Patent application number | Description | Published |
20090130021 | Methods, products and uses involving platelets and/or the vasculature - The present disclosure relates to agents which interfere with the binding of GPVI to various components. Agents which interfere with GPVI interaction with one or both of fibronectin and vitronectin or sequences thereof are also disclosed. Methods of treating disorders or diseases which involve pathological, dysfunctional or non-pathological interaction of GPVI with fibronectin and/or vitronectin are included in the present disclosure. The invention also relates to uses of agents for the prevention or treatment of disorders arising from blood platelet adhesion and aggregation. | 05-21-2009 |
20090162285 | ANTI-INFLAMMATORY FUSION PROTEIN - The present invention relates to a fusion protein comprising therapeutical and diagnostic potential against chronic vascular diseases, such as atherosclerosis, a nucleic acid molecule encoding said fusion protein, a pharmaceutical and diagnostic composition which comprises the fusion protein or the nucleic acid molecule, the use of the fusion protein or the nucleic acid molecule for the production of a pharmaceutical and diagnostic composition, a method for the diagnosis of acute or chronic vascular diseases, and a method for the production of a fusion protein. | 06-25-2009 |
20100003244 | AGENTS WHICH BIND TO EPITOPES OF GLYCOPROTEIN VI - The present invention provides anti-thrombotic agents, methods for screening for said anti-thrombotics agents and methods of treating thrombotic and other cardiovascular disorders. | 01-07-2010 |
20130130315 | FUSION PROTEIN - An isolated nucleic acid molecule selected from the group consisting of: vi. a nucleic acid molecule comprising a nucleotide sequence which is at least 85% identical to the nucleotide sequence of SEQ ID NO:1 or a complement thereof; vii. a nucleic acid molecule comprising a fragment of at least 1500 consecutive nucleotides of the nucleotide sequence of SEQ ID NO:1, or a complement thereof; viii. a nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence at least 85% identical to SEQ ID NO:2; ix. a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein the fragment comprises at least 500 contiguous amino acids of SEQ ID NO: 2; and x. a nucleic acid molecule encoding a polypeptide containing a humanized immunoglobulin or parts of an immunoglobulin having binding specificity for CD133 a nucleic acid molecule which encodes a variant of a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule comprising the entire SEQ ID NO: 1, or complement thereof under conditions of incubation at 45° C. in 6.0×SSC followed by washing in 0.2×SSC/0.1% SDS at 65° C. | 05-23-2013 |
Patent application number | Description | Published |
20080240973 | Copper-Zinc Alloy and Synchronizer Ring Produced Therefrom - A copper-zinc alloy is particularly suitable for forming synchronizer rings. The novel alloy contains 55 to 75 wt. % copper, 0.1 to 8 wt. % aluminum, 0.3 to 3.5 wt. % iron, 0.5 to 8 wt. % manganese, 0 to less than 5 wt. % nickel, 0 to less than 0.1 wt. % lead, 0 to 3 wt. % tin, 0.3 to 5 wt. % silicon, 0 to less than 0.1 wt. % cobalt, 0 to less than 0.05 wt. % titanium, 0 to less than 0.02 phosphorus, unavoidable impurities and the remainder zinc. | 10-02-2008 |
20080277234 | SYNCHRONIZER RING - A synchronizer ring ( | 11-13-2008 |
20080283353 | Brass Alloy and Synchronizing Ring - A wear-resistant brass alloy is ideally suited for manufacturing a synchronizing ring for use in couplings, brakes, transmissions, etc. The brass alloy contains 55-68% by weight of copper, 0-6% by weight of aluminium, 2-14% by weight of manganese, 0.5-3% by weight of phosphorus, 0-1% by weight of lead, unavoidable impurities and the rest zinc. | 11-20-2008 |
20100282565 | FRICTION LAYER CARRIER DEVICE AND METHOD FOR MANUFACTURING THE FRICTION LAYER CARRIER DEVICE - A friction layer carrier device has a basic element with a basic element contact surface and a friction layer lining body with a lining contact surface. The friction layer lining body is fastened to the basic element in such a way that the basic element contact surface and the lining contact surface are joined together in adhesive regions via an adhesive. At least one depression region, which allows degassing of the adhesive, is introduced into the basic element contact surface and/or into the lining contact surface. | 11-11-2010 |
20110056793 | SYNCHRONIZER RING MADE OF SHEET METAL - A sheet-metal synchronizer ring for a synchronizing device has a conical ring body, an outer toothing for blocking the axial movement of a sliding sleeve, and at least one indexing tab which is bent in the axial direction and limits the rotation of the synchronizer ring in a synchronizer hub. The indexing tab has a tab widened portion on at least one side. | 03-10-2011 |
20120030929 | METHOD FOR PRODUCING A COMPONENT OF A SYNCHRONIZATION DEVICE FOR A MANUAL TRANSMISSION - The invention relates to a method for producing a component of a synchronization device for manual transmissions, in particular a synchronizer ring ( | 02-09-2012 |
Patent application number | Description | Published |
20120108456 | DEVICE SIMILAR TO AN ELECTROMECHANICAL CAMERA AND METHOD FOR THE PRODUCTION AND USE OF THE DEVICE - A device for detecting chemical or biochemical substances in fluids includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as an electrochemical camera. | 05-03-2012 |
20120252055 | ARRANGEMENT AND METHOD USING MICROSENSORS FOR MEASURING CELL VITALITIES - An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the respective sensor. The integrated circuits are formed in the semiconductor chip spatially in each case below the associated sensor and neighboring sensors of the sensor array have a centre-to-centre in the range of micrometers. The pH and/or pO | 10-04-2012 |
20130153975 | Device Having a Plurality of Photosensitive Microcells Arranged in Row or Matrix Form - The invention provides a Silicon Photomultiplier (SiPM). The SiPM includes a plurality of microcells, a nonlinear element integrated in each one of the plurality of microcells, and a trigger line for outputting a summated current of the plurality of microcells, wherein the nonlinear element provides for a separated timing and energy signal. | 06-20-2013 |
20140048711 | System and Method of Determining Timing Triggers for Detecting Gamma Events for Nuclear Imaging - Systems and methods of generating timing triggers to determine timing resolutions of gamma events for nuclear imaging includes receiving a pulse signature representing a succession of triggers associated with a photomultiplier. When a number of triggers occurring within a predetermined time interval matches a predetermined number, an event trigger can be initiated. A delayed version of the pulse signature can be generated and compared to a predetermined timing trigger level. When the delayed version matches the predetermined timing trigger level, a timing trigger can be generated. Based on the timing trigger level, the timing trigger can be generated at the pulse of the delayed version that corresponds to the first photoelectron of a gamma event. The timing trigger can correspond to a timestamp for the first photoelectron so that a data acquisition system can identify the pulse from which to acquire energy information to generate a nuclear image. | 02-20-2014 |