Mercola
Daniel Mercola, Rancho Santa Fe, CA US
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20110236903 | MATERIALS AND METHODS FOR DETERMINING DIAGNOSIS AND PROGNOSIS OF PROSTATE CANCER - Materials and Methods related to diagnosing and/or determining prognosis of prostate cancer. | 09-29-2011 |
20140011861 | Materials and Methods for Determining Diagnosis and Prognosis of Prostate Cancer - Materials and methods related to diagnosing and/or determining prognosis of prostate cancer. | 01-09-2014 |
Daniel Mercola, Irvine, CA US
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20150218655 | BIOMARKERS FOR PROSTATE CANCER PROGNOSIS - Described are embodiments related to prostate cancer biomarkers, agents, and systems for detecting and targeting the same, and associated prostate cancer diagnostic and prognostic methods. | 08-06-2015 |
Mark Mercola, Del Mar, CA US
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20090137543 | METHOD AND COMPOUNDS FOR MODULATING INSULIN PRODUCTION - The present invention provides screening methods for the detection of agents that affect various aspects of β-cell biology, particularly insulin gene expression. Screening methods are also provided for detection of agents that affect β-cell differentiation from progenitor cells. Additionally, agents identified using such methods are provided and are useful for increasing insulin gene expression and reducing lipotoxicity. | 05-28-2009 |
20090215690 | Compositions and Methods for Inhibiting Cell Migration - The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and pathological processes. The profile of Dkk proteins expressed by human breast cancers correlates with indicators of outcome: Dkk1 associates with markers of poor prognosis whereas expression of single function Dkk2 or Dkk3 (which inhibit Wnt/β-catenin signaling and promote migration, respectively) correlates with phenotypes reflective of good prognosis. Therefore, the pro-migratory activities of Dkk1 and 3 identified here offer new insights into breast cancer progression and a potential avenue for therapeutic intervention. | 08-27-2009 |
20100286220 | HNF4alpha ANTAGONISTS AND METHODS OF USE - Disclosed are methods and compositions relating to antagonists of HNF4α. | 11-11-2010 |
20110039335 | Compositions and Methods for Inhibiting Cell Migration - The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and pathological processes. The profile of Dkk proteins expressed by human breast cancers correlates with indicators of outcome: Dkk1 associates with markers of poor prognosis whereas expression of single function Dkk2 or Dkk3 (which inhibit Wnt/β-catenin signaling and promote migration, respectively) correlates with phenotypes reflective of good prognosis. Therefore, the pro-migratory activities of Dkk1 and 3 identified here offer new insights into breast cancer progression and a potential avenue for therapeutic intervention. | 02-17-2011 |
Mark Mercola, La Jolla, CA US
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20090264309 | Methods for Screening for Compounds that Modulate Insulin Promoter Activity - Compositions and methods are provided for screening for compounds that modulate insulin promoter activity. Vectors that express green fluorescent protein under the control of the human insulin promoter are introduced into mouse and human cells in which the insulin promoter is expressed in a glucose-responsive manner. Such cells are then used to screen for compounds that modulate insulin promoter activity. | 10-22-2009 |
20100159596 | SMALL MOLECULE COMPOUNDS FOR STEM CELL DIFFERENTIATION - Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof: | 06-24-2010 |
20110281356 | COMPOUNDS FOR STEM CELL DIFFERENTIATION - Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound of Formula I: | 11-17-2011 |
20130157947 | COMPOUNDS FOR STEM CELL DIFFERENTIATION - Small molecule compounds and methods for stem cell differentiation are provided herein. An example of a class of compounds that may be used to practice the methods disclosed herein is represented by enantiomerically pure isomers of compounds of Formula I: | 06-20-2013 |
Mark Mercola, Rancho Santa Fe, CA US
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20110318775 | METHOD, SYSTEM AND COMPOSITION FOR OPTICALLY INDUCING CARDIOMYOCYTE CONTRACTION - The present invention provides a method, system and composition for screening drug candidates for cardiotoxicity and for novel drugs that effect cardiomyocyte contractility and function. The invention provides an efficient and reliable screening assay to detect the effect of new and potential drug candidates on cardiomyocyte calcium flux, membrane depolarization, and/or the propagation of action potentials. | 12-29-2011 |
20140243387 | METHODS FOR IMPROVING CARDIAC CONTRACTILITY - The present invention relates to regulation of cardiac contractile function. The present invention is based on the discovery that microRNAs contribute to the loss of cardiac contractility. Specifically, miR-25 binds to SERCA2a which results in a loss of function and interferes with Ca | 08-28-2014 |
Mark Mercola, San Diego, CA US
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20130177535 | WNT INHIBITORS FOR HUMAN STEM CELL DIFFERENTIATION - Methods and small molecule compounds for stem cell differentiation and treatment of animals with diseases are provided. One example of a class of compounds that may be used is represented by the compound of Formula I and II: | 07-11-2013 |
20130190258 | COMPOUNDS FOR INHIBITION OF CANCER CELL PROLIFERATION - Methods and small molecule compounds for inhibition of cancer cell proliferation are provided. One example of a class of compounds that may be used is represented by the compound of Formula I or a pharmaceutically acceptable salt, N-oxide or solvate thereof, wherein A, B, D, E, F, G, I, J, R, R | 07-25-2013 |