Patent application number | Description | Published |
20080280895 | 5-Amino-4-Hydroxy-7-(1H-Indolmethyl)-8-Methylnonamide Derivatives as Renin Inhibitors for the Treatment of Hypertension - The application relates to novel alkanamides of the general formula (I) where X is —CH | 11-13-2008 |
20080318978 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS ALDOSTERONE SYNTHASE INHIBITORS - The application relates to novel heterocyclic compounds of the general formula (I) in which R, R | 12-25-2008 |
20090029981 | SUBSTITUTED 4-PHENYLPIPERIDINES - The application relates to substituted 4-phenylpiperidines of the general formula and their salts, preferably their pharmaceutically acceptable salts, in which R | 01-29-2009 |
20090111840 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors - The patent application relates to new heterocyclic compounds of the general formula (I) in which R, R | 04-30-2009 |
20090118281 | Amino Alcohol Derivatives And Their Use As Renin Inhibitor - The application relates to novel amino alcohols of the general formula (I) where R, R | 05-07-2009 |
20090118512 | Process for Preparing 6,7-Dihydro-5H-Imidazo[1,5-A]Pyridin-8-One - 6,7-Dihydro-5H-imidazo[1,5-a]pyridin-8-one (I), is obtainable in high yields by: 1) a process which proceeds from a suitably protected C-(3-hydroxypyridin-2-yl)methylamine whose amine is converted to the formamide which is then cyclized to the imidazo[1,5-a]pyridine and hydrogenated to the 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one, and suitably protected C-(3-hydroxypyridin-2-yl)methylamines can be prepared either in 2 steps proceeding from commercially available 3-hydroxy-2-cyanopyridine [932-35-4] or in 3 steps proceeding from commercially available 2-hydroxymethylpyridin-3-ol [14173-30-9]; 2) a process for preparing 4-hydroxy-1-(1H-imidazol-4-yl)butan-1-one, an intermediate from the synthesis of 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one (formula I), as described in WO 2002/040484, proceeding from N,N-dimethyl-2-(trialkylsilanyl)imidazole-1-sulphonamide by lithiation and subsequent reaction with a suitably protected 4-hydroxybutyraldehyde, followed by oxidation of the secondary alcohol, acid-induced deprotection of the imidazole and deprotection of the alcohol functionality; 3) a process which proceeds from 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine [38666-30-7], which is oxidized. | 05-07-2009 |
20090197909 | Bis-Heterocyclic Imidazolyl Compounds - The patent application relates to new heterocyclic compounds of the general formula (I) in which R, R | 08-06-2009 |
20090270380 | 3,4,5-Substituted Piperidines as Renin Inhibitors - The application relates to novel substituted piperidines of the general formula (II) in which R | 10-29-2009 |
20090306062 | 2,5-Disubstituted Piperidines - The application relates to 2,5-disubstituted piperidines, their preparation and use as medicines, especially as renin inhibitors, of the general formula (I) in which R, R | 12-10-2009 |
20090306064 | Substituted Piperidines as Renin Inhibitors - Compounds of the general formula (I) in which the meanings of the substituents R | 12-10-2009 |
20100010015 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors - The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R | 01-14-2010 |
20100029628 | 2,4,5-Substituted Piperidines as Renin Inhibitors - SP-P2140 ATE-132—Abstract Novel substituted piperidines of the general formula (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent. | 02-04-2010 |
20100029694 | Heterocyclic compounds and their use as aldosterone synthase inhibitors - Heterocyclic compounds of the general formula (I) | 02-04-2010 |
20100168145 | FUSED IMIDAZOLE DERIVATIVES AND USE THEREOF AS ALDOSTERONE SYNTHASE INHIBITORS - The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R | 07-01-2010 |
20110028512 | BIS-HETEROCYCLIC IMIDAZOLYL COMPOUNDS - Heterocyclic compounds of the general formula (I) are provided in which R, R | 02-03-2011 |
20120115859 | 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS - The application relates to novel substituted piperidines of the general formula (II) in which R | 05-10-2012 |