| Patent application number | Description | Published |
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| 20090056818 | CHECK VALVES WITH NOISE REDUCER - A check valve includes a valve body, a flapper, and a seat region. The valve body has an upstream side, a downstream side, and a first valve flow channel that extends between the upstream and downstream sides. The flapper is rotationally mounted on the valve body, and is movable between a closed position and an open position. When in the closed position, the flapper at least substantially closes the first valve flow channel. When in the open position, the flapper at least substantially opens the first valve flow channel. The seat region is formed in the valve body, and is configured to seat the flapper and make contact therewith when the flapper is in the closed position. The seat region comprises an elastomer material. | 03-05-2009 |
| 20090071549 | Flapper with insert stops for check valve - A check valve is provided that includes a valve body, a stop bar, a flapper, and a protrusion. The valve body has a flow channel extending therethrough, a first stop support, and a second stop support. The first and second stop supports extend axially from the valve body. The stop bar is coupled to and extends between the first and the second stop supports. The flapper is rotationally mounted to the valve body and comprises a first material. The protrusion is integrally molded with the flapper and extends axially therefrom. The protrusion comprises a second material that is non-metallic and different than the first material. The flapper is moveable between a closed position, in which the flapper at least substantially seals the flow channel, and a fully-open position, in which the protrusion contacts the stop bar and the flapper unseals the flow channel. | 03-19-2009 |
| Patent application number | Description | Published |
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| 20090186059 | DEVICES AND METHODS FOR ELUTION OF NUCLEIC ACID DELIVERY COMPLEXES - Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a method of making a medical device. The method can include complexing nucleic acids with a carrier agent to form a delivery complex solution, applying the delivery complex solution to a substrate, and applying a polymeric solution to the substrate. In another embodiment, the invention includes a method of making a medical device including complexing nucleic acids with a carrier agent to form nucleic acid delivery complexes, combining the nucleic acid delivery complexes with a polymer solution and a cross-linking agent, wherein the cross-linking agent is positively charged or charge neutral. In an embodiment, the invention includes an implantable medical device including a substrate and a coating disposed on a surface of the substrate, the coating comprising a polymeric matrix and a plurality of disperse nucleic acid delivery complexes disposed within the polymeric matrix. Other embodiments are included herein. | 07-23-2009 |
| 20090263449 | DELIVERY OF NUCLEIC ACID COMPLEXES FROM MATERIALS INCLUDING NEGATIVELY CHARGED GROUPS - Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a medical device including a substrate surface, a polymeric coating disposed on the surface, the polymeric coating coupled to the substrate surface through the reaction product of a photoreactive group; the polymeric coating comprising negatively charged species on the surface; and a plurality of nucleic acid delivery complexes disposed on the polymeric coating, the nucleic acid delivery complexes comprising a nucleic acid and a cationic carrier agent complexed to the nucleic acid. Other embodiments are included herein. | 10-22-2009 |
| 20100008966 | Medical Devices and Methods for Delivery of Nucleic Acids - Embodiments of the invention include devices for the release of nucleic acids and related methods. In an embodiment, the invention includes an active agent eluting coating including a polymeric matrix, a cationic carrier agent disposed with the matrix, and an active agent disposed within the matrix, the active agent including nucleic acids substantially uncomplexed with the cationic carrier agent. In an embodiment, the invention includes a method of making an implantable medical device including selecting a concentration of a cationic carrier agent corresponding to a desired elution profile, combining a matrix forming polymer, an active agent, a solvent, and the cationic carrier agent to form a coating composition having the selected concentration of the cationic carrier agent, the active agent comprising nucleic acids, and depositing the coating composition onto the surface of a substrate. Other embodiments are included herein. | 01-14-2010 |
| 20100260846 | PARTICLES FOR DELIVERY OF NUCLEIC ACIDS AND RELATED DEVICES AND METHODS - Embodiments of the invention include devices and methods for the release of nucleic acid complexes. In an embodiment the invention includes a nucleic acid delivery particle. The delivery particle can include a polymeric matrix including a polyethyleneglycol containing copolymer and a nucleic acid complex disposed within the polymeric matrix. The nucleic acid complex can include a nucleic acid and a carrier agent. In an embodiment the invention includes a medical device including a first polymeric matrix comprising a first polymer and a plurality of nucleic acid delivery particles disposed within the first polymeric matrix. The medical device can be configured to release the nucleic acid complex when the medical device is implanted within a subject. Other embodiments are included herein. | 10-14-2010 |
