Mcgrath, IE
Barry Mcgrath, Parteen IE
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20100310528 | Vector System for Site-Specific Integration - The integration system comprises at least one vector capable of expressing at least one exogenous gene, the vector comprising a coding sequence for an attP gene region and a coding sequence for at least one therapeutic molecule and an integrase. The integration system has an application in bacterial metabolic engineering and in gene therapy. | 12-09-2010 |
Brendan Mcgrath, Duncannon IE
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20160003224 | Gravitational Potential Energy Storage - An energy storage system comprises a cable ( | 01-07-2016 |
Brendan Mcgrath, County Wexford IE
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20130113214 | Floating Vessel That Converts Wave Energy at Sea Into Electrical Energy - An apparatus for converting wave energy into electrical energy comprising a first floating hull ( | 05-09-2013 |
Claire Victoria Mcgrath, Dun Laoghaire IE
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20090239242 | Method for the early identification and prediction of kidney injury - A method for the early identification and prediction of elevated blood creatinine levels resulting from a reduction in kidney function in a subject, comprises contacting a urine sample from the subject with a capture molecule for a biomarker specific for the distal region of the renal tubule and which biomarker is released from said region when there is damage to said region indicative and predictive of elevated blood creatinine levels resulting from a reduction in kidney function. The method can be used to detect Acute Kidney Injury (AKI) caused by many conditions or diseases or through the administration of drugs. The method can indicate and/or predict a reduction in kidney function significantly earlier than the current standard creatinine test. Methods for predicting a need for renal replacement therapy (RRT) are also disclosed. | 09-24-2009 |
20110136138 | METHOD FOR PREDICTING A NEED FOR RENAL REPLACEMENT THERAPY (RRT) - A method for predicting a need for Renal Replacement Therapy (RRT) in a patient comprises: determining a concentration of pi glutathione S transferase-(πGST) in a first urine sample from the patient; and wherein a need for RRT is predicted when the πGST concentration is determined to be elevated in comparison to a patient without kidney injury. The method according to the invention can further comprise detecting for the presence of risk factors for RRT in a patient, the risk factors including elevated serum creatinine concentration, type I diabetes, type II diabetes, hypertension, dyslipidemia, hyperglycaemia, proteinuria and hypoalbuminemia. | 06-09-2011 |
20130236908 | METHOD FOR PREDICTING A NEED FOR RENAL REPLACEMENT THERAPY (RRT) - A method for predicting a need for Renal Replacement Therapy (RRT) in a patient comprises: determining a concentration of pi glutathione S transferase-(πGST) in a first urine sample from the patient; and wherein a need for RRT is predicted when the πGST concentration is determined to be elevated in comparison to a patient without kidney injury. The method according to the invention can further comprise detecting for the presence of risk factors for RRT in a patient, the risk factors including elevated serum creatinine concentration, type I diabetes, type II diabetes, hypertension, dyslipidemia, hyperglycaemia, proteinuria and hypoalbuminemia. | 09-12-2013 |
20130302819 | METHOD FOR THE EARLY IDENTIFICATION AND PREDICTION OF AN ABRUPT REDUCTION IN KIDNEY FUNCTION IN A PATIENT UNDERGOING CARDIOTHORACIC SURGERY - A method for the early identification and prediction of abrupt reduction in kidney function in a patient undergoing cardiothoracic (CT) surgery, including Cardio-Pulmonary Bypass (CPB), comprises contacting a urine sample from the patient with a capture molecule for a biomarker, especially πGST specific for the distal region of the renal tubule and which biomarker is released from said region when there is damage to said region indicative and predictive of an abrupt reduction in kidney function, the biomarker being detectable as early as intraoperatively or in the recovery stage post CT surgery, for example prior to transfer of the patient to the Intensive Care Unit (ICU), allowing for immediate corrective medical intervention. The method can be used to detect Acute Kidney Injury (AKI) and a requirement for Renal Replacement Therapy (RRT) namely dialysis, earlier than two hours post CT surgery and as early as zero hours post or during CT surgery or CPB. | 11-14-2013 |
Claire Victoria Mcgrath, County Dublin IE
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20090238812 | Method for the early indentification and prediction of an abrupt reduction in kidney function in a patient undergoing cardiothoracic surgery - A method for the early identification and prediction of an abrupt reduction in kidney function in a patient undergoing cardiothoracic (CT) surgery, including Cardio-Pulmonary Bypass (CPB), comprises contacting a urine sample from the patient with a capture molecule for a biomarker, especially πGST, specific for the distal region of the renal tubule and which biomarker is released from said region when there is damage to said region indicative and predictive of an abrupt reduction in kidney function, the biomarker being detectable as early as intraoperatively or in the recovery stage post CT surgery, for example prior to transfer of the patient to the Intensive Care Unit (ICU), allowing for immediate corrective medical intervention. The method can be used to detect Acute Kidney Injury (AKI) and a requirement for Renal Replacement Therapy (RRT) namely dialysis, earlier than two hours post CT surgery and as early as zero hours post or during CT surgery or CPB. | 09-24-2009 |
Conor D. Mcgrath, Dublin IE
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20150143341 | SELECTIVE OBJECT TESTING IN A CLIENT-SERVER ENVIRONMENT - Embodiments of the present invention disclose a method, computer program product, and system for testing objects in a client-server environment. A server computing system receives at least one modification to a set of objects. The server computing system registers the at least one modification with a user identifier. The server computing system receives instructions to execute the set of objects with the at least one modification that is registered to the user identifier. The server computing system determines which of the set objects the at least one modification alters. The server computing system executes the set of objects, wherein the set of objects incorporates the at least one modification associated with the user identifier. | 05-21-2015 |
Darach Mcgrath, Nenagh IE
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20100280311 | Adaptor for an Endoscope - An adaptor and a kit including an adaptor are provided. The adaptor is configured to connect an elongate medical device to an endoscope. The adaptor includes a first portion having a distal end sized and shaped to connect to an endoscope. The first portion includes a first opening defined therethrough. The adaptor further includes a second portion connectable to the first portion and including a second opening defined through the second portion and operably connectable to the first lumen. The second portion includes a connector at a proximal end portion sized and shaped to receive at least a portion of the elongate medical device so that a shaft of the elongate medical device is extendable distally through the first opening and the second opening and into the endoscope when the elongate medical device is connected to the adaptor. | 11-04-2010 |
20150265258 | FLEXIBLE BIOPSY NEEDLE - An endoscopic tissue-sampling needle includes an elongate needle shaft having a proximal and a distal shaft portion. The proximal shaft portion includes an inner tubular core that may be constructed of a same material as the distal shaft potion, having a longer length and a smaller outer diameter than the distal shaft portion. The distal shaft portion extends into and is fixedly attached to an inner diameter of a distal shaft portion lumen. The distal shaft portion lumen is configured for collection of patient tissue, with a distal penetrating tip and/or a side aperture with a cutting edge configured to excise tissue from a target site in a patient body. The proximal shaft portion includes polymer coating around the inner tubular core, which is configured to provide an outer diameter for the proximal shaft portion that may be substantially the same as the outer diameter of the distal shaft portion. | 09-24-2015 |
Darach Mcgrath, Portroe IE
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20090221873 | Adaptor for Endoscopic Orientation of an Elongate Medical Device - An adaptor, a system and a method to orient an elongate medical device in relation to an endoscope are provided. The adaptor includes a first portion and a second portion. The first portion includes a connecting portion to rotationally securable to a distal end of the first portion to the endoscope, a first lumen extending longitudinally through the first portion and operably connectable to a working channel of the endoscope, and one of an orienting key or a keyway extending longitudinally at least partially along the first portion. The second portion is releasably connectable to the first portion and includes the other of the key or the keyway extending longitudinally along at least a portion of the second portion and a second lumen operably connectable to the first lumen and configured to receive an elongate medical device rotationally secured in relation to the second portion therethrough. | 09-03-2009 |
Darach Mcgrath, Tipperary IE
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20100160731 | ULTRASOUND-VISUALIZABLE ENDOSCOPIC ACCESS SYSTEM - An endoscopic access system is provided including an outer cannula and a penetrating stylet. The stylet provides an enhanced echogenic profile configured to provide for effective navigation under ultrasound visualization in a patient body. The cannula may include a rounded distal margin configured to provide for efficient passage though the cannula distal end of tools such as a wire guide. | 06-24-2010 |
Darach Mcgrath, Co. Tipperary IE
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20130006144 | BIOPSY NEEDLE WITH FLEXIBLE LENGTH - An endoscopic tissue-sampling needle is provided including an elongate needle shaft having a proximal shaft portion and a distal shaft portion. The distal shaft portion extends into and is fixedly attached to an inner diameter of a proximal shaft portion lumen. The distal shaft portion lumen is configured for collection of patient tissue by including a distal penetrating tip and/or a side aperture with a cutting edge configured to excise tissue from a target site in a patient body. The proximal shaft portion includes a length of cable tube configured to provide enhanced flexibility in use via an endoscope. | 01-03-2013 |
20130006145 | FLEXIBLE BIOPSY NEEDLE - An endoscopic tissue-sampling needle includes an elongate needle shaft having a proximal and a distal shaft portion. The proximal shaft portion includes an inner tubular core that may be constructed of a same material as the distal shaft potion, having a longer length and a smaller outer diameter than the distal shaft portion. The distal shaft portion extends into and is fixedly attached to an inner diameter of a distal shaft portion lumen. The distal shaft portion lumen is configured for collection of patient tissue, with a distal penetrating tip and/or a side aperture with a cutting edge configured to excise tissue from a target site in a patient body. The proximal shaft portion includes polymer coating around the inner tubular core, which is configured to provide an outer diameter for the proximal shaft portion that may be substantially the same as the outer diameter of the distal shaft portion. | 01-03-2013 |
20140005478 | ENDOSCOPIC ACCESS SYSTEM HAVING A DETACHABLE HANDLE | 01-02-2014 |
20140114254 | SELF-COILING STYLET NEEDLE DEVICE - A medical device includes an elongate single-wire memory-metal body with a complete length that includes a proximal stylet length, an intermediate self-coiling stylet length, and a distal stylet length that is generally straight and non-self-coiling. The moment of force of the self-coiling stylet length is less than the moment of force of the medical endoscopy needle that is resistant to the stylet's self-coiling force. The device may further include being incorporated into an endoscopy needle system where the single-wire stylet body is disposed through a lumen of a medical endoscopy needle. | 04-24-2014 |
20140114255 | SELF-COILING STYLET NEEDLE DEVICE - A medical device includes an elongate single-wire memory-metal body with a complete length that includes a proximal stylet length, an intermediate self-coiling stylet length, and a distal stylet length that is generally straight and non-self-coiling. The moment of force of the self-coiling stylet length is less than the moment of force of the medical endoscopy needle that is resistant to the stylet's self-coiling force. The device may further include being incorporated into an endoscopy needle system where the single-wire stylet body is disposed through a lumen of a medical endoscopy needle. | 04-24-2014 |
20140121677 | Clutched-Gear Handle and System for Fiducial Deployment - Embodiments include a fiducial deployment system with a handle configured for actuation of same. A fiducial may include one or more protuberances configured to engage one or more slots in a needle of the system. The needle may be configured to deliver a plurality of fiducials to a target location in serial fashion, one at a time. In certain embodiments, echogenic placement of fiducials may present certain advantages. The handle includes a clutched-gear actuation mechanism configured for incrementally or otherwise controlled deploying one or more fiducials at a time by advancing a stylet through and/or retracting the body of a slotted needle in which fiducials are disposed with a fiducial protrusion extending into the needle slot, which also includes retaining structures that do not impede the needle lumen. | 05-01-2014 |
20140243844 | RATCHET-SLIDE HANDLE AND SYSTEM FOR FIDUCIAL DEPLOYMENT - Embodiments include a fiducial deployment system with a handle configured for actuation of same. A fiducial may include one or more protuberances configured to engage one or more slots in a needle of the system. The needle may be configured to deliver a plurality of fiducials to a target location in serial fashion, one at a time. In certain embodiments, echogenic placement of fiducials may present certain advantages. The handle includes an actuation mechanism with a toothed rack and actuation member(s) configured for incrementally or otherwise controlledly deploying one or more fiducials at a time by advancing a stylet through and/or retracting the body of a slotted needle in which fiducials are disposed with a fiducial protrusion extending into the needle slot, which also includes retaining structures that do not impede the needle lumen. | 08-28-2014 |
20150099995 | WIRE-EMBEDDED POLYMER-BODY NEEDLE - A medical needle including an elongate tubular body having an outer wall defining at least one longitudinal lumen is provided. The at least one longitudinal lumen may be configured to provide access for at least one of a wire guide, a therapeutic tool, a diagnostic tool, a medicament, and/or contrast fluid. The body may be configured with sufficient length and flexibility to be extended out of and operated through a working channel of a surgical endoscope. The body further includes one or more wires embedded in, and secured substantially immovably relative to, the outer wall. A distal end of the body includes a needle tip configured with at least one sharpened surface configured to penetrate into body tissue. | 04-09-2015 |
20150351862 | Screw-Driven Handles and Systems for Fiducial Deployment - Embodiments include a fiducial deployment system with a handle configured for actuation of same. A fiducial may include one or more protuberances configured to engage one or more slots in a needle of the system. The needle may be configured to deliver a plurality of fiducials to a target location in serial fashion, one at a time. In certain embodiments, echogenic placement of fiducials may present certain advantages. The handle includes an actuation mechanism with rotatable housing portion or member configured for incrementally or otherwise controlledly deploy one or more fiducials at a time by advancing a stylet through and/or retracting the body of a slotted needle in which fiducials are disposed with a fiducial protrusion extending into the needle slot, which also includes retaining structures that do not impede the needle lumen. | 12-10-2015 |
20150360019 | Plunger-Driven Collet Handle and System for Fiducial Deployment - Embodiments include a fiducial deployment system with a handle configured for actuation of same. A fiducial may include one or more protuberances configured to engage one or more slots in a needle of the system. The needle may be configured to deliver a plurality of fiducials to a target location in serial fashion, one at a time. In certain embodiments, echogenic placement of fiducials may present certain advantages. The handle includes an actuation mechanism with a collet and plunger actuation member configured for incrementally or otherwise controlledly deploy one or more fiducials at a time by advancing a stylet through and/or retracting the body of a slotted needle in which fiducials are disposed with a fiducial protrusion extending into the needle slot, which also includes retaining structures that do not impede the needle lumen. | 12-17-2015 |
Deirdre Mcgrath, County Limerick IE
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20130085355 | MONITORING SYSTEM - A system and method for non-invasive monitoring of cardiac activity in a human or animal is disclosed. A radiation source directs radiation through a patient site, and a detector detects radiation after passing through a patient tissue. A processor processes data derived from the detected radiation, determining pulse peaks and troughs and calculating area under a pulse peak to provide a real time cardiac output indicator. The radiation wavelength is on a haemoglobin spectral isosbestic point, not influenced by changes in SpO2 concentration. The processor performs numerical integration of pulse data between troughs, and wherein said integration is performed per pulse. Preferably, the processor monitors trends, thus providing very useful information and reducing need for calibration. | 04-04-2013 |
Liam Mcgrath, Arklow IE
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20100043261 | SELF EXPANDING DISPLAY UNIT - A self-expanding display unit ( | 02-25-2010 |
Marie G. Mcgrath, Cork IE
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20130110078 | Vaccination Method Using Microneedle Arrays | 05-02-2013 |
20130310665 | METHOD - The present invention relates to a method for fabricating a microneedle which comprises the steps of spraying a composition into a mould, drying the composition and removal of the dried composition from the mould, thereby forming a microneedle that, when applied to the skin of a subject, pierces the stratum corneum to access the underlying tissue of the subject. The present invention also relates to a method for coating a microneedle which comprises the steps of spraying a composition onto a microneedle and drying the composition at an ambient temperature, thereby forming a coated microneedle that, when applied to the skin of a subject, pierces the stratum corneum to deliver the sprayed material to the underlying tissue of the subject. | 11-21-2013 |
Michael J. Mcgrath, Dublin IE
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20110137135 | Context Aware Physiological Monitoring - To make home patient care more successful, a machine may enable context aware physiological monitoring at home. For example, in one embodiment, the machine only allows the physiological monitor measurements to be made when the patient has proven that the patient has not undergone strenuous activity in a period preceding the measurement. That activity may skew the measurement and make the measurement unreliable. Without the machine information, the clinician may be unaware of the physical activity because the patient is not present in his or her office and could misdiagnose or misprescribe based on incorrect information. | 06-09-2011 |
Michael J. Mcgrath, Clonee IE
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20100076347 | Dynamic movement analysis system - A movement analysis system may use a force sensing mat to record a pattern of applied force from the user's feet as the user undergoes a series of directed movements. The movements may be directed by the system through indicator lights in the mat and/or directions provided on a display screen. The user's response to these directions may be recorded and analyzed to derive indications of the best exercise regime based on the user's capabilities. | 03-25-2010 |
Sean A. Mcgrath, Dublin IE
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20090089745 | METHOD AND APPARATUS TO AUTOMATICALLY IDENTIFY SPECIFIC CODE CHANGES TO PROBABILISTICALLY EXCLUDE FROM REGRESSION - Techniques for efficiently isolating software regressions are provided. In one embodiment, it is determined that a particular regression is present in a particular build of a software system. A set of candidate code components that may have caused the particular regression is identified. In accordance with an order established based on historical data for the software system, one or more intermediate builds each involving some subsets of the candidate code components may be tested to identify a set of suspect code components that caused the particular regression. For each candidate code component that is not in the set of suspect code component, a likelihood factor associated with that candidate code component is decremented. | 04-02-2009 |
20090089755 | Method and Apparatus to Increase Efficiency of Automatic Regression In "Two Dimensions" - Techniques for efficiently isolating software regressions are provided. A system test tool determines that a particular regression is present in a particular build of a software system, but not in a baseline build. Using historical data, the tool determines, for each of a plurality of intermediate builds between these two builds, a likelihood that that intermediate build introduced the particular regression. A particular intermediate build can be identified as a build to be tested. Here, the particular intermediate build comprises a plurality of layered putbacks, each of which putbacks comprises one or more code changes in the software system. The tool determines, for each putback, a likelihood that that putback introduced the particular regression. A particular putback in the plurality of putbacks may be selected as a putback to be tested. In some embodiments, the particular putback is the putback that has the greatest likelihood of introducing the particular regression. | 04-02-2009 |