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Michael Clarke
Michael Clarke, Redwood City, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110081314 | ANTIVIRAL PHOSPHINATE COMPOUNDS - The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 04-07-2011 |
| 20110082112 | ANTIVIRAL PHOSPHINATE COMPOUNDS - The invention is related to a method of treating disorders associated with hepatitis C by administering to an individual a pharmaceutical composition which comprises a therapeutically effective amount of an anti-viral phosphinate compound. | 04-07-2011 |
Michael Clarke, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080220453 | Identification and isolation of squamous carcinoma stem cells - Squamous carcinoma stem cells (SCSC) are identified. The cells can be prospectively isolated or identified from primary tumor samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and to form unique histological microdomains useful in cancer diagnosis. | 09-11-2008 |
| 20110021607 | Methods and Compositions Relating to Carcinoma Stem Cells - MicroRNA markers of breast cancer stem cells (BCSC) are provided herein. The markers are polynucleotides that are differentially expressed in BCSC as compared to normal counterpart cells. Uses of the markers include use as targets for therapeutic intervention; as targets for drug development, and for diagnostic or prognostic methods relating to breast cancer and BCSC cell populations. BCSCs have the phenotype of having lower expression of certain miRNAs compared to normal breast epithelial cells, or to cancer cells that are not cancer stem cells. | 01-27-2011 |
| 20110124032 | Methods and Compositions for Treating Carcinoma Stem Cells - Cancer stem cells (CSCs) have been prospectively isolated or identified from primary tumor samples, and shown to possess the unique properties of self-renewal and differentiation, and can form unique histological microdomains useful in cancer diagnosis. Such cancer stem cells are shown herein to have the phenotype of containing decreased levels of reactive oxygen species (ROS) relative to non-tumorigenic (non-stem cell) cancer cells, as well as expression of other protective pathways. The CSCs are further shown to be more resistant to ionizing radiation (IR) and certain chemotherapies and to express high levels of ROS genes. | 05-26-2011 |
Michael Clarke, Tonbridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20100263173 | FASTENER - A fastener comprising two parts ( | 10-21-2010 |
Michael Clarke, Bedford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080225925 | System and Method for Non-Intrusive Thermal Monitor - Embodiments disclosed herein provide a non-intrusive thermal (NIT) monitor for sensing temperatures useful for semiconductor manufacturing applications. In some embodiments, a NIT monitor comprises a thermopile, a fluid housing with a fluid window, and an elongated member positioned between the thermopile and the fluid window for transmitting or reflecting infrared signals corresponding to a temperature of a fluid in the fluid housing. The fluid housing may have a cross-sectional profile to enable the manipulation of the fluid flow under the fluid window, enhancing the speed and accuracy of the temperature sampling. The elongated member, which may be hollow and coated with gold, may an extended piece of the fluid housing or a part of an optics housing. In some embodiments, the NIT monitor is connected to a main conditioning circuit board via a cable for processing the temperature measurements at a remote location. | 09-18-2008 |
| 20090316119 | Apparatus and method for conditioning an immersion fluid - The present invention includes apparatus and methods for producing a conditioned immersion fluid for use in an immersion lithography process. The conditioned immersion fluid protects the immersion system lens and reduces or eliminates deposition of contaminants onto the lens that can adversely affect the lens transmission and durability of an immersion lithography system. | 12-24-2009 |
Michael Clarke, Santa Cruz, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080302712 | Liquid filtration device - The present invention provides a liquid filtration device with internal flow paths that facilitate the purging of air bubbles from the device. The device includes internal channels that collect bubbles from fluid entering the filtration device and more efficiently direct fluid to sweep bubbles from the device during operation. The present invention also provides for an automatic means to minimize fluid loss during a vent process. | 12-11-2008 |