its own housing, are also used with the developer tank; these units use a pair of rollers and a pair of flexible barriers to separate a tank gas chamber from an air chamber which is at a lower pressure and which contains a partial pressure of nitrogen fed into the entrance sealing device. The level of developer fluid is maintained at approximately the centerline of a first roller shaft but below that of a second roller shaft. The sprocket shaft has two smaller shafts mounted in metal bearings and a center tube on which the sprockets are mounted. Oxygen sensors with throttling exhaust devices outside the developer tank sound an alarm when oxygen level is too high in the developer tank. Reservoir fluid seals may also be used on secondary tanks.04-28-2011

Seth Michelson, San Jose, CA US

Patent application numberDescriptionPublished
20090318775METHODS AND SYSTEMS FOR ASSESSING CLINICAL OUTCOMES - Described herein are methods and systems useful for characterizing clinical outcomes of a subject. Provided herein includes computer-assessed methods, medical information systems, and computer-readable instructions that can aid an end-user in diagnosis, prognosis, and treatment of a clinical outcome.12-24-2009

Seth G. Michelson, San Jose, CA US

Patent application numberDescriptionPublished
20080213786Treatment of rheumatoid arthritis with galectin-3 antagonists - The invention encompasses a novel method of treating an inflammatory disease, such as rheumatoid arthritis, and novel methods of identifying and screening for drugs useful in the treatment of inflammatory diseases, such as rheumatoid arthritis, and their clinical symptoms. The inventors have made the discovery that the activity of galectin-3, a β-galactoside-binding lectin known to have an effect on some cancers, has a significant impact on the pathophysiology of rheumatoid arthritis. The symptoms of an inflammatory disease, such as rheumatoid arthritis, may be alleviated by administering a compound that inhibits the activity of galectin-3.09-04-2008
20110093249INTEGRATED HEALTH DATA CAPTURE AND ANALYSIS SYSTEM - The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.04-21-2011

Patent applications by Seth G. Michelson, San Jose, CA US

Seth Gary Michelson, San Jose, CA US

Patent application numberDescriptionPublished
20110275527Predictive Toxicology for Biological Systems - Methods and apparatus to identify a potential toxicity of a therapy in a biological system are described. In one embodiment, a method uses a computer model that represents a set of biological processes of the biological system. The method includes executing the computer model to identify a first set of biological processes contributing to the occurrence of a toxic state of the biological system. The method also includes identifying a set of biological assays based on the first set of biological processes and testing the therapy in the set of biological assays to identify a second set of biological processes modified by the therapy. The method further includes identifying the potential toxicity of the therapy based on the second set of biological processes.11-10-2011