Patent application number | Description | Published |
20100069720 | SPECTROSCOPICALLY ENHANCED IMAGING - The present invention provides systems and methods for the spectroscopic determination of the physical characteristics of the tissue under observation by an autofluorescence or other endoscope without the requirement of contacting the tissue directly. The optical probe contained in the endoscope itself is passive and may be either built into the endoscope or positioned in a biopsy channel of same. The spectroscopic information, combined with other information provided by the endoscope such as total fluorescence, improves the sensitivity and specificity of the identification of precancerous or cancerous lesions. | 03-18-2010 |
20100249607 | QUANTITATIVE SPECTROSCOPIC IMAGING - The present invention relates to a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a powerful surveillance tool for objective early cancer detection. The design, construction, calibration, and diagnostics applications of this system is described with the use of physical tissue models. Measurements were conducted on a resected colon adenoma, and the system can be used for vivo imaging in the oral cavity. | 09-30-2010 |
20120035442 | PORTABLE RAMAN DIAGNOSTIC SYSTEM - The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general. | 02-09-2012 |
20120259228 | TRI MODAL SPECTROSCOPIC IMAGING - The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively. | 10-11-2012 |
20120302892 | PORTABLE OPTICAL FIBER PROBE-BASED SPECTROSCOPIC SCANNER FOR RAPID CANCER DIAGNOSIS - A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment. | 11-29-2012 |
20130265585 | SYSTEMS AND METHODS FOR PHASE MEASUREMENTS - Preferred embodiments of the present invention are directed to systems for phase measurement such as for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. Light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention. | 10-10-2013 |
20140361148 | SYSTEM AND METHOD FOR HILBERT PHASE IMAGING - Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets. | 12-11-2014 |
20150177133 | TOMOGRAPHIC PHASE MICROSCOPY - The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering. | 06-25-2015 |