Mcmichael
Andrew Mcmichael, Oxford GB
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20110159034 | METHODS AND REAGENTS FOR VACCINATION WHICH GENERATE A CD8 T CELL IMMUNE RESPONSE - New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition. | 06-30-2011 |
Andrew Mcmichael, Beckley GB
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20090191237 | Methods and reagents for vaccination which generate A CD8 T cell immune response - New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition. | 07-30-2009 |
20090324632 | Methods and reagents for vaccination which generate a CD8 T cell immune response - New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition. | 12-31-2009 |
20100119551 | Methods and reagents for vaccination which generate a CD8 T cell immune response - New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition. | 05-13-2010 |
Andrew J. Mcmichael, Oxford GB
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20080274475 | HLA-E BINDING - The invention relates to a method of testing a compound for biological activity, which method comprises providing cells expressing one of the CD94/NKG2 family of receptors, contacting the cells with recombinant HLA-E under binding conditions in the presence of the test compound, and determining whether the presence of the compound affects the binding of HLA-E to the cells. The HLA-E property of binding to CD94/NKG2 receptors on NK cells and a subset of CD8+ T cells is useful for targeting CD94/NKG2+ cells for a variety of purposes such as identification, isolation, killing or inactivation. | 11-06-2008 |
Andrew J. Mcmichael, Beckley, Oxford GB
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20150361180 | HLA-E BINDING - The invention relates to a method of testing a compound for biological activity, which method comprises providing cells expressing one of the CD94/NKG2 family of receptors, contacting the cells with recombinant HLA-E under binding conditions in the presence of the test compound, and determining whether the presence of the compound affects the binding of HLA-E to the cells. The HLA-E property of binding to CD94/NKG2 receptors on NK cells and a subset of CD8+ T cells is useful for targeting CD94/NKG2+ cells for a variety of purposes such as identification, isolation, killing or inactivation. | 12-17-2015 |
Andrew James Mcmichael, Oxford GB
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20100266635 | HIVCON: AN HIV IMMUNOGEN AND USES THEREOF - The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV proteins, such as Gag, Pol, Vif, and Env proteins, which are partial sequences. HIVCON is an AFP in which the HIV domains are from several HIV Glade consensus sequences and which optionally contains additional domains which may be useful, for example, in monitoring expression levels or laboratory animal immune responses. Other aspects of the invention may include compositions and methods for inducing an anti-HIV immune response in a subject, preferably with a DNA prime-MVA boost strategy, and to induce a cell-mediated immune response. | 10-21-2010 |
Andrew James Mcmichael, Beckley GB
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20080306244 | Renta: an HIV immunogen and uses thereof - The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV proteins, including Reverse Trancriptase (RT), Env (gp41), Nef and Tat proteins, as well as at least one HIV CTL epitope associated with long-term, non-progression to AIDS; these domains are biologically-inactivated for one or more of the normal activity of those proteins or are partial protein sequences (and similarly biologically-inactivated). RENTA is an AFP in which the HIV domains are from an HIV Clade A consensus sequence and contains additional domains, useful for example, in monitoring expression levels or laboratory animal immune responses. Such domains are optionally included in the AFPs. Other aspects of the invention may include compositions for and methods of inducing an anti-HIV immune response in a subject, preferably using a DNA prime-MVA boost strategy, and preferably to induce a cell-mediated immune response. | 12-11-2008 |
Dannie L. Mcmichael, New Hartford, CT US
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20130108757 | FRYING APPARATUS AND METHOD | 05-02-2013 |
20130108758 | FRYING APPARATUS AND METHOD | 05-02-2013 |
20130344212 | FRYING APPARATUS AND METHOD - A frying apparatus includes a container for holding a volume of oil, a basket dimensioned to be received in the container, a spit rod supported by said basket, and a motor having an output shaft configured for engagement with said spit rod for rotating said spit rod in relation to said basket. | 12-26-2013 |
David Mcmichael, Warwick, RI US
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20100070309 | Method and System for Assessing Insurance Risk - The disclosed technology provides systems and methods for estimating the risk of loss for a location. A computer implemented method in accordance with the disclosed technology accesses one or more geographical characteristics associated with a geographical address, considers a plurality of perils and for each peril, computes a corresponding measure of peril that indicates a risk of loss at the geographical address from that peril. The corresponding measure of peril is computed based on the geographical characteristic(s) associated with the geographical address. The individual measures of peril are combined to form a combined measure that indicates a combined risk of loss at the geographical address from the plurality of perils. In one embodiment, the combined measure is used to compute an insurance premium for property at the geographical address. The disclosed technology also includes a computer executing software, wherein the executed software causes the computer to perform the steps above. | 03-18-2010 |
Donald J. Mcmichael, Rosewell, GA US
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20140018741 | Feeding Tube Tip Reinforcement - A feeding tube assembly having an improved feeding tube body composed of a tube wall having an external tube surface and an internal tube surface, a proximal end, a distal end separated from the proximal end by a length, and a distal tip region. The internal tube surface defines a feeding passageway extending the proximal end to the distal tip region. The tube body has a first cross-sectional profile from the proximal end to the distal end and at least a second cross-sectional profile from the distal end to the distal tip region. In the first cross-sectional profile, the external tube surface defines an external circumference and the internal tube surface defines a generally non-circular internal perimeter dividing the tube wall into one thin-walled portions and thick-walled portions. In the second cross-section profile, the external tube surface defines an external circumference and the internal tube surface defines an internal circumference. | 01-16-2014 |
James W. Mcmichael, Lake Jackson, TX US
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20110008623 | COAT POLYMERIC PARTICULATE, AND A PROCESS FOR COATING A POLYMERIC PARTICULATE - The instant invention is a coated polymeric particulate, and a process for coating a polymeric particulate. The coated polymeric particulate includes a polymeric particulate; and a coating composition present on at least a portion of at least one surface of the polymeric particulate. The coating includes an interconnected media; and at least one discrete island at least partially embedded in the interconnected media. The process for coating a polymeric particulate includes the following steps: (1) selecting a polymeric particulate; (2) selecting an aqueous dispersion comprising (a) a small particle component, wherein the small particle component comprises a polyolefin polymer having an average particle size in the range of 0.02 to 0.15 μm; (b) a large particle component, wherein the large particle component comprises a polyolefin polymer having an average particle size in the range of 0.3 to 0.8 μm; and (c) water; (3) applying the aqueous dispersion to the polymeric particulate; (4) thereby coating the polymeric particulate. | 01-13-2011 |
20110178243 | Process for Attaching a Modifying Agent to a Substrate - Modifying agents, e.g., a poly(sulfonyl) azide, are attached to a substrate surface, e.g., the surface of a polyolefin particle, by a process comprising the steps of: A. Contacting in an open contact zone and under a flow of inert gas a substrate with a modifying agent, binding agent, e.g., a phenolic-based antioxidant, and a liquid mixing agent, e.g., methylene chloride, to form a substrate mixture; B. Closing the contact zone and stopping the flow of inert gas to the contact zone; C. Agitating the substrate mixture under the inert gas in the closed contact zone to commence evaporation of the liquid mixing agent; D. Reducing the temperature and pressure of the closed contact zone while continuing to agitate the substrate mixture; and E. Completing the substantial evaporation of the mixing agent from the substrate mixture by opening the contact zone and initiating an inert gas flow while continuing agitation of the substrate mixture and maintaining a reduced pressure. | 07-21-2011 |
Jerri Mcmichael, New Kensington, PA US
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20110219719 | TRANSITION-JOINTS FOR JOINING DISSIMILAR MATERIALS - An assembly includes a first structural member made from a first material, such as aluminum, and having a first and a second flange, a second structural member having a first and a second flange and made from a second material, such as magnesium, and a third and a fourth structural member made from the first material and each having a first and second flange for contacting with the flanges of the first and second structural members so as to lock the first and second members together. | 09-15-2011 |
John Mcmichael, Delanson, NY US
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20100093631 | METHOD OF TREATING CRAVINGS BY ADMINISTRATION OF NERVE GROWTH FACTOR - A method for administering nerve growth factor to treat cravings is provided. Pharmaceutical compositions for the treatment of cravings comprising nerve growth factor are also provided. | 04-15-2010 |
20100144602 | Methods of Inhibiting Metastatic Cancer by Administration of Streptolysin O - The invention provides a method for administering streptolysin O for treatment of various conditions including connective tissue disorders, reproductive fibroses and conditions mediated by the CD44 receptor. The invention also provides methods for protecting nerve cells from the effects of neurotoxic agents by the administration of streptolysin O. | 06-10-2010 |
20110230554 | Method of Treating Viral Infections by Administration of Ethyl Mercury or Thiol Derivative Thereof - Disclosed herein are methods of treating viral infections by administration of ethyl mercury or thiol derivative thereof in an amount effective to treat the viral infection. | 09-22-2011 |
20130178419 | METHOD OF TREATING PAIN BY ADMINISTRATION OF NERVE GROWTH FACTOR - The invention provides methods and compositions for treatment of acute and chronic pain comprising the administration of Nerve Growth Factor. | 07-11-2013 |
20130225480 | Method of Treating Chronic Obstructive Pulmonary Disease - The present invention relates to a method of promoting bronchodilation by administration of streptolysin O to a subject in need thereof. | 08-29-2013 |
20140120191 | METHOD OF TREATING A DISORDER ASSOCIATED WITH SEQUESTERED BACTERIA - Disclosed herein are methods and compositions for treating a disorder associated with sequestered bacteria in a mammalian subject comprising the step of administering to the subject a combination therapy comprising streptolysin O and antibiotic therapy in an amount effective to treat the disorder. | 05-01-2014 |
20140121256 | METHOD OF TREATING MUSCULAR WEAKNESS COMPRISING ADMINISTERING A COMPOSITION COMPRISING AN EFFECTIVE AMOUNT OF HISTAMINE AND/OR SEROTONIN - The present invention relates to a treatment of muscle weakness resulting from a disease state or injury in a subject suffering therefrom by administering a composition including histamine in an amount effective to alleviate muscle weakness in the subject suffering therefrom. | 05-01-2014 |
20140194368 | Method of Treating Cancer by Administration of Low Levels of Heat Shock Protein 70 (HSP70) - The invention is directed to methods of treating cancer by administration of heat shock protein 70 (Hsp70) to the subject suffering from cancer. | 07-10-2014 |
20150320849 | Method of treating central nervous system disorders with Borrelia burgdorferi antigen - The present invention relates to a treatment for mammalian subjects suffering from a central nervous system (CNS) disorder by administering a composition comprising an | 11-12-2015 |
John Christian Mcmichael, Clarksville, MD US
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20140350474 | UNIVERSAL CATHETER SECUREMENT DEVICE - An intravenous catheter securement device comprises of an intravenous catheter board stabilizer that conforms to patients' bodies and an adjustable elastic sleeve with a hole for catheter insertion, with two overlying flaps for catheter securement. The intravenous catheter hoard base has holes on either side, one side for connection of the elastic sleeve, and the other side provides a fastening location for elastic bands attached to the sleeve for tightness adjustment. An embodiment of the invention involving the intravenous board is displayed separately as an alternative innovation. This device is comprised of a simple form fitting elastic sleeve having a catheter opening with the intent of applying a removable adhesive to the sleeve itself over the catheter for securement purposes. These embodiments establish a simple, standardized, and safe method of securing intravenous catheters sans adhesive material in contact with the epidermis. | 11-27-2014 |
Jonathan R. Mcmichael, Canton, OH US
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20150306604 | DUAL WEDGE CLAMP ANGLES BLADE CUTTER SYSTEM - A cutter head assembly for a fiber roving chopper includes a cylindrical blade cartridge extending axially between a cartridge first end and a cartridge second end. The cylindrical blade cartridge includes a first surface that extends between the cartridge first and second ends and is angled with respect to a central axis of the cylindrical blade cartridge. A second surface extends between the cartridge first and second ends parallel to the first surface and the second surface faces the first surface. A blade body extends between the cartridge first end and the cartridge second end and is disposed between the first surface and the second surface. | 10-29-2015 |
Jonathan R. Mcmichael, North Canton, OH US
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20120222317 | CUTTER BLADE HEAD FOR FIBER ROVING CHOPPER - A blade cartridge for a fiber roving chopper comprises an annular support and a plurality of blade holders. Each of the plurality of blade holders comprises a main body portion, a first end, a second end, and a blade. The first end of the main body portion is connected to the annular support. The second end of the main body portion is opposite the first end such that the main body portion is cantilevered from the annular support. The blade is integrally seated in the main body portion and extends between the first end and the second end. In a further embodiment of the invention, the main body portion of the blade holder includes first and second end notches that extend through the main body portion and the blade. | 09-06-2012 |
20120273520 | VALVE ACTUATOR - A dispensing gun has a gun body, a first component inlet, a second component inlet, a dispense head, a first valve, a second valve, a clamp, and a trigger. The component inlets are attached to the gun body for receiving components. The dispense head is for dispensing the components. The valves are attached to the gun body and there are valve stems for controlling the dispensing of the components. The clamp has an upper portion and a lower portion, with the first and second valve stems positioned in between the upper and lower portions. The two portions are attached such that the first and second valve stems move with movement of the valve actuator in a direction parallel to the axes of the valve stems. The trigger is attached to the gun body and controls movement of the clamp. | 11-01-2012 |
Kelly Mcmichael, San Mateo, CA US
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20150095777 | INITIALLY ESTABLISHING AND PERIODICALLY PREFETCHING DIGITAL CONTENT - Content playback that includes maintaining a connection between an electronic device and a content source. Content is prefetched prior to attempting to play one or more stations on the electronic device. Scanning a multiple stations and listening to a particular one station is distinguishable. | 04-02-2015 |
Lonny Dean Mcmichael, Fall City, WA US
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20090183263 | SIMULTANEOUS TAMPER-PROOFING AND ANTI-PIRACY PROTECTION OF SOFTWARE - Simultaneous tamper-proofing and anti-piracy protection of software is provided by splitting applications into two parts: an application, and an application launcher. The application is subject to the tamper-proofing protections deployed by a networked service, while the application launcher is subject to anti-piracy protections. To ensure that the application benefits from the anti-piracy protection of the application launcher, the application and application launcher share a trusted challenge-response relationship. The application includes a challenger library for issuing challenges to the application launcher, and the application launcher includes a responder library for responding to such challenges. | 07-16-2009 |
20100186095 | METHOD AND SYSTEM FOR GAP BASED ANTI-PIRACY - In order to achieve a more robust level of piracy protection, a gap protection scheme is utilized. This protection scheme may utilize the notion of a gap, which may comprise any entity or component that is withheld from a distribution that is required in order to run or execute a software title or is required in order to play and enjoy any other type of protected asset. | 07-22-2010 |
20100223656 | TRUSTED ENTITY BASED ANTI-CHEATING MECHANISM - An anti-cheating system may comprise a combination of a modified environment, such as a modified operating system, in conjunction with a trusted external entity to verify that the modified environment is running on a particular device. The modified environment may be may be modified in a particular manner to create a restricted environment as compared with an original environment which is replaced by the modified environment. The modifications to the modified environment may comprise alternations to the original environment to, for example, detect and/or prevent changes to the hardware and/or software intended to allow cheating or undesirable user behavior. | 09-02-2010 |
Noel Bradley Mcmichael, San Francisco, CA US
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20150088612 | Method for Analyzing Website Visitors Using Anonymized Behavioral Prediction Models - A method for analyzing web visitors using anonymized behavior production models begins with a website visitor accessing a website. The website includes a web beacon, which redirects the website visitor's browser to the server of a marketing services provider (MSP). The MSP server reads a cookie previously set by the MSP that includes an anonymous link. The anonymous link may be used to match data related to the website visitor that is maintained by the MSP, and browsing activity for that visitor is stored in an activity database from which periodic reports may be constructed for the website owner. The anonymous link is not associated with any personally identifiable information (PII), and thus privacy for the visitor is maintained. | 03-26-2015 |
Paul C. Mcmichael, Round Hill, VA US
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20110247266 | Garden plant protector - For the protection of domestic gardens against varmints, birds, and the like, this frame screen, or multiple outdoor screens thereof, guard against invasion and are readily portable for shipping. The screen is preferably formed by stamping of a platen wherein multiple cavities are defined end-to-end and side-by-side, exposing the covered garden rows of seedlings or plants to the atmosphere, which thus exclude voracious animals from feeding on the plants. Each screen unit may be closed at ends or extended in-line to accommodate the garden rows. Alternately, the units may serve as a frame to support a flexible cover against frost, excessive wind, rain, snow and the like. For transportation, multiple frame units are fitted upon one another into a compact, moveable bundle. | 10-13-2011 |
20140083002 | GARDEN PLANT PROTECTOR - A freestanding foraminous frame is provided for the protection of gardens against deer, varmints, birds, and the like. The frame may include three planar sections, including a top section and a pair of side sections. The three planar sections form a protective coop within. The side sections are attached to the top section and extend downward from the top section and outward away from each other. The frame may be made of criss-crossing metal wire segments allowing gases, liquids, and light to move freely within. A plurality of frames may be placed end to end to extend the length of the protective coop. | 03-27-2014 |
Todd R. Mcmichael, Rochester, NY US
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20110292527 | X-Y ADJUSTABLE OPTICAL MOUNT WITH Z ROTATION - An optical element mount has an inner member suspended within an outer member by a number of flexures. A first translational actuator is movable within the outer member and coupled to the inner member by a first shaft and is actuable to translate the inner member along a first substantially linear travel path within a translation plane that is orthogonal to an optical axis. A second translational actuator is movable within the outer member and coupled to the inner member by a second shaft and is actuable to translate the inner member along a second substantially linear travel path within the translation plane. A rotational actuator is movable within the outer member and coupled to the inner member by a third shaft and actuable to rotate the inner member about an instant point of rotation that is defined at the intersection of the first and second linear travel paths. | 12-01-2011 |
Todd Robert Mcmichael, Rochester, NY US
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20140304963 | METHOD OF MINIMIZING STACKING ELEMENT DISTORTIONS IN OPTICAL ASSEMBLIES - A compound optical assembly is constructed from a plurality of stacking elements for spacing, aligning, and retaining optical elements within the assembly. Stacking faces of the stacking elements are measured and low-order surface errors are extracted, represented by mathematical approximations having a primary angular frequency. The stacking elements including the optic holders are relatively oriented to promote complementarity between the low-order surface errors of mating stacking faces. | 10-16-2014 |
20150064447 | ADHESIVE WITH EMBEDDED WAVEGUIDES FOR CURING - An optical device includes a support structure configured to retain an optical element using a cured adhesive composition that is disposed between a surface of the support structure and a surface of the optical element, wherein a structured optical particulate material is dispersed throughout the cured adhesive. The structured optical particulate material redirects curing radiation via a scattering mechanism to facilitate curing of portions of the adhesive compositions that cannot be directly exposed to the radiation, thereby facilitating rapid and more thorough curing than could otherwise be achieved without the structured optical particulate material. | 03-05-2015 |
20150098131 | LENS ASSEMBLIES AND OPTICAL SYSTEMS INCORPORATING LENS ASSEMBLIES - An optical system includes a lens assembly and a light source. The lens assembly includes an optical lens positioned to transmit and refract light provided by the light source, and a lens holder coupled to the optical lens and maintaining a position of the optical lens relative to the light source. The optical lens is coupled to the lens holder with a bonding agent arranged in an interrupted configuration at positions proximate to a circumference of the optical lens. The light source provides light to the optical lens of the lens assembly. The light provided to the optical lens has an optical footprint that includes a plurality of high-intensity regions separated from one another by low-intensity regions and the bonding agent is positioned in a circumferential orientation relative to the light source such that the bonding agent is spaced apart from the high-intensity regions of the optical footprint of the light. | 04-09-2015 |