Metselaar
John Metselaar, Paris CA
Patent application number | Description | Published |
---|---|---|
20130018513 | HVAC Controller with Predictive Set-Point ControlAANM METSELAAR; JohnAACI ParisAACO CAAAGP METSELAAR; John Paris CA - A controller is provided for operating HVAC equipment using an environmental control program. The controller has an environmental sensor operable to provide a measured temperature value to the environmental control program. The controller further runs a dynamic temperature control program that is operable to provide a dynamic correction factor to the environmental control program that dynamically compensates the measured temperature value for waste heat generated by power consumption within the controller. | 01-17-2013 |
Josbert M. Metselaar, Amsterdam NL
Patent application number | Description | Published |
---|---|---|
20110189266 | CORTICOSTEROID MICROVESICLES FOR TREATMENT OF CARDIOVASCULAR DISEASES - The invention provides a use of a long-circulating microvesicle comprising a sterol, partially synthetic or wholly synthetic vesicle-forming phospholipids, and a corticosteroid in water soluble form, which microvesicle has a mean particle diameter size range of between about 75 and 150 nm and which microvesicle is non-charged or negatively charged at physiological conditions, for the preparation of a medicament for the treatment of atherosclerosis and/or cardiovascular disease. A method for treating a subject suffering from, or at risk of suffering from, atherosclerosis and/or cardiovascular disease, comprising administering to said subject a therapeutically effective amount of such long-circulating microvesicles is also provided. | 08-04-2011 |
Josbert Maarten Metselaar, Utrecht NL
Patent application number | Description | Published |
---|---|---|
20100145018 | Lipid-Polymer-Conjugates - Lipid conjugates of a poly-(amino acid), a poly-(amino acid derivative) or a poly-(amino acid analogue), such as poly-[N-(2-hydroxyethyl)-glutamine](PHEG), are provided. | 06-10-2010 |
Josbert Maarten Metselaar, Amsterdam NL
Patent application number | Description | Published |
---|---|---|
20100143452 | POLYPHENOL CONTAINING COMPOSITIONS - The present invention relates to liposomal compositions comprising polyphenol in the interior of a colloidal carrier, and especially to the use of such compositions in the treatment of cancer or in the inhibition of cancer growth and in the treatment of inflammatory and autoimmune conditions. More specifically, the invention relates to a method for targeting a polyphenol to tumor tissue, or to sites in the body requiring anti-inflammatory activity or activity against autoimmune conditions. Furthermore, the present invention describes a method of post-loading a polyphenol derivate such as caffeic acid into a liposome. | 06-10-2010 |
20100143453 | ANTI-INFLAMMATORY COMPOUNDS CONTAINING COMPOSITIONS FOR TREATMENT OF CANCER - The present invention relates to compositions comprising non-steroidal anti-inflammatory compounds, and especially to the use of such compositions in the treatment of cancer or in the inhibition of cancer growth. More specifically, the invention relates to a method for targeting an anti-inflammatory compound to tumor tissue. | 06-10-2010 |
Josbert Maarten Metselaar, Naarden NL
Patent application number | Description | Published |
---|---|---|
20140255474 | Composition for Treatment of Inflammatory Disorders - A pharmaceutical composition for parenteral administration, comprising liposomes composed of non-charged vesicle-forming lipids, optionally including not more than five (5) mole percent of charged vesicle-forming lipids, the liposomes having a selected mean particle diameter in the size range between about 40-200 nm and containing a water soluble corticosteroid for the site-specific treatment of inflammatory disorders, is provided. | 09-11-2014 |
20140287027 | Vesicle-encapsulated corticosteroids for the treatment of cancer - The invention relates to the use of a composition comprising a corticosteroid encapsulated in a vesicle for the manufacture of a medicament for treating cancer, such as the use of a composition comprising a corticosteroid and liposomes, the liposomes comprising a non-charged vesicle-forming lipid, and optionally an amphipathic vesicle-forming lipid and/or a negatively charged vesicle-forming lipid. | 09-25-2014 |
20150050329 | LIPOSOMAL CORTICOSTEROIDS FOR TREATMENT OF INFLAMMATORY DISORDERS IN HUMANS - The invention relates to a pharmaceutical composition comprising liposomes composed of non-charged vesicle-forming lipids, optionally including not more than 10 mole percent of negatively charged vesicle-forming lipids and/or not more than 10 mole percent of PEGylated lipids, the liposomes having a selected mean particle diameter in the size range of 40-200 nm and comprising a first corticosteroid in water soluble form, for the site-specific treatment of inflammatory disorders in humans, providing in human patients a fast, strong, and durable anti-inflammatory effect for at least 2 weeks at a dose of at most 5 mg/kg body weight of prednisolone or an equipotent dose corticosteroid other than prednisolone at a treatment frequency of at most once per two weeks. Furthermore the present invention relates to the application of the above-mentioned pharmaceutical composition given as intervention therapy in inflammatory disorders such as rheumatic disease or a related inflammatory connective tissue disorder, inflammatory diseases of the kidney or inflammatory bowel disorders, in combination with chronic therapy with a second free corticosteroid formulation or in combination with chronic treatment with a disease-modifying agent such as methotrexate. | 02-19-2015 |
Ronald Metselaar, Capelle And Ussel NL
Patent application number | Description | Published |
---|---|---|
20110104354 | LOW FAT SHORTENING - The present invention relates to a water-in-oil emulsion which comprises oil or fat or a mixture of one or more oils and fats, and water and amylomaltase treated starch present in the water phase. The product can be used as a baking margarine. | 05-05-2011 |
Ronald Metselaar, Capelle A/d Ijssel NL
Patent application number | Description | Published |
---|---|---|
20120301576 | USE OF SIALIDASE IN DAIRY TECHNOLOGY - This invention relates to a method of manufacturing sour milk preparations, such as soured fresh dairy products with the use of a sialidase enzyme. The method enables the modification of the texture of sour dairy products more advantageously and easily than known methods. In addition, the method enables a significant reduction in the added protein content of sour dairy products without any damage to or adverse effect to the texture of the preparation. | 11-29-2012 |