Patent application number | Description | Published |
20130004982 | METHOD AND APPARATUS FOR MAGNETIC FLOW CYTOMETRY - A magnetic flow cytometry apparatus for detection of cells labeled with magnetic nanoparticles has at least one pair of oppositely oriented magnets to provide between the magnets a first magnetic field region with a low magnetic field strength and to provide at poles of the magnets second magnetic field regions with a high magnetic field strength. The magnetic labeled cells provided within a flow input into the magnetic flow cytometry apparatus are enriched in at least one of the second magnetic field regions and supplied to the first magnetic field region, where a magnetic field is applied to the enriched magnetic labeled cells to measure the magnetic relaxation of the magnetic labeled cells in response to the applied magnetic field. | 01-03-2013 |
20130164777 | Magnetic Flow Cytometry for Individual Cell Detection - The disclosure relates to flow cytometry. A method for precise individual cell detection and cell measurement of cells in the flow is disclosed. A pair of magnetoresistive components are used to produce a characteristic measuring signal profile from which the following information can be obtained: number of measurement deviations, measurement deviation distances, measurement deviation amplitudes, measurement deviation direction and measurement deviation direction sequence. The flow speed and the cell diameter can also be determined. Also, the signal noise ratio can be determined using the measurement deviation amplitude | 06-27-2013 |
20130224762 | MAGNETIC CELL DETECTION - Specific labeling of cells enables magnetic cell detection. The cell type to be detected is labeled, magnetic labels being bound to epitopes of a first cell-specific epitope type via antibodies of a first antibody type. Additionally, second/further magnetic labels are bound to epitopes of a second cell-specific epitope type on the cells via antibodies of a second antibody type, or the magnetic labels are bound to the antibodies of the first antibody type via antibodies of another antibody type and the antibodies of the first antibody type are bound to the epitopes of the first cell-specific epitope type on the cells. | 08-29-2013 |
20130330828 | MINIATURIZED MAGNETIC FLOW CYTOMETRY - A measuring device for magnetic flow cytometry has a microfluidic channel disposed along an enriching route such that a magnetically marked cell sample flowing through the microfluidic channel is aligned to magnetic guide strips, enriched by the magnetic field of a magnet at the floor of the channel, and guided past a sensor. The sensor and the magnetic guide strips are integrated on a semiconductor chip. | 12-12-2013 |
20130337497 | MAGNETIC FLOW CYTOMETRY FOR HIGH SAMPLE THROUGHPUT - In a measuring device, a production thereof, and a use thereof for magnetic flow cytometry, a microfluidic channel is disposed along an enrichment route such that a magnetically marked cell sample flowing through the microfluidic channel is aligned to magnetic guide strips, enriched by the magnetic field of a magnet at the floor of the channel, and guided past a sensor. The enrichment route is thereby implemented with the microfluidic channel on the packaging of the semiconductor chip carrying the sensor. This construction ensures a long enrichment route for high throughput of large sample volumes. | 12-19-2013 |
20130344605 | METHOD AND ARRANGEMENT FOR PARTIAL LABELING AND SUBSEQUENT QUANTIFICATION OF CELLS OF CELL SUSPENSION - Cells of a cell suspension are labeled by providing a microfluidic chamber having superparamagnetic labeling particles that are concentrated exactly at one inner surface of the chamber and charging the cell suspension into the chamber. | 12-26-2013 |
20140127710 | BACKGROUND-FREE MAGNETIC FLOW CYTOMETRY - The invention relates to an apparatus and a method for magnetic flow cytometry, wherein magnetic units ( | 05-08-2014 |
20140159714 | FLUIDIC CELL GUIDANCE FOR FLOW CYTOMETRY - The invention relates to a device and a method for fluidic cell guidance for flow cytometry or analyte enrichment. This allows magnetically marked analytes, in particular cells ( | 06-12-2014 |
20140193851 | Detecting Individual Analytes by Means of Magnetic Flow Measurement - In a magnetic flow measurement, such as flow cytometry, individual analytes are detected in the through-flow. The analytes (e.g., cells) are marked with magnetic labels directly in the medium surrounding the analytes. The analytes are transported through the flow channel of a measuring device including at least one magnetic sensor. Using the magnetic marking of the analytes, the magnetic analyte diameter (r | 07-10-2014 |
20140356891 | Determining the Dynamic State of Analytes by Magnetic Flow Measurement - Devices and methods for magnetic flow measurement are provided. Individual analytes are detected in the through-flow, and a dynamic detection of a changing analyte state is carried out, for example with respect to the analyte size or morphology. For this purpose, the analytes to be detected, such as cells for example, are directly marked in the medium surrounding said analytes with magnetic labels and transported through the flow channel of a measuring device comprising at least two magnetic sensors. A characteristic measurement signal is generated by means of the magnetic sensors that are mutually spaced in the flow direction. The magnetic analyte diameter is calculated using the interval between the measurement deflections, and the analyte state can be evaluated using the magnetic analyte diameter. | 12-04-2014 |