Merschaert
Alain Merschaert, Rue Granbonpre BE
Patent application number | Description | Published |
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20090156808 | PROCESSES FOR THE PREPARATION OF 3,4-SUBSTITUTED-1,2,5-THIADIAZOLES AND INTERMEDIATES THEREOF - The present invention relates to intermediate compounds useful for the preparation of 1,2,5-thiadiazole compounds, including unsymmetrically substituted compounds such as 4-(3-secondary amino-2-hydroxy-propoxy)-1,2,5-thiadiazole compounds and azacyclic or azabicyclic 1,2,5-thiadiazole compounds and to processes for making the same. | 06-18-2009 |
Alain Merschaert, Brussels BE
Patent application number | Description | Published |
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20110263899 | Novel Process for the Preparation of Amino Acid Derivatives - The present patent application relates to an alternative process for the preparation of amino derivatives. In particular, the present application relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide, which is useful as an anticonvulsive drug. In a particular aspect, the present invention relates to a process of manufacture of optically enriched (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (I) comprising resolution of 2-acetamido-N-benzyl-3-methoxypropion-amide (II). | 10-27-2011 |
20130190533 | PROCESS FOR THE PREPARATION OF AMINO ACID DERIVATIVES - The present invention relates to a process of manufacture of compounds of formula (B) wherein R | 07-25-2013 |
20140018577 | Process for Preparing Lacosamide - The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine. | 01-16-2014 |
Alain Merschaert, Petitenghien BE
Patent application number | Description | Published |
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20140163283 | METHOD OF CARRYING OUT CC-COUPLING REACTIONS USING OXIDE SUPPORTED PD-CATALYSTS - A method of carrying out Suzuki-Miyaura CC-coupling reactions, includes reacting an aryl halide with an aryl boronic acid in an organic solvent in the presence of an oxide supported palladium catalyst and a base, characterized in that the base is added in the form of an aqueous solution with a constant flow rate within a predetermined period of time at the beginning of the reaction. | 06-12-2014 |