Meulemans
Alain Meulemans, Paris Cedex 18 FR
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20100303724 | Polypeptides, Cyclic Polypeptides and Pharmaceutical Comprising Thereof for Non Invasive Specific Imaging of Fibrosis - The present invention relates to diagnostic imaging and in particular to the diagnostic imaging of fibrosis. More particularly, the present invention provides a polypeptides, cyclic polypeptides and pharmaceutical compositions suitable for the non-invasive visualization of fibrosis. The polypeptide of the invention may comprise an amino acid sequence consisting of: X1-X2-M-H-G-L-X7-L-X9-X10-D-E wherein amino acid X1 is R, F or P; amino acid X2 is F or V; amino acid X7 is Q, H or L; amino acid X9 is W or G and amino acid X10 is A or D. | 12-02-2010 |
Alain Meulemans, Paris Cedex FR
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20120093725 | Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies - The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis. | 04-19-2012 |
20120183475 | Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies - The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis. | 07-19-2012 |
20140134102 | Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies - The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis. | 05-15-2014 |
Ann Meulemans, Turnhout BE
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20110313153 | 5-HT4 INHIBITORS FOR TREATING AIRWAY DISEASES, IN PARTICULAR ASTHMA - The invention relates generally to the treatment of diseases of the respiratory system such as asthma and chronic obstructive pulmonary disease. More particularly, the present invention relates to methods of treating and preventing asthmatic airway inflammation. The treatment involves the administration of a 5-HT4 receptor antagonist to the subject in need thereof; more in particular the administration of aroylated 4-aminomethylpiperidine derivatives as defined herein. Other aspects of the invention are directed to compositions for treating or preventing respiratory disorders, including pharmaceutical compositions. | 12-22-2011 |
20120184537 | [1,4]-BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS - The invention relates to a novel class of [1,4]-benzodiazepine derivatives, processes for their preparation, intermediates usable in these processes, and pharmaceutical compositions containing the compounds. Other aspects of the invention are directed to the use of said [1,4]-benzodiazepine derivatives in therapy based on the capability of said compounds to interfere with the binding of the peptide hormone, vasopressin, to its receptors. In particular as vasopressin V2 receptor antagonists and therefore useful for treating involving increased vascular resistance, cardiac insufficiency, and water retention. | 07-19-2012 |
Ann Louise Gabrielle Meulemans, Mol BE
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20090048194 | Vagal Afferent Neurons as Targets for Treatment - A method of identifying a compound capable of reducing or preventing prolonged sensory neuron hyper-excitability comprising the steps of: (a) administering the compound to an experimental non-human animal having prolonged sensory neuron hyper-excitability; (b) generating an expression profile of the genes modulated in the Nodose Ganglia (NG) of the animal of step (a); (c) comparing the expression profile obtained in (b) with the expression profile of a corresponding panel of genes expressed in the NG of an experimental non-human animal having no prolonged sensory neuron hyper-excitability; wherein a positive correlation of the expression profiles is indicative that the compound is capable of reducing or preventing prolonged sensory neuron hyper-excitability in NG. | 02-19-2009 |
Michael J. Meulemans, North Muskegon, MI US
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20100083599 | PANEL TRIM AND RELATED METHOD OF MANUFACTURE - A panel trim including a cover and a base joined at opposite ends of a flange to form channels on opposite sides of the flange. The channels are adapted to receive panels, with the cover adapted to conceal the gap between the panels. The panel trim can include at least one ramp joined with the base. The panel trim can also include a flex region to enable independent flexing of opposite sides of the cover as panels are inserted into respective channels. The panel trim can be modified to accommodate linearly aligned panels, as well as panels that are at an angle to one another. | 04-08-2010 |
20120079771 | BOTTOM SEAL FOR GARAGE DOOR - A two-piece bottom seal assembly that adjusts to doors of different thicknesses during installation. The bottom seal assembly generally includes two frame components configured to close on the bottom of a door from opposite sides. The frame components are configured to interfit with one another at different fixed distances to accommodate doors of different thicknesses. In one embodiment, the frame components are generally L-shaped, each having a horizontal leg and a vertical leg. One of the two horizontal legs may include a pair of spaced walls that define a channel dimensioned to receive the other horizontal leg. The leg may include a head configured to interlock with corresponding features on the inside of the channel Each of the frame components may support a seal. | 04-05-2012 |
Robert E. Meulemans, Appleton, WI US
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20120007421 | SNOWMOBILE TRACTION DEVICE - A traction enhancement device for a snowmobile including a plurality of traction studs extending from a stud plate. The device configured for mounting to a snowmobile track by a central mounting stud extending through the track and the stud plate. The device provides for a plurality of traction studs to be mounted to the track with only a single hole in the track. A method of mounting a fraction enhancement device to a snowmobile track that provides a plurality of traction studs with only a single hole through the track. | 01-12-2012 |