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Meana
Javier Meana, Bizkaia ES
| Patent application number | Description | Published |
|---|---|---|
| 20100331384 | GUANIDINE BASED COMPOUNDS - The adrenergic receptors or adrenoceptors are a family of G-protein coupled receptors split into α and β subclasses. The adrenoceptors have important roles in regulating a myriad of physiological conditions and their malfunction has been implicated in the pathophysiology of a number of diseases. Disclosed herein are a series of novel guanidine and 2-aminoimidazoline compounds which are ligands of the alpha2-adrenoceptor (α2-ARs) subclass of adrenergic receptors. The invention also provides for pharmaceutical compositions comprising the novel compounds. The compounds are suitable for use in the manufacture of medicaments for the treatment of α2-ARs associated disorders, such as depression, schizophrenia, glaucoma and analgesia. | 12-30-2010 |
Jose Javier Meana, Bizkaia ES
| Patent application number | Description | Published |
|---|---|---|
| 20110268747 | STXBP1 AS PSYCHIATRIC BIOMARKER IN MURINE MODEL SYSTEM AND THEIR USES - A non-human transgenic animal having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illness are disclosed. | 11-03-2011 |
Oscar Vicente Meana, Almassera ES
| Patent application number | Description | Published |
|---|---|---|
| 20100095398 | Protection against environmental toxicity through manipulation of the processing of messenger RNA precursors - This invention describes the identification of pre-messenger RNA processing as a novel target of environmental stress caused by example of lithium and sodium toxicity. Overexpression of different types of proteins (or protein fragments) from different organisms but all involved in pre-mRNA processing, protects yeast from salt stress, which indicates that any stimulation of this process, independently of its mechanism, may counteract the toxic effects of mineral salts. A similar phenotype of tolerance to NaCl and to LiCl has been observed by overexpression of these types of proteins in transgenic | 04-15-2010 |