Mermelstein
Fred Mermelstein US
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20090092656 | METHOD OF TREATING ATROPHIC VAGINITIS - The present invention provides novel pharmaceutical compositions containing triphenylethylene derivative compounds, and methods of using the composition for treatment of symptoms associated with atrophic vaginitis. The pharmaceutical compositions are prepared for the vaginal administration of triphenylethylene derivative compounds in single or combination therapies. Preferably, the triphenylethylene derivative is tamoxifen. | 04-09-2009 |
Fred Mermelstein, Newton, MA US
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20130102948 | PORTABLE BLOOD FILTRATION DEVICES, SYSTEMS, AND METHODS - A blood filtration device, system, and method that can and selectively remove or reduce an unwanted, in certain cases unknown, substance from a patient's blood stream. More specifically, a specific size or size range of unwanted substance is selectively removed. The unwanted substance includes one or more of a pathogen, a toxin, an activated cell, and an administered drug. The device and system employ a microfluidic separation device that minimizes thrombogenesis and can permit the use of anticoagulants to be avoided. The device or system can be portable and can include its own power supply. Sensors in the system may monitor for the presence and/or concentration of unwanted species including pathogens or drugs and invoke a blood cleansing process responsively to the sensor signals in closed loop control process. The control may combine the infusion of therapeutic agents into the blood of a patient as well. | 04-25-2013 |
Fred H. Mermelstein, Upper Montclair, NJ US
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20080221144 | Controlled Release Formulations - The present invention relates to controlled release transmucosal formulations which mediate absorption and methods of use comprising a pharmaceutically active agent, preferably morphine, and a water soluble polymer, chitosan, and preferably one more antioxidants, one or more antimicrobial agents, and water. | 09-11-2008 |
20140171514 | NMDA RECEPTOR ANTAGONIST FORMULATION WITH REDUCED NEUROTOXICITY - The present invention is directed to pharmaceutical compositions of effective amounts of NMDA receptor antagonists and preservative for the administration to a patient in need of effective analgesia and anesthesia. The compositions of the invention advantageously do not cause any significant neurotoxicity. The preferred NMDA receptor antagonist is ketamine. The preferred preservative is benzalkonium chloride. | 06-19-2014 |
Fred H. Mermelstein, Newton, MA US
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20110218247 | FORMULATIONS OF LOW DOSE DICLOFENAC AND BETA-CYCLODEXTRIN - The present invention is directed to a pharmaceutical composition containing a unit dose of a diclofenac compound effective to induce analgesia; and a beta-cyclodextrin compound; wherein the dose of the diclofenac compound is less than 10 mg. The present invention is also directed to methods of treating a subject in need of analgesia with the pharmaceutical compositions of the invention. | 09-08-2011 |
20140107209 | FORMULATIONS OF LOW DOSE DICLOFENAC AND BETA-CYCLODEXTRIN - The present invention is directed to a pharmaceutical composition containing a unit dose of a diclofenac compound effective to induce analgesia; and a beta-cyclodextrin compound; wherein the dose of the diclofenac compound is less than 10 mg. The present invention is also directed to methods of treating a subject in need of analgesia with the pharmaceutical compositions of the invention. | 04-17-2014 |
20150105467 | FORMULATIONS OF LOW DOSE DICLOFENAC AND BETA-CYCLODEXTRIN - The present invention is directed to a pharmaceutical composition containing a unit dose of a diclofenac compound effective to induce analgesia; and a beta-cyclodextrin compound; wherein the dose of the diclofenac compound is less than 10 mg. The present invention is also directed to methods of treating a subject in need of analgesia with the pharmaceutical compositions of the invention. | 04-16-2015 |
Harold Mermelstein, Bronx, NY US
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20120294917 | Topical Drying Composition Comprising Encapsulated Trehalose and Method of Using Same - A topical drying composition is provided for removal of sweat from skin areas which are vulnerable to sweating after sweat producing activities. The drying efficacy of the composition is due to the presence of encapsulated trehalose, with or without aluminum used as aluminum zirconium compound. Application of an effective amount of the composition to the skin prior to exercise or sweat removal activity reduces sweating and accelerates drying of the skin. | 11-22-2012 |
Harold J. Mermelstein, Bronx, NY US
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20090317493 | Trehalose-containing topical drying composition and method of using same - A topical drying composition is providing containing trehalose as the effective moisture (sweat) removing ingredient. The composition may be used in aqueous form or preferably as a cream and in addition to trehalose it contains several ingredients such as sorbitan monolaurate, polysorbitan, a moisturizer, a thickener, a softener, an antibacterial agent and a pH adjusting component to adjust the pH of the composition between about 5.5 to about 7.5. Sterilized water is used as the carrier for the composition. | 12-24-2009 |
20110318291 | Trehalose-containing topical drying composition and method of using same - A topical drying composition is providing containing trehalose as the effective moisture (sweat) removing ingredient. The composition may be used in aqueous form or preferably as a cream and in addition to trehalose it contains several ingredients such as sorbitan monolaurate, polysorbitan, a moisturizer, a thickener, a softener, an antibacterial agent and a pH adjusting component to adjust the pH of the composition between about 5.5 to about 7.5. Sterilized water is used as the carrier for the composition. | 12-29-2011 |
Jeffrey Mermelstein, Lincolnwood, IL US
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20080243681 | METHOD AND SYSTEM FOR ON-LINE CUSTOMER SCREENING - In one embodiment of the present invention there is provided a computer implemented method for pre-qualifying a customer interested in leasing an item owned by a third party, when the item is listed on an on-line database. The method includes receiving credit information related to said customer; retrieving decision criteria stored on a database and corresponding to said item; comparing the credit information to the decision criteria; generating an acceptance notice, when the credit information passes the decision criteria, or generating a declination notice, when the credit information fails the decision criteria; and sending the acceptance notice or declination notice to the customer and the third party. | 10-02-2008 |
Joshua M. Mermelstein, Laguna Niguel, CA US
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20150380748 | HEAT RECLAMATION AND TEMPERATURE CONTROL FOR SUBMERSIBLE VEHICLES THAT UTILIZE FUEL CELLS - Embodiments described herein provide for heat reclamation and temperature control of a SOFC for a submersible vehicle. The vehicle includes a SOFC, a hot box that surrounds the SOFC, a cooling loop, and a Stirling engine. The cooling loop has a heat exchanger and a coolant pump. The heat exchanger thermally couples the cooling loop to the water. The Stirling engine has a first end thermally coupled to an interior of the hot box and a second end thermally coupled to the cooling loop. The coolant pump modifies a rate of heat removal from the second end of the Stirling engine based on a pump control signal. A thermal management controller monitors a temperature of a cathode outlet of the SOFC, and modifies the pump control signal to maintain the temperature of the cathode outlet within a temperature range. | 12-31-2015 |
Marc Mermelstein, Highland Park, NJ US
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20100008633 | Segmented Gain-Doping Of An Optical Fiber - The present disclosure provides an approach to more efficiently amplify signals by matching either the gain materials or the pump profile with the signal profile for a higher-order mode (HOM) signal. By doing so, more efficient energy extraction is achieved. | 01-14-2010 |
20140270668 | REMOVING UNWANTED LIGHT FROM HIGH-POWER OPTICAL SYSTEMS - The present disclosure is directed to removing unabsorbed cladding light in high-power optical systems. Some embodiments comprise a glass block with a refractive index that is greater than a refractive index of a fiber cladding, and a metal housing that is located external to the glass block. The glass block and the metal housing, in combination, removes excess light. | 09-18-2014 |
20140314372 | SUPPRESSION OF STIMULATED BRILLOUIN SCATTERING IN HIGHER-ORDER- MODE OPTICAL FIBER AMPLIFIERS - An HOM-based optical fiber amplifier is selectively doped within its core region to minimize the presence of dopants in those portions of the core where the unwanted lower-order modes (particularly, the fundamental mode) of the signal reside. The reduction (elimination) of the gain medium from these portions of the core minimizes (perhaps to the point of elimination) limits the amount of amplification impressed upon the backward-propagating Stokes wave. This minimization of amplification will, in turn, lead to a reduction in the growth of the Stokes power that is generated by the Brillouin gain, which results in increasing the amount of power present in the desired, forward-propagating HOM amplified optical signal output. | 10-23-2014 |
20150062693 | HIGH-POWER LIQUID-COOLED PUMP AND SIGNAL COMBINER - Embodiments of the present invention are generally related to a high-power liquid-cooled pump and signal combiner and methods thereof for fiber optic applications. More specifically, embodiments of the present invention relate to a pump and signal combiner capable of conveying several kilowatts of pump laser power for kilowatt class rare-earth doped fiber amplifiers without suffering thermal damage. In one embodiment of the present invention, a high-power, heat dissipating optical fiber device comprises a section of optical fiber configured to propagate light, a cooling chamber, substantially encapsulating the optical fiber, and a fluid within the cooling chamber having a refractive index selected to control the interaction and propagation of the light in the fluid. | 03-05-2015 |
Marc D. Mermelstein, Highland Park, NJ US
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20090116800 | Large mode area fiber amplifiers with reduced stimulated brillouin scattering - A large mode area fiber amplifier suitable for high power applications includes a core region specifically configured to allow for high power operation while also limiting the amount of SBS that is generated. The composition of the core region is selected to include a dopant (such as aluminum) in selected areas to reduce the acoustic refractive index of the core and limit the spatial overlap between the acoustic and optical fields. The acoustic refractive index is also structured so that the acoustic field is refracted away from the central core area. In one embodiment, the core may comprise a depressed index center portion and surrounding ring core area, with the center portion including the aluminum doping and the ring formed to have a diameter less that the phonon decay length for the operating wavelength(s). | 05-07-2009 |
20100046898 | Large mode area fiber amplifiers with reduced stimulated brillouin scattering - A large mode area fiber amplifier suitable for high power applications includes a core region specifically configured to allow for high power operation while also limiting the amount of SBS that is generated. The composition of the core region is selected to include a dopant (such as aluminum) in selected areas to reduce the acoustic refractive index of the core and limit the spatial overlap between the acoustic and optical fields. The acoustic refractive index is also structured so that the acoustic field is refracted away from the central core area. In one embodiment, the core may comprise a depressed index center portion and surrounding ring core area, with the center portion including the aluminum doping and the ring formed to have a diameter less that the phonon decay length for the operating wavelength(s). | 02-25-2010 |
Michael Mermelstein, Cambridge, MA US
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20140160559 | llumination System - The invention is a system and method for controllable alignment of any of a plurality of electro-optical components mounted to a circuit board with an optical axis. In one embodiment, the invention provides an improved illumination system for microscopy. The system incorporates a circuit board 31 providing structure and directly mounting a plurality of light emitting sources. The mounted light sources are rotatably alignable with a plurality of optical axes. The system further includes selectable conditioning of the sources. | 06-12-2014 |
20140176694 | Imaging system - The invention provides an novel imaging system for microscopy including both continuous motion and stationary field image acquisition. More specifically, the invention provides a system that can translate a specimen relative to the field-of-view of an imager while synchronously acquiring image data. Using the same imaging optics and imager, the system can acquire stationary images at any location on the specimen. | 06-26-2014 |
20140178158 | Robotic instrument rack - The invention provides an improved robotic handler for multi-well plates. The handler comprises a vertical elevator with integral mounts for instruments used in cellular experiments. This solution reduces overall mechanical complexity while reducing the working volume of previous collections of devices with similar function. | 06-26-2014 |
Michael Stephen Mermelstein, Cambridge, MA US
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20130044203 | OPTICALLY ENHANCED DIGITAL IMAGING SYSTEM - Improved methods and systems for imaging are provided. Specifically, systems and methods for extending the range of a digital zoom are provided in which an imaging system provides continuous magnification over a plurality of interleaved optical pathways and digital zooming imagers. Systems and methods of centering an image as the field of view changes, and for masking out undesirable obstacles from a magnified image are also provided. | 02-21-2013 |
Yakov Z. Mermelstein, Spring Valley, NY US
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20140236478 | METHOD AND SYSTEM THAT OPEN DATA, FILES AND APPLICATIONS AUTOMATICALLY BASED ON GEOGRAPHIC LOCATION - In its simplest, basic form, the invention involves personal electronic devices that automatically open data, files and applications, based on geographic location. The device for automatically using data, files and/or applications includes means for continuously automatically precisely locating the exact global physical location of the device; and, means for identifying each data, file and/or application having a specific global physical location corresponding to a current exact global physical location of the device and for then using said data or file and/or initiating said application. In a preferred embodiment, there is also a means for tagging each data, file and application at the time of creation and/or editing to identify a specific global physical location. | 08-21-2014 |
20140244332 | APPARATUS, METHOD AND SOFTWARE PRODUCTS FOR AUTOMATIC APPOINTMENT MATCHING - The present invention provides systems, software and methods for automatic event matching, the method including receiving time, location and duration data of planned events from a plurality of individual users and to store the data in a database, dynamically adjusting the data associated with each user to define individual dynamic user-data based profile rankings; minimizing total duration data responsive to the profile rankings and outputting future individualized events schedules responsive to the minimizing step. | 08-28-2014 |
20140273988 | METHOD FOR SCHEDULING PHONE CALLS - The herein method for facilitating scheduling of phone calls involves establishing electronic communications between participants of the phone call. One participant sends a notice of an intent to have a phone call. Then there is a search of the electronic calendars of these participants to identify open times where both are available for a phone call. Thereafter, the system searches electronic calendars of the participants to identify the location of each participant during these open times, Finally, it verifies that each of the participants is available at a suitable location for the phone call at those open times. | 09-18-2014 |
20140278670 | METHOD FOR IDENTIFYING PEOPLE TO MEET - The herein method involves electronically searching for people with a certain characteristic. Once these people are identified, then there is a search of to see if there is a common available time for a meeting, both with respect to time and location. | 09-18-2014 |
20140278672 | METHOD FOR ALERTING PEOPLE TO EVENTS - Upon receipt of an electronic notice about an event, the recipient's electronic calendar is automatically updated so as to show the dates of the event. In particular, the method for alerting people to events includes: sending an electronic communication to a preselected group of people; and automatically inserting dates, times and locations of a subject matter of electronic communication on electronic calendars of recipients of the electronic communication. | 09-18-2014 |
20140278680 | METHOD FOR ALERTING PEOPLE TO EVENTS - This method involves automatically inserting information about an event onto electronic calendars of persons in a network concurrently with such information being inserted onto an electronic calendar of a member of that network. More particularly, the electronic method of alerting recipients of an event, includes: creating an electronic network of persons for the transmission and sharing of information; entering selected event data onto an electronic calendar of a user who is one of the persons of the electronic network; and, automatically inserting the selected event data onto electronic calendars of other persons in the electronic network without active involvement by the user or the other persons and concurrently with the user entering said selected event data onto the electronic calendar of the user. | 09-18-2014 |
20150030211 | METHOD OF IDENTIFYING A PERSON - The Invention involves a person being able to quickly access the electronic profile of another person. When a person wants someone to receive his profile (or a portion of the profile), he obtains the electronic address of that person. Then the pertinent information from the profile is sent in real time to that electronic address. Another embodiment involves a person providing an electronic identifier to a second person, and that electronic identifier is then used by him to access the profile. | 01-29-2015 |
20150032484 | METHOD FOR MAKING RESERVATIONS - The concept of this invention centers around the “one click” method of initiating action. In particular, the single action being performed is clicking an icon or electronic button or even a voice command. For example, on the screen of the user's personal electronic device when the electronic calendar appears next to each meeting, there is an icon or electronic button for “one click” travel arrangements. By clicking that icon or button, the travel arrangements procedure is started with no further user action. | 01-29-2015 |
20150032650 | METHOD OF VERIFYING REVIEW - The Invention involves using GPS technology to determine where a person has been and then permitting posting of reviews of subjects only if the reviewer has visited that subject within a specified period of time. | 01-29-2015 |
20150032700 | ELECTRONIC INTERACTIVE PERSONAL PROFILE - The invention involves an interactive live verified profile. Any type of information can be stored in the profile, such as text, audio, video, graphics, etc. The owner of the profile then designates which information can be seen by which people. Most importantly, before being made available, the information is verified. The people who are designated to see the important also get the benefit of automatically getting updates when information is changed, modified, or updated | 01-29-2015 |
20150262131 | SYSTEM FOR IDENTIFYING PEOPLE AND ENTITIES TO MEET AND METHODS OF ITS USE - The herein method involves electronically searching for people and entities with a certain characteristic. Once these people and entities are identified, there is a search of to see if there is a commonly available time for a meeting, both with respect to time and location. Meetings scheduled for commonly available times are automatically inserted into electronic calendars curated by at least one of the meeting parties. | 09-17-2015 |
20150371197 | SYSTEM AND METHOD TO DETERMINE APPOINTMENT DATES - A first participant having a scheduled meeting time slot with a service provider may exchange meeting time slots with other participants should the first participant be unable to attend the scheduled meeting time slot. Electronic calendars are monitored to allow for automatic, computerized exchange of meeting time slots. Participant-defined priorities and location information are taken into account to facilitate meeting time slot exchange. | 12-24-2015 |