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| 20080249442 | Breathable Compression Device - A compression device for applying compression treatment to a part of a wearer's body includes bladder material defining at least one inflatable bladder and a breathable wicking layer connected to the bladder. A plurality of openings extend through the bladder material to the wicking layer. A breathable outer cover overlies the bladder. In use, the wicking layer wicks moisture from the wearer's skin and heat and the moisture is allowed to dissipate through the device through the wicking layer, the openings and the breathable outer cover. A garment includes a sheet of mesh material formed with loops for use in a hook and loop fastener. | 10-09-2008 |
| 20080249447 | Compression Device Having Cooling Capability - A compression device has improved cooling capability. The device includes a wicking layer adapted to move moisture. A portion of the wicking layer is exposed from under bladder material defining a bladder. In use, the wicking layer wicks moisture from the patient's limb and the wicked moisture is able to evaporate through the device at the portion of the wicking layer that is exposed. | 10-09-2008 |
| 20090062703 | Compression Sleeve Having Air Conduits - A compression sleeve is described as having a first sheet, a second sheet attached to said first sheet and defining at least one inflatable section, and at least one conduit disposed within the boundary of the least one of said inflatable sections. | 03-05-2009 |
| 20110009785 | COMPRESSION SLEEVE HAVING AIR CONDUITS FORMED BY A TEXTURED SURFACE - A compression sleeve is described as having a first sheet and a second sheet attached to the first sheet. The first and second sheets define at least one inflatable section. At least one conduit including a textured inner surface on each of the first and second sheets is disposed within the inflatable section. | 01-13-2011 |
| 20110306908 | Compression Device Having Cooling Capability - A compression device has improved cooling capability. The device includes a wicking layer adapted to move moisture. A portion of the wicking layer is exposed from under bladder material defining a bladder. In use, the wicking layer wicks moisture from the patient's limb and the wicked moisture is able to evaporate through the device at the portion of the wicking layer that is exposed. | 12-15-2011 |
| 20120316537 | SAFETY CONNECTOR APPARATUS - A connector apparatus includes first and second mating connectors that can be joined to make a fluid connection. The connectors are constructed to discriminate improper connectors so that no fluid tight connection can be formed with improper connectors. The connector apparatus can be used with a system for compression therapy to prevent deep vein thrombosis. | 12-13-2012 |
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| 20110202344 | METHOD AND APPARATUS FOR PROVIDING SPEECH OUTPUT FOR SPEECH-ENABLED APPLICATIONS - Techniques for providing speech output for speech-enabled applications. A synthesis system receives from a speech-enabled application a text input including a text transcription of a desired speech output. The synthesis system selects one or more audio recordings corresponding to one or more portions of the text input. In one aspect, the synthesis system selects from audio recordings provided by a developer of the speech-enabled application. In another aspect, the synthesis system selects an audio recording of a speaker speaking a plurality of words. The synthesis system forms a speech output including the one or more selected audio recordings and provides the speech output for the speech-enabled application. | 08-18-2011 |
| 20110202345 | METHOD AND APPARATUS FOR GENERATING SYNTHETIC SPEECH WITH CONTRASTIVE STRESS - Techniques for generating synthetic speech with contrastive stress. In one aspect, a speech-enabled application generates a text input including a text transcription of a desired speech output, and inputs the text input to a speech synthesis system. The synthesis system generates an audio speech output corresponding to at least a portion of the text input, with at least one portion carrying contrastive stress, and provides the audio speech output for the speech-enabled application. In another aspect, a speech-enabled application inputs a plurality of text strings, each corresponding to a portion of a desired speech output, to a software module for rendering contrastive stress. The software module identifies a plurality of audio recordings that render at least one portion of at least one of the text strings as speech carrying contrastive stress. The speech-enabled application generates an audio speech output corresponding to the desired speech output using the audio recordings. | 08-18-2011 |
| 20110202346 | METHOD AND APPARATUS FOR GENERATING SYNTHETIC SPEECH WITH CONTRASTIVE STRESS - Techniques for generating synthetic speech with contrastive stress. In one aspect, a speech-enabled application generates a text input including a text transcription of a desired speech output, and inputs the text input to a speech synthesis system. The synthesis system generates an audio speech output corresponding to at least a portion of the text input, with at least one portion carrying contrastive stress, and provides the audio speech output for the speech-enabled application. In another aspect, a speech-enabled application inputs a plurality of text strings, each corresponding to a portion of a desired speech output, to a software module for rendering contrastive stress. The software module identifies a plurality of audio recordings that render at least one portion of at least one of the text strings as speech carrying contrastive stress. The speech-enabled application generates an audio speech output corresponding to the desired speech output using the audio recordings. | 08-18-2011 |
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| 20100035251 | BioMarkers for the Progression of Alzheimer's Disease - The genetic polymorphism LRRK2 (leucine-rich repeat kinase 2)-T1602S is significantly associated with conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD), with the patients with TT genotype being at greater risk to progress to Alzheimer's disease. The LRRK2-T2352 also showed a trend for conversion to Alzheimer's disease, with the patients with CC genotype tending to progress to Alzheimer's disease. Similar to the APOE-E4 allele, in the presence of a BuChE-K variant, LRRK2-T1602S and LRRK2-T2352 showed a greater association with the rate of conversion from mild cognitive impairment to Alzheimer's disease. In another study with placebo-treated Alzheimer's disease patients, LRRK2-T1602S and LRRK2-T2352 showed a same trend of association. The Alzheimer's disease patients with TT genotype of LRRK2-T1602S or CC genotype of LRRK2-T2352 tended to decline faster on cognitive performance over 6 months, especially in the presence of a BuChE-K variant. The association between the two common LRRK2 polymorphisms and Alzheimer's disease progression shows that LRRK2 may play a role in Alzheimer's disease pathogenesis, especially disease progression, and that polymorphisms of LRRK2 can be used as biomrkers of this progression. | 02-11-2010 |
| 20100240760 | Biomarkers for Efficacy of Aliskiren as a Hypertensive Agent - A retrospective pharmacogenetic analysis was conducted in an attempt to evaluate potential association between genetic variation and outcome of a clinical trial of efficacy of aliskiren as an antihypertensive agent. Forty-eight polymorphisms were examined in twelve genes from the renin-angiotensin-aldosterone system (RAS) or previously implicated in blood pressure regulation. Significant associations were seen between one polymorphism in the angiotensin converting enzyme (ACE) gene, two polymorphisms in the angiotensin II type 2 receptor (AGTR2) gene, and clinical parameters of mean sitting diastolic and systolic blood pressure decrease. These effects were not found with irbesartan and placebo treatment, but instead were specific to aliskiren treatment. | 09-23-2010 |
| 20110144206 | USE OF A COX-2 INHIBITOR FOR THE TREATMENT OF A COX-2 DEPENDENT DISORDER IN A PATIENT NOT CARRYING HLA ALLELES ASSOCIATED WITH HEPATOTOXICITY - This disclosure relates to a method of determining the presence of at least one HLA allele, preferably selected from the group consisting of DQA1*0102, DRB1*1501, DQB1*0602 and DRB5*0101 to assess whether a patient is at risk for developing hepatotoxicity upon administration of the COX-2 inhibitor lumiracoxib. Also disclosed is the use of a kit for carrying out this method. The disclosure also relates to a method of treating cyclooxygenase-2 dependent disorders with lumiracoxib in a subject that is not a carrier of one or more HLA alleles, preferably selected from the group consisting of DQA1*0102, DRB1*1501, DQB1*0602 and DRB5*0101. | 06-16-2011 |
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| 20090149084 | Biomedical Electrode Connectors - A biomedical electrode connector for coupling with a biomedical electrode of the type including an electrode base and a male terminal projecting from the electrode base is provided. | 06-11-2009 |
| 20090149731 | ECG Electrode Connector - Disclosed is an ECG electrode lead wire connector which provides improved electrical and mechanical coupling of the ECG electrode press stud to the lead wire, provides enhanced ergonomics to the clinician, and may alleviate patient discomfort associated with the attachment and removal of ECG leads. The connector may be engaged and disengaged with little or no force imparted to the patient or the ECG pad, which significantly minimizes the risk of inadvertent dislodgement of the pad. In one embodiment the disclosed connector provides a thumb cam lever which affirmatively engages the press stud to the connector, and provides tactile feedback to the clinician that the connector is properly engaged. In other embodiments, the connector provides a pushbutton to enable the clinician to easily engage and disengage the connector from the ECG stud. The disclosed connectors may also decrease clinician fatigue, and may provide more reliable ECG results. | 06-11-2009 |
| 20090270710 | Novel Electrodes - The present disclosure provides electrodes that possess components capable of indicating to an end-user when the electrode is in need of replacement. | 10-29-2009 |
| 20110117793 | Biomedical Electrode Connectors - A biomedical electrode connector for coupling with a biomedical electrode of the type including an electrode base and a male terminal projecting from the electrode base is provided. | 05-19-2011 |
| 20110275252 | ECG Electrode Connector - Disclosed is an ECG electrode lead wire connector which provides improved electrical and mechanical coupling of the ECG electrode press stud to the lead wire, provides enhanced ergonomics to the clinician, and may alleviate patient discomfort associated with the attachment and removal of ECG leads. The connector may be engaged and disengaged with little or no force imparted to the patient or the ECG pad, which significantly minimizes the risk of inadvertent dislodgement of the pad. In one embodiment the disclosed connector provides a thumb cam lever which affirmatively engages the press stud to the connector, and provides tactile feedback to the clinician that the connector is properly engaged. In other embodiments, the connector provides a pushbutton to enable the clinician to easily engage and disengage the connector from the ECG stud. The disclosed connectors may also decrease clinician fatigue, and may provide more reliable ECG results. | 11-10-2011 |
| 20120196474 | ECG Electrode Connector - Disclosed is an ECG electrode lead wire connector which provides improved electrical and mechanical coupling of the ECG electrode press stud to the lead wire, provides enhanced ergonomics to the clinician, and may alleviate patient discomfort associated with the attachment and removal of ECG leads. The connector may be engaged and disengaged with little or no force imparted to the patient or the ECG pad, which significantly minimizes the risk of inadvertent dislodgement of the pad. In one embodiment the disclosed connector provides a thumb cam lever which affirmatively engages the press stud to the connector, and provides tactile feedback to the clinician that the connector is properly engaged. In other embodiments, the connector provides a pushbutton to enable the clinician to easily engage and disengage the connector from the ECG stud. The disclosed connectors may also decrease clinician fatigue, and may provide more reliable ECG results. | 08-02-2012 |
| 20120226129 | ECG Lead Wire Organizer And Dispenser - An ECG lead set including an ECG electrode assembly and a lead set hub. ECG electrode includes at least one electrode configured to receive biopotential signals from a patient, a plug connector for connecting said ECG electrode assembly, a web, connected between the at least one electrode and the plug connector and configured to form an electrical connection therebetween. The lead set hub includes at least one receptacle configured to receive the plug connector of the ECG electrode assembly. | 09-06-2012 |
| 20120226131 | ECG Lead Wire Organizer And Dispenser - An ECG lead set including an ECG electrode assembly and a lead set hub. ECG electrode includes at least one electrode configured to receive biopotential signals from a patient, a plug connector for connecting said ECG electrode assembly, a web, connected between the at least one electrode and the plug connector and configured to form an electrical connection therebetween. The lead set hub includes at least one receptacle configured to receive the plug connector of the ECG electrode assembly. | 09-06-2012 |
| 20120226177 | ECG LEAD WIRE ORGANIZER AND DISPENSER - An ECG lead set including an ECG electrode assembly and a lead set hub. ECG electrode includes at least one electrode configured to receive biopotential signals from a patient, a plug connector for connecting said ECG electrode assembly, a web, connected between the at least one electrode and the plug connector and configured to form an electrical connection therebetween. The lead set hub includes at least one receptacle configured to receive the plug connector of the ECG electrode assembly. | 09-06-2012 |
| 20120290061 | Electrode Pad Packaging Systems And Methods - An electrode pad packaging system including an electrode pouch, an electrode pad (e.g., a defibrillation electrode pad), a wire and a shell is disclosed. The electrode pad is disposed at least partially within the electrode pouch. The wire extends from the electrode pad and, in a disclosed embodiment, at least a portion of the wire is attached to the shell. The shell is disposed in mechanical cooperation with the electrode pouch (e.g., the shell is secured to a portion of the electrode pouch). The shell includes a valve thereon that is configured to allow air to exit the electrode pouch. The valve may be configured to prevent air from entering the electrode pouch. A method of packaging an electrode pad is also disclosed. The method includes providing an electrode pouch, an electrode pad, a wire and a shell. A valve on the shell allows air to exit the electrode pouch. | 11-15-2012 |
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| 20090326344 | System and Method for Optical Continuous Detection of an Analyte In Bloodstream - A method for performing a blood assay includes the steps of positioning an optical biosensor in fluid communication with a blood vessel whereby blood from the blood vessel contacts the biosensor. The biosensor includes at least one material adapted to bind to an analyte. The method also includes the steps of detecting a change in at least one optical property of the biosensor resulting from binding of the at least one material with the analyte and transmitting a continuous signal representative of the change in at least one optical property of the biosensor to a display module to provide real time analysis by a clinician. | 12-31-2009 |
| 20100022865 | Radial Electrode Array - A sensor array apparatus for monitoring medical signals includes a first flexible substrate defining a central focal point and a second flexible substrate associated with the central focal point. A plurality of medical electrodes are disposed on the periphery of the first flexible substrate and a reference electrode is disposed on the second flexible substrate. A connector is in electrical communication with the medical electrodes and the reference electrode and adapted to connect to an electronic system. Bio-electric information is monitored between one of the medical electrodes and the reference electrode. | 01-28-2010 |
| 20100241196 | PHOTOTHERAPY WOUND TREATMENT - A wound treatment for use during phototherapy treatment of a wound includes a pliable optical component adapted to be applied over the wound and to direct light rays during phototherapy treatment, and a bandage for securing the Fresnel lens over the wound. The optical component may be configured to direct light rays toward a perimeter edge of the wound. A wound treatment kit for phototherapy treatment of a wound includes a package and a sterile, pliable optical component in the package. The optical component is removable from the sterile package and is placed over the wound during the phototherapy treatment. The optical component directs light rays toward a selected area of the wound during phototherapy treatment. | 09-23-2010 |
| 20120130239 | Cable Monitoring Apparatus - A cable monitoring apparatus includes a housing having an input interface adapted to electrically connect to one end of a medical cable and an output interface adapted to electrically connect to an electrical system. Signal processing circuitry is incorporated within the housing for receiving a medical signal from the medical cable via the input interface and for selectively passing the medical signal to the electrical system via the output interface when in a first mode of operation, and has application software for selectively testing functionality of the medical cable when in a second mode of operation. The medical signal may include at least one monitoring signal selected from a group consisting of fetal and maternal medical signals. | 05-24-2012 |
| 20120259269 | IONTOPHORESIS DRUG DELIVERY SYSTEM AND METHOD FOR DENERVATION OF THE RENAL SYMPATHETIC NERVE AND IONTOPHORETIC DRUG DELIVERY - A system for denervation of the renal sympathetic nerve and iontophoresis drug delivery includes an iontophoresis catheter fitted with a drug coated balloon. The balloon contacts the vessel wall when inflated. One or more electrodes are associated with a surface of the balloon, and may be disposed on an outer surface of the balloon. The electrodes are operably coupled to an energy source configured to produce a bipolar or monopolar electric field between two balloon electrodes and/or between one balloon electrode and another electrode placed in contact with the patient's body. The drug-delivery catheter produces an electric potential gradient within adjacent tissue, that, facilitates iontophoresis delivery of a drug. The catheter can also include a store of one or more drugs to be delivered to the targeted tissue. | 10-11-2012 |
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| 20080230384 | LOW VOLUME ELECTROCHEMICAL BIOSENSOR - A biosensor in which at least one reagent constitutes a portion of a working electrode, a conductive track leading from a working electrode to an electrical contact associated with a working electrode, or an electrical contact associated with a working electrode. For example, the biosensor can have a mediator or an enzyme or both incorporated into the working electrode, into the conductive track leading from the working electrode to an electrical contact associated with the working electrode, and/or into the electrical contact associated with the working electrode. Other reagents can be dispensed on the electrode itself either directly or by impregnating a matrix, such as a mesh or a membrane, with the enzyme, and then placing the impregnated mesh or membrane over the electrode. | 09-25-2008 |
| 20100084268 | LOW VOLUME ELECTROCHEMICAL BIOSENSOR - A biosensor in which at least one reagent constitutes a portion of a working electrode, a conductive track leading from a working electrode to an electrical contact associated with a working electrode, or an electrical contact associated with a working electrode. For example, the biosensor can have a mediator or an enzyme or both incorporated into the working electrode itself. Other reagents can be dispensed on the electrode itself either directly or by impregnating a matrix, such as a mesh or a membrane, with the enzyme, and then placing the impregnated mesh or membrane over the electrode. Alternatively, the biosensor can have a mediator or an enzyme or both incorporated into the conductive track leading from the working electrode to an electrical contact associated with the working electrode. In another alternative, the biosensor can have a mediator or an enzyme or both incorporated into the electrical contact associated with the working electrode itself. Furthermore, the biosensor can have a mediator or an enzyme or both incorporated into at least two of the foregoing components of the biosensor. | 04-08-2010 |
