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Michael D. Smith
Michael D. Smith, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100015683 | THERMOSTABLE REVERSE TRANSCRIPTASES AND USES THEREOF - The present invention is in the fields of molecular and cellular biology. The invention is generally related to reverse transcriptase enzymes and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to reverse transcriptase enzymes which have been mutated or modified to increase thermostability, decrease terminal deoxynucleotidyl transferase activity, and/or increase fidelity, and to methods of producing, amplifying or sequencing nucleic acid molecules (particularly cDNA molecules) using these reverse transcriptase enzymes or compositions. The invention also relates to nucleic acid molecules produced by these methods and to the use of such nucleic acid molecules to produce desired polypeptides. The invention also concerns kits comprising such enzymes or compositions. | 01-21-2010 |
| 20110008770 | COMPOSITIONS AND METHODS FOR REVERSE TRANSCRIPTION OF NUCLEIC ACID MOLECULES - The present invention is generally related to compositions and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to compositions comprising mixtures of polypeptides having reverse transcriptase (RT) activity, and to methods of producing, amplifying or sequencing nucleic acid molecules (particularly cDNA molecules) using these compositions or polypeptides, particularly at temperatures above about 55° C. The invention also relates to nucleic acid molecules produced by these methods, to vectors and host cells comprising these nucleic acid molecules, and to the use of such nucleic acid molecules to produce desired polypeptides. The invention also relates to methods for producing Rous Sarcoma Virus (RSV) and Avian Myeloblastosis Virus (AMV) RTs or other Avian Sarcoma-Leukosis Virus (ASLV) RTs (α and/or β subunits thereof), to isolated nucleic acid molecules encoding such RSV RT, AMV RT or other ASLV RT subunits, to vectors and host cells comprising these isolated nucleic acid molecules and to RSV RT, AMV RT and other ASLV RT subunits produced by these methods. The invention further relates to nucleic acid molecules encoding recombinant heterodimeric RT holoenzymes, particularly heterodimeric RSV RTs, AMV RTs or other ASLV RTs (which may be αβ RTs, ββ RTs, or α RTs), vectors (particularly baculovirus vectors) and host cells (particularly insect and yeast cells) comprising these nucleic acid molecules, methods for producing these heterodimeric RTs and heterodimeric RTs produced by these methods. The invention also relates to kits comprising the compositions, polypeptides, or RSV RTs, AMV RTs or other ASLV RTs of the invention. | 01-13-2011 |
| 20110081704 | THERMOSTABLE REVERSE TRANSCRIPTASES AND USES THEREOF - The present invention is in the fields of molecular and cellular biology. The invention is generally related to reverse transcriptase enzymes and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to reverse transcriptase enzymes which have been mutated or modified to increase thermostability, decrease terminal deoxynucleotidyl transferase activity, and/or increase fidelity, and to methods of producing, amplifying or sequencing nucleic acid molecules (particularly cDNA molecules) using these reverse transcriptase enzymes or compositions. The invention also relates to nucleic acid molecules produced by these methods and to the use of such nucleic acid molecules to produce desired polypeptides. The invention also concerns kits comprising such enzymes or compositions. | 04-07-2011 |
Michael D. Smith, Bartlesville, OK US
| Patent application number | Description | Published |
|---|---|---|
| 20100163401 | SULFUR DEGASSING PROCESS - A process is disclosed for removing hydrogen sulfide from liquid sulfur including: passing a liquid sulfur feed comprising liquid sulfur and hydrogen sulfide to a vaporizer; vaporizing at least a portion of the liquid sulfur feed in the vaporizer to thereby form a first vapor stream comprising gaseous sulfur and gaseous hydrogen sulfide; partially condensing the first vapor stream in a condenser to form a liquid product stream comprising liquid sulfur and a second vapor stream comprising hydrogen sulfide; wherein the liquid product stream has a lower concentration of hydrogen sulfide than the liquid sulfur feed. | 07-01-2010 |
| 20110266135 | SULFUR DEGASSING PROCESS - A process is disclosed for removing hydrogen sulfide from liquid sulfur including: passing a liquid sulfur feed comprising liquid sulfur and hydrogen sulfide to a vaporizer; vaporizing at least a portion of the liquid sulfur feed in the vaporizer to thereby form a first vapor stream comprising gaseous sulfur and gaseous hydrogen sulfide; partially condensing the first vapor stream in a condenser to form a liquid product stream comprising liquid sulfur and a second vapor stream comprising hydrogen sulfide; wherein the liquid product stream has a lower concentration of hydrogen sulfide than the liquid sulfur feed. | 11-03-2011 |
Michael D. Smith, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090290719 | STETHOSCOPIC ASSEMBLY WITH RECORD/PLAYBACK FEATURE - A stethoscopic assembly includes a stethoscope having a chest piece interconnected to at least one earpiece, the chest piece having an acoustical sensor enabling patient sounds to be heard through the at least one earpiece. A microprocessor connected to the acoustical sensor of the stethoscope includes a buffer wherein sound data picked up from the microphone is stored in volatile memory for a predetermined time period. At least one user operable switch connected to the microprocessor enables selective capture of sound data for storage and playback, such as through at least one speaker. In some versions the acoustical sensor is releasable from the chest piece. | 11-26-2009 |
| 20100022910 | RAPID ALLERGY TEST - A flexible and disposable allergen-containing patch is provided with markings transferable to the skin. The patch may also include piercing elements to become an all-in-one system. A reusable actuator enables a user with little training or experience to administer multiple test injections with the disposable patch. A scope allows magnified viewing of a test site after the skin test is provided, the scope incorporating the patch as a releasable component. An all-in-one applicator assembly that can be bent to fit a convex engagement surface of a rolling actuator is also provided. | 01-28-2010 |
Michael D. Smith, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080268463 | Methods for Prognosis and Diagnosis of Chronic Prostatitis/Pelvic Pain Syndrome and Interstitial Cystitis - We have discovered that levels of specific protein biomarkers present in urine samples of subjects correlate with the presence, or absence of, chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men or interstitial cystitis (IC) in women. These protein biomarkers are cortitropin releasing hormone (CRH), dehydroepiandrosterone (DHEA), neuropeptide Y (NPY) and Galanin. Accordingly, the invention is directed to methods for diagnosis of CP/CPPS and IC by monitoring the levels of at least one of these proteins in urine, as well as to diagnostic kits designed for diagnosis of CP/CPPS and IC. | 10-30-2008 |
Michael D. Smith, Winnebago, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20080209679 | Vertically Adjustable Hinge - A vertically adjustable hinge is disclosed. The hinge comprises a housing for attachment to a first structure. The housing has a housing cavity and an opening into the cavity. The cavity has an upper portion, a lower portion and a retaining portion forming a channel defining the upper portion and the lower portion. The hinge further includes a first leaf extending through the cavity opening and into the cavity upper portion, threaded nut rotationally fixed to the first leaf, and an adjustment mechanism disposed in the housing cavity. The adjustment mechanism comprises a jack screw extending between the upper cavity portion and the lower cavity portion. The jack screw has a threaded portion threadably engaging the nut in the upper cavity portion and a geared portion disposed in the cavity lower portion. The hinge further includes a worm gear engaging the jack screw geared portion, wherein rotation of the worm gear rotates the jack screw threaded portion in the nut, thereby moving the first leaf relative to the housing. | 09-04-2008 |
Michael D. Smith, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120005515 | ADAPTIVE EVENT-GUIDED SYSTEM AND METHOD FOR AVOIDING VOLTAGE EMERGENCIES - In a preferred embodiment, the present invention is a system for avoiding voltage emergencies. The system comprises a microprocessor, an actuator for throttling the microprocessor, a voltage emergency detector and a voltage emergency predictor. The voltage emergency detector may comprise, for example, a checkpoint recovery mechanism or a sensor. The voltage emergency predictor of a preferred embodiment comprises means for tracking control flow instructions and microarchitectural events, means for storing voltage emergency signatures that cause voltage emergencies, means for comparing current control flow and microarchitectural events with stored voltage emergency signatures to predict voltage emergencies, and means for actuating said actuator to throttle said microprocessor to avoid predicted voltage emergencies. | 01-05-2012 |
Michael D. Smith, Horace, ND US
| Patent application number | Description | Published |
|---|---|---|
| 20120005722 | Application Context Based Access Control - Access control for an application is described. An exemplary method includes receiving a first command of an application to invoke a function of a user interface, identifying a first authorization context based on a first user context and the function of the user interface invoked, retrieving a first access policy providing access criteria associated with the first authorization context, and applying the first access policy to the accessibility of the function. The method includes receiving a second command to invoke the function in a second instance of the application and identifying a second authorization context based on a second user context and the function of the user interface invoked. The second authorization context is different than the first authorization context. The method includes retrieving a second access policy providing second access criteria associated with the second authorization context and applying the second access policy to the accessibility of the function. | 01-05-2012 |