Miao, US
Benchun Miao, Quincy, MA US
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20120016033 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof - Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided. | 01-19-2012 |
20140187639 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof - Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided. | 07-03-2014 |
Bingjie Miao, Tigard, OR US
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20090055352 | METHODS OF COST ESTIMATION USING PARTIALLY APPLIED PREDICATES - In accordance with aspects of the present invention, provided are methods for incrementally estimating the cardinality of a derived relation including statistically correlated partially applicable predicates for a range-partitioned table. During the generation of a QEP a cardinality estimate is calculated in which one or more partially applicable predicates is correlated to another partially applicable predicate and/or to one or more fully applicable predicates. The cardinality includes a number of rows expected to be returned by the QEP and is computed in an incremental fashion for each operator of the QEP. | 02-26-2009 |
20120130989 | SYSTEMS AND COMPUTER PROGRAM PRODUCT FOR COST ESTIMATION USING PARTIALLY APPLIED PREDICATES - In accordance with aspects of the present invention, provided are systems and computer program products for incrementally estimating the cardinality of a derived relation including statistically correlated partially applicable predicates for a range-partitioned table. During the generation of a QEP a cardinality estimate is calculated in which one or more partially applicable predicates is correlated to another partially applicable predicate and/or to one or more fully applicable predicates. The cardinality includes a number of rows expected to be returned by the QEP and is computed in an incremental fashion for each operator of the QEP. | 05-24-2012 |
20130042085 | Group-By Size Result Estimation - A method and system for accurately estimating a result size of a Group-By operation in a relational database. The estimate utilizes the probability of union of the columns involved in the operation, as well as the relative cardinality of each column with respect to the other columns in the operation. In addition, the estimate incorporates the use of table filters when indicated such that table filters are applied prior to determining the size of the tables in the operation, as well as including equivalent columns into the list of columns that are a part of the Group-By operation. Accordingly, the estimate of the result size of the operation includes influencing factors that provide an accurate estimation of system memory requirements. | 02-14-2013 |
Bingjie Miao, Englewood, CO US
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20140115009 | Gathering Index Statistics Using Sampling - An approach is provided in which a sample point system allocates sample point identifiers to a root node included an index tree that includes multiple leaf nodes. The sample point system distributes the sample point identifiers to the root node's child nodes, and recursively traverses through the index tree's hierarchical index levels and distributes the sample point identifiers from the child nodes to a subset of the index tree's leaf nodes. In turn, the sample point system collects sample data from the subset of the plurality of leaf nodes corresponding to the distributed sample point identifiers. | 04-24-2014 |
20140207754 | Gathering Index Statistics Using Sampling - An approach is provided in which a sample point system allocates sample point identifiers to a root node included an index tree that includes multiple leaf nodes. The sample point system distributes the sample point identifiers to the root node's child nodes, and recursively traverses through the index tree's hierarchical index levels and distributes the sample point identifiers from the child nodes to a subset of the index tree's leaf nodes. In turn, the sample point system collects sample data from the subset of the plurality of leaf nodes corresponding to the distributed sample point identifiers. | 07-24-2014 |
Bowman Miao, Churchville, PA US
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20100003736 | Polynucleotides encoding novel PCSK9 variants - The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention. | 01-07-2010 |
20110076742 | POLYNUCLEOTIDES ENCODING NOVEL PCSK9 VARIANTS - The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention. | 03-31-2011 |
20120094909 | FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO PCSK9 - The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein. | 04-19-2012 |
20120129237 | POLYNUCLEOTIDES ENCODING NOVEL PCSK9 VARIANTS - The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention. | 05-24-2012 |
20130108612 | POLYNUCLEOTIDES ENCODING NOVEL PCSK9 VARIANTS | 05-02-2013 |
20140161808 | ANTIBODIES THAT BIND NOVEL PCSK9 VARIANTS - The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention. | 06-12-2014 |
Bowman Miao, Chruchville, PA US
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20130210703 | FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND PCSK9 - The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein. | 08-15-2013 |
Chunlin Miao, Rochester, NY US
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20100171065 | MAGNETORHEOLOGICAL MATERIALS, METHOD FOR MAKING, AND APPLICATIONS THEREOF - A magnetorheological material comprises a magnetic particle and a ceramic material, wherein the magnetorheological material is in a dried form and further wherein a portion of the ceramic material is in the form of a nanocrystalline coating over the entire exterior surface of the magnetic particle and another portion of the ceramic material is in the form of a free nanocrystal. A magnetorheological material comprises a magnetic particle having a ceramic material coating over an external surface thereof as a result of a coating process, and a free nanocrystal of the ceramic material in the form of a residual by-product of the coating process. A sol-gel process for making a magnetorheological product comprises providing a sol of a desired ceramic coating material; combining a desired quantity of carbonyl iron (CI) particles with the sol to coat the CI particles with the ceramic coating material; creating a resulting quantity of nanocrystalline ceramic material-coated CI particles and a quantity of free nanocrystals of the ceramic material; and, drying the resulting quantity of coated CI particles and free nanocrystals to a moisture content equal to or less than 2 wt %. | 07-08-2010 |
Edward A. Miao, Seattle, WA US
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20090297552 | FLAGELLIN POLYPEPTIDE VACCINES - Vaccines that comprise or generate immunomodulatory flagellin polypeptides able to stimulate an innate immune response intracellularly and extracellularly employ viruses, bacteria or parasitic cells that contain expression systems for such polypeptides, as well as fusion proteins that contain antigens and/or cell penetrating peptides along with the immunomodulatory peptide. | 12-03-2009 |
20100322957 | SECRETION-RELATED BACTERIAL PROTEINS FOR NLRC4 STIMULATION - Introduction of immunomodulatory T3SS polypeptides (IT3SSP's) into cells stimulates a response mediated by NLRC4 intracellularly. Introduction of said IT3SSP into the cells of a subject evoke an innate immune response in the subject. | 12-23-2010 |
Fudu Miao, Chester Springs, PA US
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20090171129 | RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS - This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs. | 07-02-2009 |
20120064590 | RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS - This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs. | 03-15-2012 |
20120107890 | RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS - This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs. | 05-03-2012 |
20120107891 | RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS - This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs. | 05-03-2012 |
20130059370 | RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS - This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs. | 03-07-2013 |
20130183730 | RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS - This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs. | 07-18-2013 |
20140360376 | RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS - This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs. | 12-11-2014 |
Gang Miao, Katy, TX US
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20110206466 | Tension Leg Platform With Improved Hydrodynamic Performance - A tension leg platform that is stable with a quayside-integrated deck without the use of temporary stability modules or specialized installation techniques. The hull preferably consists of four radially-oriented vertical corner columns connected with four central ring pontoon segments. The vertical columns are fixed to the outer periphery of the central pontoon. The columns are characterized by a major radial axis and a minor transverse axis. The mooring system includes tendons supported at tendon porches directly at the four column outboard lower corners, without additional radially-extending tendon support structures. | 08-25-2011 |
Guowang Miao, Plano, TX US
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20120026972 | APPARATUS AND METHOD FOR SUPPORTING RANGE EXPANSION IN A WIRELESS NETWORK - A wireless network for communicating with a mobile station capable of operating in a range expansion mode. The wireless network comprises a macro-base station (BS) operable to communicate with the mobile station and a micro-base station (BS) in a coverage area associated with the macro-BS. The macro-BS transmits to the micro-BS a first control message indicating a range expansion (RE) capability of the mobile station. In response, the micro-BS transmits to the macro-BS PCFICH information associated with the micro-BS. The macro-BS transmits the PCFICH information to the mobile station and the mobile station uses the PCFICH information to perform a handover procedure to the micro-BS. | 02-02-2012 |
20120083280 | METHODS AND APPARATUS FOR ENABLING INTERFERENCE COORDINATION IN HETEROGENEOUS NETWORKS - For use in a heterogeneous network, a method for enabling interference coordination includes, upon occurrence of a trigger condition, determining, at a first low power node, that the first low power node is approaching a second low power node. The method also includes sending, at the first low power node, an entering message to an evolved Node-B (eNB) that serves the first low power node. The method further includes receiving, at the first low power node, configuration information from the eNB to perform at least one measurement of the second low power node. | 04-05-2012 |
20120108177 | APPARATUS AND METHOD FOR CHANNEL MEASUREMENT IN RADIO LINK MONITORING IN A WIRELESS NETWORK - A subscriber station is configured to perform a channel measurement on a communication channel in restricted sub-frames for DRX and NON-DRX modes. The subscriber station includes a receiver configured to receive signals from a base station. The subscriber station also includes processing circuitry. When the receiver receives higher layer signaling indicating that channel quality measurement is to be performed in restricted sub-frames for measurement (RFSM), the processing circuitry is configured to extend an evaluation period for monitoring a quality of the communication channel. | 05-03-2012 |
20120120888 | APPARATUS AND METHOD FOR PRIMARY UPLINK SHARED CHANNEL HOPPING IN A WIRELESS NETWORK - A wireless communication system includes a base station capable of communicating with a plurality of subscriber stations includes a controller configured to perform a frequency hop within a selected subset of a physical uplink shared channel (PUSCH). The PUSCH includes a plurality of available resource blocks and a plurality of restricted resource blocks. The base station includes a transmit path comprising circuitry configured to transmit control information and data to at least one of the plurality of subscriber stations in a sub-frame. The transmit path is also configured to transmit a plurality of resource blocks in the sub-frame. Further, the transmit path maps a plurality virtual resource blocks (VRB) to a plurality of available physical resource blocks (PRB) within a limited bandwidth of the sub-frame. The sub-frame includes the limited bandwidth and a plurality of restricted resource blocks. | 05-17-2012 |
Guowang Miao, Atlanta, GA US
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20090170497 | PROBABILISTIC INTERFERENCE MITIGATION FOR WIRELESS CELLULAR NETWORKS - An interference mitigation system randomizes transmissions to cell-edge users by carefully controlling the probability of transmission to these users, thereby creating a virtual fractional frequency system that does not require extensive frequency management and coordination across the network. In some embodiments, the interference mitigation system identifies severely interfered links and reduces the probability of transmission on these links, with the result being a reduced probability of interference. | 07-02-2009 |
20090316805 | ENERGY-EFFICIENT LINK ADAPTATION AND RESOURCE ALLOCATION FOR WIRELESS OFDMA SYSTEMS - An energy-efficient framework for active transmission in OFDMA-based long-range wireless networks is disclosed. This frame-work is based on using energy-aware metrics for resource allocation and link adaptation. By casting the optimal energy-efficient resource allocation problem as utility-based optimization problem, low-complexity utility-based resource allocation schemes developed here can be applied to reduce the complexity of resource allocation decisions. | 12-24-2009 |
20120058789 | PROBABILISTIC INTERFERENCE MITIGATION FOR WIRELESS CELLULAR NETWORKS - An interference mitigation system randomizes transmissions to cell-edge users by carefully controlling the probability of transmission to these users, thereby creating a virtual fractional frequency system that does not require extensive frequency management and coordination across the network. In some embodiments, the interference mitigation system identifies severely interfered links and reduces the probability of transmission on these links, with the result being a reduced probability of interference. | 03-08-2012 |
Guo-Xing Miao, Somerville, MA US
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20140062530 | SWITCHING MECHANISM OF MAGNETIC STORAGE CELL AND LOGIC UNIT USING CURRENT INDUCED DOMAIN WALL MOTIONS - A magnetic memory cell is provided that includes a free layer that is pinned on both of its sides to form one or more domain wall structures. The one or more domain wall structures define one or more logic states by controlling the motion of the one or more domain wall structures. | 03-06-2014 |
Harry H. Miao, Wellsley, MA US
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20120157400 | METHODS FOR TREATING KAPOSI SARCOMA - Methods for treating Kaposi's sarcoma involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment. | 06-21-2012 |
20120157401 | METHODS FOR TREATING NEUROFIBROMATOSIS - Methods for treating neurofibromatosis involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment. | 06-21-2012 |
20120157402 | METHODS FOR TREATING BRAIN TUMORS - Methods for treating brain tumors involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatment. | 06-21-2012 |
20120178707 | METHODS FOR TREATING PROSTRATE CONDITIONS - Methods for treating prostate cancer involving the administration of a compound that selectively inhibits pathological production of human vascular endothelial growth factor (VEGF) are described. Methods for treating benign prostatic hyperplasia involving the administration of a compound that selectively inhibits pathological production of human VEGF are also described. The compound may be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment. | 07-12-2012 |
Harry H. Miao, Wellesley, MA US
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20120202763 | METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS - Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments. | 08-09-2012 |
20120202801 | METHODS FOR TREATING BREAST CANCER - Methods for treating breast cancer involving the administration of a compound that selectively inhibits pathological production of human vascular endothelial growth factor (VEGF) are described. The compound can be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatment. | 08-09-2012 |
Harry Hua-Quan Miao, Edison, NJ US
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20110002919 | ANTAGONISTS OF NEUROPILIN RECEPTOR FUNCTION AND USE THEREOF - The present invention relates to antagonists of neuropilin receptor fuction and use thereof in the treatment of cancer, particularly metastatic cancer, and angiogenic diseases. | 01-06-2011 |
20140056872 | ANTAGONISTS OF NEUROPILIN RECEPTOR FUNCTION AND USE THEREOF - The present invention relates to antagonists of neuropilin receptor function and use thereof in the treatment of cancer, particularly metastatic cancer, and angiogenic diseases. | 02-27-2014 |
20150025224 | ANTAGONISTS OF NEUROPILIN RECEPTOR FUNCTION AND USE THEREOF - The present invention relates to antagonists of neuropilin receptor function and use thereof in the treatment of cancer, particularly metastatic cancer, and angiogenic diseases. | 01-22-2015 |
Houxun Miao, Gaithersburg, MD US
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20090285582 | POLARIZATION MODE DISPERSION COMPENSATION - An apparatus and method for correcting for the polarization mode distortion of an optical signal is described. The optical data signal to be transmitted is processed by a switch configured to place the signal into a plurality of polarization states on a periodic basis. At the receiving end of the system, a portion to the signal is coupled to a polarimeter and the wavelength-dependent state of polarization (SOP) of the received signal determined for the plurality of polarization states imposed on the transmitted signal. The data for two of the transmitted polarization states is selected to be used as the basis for correcting the SOP so as to compensate for the wavelength dependence thereof. The corrections may be applied in an optical pulse shaper. | 11-19-2009 |
Hsu-Chiang Miao, Troy, MI US
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20090107442 | HIGH PRESSURE PISTON PUMP ACTUATING SYSTEM USING AUTOMOTIVE STARTER SYSTEM - An apparatus for providing pressurized fuel for an engine includes an electric motor operative to crank said engine, a fuel pump, and a gear reduction device. This gear reduction device includes a worm and worm wheel and operates to receive a high speed input from said electric motor and to deliver a low speed output to said fuel pump. | 04-30-2009 |
20100018505 | METHOD AND APPARATUS FOR SUPPORTING STOP-AND-GO ENGINE FUNCTIONALITY - A vehicle includes a direct-start engine and a fuel rail with a threshold fuel pressure, a transmission having a threshold fluid pressure, and a fuel delivery system. The system has a controller, a motor having a shaft, and an integrated pump assembly including a high-pressure (HP) fuel pump and a low-pressure (LP) fluid pump each connected to the shaft. Threshold pressures are maintained during the predetermined engine state, which includes an engine idling and an engine cranking state. A method for providing stop-and-go functionality in a vehicle having a direct-start engine includes detecting a current engine state, rotating a motor shaft to energize a secondary HP fuel pump at a first threshold pressure during engine cranking, and rotating the shaft to energize an LP fluid pump at a second threshold pressure during engine idling and engine cranking. The secondary pumps can also be used when primary pumps are temporarily inoperable. | 01-28-2010 |
20100100301 | METHOD AND APPARATUS FOR SUPPORTING STOP-AND-GO ENGINE FUNCTIONALITY - A vehicle includes a direct start engine, an automatic transmission having a threshold fluid pressure sufficient for enabling operation of the transmission when the engine is off, a controller, and a fuel delivery system. The controller determines the presence of predetermined engine states, and optimizes a stop-and-go functionality of the engine. The fuel delivery system includes a motor and an integrated pump assembly having a secondary high-pressure (HP) fuel pump which is selectively connectable to a rotatable shaft of the motor, and a secondary low-pressure (LP) fluid pump which is continuously connected to the shaft. The motor continuously energizes the secondary LP fluid pump via the rotatable shaft to thereby maintain the threshold fluid pressure during a first or second engine state, and selectively energizes the secondary HP fuel pump via the rotatable shaft to maintain the threshold fuel pressure during the second engine state. | 04-22-2010 |
Hui Miao, Rocky River, OH US
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20110027801 | EphA KINASE CANCER DIAGNOSTIC - A method of detecting malignant progression of neoplastic cells in an animal includes obtaining a sample of neoplastic cells from the animal, determining a level of S897-EphA2 phosphorylation in the neoplastic cells of the samplem, and comparing the determined level of S897-EphA2 phosphorylation in the sample to a control value, wherein an increased level of S897-EphA2 phosphorylation compared to the control value is indicative of malignant progression of the neoplastic cell in the animal. | 02-03-2011 |
20130072564 | PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND THEIR USES - Methods and compositions for activating an EphA receptor can be used for identifying therapeutic agents for cancer. | 03-21-2013 |
Jiangbo Miao, Redmond, WA US
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20110172988 | ADAPTIVE CONSTRUCTION OF A STATISTICAL LANGUAGE MODEL - A statistical language model (SLM) may be iteratively refined by considering N-gram counts in new data, and blending the information contained in the new data with the existing SLM. A first group of documents is evaluated to determine the probabilities associated with the different N-grams observed in the documents. An SLM is constructed based on these probabilities. A second group of documents is then evaluated to determine the probabilities associated with each N-gram in that second group. The existing SLM is then evaluated to determine how well it explains the probabilities in the second group of documents, and a weighting parameter is calculated from that evaluation. Using the weighting parameter, a new SLM is then constructed as a weighted average of the existing SLM and the new probabilities. | 07-14-2011 |
20140149108 | ADAPTIVE CONSTRUCTION OF A STATISTICAL LANGUAGE MODEL - A statistical language model (SLM) may be iteratively refined by considering N-gram counts in new data, and blending the information contained in the new data with the existing SLM. A first group of documents is evaluated to determine the probabilities associated with the different N-grams observed in the documents. An SLM is constructed based on these probabilities. A second group of documents is then evaluated to determine the probabilities associated with each N-gram in that second group. The existing SLM is then evaluated to determine how well it explains the probabilities in the second group of documents, and a weighting parameter is calculated from that evaluation. Using the weighting parameter, a new SLM is then constructed as a weighted average of the existing SLM and the new probabilities. | 05-29-2014 |
Jianjun Miao, Troy, NY US
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20110305903 | SHEATHED NANOTUBE FIBER AND METHOD OF FORMING SAME - Embodiments of the invention provide a cellulose-sheathed carbon nanotube fiber. One aspect of the invention provides a sheathed nanotube fiber comprising: a carbon nanotube fiber; and a cellulose sheath extending co-axially along at least a first portion of a length of the carbon nanotube fiber. Another aspect of the invention provides a method of forming a sheathed carbon nanotube fiber, the method comprising: co-electrospinning a carbon nanotube fiber gel core within a cellulose solution sheath. | 12-15-2011 |
Kai Miao, Boonton Township, NJ US
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20130022057 | Communicating Tone Information in a Network - A method and apparatus to communicate tones is described. | 01-24-2013 |
Kai X. Miao, Boonton, NJ US
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20090150568 | METHOD AND APPARATUS FOR SYNCHRONIZING BETWEEN A CENTRALIZED SYSTEM AND A DECENTRALIZED SYSTEM - Machine-readable media, methods, apparatus and system for synchronizing between a decentralized computing system and a centralized computing system. In some embodiments, a decentralized record may be received from a computing platform, wherein the decentralized record may be created when the computing platform communicates in a decentralized pattern. Information may be detected from the decentralized record to provide detected information, wherein the detected information may reveal a decentralization characteristic of the decentralized record. Then, the decentralized record may be converted into a centralized record while hiding the detected information from the centralized record and the centralized record may be sent to a server. | 06-11-2009 |
Lidan Miao, Issaquah, WA US
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20120101800 | MODEL CHECKING FOR DISTRIBUTED APPLICATION VALIDATION - A model checking system is described herein that more effectively verifies and validates the design of distributed applications by providing a model and a generic framework to check application invariant properties, detect anomaly behaviors, and monitor application health. The model checking system checks on-line application behavior against application models derived from formal descriptions of the application. The system formulates the concrete application as an abstract model and a number of rules or properties that are expected to hold for the application under all conditions. The model checker compares the actual application execution with the models and either confirms that the properties hold true or reports that the properties are violated. Thus, the model checking system provides more efficient and thorough validation of distributed applications under more realistic production conditions. | 04-26-2012 |
Lynn Y. Miao, Athens, OH US
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20110305715 | ANTIBODIES TO 3-HYDROXYCOTININE AND METHODS OF USE THEREOF - The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to 3-hydroxycotinine (3HC). The invention also provides compositions containing these antibodies and fragments thereof, and to their use in diagnostic and therapeutic applications for diseases involving nicotine activity (e.g., smoking and/or smokeless tobacco use). | 12-15-2011 |
Qin Miao, Seattle, WA US
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20120196320 | Optical Projection Tomography Microscopy (OPTM) for Large Specimen Sizes - Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube. | 08-02-2012 |
20140342395 | OPTICAL PROJECTION TOMOGRAPHY MICROSCOPY (OPTM) FOR LARGE SPECIMEN SIZES - Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube. | 11-20-2014 |
Quing Miao, New Berlin, WI US
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20090305971 | Nogo-B Receptor - Nogo-B receptors bind to Nogo-B and mediate its biological function. We have discovered that Nogo-B receptor is a component of endothelial cells, and is highly expressed in intact blood vessels. The present invention provides compositions comprising the Nogo-B receptor and fragments and fusion proteins thereof. The present invention also relates to nucleic acids encoding the Nogo-B receptor and fragments and fusion proteins thereof, as well as vectors and cells comprising such nucleic acids. The present invention also relates to antibodies specific for the Nogo-B receptor and fragments and fusion proteins thereof. The present invention also provides methods for preventing, detecting and treating Nogo-B receptor-related diseases, disorders and conditions. | 12-10-2009 |
Ran Miao, Blacksburg, VA US
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20080260633 | SUPRAMOLECULAR COMPLEXES AS PHOTOCATALYSTS FOR REDUCTION OF SUBSTRATES - Supramolecular complexes, methods and systems for photocatalysis of the reduction of substrates are described. The supramolecular complexes of the invention have a light absorbing metal center, an electron collector ligand and a catalytically active metal. When the supramolecular complexes are exposed to radiant energy, the light absorbing metal center creates a charge that is transferred to the electron collector ligand to form a charge transfer state. The charge is then transferred through the catalytically active metal to a substrate, cause the reduction of the substrate, e.g. the reduction of water to molecular hydrogen. | 10-23-2008 |
20140332368 | SUPRAMOLECULAR COMPLEXES AS PHOTOCATALYSTS FOR REDUCTION - Supramolecular complexes, methods and systems for photocatalysis of the reduction of substrates are described. The supramolecular complexes of the invention have a light absorbing metal center, an electron collector ligand and a catalytically active metal. When the supramolecular complexes are exposed to radiant energy, the light absorbing metal center creates a charge that is transferred to the electron collector ligand to form a charge transfer state. The charge is then transferred through the catalytically active metal to a substrate, cause the reduction of the substrate, e.g. the reduction of water to molecular hydrogen. | 11-13-2014 |
Shouwu Miao, Edison, NJ US
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20090069284 | Substituted 3-alkyl and 3-alkenyl azetidine derivatives - Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver. | 03-12-2009 |
20100137297 | SPIROINDALONES - The present invention relates to spiroindalone compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions. | 06-03-2010 |
20100317645 | SUBSTITUTED DIAZEPINE SULFONAMIDES AS BOMBESIN RECEPTOR SUBTYPE-1 MODULATORS - Certain novel substituted diazepine sulfonamides are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes. | 12-16-2010 |
20110152304 | SPIROAZAINDOLES - The present invention relates to spiroazaindole compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions. | 06-23-2011 |
20120095001 | SUBSTITUTED-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONES - The present invention relates to substituted 1,3,8-triazaspiro[4.5]decame-2,4-diones useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions. | 04-19-2012 |
20130072492 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS - A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof. | 03-21-2013 |
20140057836 | HCV NS3 PROTEASE INHIBITORS - The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds. | 02-27-2014 |
Shun Miao, Plainsboro, NJ US
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20120163686 | SYSTEM AND METHOD FOR 2-D/3-D REGISTRATION BETWEEN 3-D VOLUME AND 2-D ANGIOGRAPHY - A method for registering a 2-D DSA image to a 3-D image volume includes calculating a coarse similarity measure between a 2-D DRR of an aorta and a cardiac DSA image, and a 2-D DRR of a coronary artery and the cardiac DSA image, for a plurality of poses over a range of 2-D translations. Several DRR-pose combinations with largest similarity measures are selected as refinement candidates. The similarity measure is calculated between the refinement candidate DRRs and the DSA, for a plurality of poses over a range of 3-D translations and in-plane rotations. One or more DRR-pose combinations with largest similarity measures are selected as final candidates. The similarity measure between the final candidate DRRs the DSA are calculated for a plurality of poses over a range of 3D translations and 3D rotations, and a DRR-pose combination with a largest similarity measure is selected as a final registration result. | 06-28-2012 |
20130058555 | AUTOMATIC POSE INITIALIZATION FOR ACCURATE 2-D/3-D REGISTRATION APPLIED TO ABDOMINAL AORTIC ANEURYSM ENDOVASCULAR REPAIR - A method for automatically initializing pose for registration of 2D fluoroscopic abdominal aortic images with a 3D model of an abdominal aorta includes detecting a 2D iliac bifurcation and a 2D renal artery bifurcation from a sequence of 2D fluoroscopic abdominal aortic images, detecting a spinal centerline in a 2D fluoroscopic spine image, providing a 3D iliac bifurcation and a 3D renal artery bifurcation from a 3D image volume of the patient's abdomen, and a 3D spinal centerline from the 3D image volume of the patient's abdomen, and determining pose parameters {x, y, z, θ}, where (x, y) denotes the translation on a table plane, z denotes a depth of the table, and θ is a rotation about the z axis, by minimizing a cost function of the 2D and 3D iliac bifurcations, the 2D and 3D renal artery bifurcation, and the 2D and 3D spinal centerlines. | 03-07-2013 |
Wei Miao, Cambridge, MA US
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20120011164 | LIFE CYCLE BASED DATA COORDINATION - A system may include a data store storing global data mapped from local data maintained by a plurality of heterogeneous data subsystems. The system may further include a life cycle coordinator including a global data life cycle model defining at least one life cycle for the global data, said life cycle coordinator being configured to receive a data update message defined in accordance with the global data life cycle model and representative of an update of the local data of one of the heterogeneous data subsystems, the data update message including a life cycle status identifier of a data record associated with the update, translate the data update message to at least one global data operation, the translation being based at least in part on the life cycle status identifier, and apply the update to the global data by performing the at least one global data operation | 01-12-2012 |
Wei Miao, Lexington, MA US
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20090119348 | DATA STRUCTURE VERSIONING FOR DATA MANAGEMENT SYSTEMS AND METHODS - In one of many possible implementations, an exemplary system includes a data integration subsystem configured to maintain a baseline data structure representing a base set of data relationships. The data integration subsystem in further configure to maintain a mapping of the baseline data structure to local data maintained by a plurality of local data subsystems. The system further includes a portal subsystem configured to provide a first customizable data structure associated with the baseline data structure for user access, create a copy of at least a subset of the baseline data structure, and provide a second customizable data structure associated with the copy of the baseline data structure for user access. The first and second customizable data structures are independently customizable to represent different custom sets of data relationships. | 05-07-2009 |
20110208781 | DATA STRUCTURE VERSIONING FOR DATA MANAGEMENT SYSTEMS AND METHODS - In one of many possible implementations, an exemplary method comprises maintaining a baseline data structure comprising a plurality of baseline data records and a base set of relationships between the baseline data records, providing, for access by an external party, a customizable data structure comprising copies of the baseline data records and a customizable set of relationships between the copies of the baseline data records, fixing the base set of relationships in the baseline data structure to be unchangeable by the external party, and defining the customizable set of relationships in the customizable data structure to be changeable by the external party. Corresponding systems and methods are also disclosed. | 08-25-2011 |
Weifang Miao, Columbus, OH US
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20090011237 | Superfine powders and their methods of manufacture - Superfine powders composed of mineral materials selected from the group consisting of talc, calcium carbonate, zeolite, clay, aluminum hydroxide, aluminum silicate, iron oxide and magnesium oxide are claimed. Such powders are produced when the subject mineral material is combined with a dry separation agent such as sodium chloride and ground for a sufficient time to produce the superfine mineral material of predetermined size or specific surface area. The separation agent is then removed from the final product by washing with a solvent such as water. | 01-08-2009 |
20110056828 | MONOLITHIC ALUMINUM ALLOY TARGET AND METHOD OF MANUFACTURING - Aluminum or aluminum alloy sputter targets and methods of making same are provided. The pure aluminum or aluminum alloy is mechanically worked to produce a circular blank, and then the blank is given a recrystallization anneal to achieve desirable grain size and crystallographic texture. A 10-50% additional strain is provided to the blank step after the annealing to increase the mechanical strength. Further, in a flange area of the target, the strain is greater than in the other target areas with the strain in the flange area being imparted at a rate of about 20-60% strain. The blank is then finished to form a sputtering target with desirable crystallographic texture and adequate mechanical strength. | 03-10-2011 |
20130306467 | MONOLITHIC ALUMINUM ALLOY TARGET AND METHOD OF MANUFACTURING - Aluminum or aluminum alloy sputter targets and methods of making same are provided. The pure aluminum or aluminum alloy is mechanically worked to produce a circular blank, and then the blank is given a recrystallization anneal to achieve desirable grain size and crystallographic texture. A 10-50% additional strain is provided to the blank step after the annealing to increase the mechanical strength. Further, in a flange area of the target, the strain is greater than in the other target areas with the strain in the flange area being imparted at a rate of about 20-60% strain. The blank is then finished to form a sputtering target with desirable crystallographic texture and adequate mechanical strength. | 11-21-2013 |
20140034490 | DIFFUSION-BONDED SPUTTER TARGET ASSEMBLY AND METHOD OF MANUFACTURING - A method of making a diffusion bonded sputter target assembly is provided. A target blank comprising a first metal or alloy has a first surface defining a sputtering surface and a second surface. A second metal or alloy is placed around the target blank. A backing plate is provided adjacent the second metal or alloy that is positioned alongside of the second target surface. This assembly is then diffusion bonded, and a portion of the second metal overlying the sputtering surface of the target is removed to expose the target sputtering surface. W target or W alloy target/Ti or Ti alloy backing plate assemblies are provided with an Al inter-layer positioned intermediate the W or W alloy target and backing plate. The assembly has a bond strength exceeding 50 MPa. | 02-06-2014 |
20140311900 | SILICON SPUTTERING TARGET WITH SPECIAL SURFACE TREATMENT AND GOOD PARTICLE PERFORMANCE AND METHODS OF MAKING THE SAME - A sputter target assembly comprising a Si target and a backing plate is provided wherein the backing plate is bonded to the target. The Si target comprises a smooth, mirror-like surface and has a surface roughness of less than about 15.0 Angstroms. Methods are provided for producing silicon target/backing plate assemblies wherein a silicon blank is processed to remove scratches from the blank surface resulting in a mirror like surface on the target, and a surface roughness of 15.0 Angstroms or less. The method comprises a first and second cleaning step with the first step being performed before the scratch removal step, and the second step being performed after the scratch removal. | 10-23-2014 |
Weifeng Miao US
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20120045658 | METALIZED PLASTIC ARTICLES AND METHODS THEREOF - Metalized plastic substrates, and methods thereof are provided herein. The method includes providing a plastic substrate having a plurality of accelerators dispersed in the plastic substrate. The accelerators have a formula selected from the group consisting of: CuFe | 02-23-2012 |
Weiguo Miao, Big Flats, NY US
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20100234206 | Controlled Pore Size Distribution Porous Ceramic Honeycomb Filter, Honeycomb Green Body, Batch Mixture And Manufacturing Method Therefor - A porous ceramic honeycomb filter manufactured from an oxide-based ceramic material having a pore size distribution with d | 09-16-2010 |
Weiguo Miao, Horseheads, NY US
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20110291313 | Methods For Forming Ceramic Honeycomb Articles - Processes for manufacturing porous ceramic honeycomb articles are disclosed. The processes include mixing a batch of inorganic components with processing aids to form a plasticized batch. The batch of inorganic components include talc having d | 12-01-2011 |
20110293883 | Cordierite Porous Ceramic Honeycomb Articles - Porous ceramic honeycomb articles for use as particulate filters and processes for making the same are described herein. The porous ceramic honeycomb articles include a fired cordierite body. The fired cordierite body has a microcrack parameter (Nb | 12-01-2011 |
20120134891 | Porous Ceramic Honeycomb Articles and Methods for Making The Same - A porous ceramic honeycomb article comprising a honeycomb body formed from cordierite ceramic, wherein the honeycomb body has a porosity P %≧55% and a cell channel density CD ≧150 cpsi. The porous channel walls have a wall thickness T, wherein (11+(300−CD)*0.03)≧T≧(8+(300−CD)*0.02), a median pore size ≦20 microns, and a pore size distribution with a d-factor of ≦0.35. The honeycomb body has a specific pore volume of VP≦0.22. The porous ceramic honeycomb article exhibits a coated pressure drop increase of ≦8 kPa at a flow rate of 26.5 cubic feet per minute when coated with 100 g/L of a washcoat catalyst and loaded with 5 g/L of soot. | 05-31-2012 |
20120272823 | Article for CO2 Capture Having Heat Exchange Capability - An article comprising a plurality of intersecting walls having outer surfaces that define a plurality of cells extending from one end to a second end, wherein the walls forming each cell in a first subset of cells are covered by a barrier layer to form a plurality of heat exchange flow channels, and wherein the walls forming each cell in a second subset of cells different from the first subset of cells, comprise a CO | 11-01-2012 |
20140060116 | DOWNSTREAM ROLLS FOR GLASS MANUFACTURE AND METHODS - A downstream roll for glass manufacture comprises at least one millboard piece. At least a portion of an outer peripheral surface of the downstream roll comprises infiltrated ceramic particles. The infiltrated ceramic particles are infiltrated to a depth of about 1 mm to about 10 mm. Further examples of the disclosure include methods for manufacturing a glass ribbon and a downstream roll for glass manufacture. | 03-06-2014 |
20140070441 | POROUS CERAMIC HONEYCOMB ARTICLES AND METHODS FOR MAKING THE SAME - A porous ceramic honeycomb article comprising a honeycomb body formed from cordierite ceramic, wherein the honeycomb body has a porosity P %≧55% and a cell channel density CD≧150 cpsi. The porous channel walls have a wall thickness T, wherein (11+(300−CD)*0.03)≧T≧(8+(300−CD)*0.02), a median pore size≦20 microns, and a pore size distribution with a d-factor of ≦0.35. The honeycomb body has a specific pore volume of VP≦0.22. The porous ceramic honeycomb article exhibits a coated pressure drop increase of ≦8 kPa at a flow rate of 26.5 cubic feet per minute when coated with 100 g/L of a washcoat catalyst and loaded with 5 g/L of soot. | 03-13-2014 |
20140151913 | COST EFFECTIVE Y2O3 SYNTHESIS AND RELATED FUNCTIONAL NANOCOMPOSITES - In one aspect the disclosure is directed to a method for inexpensively producing a Y | 06-05-2014 |
Weiguo Miao, Corning, NY US
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20100009024 | Asymmetric Honeycomb Wall-Flow Filter Having Improved Structural Strength - A honeycomb filter includes an array of interconnecting porous walls which define an array of first channels and second channels. The first channels are bordered on their sides by the second channels and have a larger hydraulic diameter than the second channels. The first channels have a square cross-section, with corners of the first channels having a shape, such as a bevel or fillet, such that the thickness, t | 01-14-2010 |
Wujian Miao, Hattiesburg, MS US
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20120329173 | METHOD AND FOR THE DETECTION OF BIOLOGICAL MOLECULES USING A TWO PARTICLE COMPLEX - Methods, compositions and kits for detecting analytes of interest in a sample using electrogenerated chemiluminescence are provided. Compositions comprising at least one solid support that entraps or contains an electrogenerated chemiluminescent moiety also provided. | 12-27-2012 |
20150044669 | METHOD FOR THE DETECTION OF BIOLOGICAL MOLECULES USING A TWO PARTICLE COMPLEX - Methods, compositions and kits for detecting analytes of interest in a sample using electrogenerated chemiluminescence are provided. Compositions comprising at least one solid support that entraps or contains an electrogenerated chemiluminescent moiety also provided. | 02-12-2015 |
Xiangyang Miao, Flower Mound, TX US
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20130254669 | DEVELOPMENT LIFE CYCLE MANAGEMENT TOOL FOR SET-TOP BOX WIDGETS - A network device presents a widget development web user interface to a user, and receives code for script of a widget from the user via the web user interface. The network device receives a selection of a type of set-top box (STB) from a list of multiple types of STBs from the user via the web user interface. The network device receives a selection of a STB environment, from a list of STB environments, associated with the selected type of STB. The network device executes the script of the widget within the selected type of STB having the selected STB environment to test the widget. | 09-26-2013 |
Xiaoyu Miao, Seattle, WA US
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20100167958 | TRAPPING OF MICRO AND NANO SCALE OBJECTS BASED ON LOCALIZED SURFACE PLASMON - Methods for optically trapping and manipulating micro- and nano-sized particles by using light to induce localized surface plasmon resonance on metallic surface of a substrate. The method includes the steps of contacting a substrate with a medium having particles suspended therein; focusing a beam of coherent light onto the substrate such that the beam induces surface plasmon resonance; and trapping at least one of the suspended particles using a light induced dielectrophoresis force generated by the surface plasmon resonance. | 07-01-2010 |
20110201527 | TRAPPING OF MICRO AND NANO SCALE OBJECTS BASED ON LOCALIZED SURFACE PLASMON - Methods for optically trapping and manipulating micro- and nano-sized particles by using light to induce localized surface plasmon resonance on metallic surface of a substrate. The method includes the steps of contacting a substrate with a medium having particles suspended therein; focusing a beam of coherent light onto the substrate such that the beam induces surface plasmon resonance; and trapping at least one of the suspended particles using a light induced dielectrophoresis force generated by the surface plasmon resonance. | 08-18-2011 |
Yi Miao, Bellevue, WA US
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20110320433 | Automated Joining of Disparate Data for Database Queries - Described is associating metadata with different sources of data (e.g., database tables) that allows a single view of data from the sources to be created. An administrator creates baseviews corresponding to database tables and associates metadata with the baseviews, including primary key metadata for the baseviews and meta-tags for one or more of the columns of each baseview. A user selects fields (corresponding to table columns) from a starting baseview, along with fields from any other baseview that has metadata that matches the starting baseview's metadata. A join mechanism automatically creates the view if a metadata match is detected. | 12-29-2011 |
Yi Miao, Redmond, WA US
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20130117313 | ACCESS CONTROL FRAMEWORK - The described implementations relate to an access control framework for a database system. One implementation can receive, from a user, a request for data that identifies a resource, such as a view that obtains data from a database. The implementation can check the identity of the user to identify user roles associated with the user. The implementation can identify an access policy that is associated with the resource, and a rule that is associated with the access policy and applies to the user roles associated with the user. The rule can be applied to the request for data using attributes of the access policy. For example, if the request for data is a query on a view, the query can be rewritten to apply the rule. | 05-09-2013 |
Yi-Jun Miao, Falls Church, VA US
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20100213451 | EMISSIVE POLYMERS AND DEVICES INCORPORATING THESE POLYMERS - The present invention relates to a class of luminescent and conductive polymer compositions having chromophores, and particularly solid films of these compositions exhibiting increased luminescent lifetimes, quantum yields and amplified emissions. These desirable properties can be provided through polymers having rigid groups designed to prevent polymer reorganization, aggregation or π-stacking upon solidification. These polymers can also display an unusually high stability with respect to solvent and heat exposures. The invention also relates to a sensor and a method for sensing an analyte through the luminescent and conductive properties of these polymers. Analytes can be sensed by activation of a chromophore at a polymer surface. Analytes include aromatics, phosphate ester groups and in particular explosives and chemical warfare agents in a gaseous state. The present invention also relates to devices and methods for amplifying emissions by incorporating a polymer having an energy migration pathway and/or providing the polymer as a block co-polymer or as a multi-layer. | 08-26-2010 |
20110175035 | EMISSIVE POLYMERS AND DEVICES INCORPORATING THESE POLYMERS - The present invention relates to a class of luminescent and conductive polymer compositions having chromophores, and particularly solid films of these compositions exhibiting increased luminescent lifetimes, quantum yields and amplified emissions. These desirable properties can be provided through polymers having rigid groups designed to prevent polymer reorganization, aggregation or π-stacking upon solidification. These polymers can also display an unusually high stability with respect to solvent and heat exposures. The invention also relates to a sensor and a method for sensing an analyte through the luminescent and conductive properties of these polymers. Analytes can be sensed by activation of a chromophore at a polymer surface. Analytes include aromatics, phosphate ester groups and in particular explosives and chemical warfare agents in a gaseous state. The present invention also relates to devices and methods for amplifying emissions by incorporating a polymer having an energy migration pathway and/or providing the polymer as a block co-polymer or as a multi-layer. | 07-21-2011 |
Yong Miao, Ann Arbor, MI US
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20100028228 | CURRENT STORAGE ESTIMATION FOR SELECTIVE CATALYTIC REDUCTION CATALYSTS - A dosing control system comprises a selective catalytic reduction (SCR) analysis module and a dosing management module. The SCR analysis module estimates an ammonia (NH3) slip rate downstream of an SCR catalyst, an NH3 conversion rate, an NH3 supply rate, and an NH3 oxidation rate. The SCR analysis module estimates an NH3 rate of change based on the NH3 slip, conversion, supply, and oxidation rates and estimates an NH3 storage change based on the NH3 rate of change. The SCR analysis module estimates NH3 stored by the SCR catalyst based on the NH3 storage change. The dosing management module controls dosing agent injection into an exhaust system upstream of the SCR catalyst based on the NH3 stored by the SCR catalyst. | 02-04-2010 |
20120255278 | RECONFIGURABLE BI-METALLIC MIXER FOR AN EXHAUST AFTERTREATMENT SYSTEM AND METHOD OF USING THE SAME - A mixer for an exhaust aftertreatment system is disclosed. The mixer includes a body portion that is configured to be disposed in an exhaust conduit of an exhaust aftertreatment system upstream of an exhaust aftertreatment device. The mixer also includes an airfoil portion that is disposed on the body portion and reversibly movable between a deployed position and a retracted position, wherein in the deployed position the airfoil portion provides a deployed resistance to an exhaust gas flow and in the retracted position provides a retracted resistance thereto, and the deployed resistance is greater than the retracted resistance, the body portion and airfoil portion comprising a mixer. The mixer further includes a bimetallic couple that is operatively joined to the mixer and configured to reversibly move the airfoil portion from the retracted position to the deployed position. | 10-11-2012 |
20130139488 | System And Method For Determining A Maximum Dose Rate Reductant - An exhaust gas treatment system for an internal combustion engine is provided, having an exhaust gas conduit, a reductant source, a temperature sensor, an intake mass air flow sensor, and a control module. The exhaust gas conduit is in fluid communication with, and is configured to receive an exhaust gas from the internal combustion engine. The exhaust gas contains oxides of nitrogen (“NO | 06-06-2013 |
20130180231 | EXHAUST AFTERTREATMENT SYSTEM - In one exemplary embodiment of an exhaust aftertreatment system, the system includes an oxidation catalyst configured to receive an exhaust gas flow from an internal combustion engine and a particulate filter positioned downstream of the oxidation catalyst, the particulate filter comprising a substrate. The system also includes a nitrogen oxide adsorbing catalyst applied to a downstream portion of the substrate and a selective catalytic reduction device positioned downstream of the nitrogen oxide adsorbing catalyst, wherein the selective catalytic reduction device is configured to remove nitrogen oxides from the exhaust gas flow. | 07-18-2013 |
20130263593 | Exhaust Aftertreatment And Exahust Gas Recirculation Systems - In an exemplary embodiment, an internal combustion engine includes an oxidation catalyst configured to receive an exhaust gas flow from the internal combustion engine, a urea injector positioned downstream of the oxidation catalyst to inject a urea flow into the exhaust gas flow and a mixer positioned downstream of the urea injector to mix the exhaust gas flow and the urea flow to form a mixed exhaust gas and urea flow. The engine also includes a particulate filter and catalytic reduction assembly positioned downstream of the mixer to receive the mixed exhaust and urea flow from the mixer to form a treated exhaust gas flow and an exhaust gas recirculation system coupled to the particulate filter to receive a portion of the treated exhaust gas flow and recirculate the portion of the exhaust gas flow to be mixed with a fresh air flow for the internal combustion engine. | 10-10-2013 |
Yubin Miao, Albuquerque, NM US
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20120107237 | ARG-GLY-ASP-CONJUGATED ALPHA-MELANOCYTE STIMULATING HORMONE HYBRID PEPTIDE FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME - The present invention is directed to novel non-invasive diagnostic and therapeutic tools/compounds comprising a hybride cyclic peptide which utilizes a cyclic peptide chelating group wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compound according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. | 05-03-2012 |
20120225016 | COMPOUNDS WITH REDUCED RING SIZE FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME - The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. | 09-06-2012 |
20140147385 | COMPOUNDS FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME - The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. | 05-29-2014 |
Zhixin Miao, Athens, OH US
Patent application number | Description | Published |
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20100059674 | METHOD AND APPARATUS OF LIQUID SAMPLE-DESORPTION ELECTROSPRAY IONIZATION-MASS SPECROMETRY (LS-DESI-MS) - An apparatus and method for direct analysis of continuous-flow liquid samples by desorption electrospray ionization-mass spectrometry (DESI-MS) including a sample stage that is adapted to receive a liquid sample and a nebulizing ionizer that is configured to generate a charged, nebulized solvent and thereby desorb at least a portion of the liquid sample from the sample stage. | 03-11-2010 |
20100258717 | ON-LINE AND OFF-LINE COUPLING OF ELECTROCHEMISTRY (EC) WITH LIQUID SAMPLE DESORPTION ELECTROSPRAY-MASS SPECTROMETRY (DESI-MS) - An apparatus for direct analysis of the redox products, or intermediates, of an electrochemical reaction by coupling an electrochemical cell to desorption electrospray ionization mass spectrometry. | 10-14-2010 |
Zhixin Miao, Fitchburg, WI US
Patent application number | Description | Published |
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20140147921 | MICROSECOND TIME-RESOLVED MASS SPECTROMETRY - A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization ( | 05-29-2014 |