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Michael Adler
Michael Adler, Riehen CH
| Patent application number | Description | Published |
|---|---|---|
| 20110044977 | Subcutaneous anti-HER2 antibody formulations and uses thereof - The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided. | 02-24-2011 |
| 20110076273 | Highly Concentrated Pharmaceutical Formulations - The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-CD20 antibody, such as e.g. Rituximab, Ocrelizumab, or HuMab | 03-31-2011 |
| 20110158987 | NOVEL ANTIBODY FORMULATION - This invention relates to a pharmaceutical formulation of an antibody against Epidermal Growth Factor Receptor (EGFR), a process for the preparation and uses of the formulation. | 06-30-2011 |
Michael Adler, Langen-Debstedt DE
| Patent application number | Description | Published |
|---|---|---|
| 20100143925 | CONJUGATE COMPLEXES FOR ANALYTE DETECTION - The present invention relates to novel conjugate complexes for immunoassays as well as kits comprising these conjugate complexes, methods of producing these complexes, and methods of detecting an analyte by use of these complexes. The conjugate complexes of the invention comprise one or more non-nucleic acid receptors capable of specifically binding an analyte, one or more nucleic acid markers comprising a predetermined nucleotide sequence, one or more first linker molecules capable of specifically binding the non-nucleic acid receptor and the nucleic acid marker, and one or more second linker molecules capable of specifically binding the first linker molecules. | 06-10-2010 |
| 20100291562 | METHOD FOR THE DETECTION OF AN ANALYTE IN BIOLOGICAL MATRIX - The present invention relates to a method for the highly sensitive Immuno-PCR detection of an analyte in a sample comprising the use of a nucleic acids containing sample dilution buffer for diluting the sample as well as methods for the preparation of the sample dilution buffer and the use thereof. | 11-18-2010 |
Michael Adler, Holzweissig DE
| Patent application number | Description | Published |
|---|---|---|
| 20100239392 | BOOK BINDING MACHINE AND METHOD FOR OPERATING A BOOK BINDING MACHINE - A book binding machine includes a collating machine, a perfect binder and a transfer device disposed between the collating machine and the perfect binder. The collating machine and the perfect binder are actuated by a common control device. In each case, one transport segment is assigned to a respective book block clamp by the control device. The control device also has a program which, if a defective or missing book block clamp is detected, actuates the collating machine in such a way that no book block is collated for that book block clamp. A method for operating a book binding machine is also provided. | 09-23-2010 |
Michael Adler, Freiburg DE
| Patent application number | Description | Published |
|---|---|---|
| 20090162352 | ANTIBODY FORMULATION - The present invention relates to a pharmaceutical formulation comprising an anti-CD20 antibody. The formulation may additionally comprise a buffer, a surfactant and/or an isotonicity agent. | 06-25-2009 |
| 20100098712 | Pharmaceutical formulation of an antibody against OX40L - Pharmaceutical formulations of an antibody against OX40L and processes for making the same. | 04-22-2010 |
Michael Adler, Leipzig DE
| Patent application number | Description | Published |
|---|---|---|
| 20090047101 | Book Binding Machine with a Book Block Transport System and Lubrication Clamp for a Book Block Transport System in a Book Binding Machine - A book binding machine includes a book block transport system and a plurality of clamps for clamping stacks of leaves. The clamps are disposed at a distance from each other and are guided in guide tracks of a machine frame. The book block transport system includes a clamp, which is also referred to as a lubrication clamp, having a device for lubricating the guide track. An applicator is assigned to each track roller of the clamp, and the lubricant is transferred to the track rollers through the use of a respective applicator such as a brush. The track rollers transfer the lubricant to contact surfaces of the guide track. A lubrication clamp for a book block transport system in a book binding machine, is also provided. | 02-19-2009 |
Michael Adler, Bel Air, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090023706 | Method of Treating Organophosphorous Poisoning - The present invention is directed to various methods for treating organophosphorus poisoning in an animal that is at risk of exposure to an organophosphorus compound or preventing organophosphorus poisoning in an animal that has been exposed to an organophosphorus compound, by administering a therapeutically effective amount of galantamine or a salt thereof, or a biologically active analog, derivative, fragment or variant thereof. | 01-22-2009 |
| 20110144093 | METHOD OF TREATING ORGANOPHOSPHOROUS POISONING - A method for treating organophosphorous poisoning (OP) comprising administering to a mammal at risk for OP poisoning an OP poisoning-inhibiting amount of galantamine. | 06-16-2011 |
Michael Adler, Murzelen CH
| Patent application number | Description | Published |
|---|---|---|
| 20080289542 | Hydraulic Binder - In a hydraulic binder containing slags, aluminium-silicates and calcium sulphate, slag, in particular furnace slag, in amounts below 50% (w/w) as well as aluminium-silicates different from furnace slag, as for example flue-ash and natural aluminium-silicates, as for example basalt or andesite, in amounts of 5 to 75% (w/w) respectively related to the entire blend with the requirement that the stm of slag and aluminium-silicates is between 82 and 95.9% (w/w) and as one of the activators CaSO | 11-27-2008 |