Menetrier-Caux
Christine Menetrier-Caux, Bressolles FR
Patent application number | Description | Published |
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20120309013 | Use of the Combinatorial Diversity of T-Lymphocyte Repertoire as a Prognostic Marker of Cancer - The present invention relates to a method making it possible to identify the patients, from among those affected by a given solid cancer, that have increased risk of premature death. Said method is based on the ex vivo analysis of the lymphocytic diversity of the patients on the basis of a biological sample containing lymphocytes. In fact, low lymphocytic diversity is related to a poor prognosis. Specifically, it is possible to set a diversity threshold, depending on the analysis technology used and the cancer affecting the patient, beyond which the life expectancy of the patient is significantly less than that, in general, of the patients affected by the same disease. | 12-06-2012 |
Christine Menetrier-Caux, Lyon Cedex 08 FR
Patent application number | Description | Published |
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20140086923 | Antibodies Directed Against ICOS and Uses Thereof - The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg. | 03-27-2014 |
Christine Menetrier-Caux, Lyon FR
Patent application number | Description | Published |
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20150239978 | ANTIBODIES DIRECTED AGAINST ICOS FOR TREATING GRAFT-VERSUS-HOST DISEASE - The invention relates to a specific antibody directed against, for use for treating graft versus host disease. | 08-27-2015 |