Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


Michael Donovan

Michael Donovan, Huntley, IL US

Patent application numberDescriptionPublished
20100189509GEOTECHNICAL APPLICATIONS OF IMPROVED NANOCOMPOSITES - The apparatuses, compositions and methods described herein generally relate to a new application for and formulation of composite-polymer composition. This composition is a nanocomposite, comprising a polymer and a clay, preferably a recycled polymer and a nanoclay. The nanocomposite composition has improved performance characteristics, such as lower creep values and lower coefficients of linear thermal expansion, and can reduce the dependency of plastic product manufacturing on virgin (unrecycled) polymers. Moreover, the nanocomposite is formed into geosynthetic materials, e.g., geomembranes, and storm water retention/detention systems.07-29-2010
20100314026WINDOW AND DOOR FLASHING, ROOFING UNDERLAYMENT, PROTECTION COURSE, ROOT BLOCK AND SOUND CONTROL UNDERLAYMENT MATERIAL PRODUCTS - A window or door flashing or roofing material, containing no asphalt, either mechanically fastened or self-adhering comprising a mixture of: one or more ethylene based elastomers having a melting point below 160° F., in an amount of 10-40% based on the total weight of the product; one or more semi-crystalline, non-elastomer alpha olefin-based polymers having a melting point above 160° F. in an amount of about 10-40% based on the total weight of the product; and a rubber fraction of ground, vulcanized rubber having a size up to about 18 mesh, US Sieve Series, in an amount of about 10% to about 75%, based on the total weight of the product.12-16-2010
20110045726SALT WATER SWELLABLE COMPOSITIONS AND ARTICLES - The compositions, articles and methods described herein remain intact for sealing between and around structures that contact salt water. The compositions include: (i) a partially cross-linked polyacrylamide/partially neutralized polyacrylic acid copolymer; (ii) a smectite clay; (iii) an elastomer, e.g., butyl rubber; (iv) a polyolefin polymer or copolymer; and (v) a cationic flocculant, the compositions have exceptional and unexpected free swell and cohesiveness when in contact with high conductivity water or multivalent ion-containing-contaminated water. The articles of manufacture described herein all include a combination of (i) a partially cross-linked acrylamide/acrylate/acrylic acid copolymer; (ii) a smectite clay; (iii) an elastomer, e.g., butyl rubber; (iv) polyisobutene or polyisopropene; and (v) a cationic flocculent, and are used for waterproofing against high conductivity salt-containing water preferably when used in putty-like or paste-like consistency to fill areas between and around structures, e.g., to surround a pipe inserted in a concrete wall, or to seal between two concrete sections.02-24-2011
20110177736Self Healing Salt Water Barrier - Geocomposite articles that can provide a barrier against high conductivity water e.g., ocean water, are described and their method of manufacture, for waterproofing surfaces that contact high conductivity water. The geocomposite article mat includes a woven or non-woven geotextile sheet or mat containing a powdered or granular partially cross-linked acrylamide/acrylate/acrylic acid copolymer across its entire major surface(s). The powdered or granular copolymer has an unexpectedly high free-swell when hydrated with High Conductivity water, such as ocean water. A liquid-impermeable cover sheet is adhered to the upper major surfaces of the filled copolymer-carrying geotextile to provide a primary high conductivity water barrier layer that, if ruptured, is sealed by the swell of an underlying layer of water-insoluble, partially cross-linked acrylamide/acrylic acid copolymer.07-21-2011

Michael Donovan, Boston, MA US

Patent application numberDescriptionPublished
20110040544Systems And Methods For Treating, Diagnosing And Predicting The Response To Therapy Of Breast Cancer - This present invention systems and methods of accessing/monitoring the responsiveness of a breast cancer to a therapeutic compound.02-17-2011

Michael Donovan, Cambridge, MA US

Patent application numberDescriptionPublished
20100177950Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition - Clinical information, molecular information and/or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts risk of prostate cancer progression in a patient, where the model is based on features including one or more (e.g., all) of preoperative PSA, dominant Gleason Grade, Gleason Score, at least one of a measurement of expression of AR in epithelial and stromal nuclei and a measurement of expression of Ki67-positive epithelial nuclei, a morphometric measurement of average edge length in the minimum spanning tree (MST) of epithelial nuclei, and a morphometric measurement of area of non-lumen associated epithelial cells relative to total tumor area. In some embodiments, the morphometric information is based on image analysis of tissue subject to multiplex immunofluorescence and may include characteristic(s) of a minimum spanning tree (MST) and/or a fractal dimension observed in the images.07-15-2010
20100184093Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition - Clinical information, molecular information and/or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts whether a patient is likely to have a favorable pathological stage of prostate cancer, where the model is based on features including one or more (e.g., all) of preoperative PSA, Gleason Score, a measurement of expression of androgen receptor (AR) in epithelial and stromal nuclei and/or a measurement of expression of Ki67-positive epithelial nuclei, a morphometric measurement of a ratio of area of epithelial nuclei outside gland units to area of epithelial nuclei within gland units, and a morphometric measurement of area of epithelial nuclei distributed away from gland units. In some embodiments, quantitative measurements of protein expression in cell lines are utilized to objectively assess assay (e.g., multiplex immunofluorescence (IF)) performance and/or to normalize features for use within a predictive model.07-22-2010

Michael Donovan, Montreal CA

Patent application numberDescriptionPublished
20090041323Systems and Methods for Constructing Images - Techniques and systems for constructing a three-dimensional representations of anatomical structures from a series of images of the structure include creating interpolated images between actual images and defining voxels based on pixel values of the actual and interpolated images. A three-dimensional representation of the structure may be constructed based on the voxels.02-12-2009

Michael Donovan, Dover, MA US

Patent application numberDescriptionPublished
20080310595THIN WALLED TUBE RADIATOR FOR BREMSSTRAHLUNG AT HIGH ELECTRON BEAM INTENSITIES - Methods and systems for generating bremsstrahlung with enhanced photon flux in a narrow cone at forward angles utilize a thin target of a high-Z material such as gold as radiator, supported on a tube of a low-Z material such as titanium, which tube contains a circulating fluid such as water which acts as a coolant and also may absorb the incident electron beam.12-18-2008
20110255669THIN WALLED TUBE RADIATOR FOR BREMSSTRAHLUNG AT HIGH ELECTRON BEAM INTENSITIES - Methods and systems for generating bremsstrahlung with enhanced photon flux in a narrow cone at forward angles utilize a thin target of a high-Z material such as gold as radiator, supported on a tube of a low-Z material such as titanium, which tube contains a circulating fluid such as water which acts as a coolant and also may absorb the incident electron beam.10-20-2011

Michael Donovan US

Patent application numberDescriptionPublished
20120010528Systems and methods for predicting disease progression in patients treated with radiotherapy - Clinical information, molecular information and/or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts whether a disease (e.g., prostate cancer) is likely to progress in a patient after radiation therapy. In some embodiments, the molecular and computer-generated morphometric information is obtained through computer analysis of tissue obtained from the patient via a needle biopsy at diagnosis and before treatment of the patent with radiation therapy.01-12-2012