Patent application number | Description | Published |
20120046322 | Bioavailable Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex - The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. | 02-23-2012 |
20130035487 | Bioavailable Diacylhydrazine Ligands for Modulations the Expression of Exogenous Genes via an Ecdysone Receptor Complex - The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. | 02-07-2013 |
20130040389 | Bioavailable Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex - The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. | 02-14-2013 |
20140045903 | Bioavailable Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex - The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. | 02-13-2014 |
20150240244 | BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX - The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. | 08-27-2015 |
20160039750 | Bioavailable Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex - The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. | 02-11-2016 |
Patent application number | Description | Published |
20080248062 | Papillomavirus vaccine compositions - The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection. | 10-09-2008 |
20100216667 | METHOD FOR DETERMINING COMPATIBILITY OF AN ACTIVE PHARMACEUTICAL INGREDIENT WITH MATERIALS - Disclosed is a system or matrix approach for determining compatibility of a pharmaceutically active substance, such as small molecule drug candidate, therapeutic proteins, peptides, vaccines or RNAi, with materials used in the research and development of pharmaceuticals, including plastics, polymers, resins, rubbers, elastomers, glass and steel. | 08-26-2010 |
20120121580 | METHODS FOR PRODUCING HIGH CONCENTRATION LYOPHILIZED PHARMACEUTICAL FORMULATIONS - The present invention relates to methods of producing lyophilized pharmaceutical compositions comprising a high concentration of therapeutic protein or antibody prior to lyophilization, wherein the lyophilized formulation can be reconstituted with a diluent in about 15 minutes or less. The invention also relates to the high concentration lyophilized formulations produced by the methods described herein. The lyophilized formulations produced by the methods of the invention are stable and are suitable for veterinary and human medical use and are suitable for modes of administration including oral, pulmonary and parenteral, such as intravenous, intramuscular, intraperitoneal, or subcutaneous injection. Also provided by the invention are high concentration pharmaceutical compositions that have long term stability and can be reconstituted, following lyophilization, in a short period of time, preferably 15 minutes or less. | 05-17-2012 |
20120177684 | PAPILLOMAVIRUS VACCINE COMPOSITIONS - The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection. | 07-12-2012 |
Patent application number | Description | Published |
20080258909 | METHODS AND SYSTEMS FOR AUTOMATED DATA MANAGEMENT - Methods and systems for preserving content in a data recorder are provided. The method includes acquiring at least one of image data and audio data relative to an environment in a vicinity of a camera, receiving a data preservation request, and stamping the at least one of image data and audio data for future download using the data preservation request. | 10-23-2008 |
20140188375 | SYSTEM AND METHOD FOR ASYNCHRONOUSLY CONTROLLING A VEHICLE SYSTEM - A method includes identifying power outputs to be provided by propulsion-generating vehicles of a vehicle system for different locations along a route and calculating handling parameters of the vehicle system at the locations along the route. The handling parameters are representative of at least one of coupler forces, coupler energies, relative vehicle velocities, or natural forces exerted on the vehicle system. The method also includes determining asynchronous operational settings for the propulsion-generating vehicles at the locations. The asynchronous operational settings represent different operational settings that cause the propulsion-generating vehicles to provide at least the power outputs at the locations while changing the handling parameters of the vehicle system to designated values at the locations. The method further includes communicating the asynchronous operational settings to the propulsion-generating vehicles in order to cause the propulsion-generating vehicles to implement the asynchronous operational settings at the different locations. | 07-03-2014 |
20150232097 | ENERGY MANAGEMENT SYSTEM AND METHOD FOR VEHICLE SYSTEMS - An energy management system and method for a vehicle system operate the vehicle system according to a current trip plan as the vehicle system travels along a route during a trip. The current trip plan designates operational settings of the vehicle system. The system and method also revise the current trip plan into a revised trip plan responsive to current, actual operation of the vehicle system differing from the current trip plan by at least a designated threshold amount. The revised trip plan designates operational settings of the vehicle system and includes an initial designated operational setting that matches the current, actual operation of the vehicle system. | 08-20-2015 |
20160047656 | SYSTEM AND METHOD FOR VEHICLE OPERATION - A system includes an energy management processing unit that includes a trip planning module, a plurality of estimator modules, and an arbiter module. The trip planning module plans a trip profile specifying power settings based on trip data including a plurality of parameters having expected values. Each of the estimator modules generates an estimation re-plan request when the difference between an expected and experienced respective trip planning parameter value exceeds a threshold. The arbiter module receives at least one estimation re-plan request from the plurality of estimator modules, determines whether a re-plan is to be performed based on at least one of a state of the vehicle system or additional estimation re-plan requests, and provides an arbitrated re-plan request to the trip planning module for re-planning the trip profile when it is determined that a re-plan is to be performed. | 02-18-2016 |
Patent application number | Description | Published |
20100070546 | Providing Local File Storage within a Java Server Environment - A local file storage is provided for a virtual machine running on a server. A common directory is created on the local file storage, including files usable by the virtual machine. A private directory is created on the local file storage, including user files accessible only by a single user of the virtual machine, wherein each virtual machine user has a separate private directory. The common directory and the private directory are accessed via the virtual machine and a common nomenclature, whereby the implementation of the common directory and the private directory on the local file storage is hidden from the user. The virtual machine may be accessed through a host environment, and each host environment user has a separate private directory. | 03-18-2010 |
20100070552 | Providing a Socket Connection between a Java Server and a Host Environment - A method for processing a communication socket request begins by generating a socket request by a virtual machine running on a server. The virtual machine examines the socket request and determines whether the socket is identified by a host name or by an Internet Protocol (IP) address. The socket request is forwarded to a host environment if the socket is identified by a host name or by an IP address other than a predetermined IP address of the host environment, and the host environment creates the socket. The server processes the socket request if the socket is identified by the predetermined IP address of the host environment, and the server creates the socket. In one implementation, the virtual machine is a Java virtual machine and the server is a Java server. | 03-18-2010 |
20100070560 | Implementing a Java Server in a Multiprocessor Environment - A method for utilizing multiple servers begins by selecting a program to be run on one of a plurality of servers and selecting one server to run the program. A virtual machine is instantiated on the selected server and the program is run on the virtual machine. A method for utilizing multiple processors begins by initializing a virtual machine on a server and running a program on the virtual machine. Task requests are sent from the program to a control process on a host environment. The control process initializes a worker thread for each task request. Each worker thread is run on a different processor on the host environment. In one embodiment, the server is a Java server and the virtual machine is a Java virtual machine. | 03-18-2010 |
Patent application number | Description | Published |
20080299005 | DISINTEGRATABLE FILMS FOR DIAGNOSTIC DEVICES - The invention provides disintegratable film compositions for diagnostic test devices. The films are prepared with a combination of components that yield films of sufficient film strength and desired disintegration profiles. A disintegratable film according to the present invention contains a water soluble high molecular weight component, a water soluble low molecular weight component, and one or more reagents for use in a diagnostic device. Optionally, the films further contain a starch component, a glucose component, a plasticizer and/or a humectant, and/or a filler. The invention further provides a diagnostic testing device, which includes a film according to an embodiment of the invention, and methods of using such devices. | 12-04-2008 |
20090142850 | Disintegratable Films for Diagnostic Devices - The invention provides disintegratable film compositions for diagnostic test devices. The films are prepared with a combination of components that yield films of sufficient film strength and desired disintegration profiles. A disintegratable film according to the present invention contains a water soluble high molecular weight component, a water soluble low molecular weight component, and one or more reagents for use in a diagnostic device. Optionally, the films further contain a starch component, a glucose component, a plasticizer and/or a humectant, and/or a filler. The invention further provides a diagnostic testing device, which includes a film according to an embodiment of the invention, and methods of using such devices. | 06-04-2009 |
Patent application number | Description | Published |
20090049918 | COMPOSITION FOR ACOUSTIC DAMPING - In one embodiment of the invention, a composition for a damping wedge in an ultrasonic probe having a wedge body is disclosed, the composition comprising: a viscoelastic material having a ratio of the imaginary part to the real part of the modulus of elasticity of at least about 5% and an acoustic impedance less than that of the wedge body; a filament-shaped filler in an effective amount to provide good dispersability in the viscoelastic material and to substantially match the acoustic impedance of the damping wedge to the wedge body; and a viscosity enhancer in an effective amount to increase the viscosity of the composition to maintain a homogenous distribution of the filament-shaped filler by preventing the filament-shaped filler from settling. | 02-26-2009 |
20090199392 | ULTRASOUND TRANSDUCER PROBES AND SYSTEM AND METHOD OF MANUFACTURE - A method for fabricating an ultrasound transducer structure is disclosed. The method includes performing the steps of forming a functional layer, including an ultrasound transducer material and a photopolymer, and exposing a plurality of selected regions of the functional layer to a programmable light pattern to cure the selected regions of the functional layer to form polymerized ultrasound transducer material regions, repeatedly. The method further includes selectively removing unexposed regions of the functional layer to obtain a green component, and sintering the green component to obtain the sensing structure. A system for making at least one piezoelectric element is also disclosed. | 08-13-2009 |
20120019105 | DEVICE AND SYSTEM FOR MEASURING MATERIAL THICKNESS - A piezoelectric sensing device is described for measuring material thickness of target such as pipes, tubes, and other conduits that carry fluids. The piezoelectric sensing device comprises a substrate such as a flexible circuit material, a piezoceramic element, and a solder layer disposed therebetween. These features are arranged in manner that provides a low-profile measurement device suitable for high-temperature applications such as those applications in which the temperature exceeds 120° C. Embodiments of the piezoelectric sensing device can be configured for use as stand-alone units separately located on the target or for use as a string of sensing elements coupled together by way of the flexible circuit material. | 01-26-2012 |
20120119622 | DEVICE FOR MEASURING MATERIAL THICKNESS - A piezoelectric sensing device is described for measuring material thickness of targets such as pipes, tubes, and other conduits that carry fluids. The piezoelectric sensing device includes a piezoelectric element mounted to a flexible circuit with glass reinforced polyimide C-stage cover layers surrounding a pure polyimide C-stage core. | 05-17-2012 |
20120294124 | DEVICE AND SYSTEM FOR MEASURING MATERIAL THICKNESS - A piezoelectric sensing device is described for measuring material thickness of target such as pipes, tubes, and other conduits that carry fluids. The piezoelectric sensing device comprises a substrate such as a flexible circuit material, a piezoceramic element, and a solder layer disposed therebetween. These features are arranged in manner that provides a low-profile measurement device suitable for high-temperature applications such as those applications in which the temperature exceeds 120° C. Embodiments of the piezoelectric sensing device can be configured for use as stand-alone units separately located on the target or for use as a string of sensing elements coupled together by way of the flexible circuit material. | 11-22-2012 |
20130076207 | TRANSDUCER STRUCTURE FOR A TRANSDUCER PROBE AND METHODS OF FABRICATING SAME - A composite ceramic transducer structure for use in the construction of an ultrasound probe includes a substrate and a plurality of piezoelectric transducer posts. The plurality of piezoelectric transducer posts are controllably formed on the substrate in a plurality of spatial positions located on an X-Y plane of the substrate. The plurality of piezoelectric posts includes a plurality of shapes defined in an X-Y-Z plane of the substrate, wherein the plurality of piezoelectric transducer posts are configured to facilitate minimizing shear waves within the ultrasound probe. | 03-28-2013 |
20130269437 | SENSING DEVICE AND METHOD OF ATTACHING THE SAME - A sensing device and a method of attaching the sensing device to a target object is disclosed. The substrate of the sensing device has one or more bonding material vias that allows the bonding material used to attach the substrate to the target object to flow from one side of the substrate to the other side of the substrate. The bonding material forms rivets to secure the substrate to the target object and to secure the layers of the substrate to each other. | 10-17-2013 |
20130283935 | APPARATUS, SYSTEM, AND METHOD FOR ATTACHING A SENSING DEVICE - An apparatus, system, and method for attaching a sensing device to a target object. The apparatus includes one or more magnets that attach the apparatus to a target object. The sensing device is coupled to the target object with a coupling material and is held in place against the target object by the apparatus. | 10-31-2013 |
Patent application number | Description | Published |
20130261791 | ITEM DISPENSING UNIT - Systems, methods, apparatus, and computer program products are provided for dispensing items. In one embodiment, a magazine defining a channel adapted to store a plurality of items of substantially similar size in a uniform manner is provided. The magazine may also define (a) a rake element path adapted to allow one item of the plurality of items to be engaged and (b) a dispensing opening adapted to allow the engaged item to be urged out of the dispensing opening. In such an embodiment, a receptacle may also be provided. The receptacle may comprise a storage cavity and a rake element, wherein the rake element is adapted to (a) pass through the rake element path of the magazine to engage the item and (b) urge the item out of the dispensing opening of the magazine into the storage cavity of the receptacle. | 10-03-2013 |
20130262002 | MONITORING AND MATCHING BATTERIES AND BATTERY POWERED DEVICES - Provided herein are systems, methods and computer readable media for matching one or more batteries that were charged in a charging station with a remote device that is depleting its availble battery power. In providing such matching functionality, the system can be configured to, for example, monitor the amount of power the remote device, such as a rechargeable battery-powered device used in a hospital, requires over one or more periods of time, monitor the health of a number of batteries, match one or more of the batteries to the rechargeable battery-powered device, and then convey to a user which rechargeable battery-powered device should have its depleted battery replaced with a remotely-charged battery. | 10-03-2013 |
20140001012 | MODULAR, MULTI-ORIENTATION CONVEYOR | 01-02-2014 |
20140034535 | STORAGE APPARATUS WITH SUPPORT STRUCTURES - A storage apparatus is provided. The storage apparatus defines a storage cavity having an opening at the upper surface of the storage apparatus with a substantially planar flange extending outwardly from the opening of the storage cavity and defines a plurality of support structures, each support structure (a) having an opening at the upper surface of the storage apparatus and (b) adapted to support the storage apparatus. | 02-06-2014 |
20140108028 | APPARATUSES, SYSTEMS, AND METHODS FOR ANTICIPATING AND DELIVERING MEDICATIONS FROM A CENTRAL PHARMACY TO A PATIENT IN A HEALTHCARE FACILITY - Provided herein are various apparatuses, systems, and methods for improving the efficiency of medication distribution within a healthcare facility. In particular, embodiments may provide for dispensing medications needed and medications anticipated to be needed to an authorized medical person for administration to a patient in a healthcare facility. A method may include anticipating, by a processor, the need for one or more unit dose medications for a patient; directing the one or more unit dose medications to be placed into a patient specific overpack; directing the patient-specific overpack to be staged at a first location; receiving a request for the one or more unit dose medications; and causing the one or more unit dose medications to be dispensed to an authorized medical person in response to receiving the request. | 04-17-2014 |