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Mccaffrey, US
Anton Mccaffrey, Pacifica, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090264505 | METHODS AND COMPOSITIONS FOR RNAI MEDIATED INHIBITION OF GENE EXPRESSION IN MAMMALS - Methods and compositions are provided for modulating, e.g., reducing, expression of a target sequence in mammals and mammalian cells. In the subject methods, an effective amount of an RNAi agent, e.g., an interfering ribonucleic acid (such as an siRNA or shRNA) or a transcription template thereof, e.g., a DNA encoding an shRNA, is introduced into a target cell, e.g., by being administered to a mammal that includes the target cell, e.g., via a hydrodynamic administration protocol. Also provided are RNAi agent pharmaceutical preparations for use in the subject methods. The subject methods and compositions find use in a variety of different applications, including academic and therapeutic applications. | 10-22-2009 |
| 20100099740 | METHODS AND COMPOSITIONS FOR RNAI MEDIATED INHIBITION OF GENE EXPRESSION IN MAMMALS - Methods and compositions are provided for modulating, e.g., reducing, expression of a target sequence in mammals and mammalian cells in vivo. In the subject methods, an effective amount of an RNAi agent, e.g., an interfering ribonucleic acid (such as an siRNA or shRNA) is introduced into a target cell, e.g., by being administered to a mammal that includes the target cell, e.g., via intravascular injection. Also provided are RNAi agent pharmaceutical preparations for use in the subject methods. The subject methods and compositions find use in a variety of different applications, including academic and therapeutic applications. | 04-22-2010 |
Anton P. Mccaffrey, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120297495 | ZINC-FINGER NUCLEASE AND RNA INTERFERENCE MEDIATED INACTIVATION OF VIRAL GENOMES - Embodiments of the present invention provide methods for targeted inactivation of viral genomes. In one embodiment, zinc-finger proteins in which DNA binding sites are altered such that they recognize and bind different, desired DNA sequences contained in hepatitis B virus (HBV) and that include nuclease domains are used for inactivation. Other embodiments for targeted inactivation of viral genomes use small nucleic acid molecules, such as short micro-RNA molecules or short hairpin RNA molecules capable of mediating RNA interference (RNAi) against the hepatitis B virus. | 11-22-2012 |
Anton P. Mccaffrey, Iowa City, IA US
| Patent application number | Description | Published |
|---|---|---|
| 20100235936 | ZINC-FINGER NUCLEASE AND RNA INTERFERENCE MEDIATED INACTIVATION OF VIRAL GENOMES - Embodiments of the present invention provide methods for targeted inactivation of viral genomes. In one embodiment, zinc-finger proteins in which DNA binding sites are altered such that they recognize and bind different, desired DNA sequences contained in hepatitis B virus (HBV) and that include nuclease domains are used for inactivation. Other embodiments for targeted inactivation of viral genomes use small nucleic acid molecules, such as short micro-RNA molecules or short hairpin RNA molecules capable of mediating RNA interference (RNAi) against the hepatitis B virus. | 09-16-2010 |
| 20120014875 | NUCLEIC ACID APTAMERS - The present invention relates to optimized aptamers and methods of using these aptamers. | 01-19-2012 |
Corey Mccaffrey, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090138504 | ELECTRONIC CALENDAR SCHEDULING METHOD - A method of applying an action to an electronic calendar entry is disclosed. The method includes specifying a criteria and an associated event action and determining if the electronic calendar entry meets the specified criteria. In response to determining that the electronic calendar entry meets the specified criteria, applying the associated event action to the electronic calendar entry. | 05-28-2009 |
| 20090150494 | JUST-IN TIME MAILING LIST TRAFFIC INDICATOR - Traffic of email messages sent to an email list is monitored, and a number of email messages sent to the email list per day is determined. An average number of email messages sent to the email list per day is determined over a number of days. The determined average number of email message sent to the email list per day is updated every day. In response to a user request to send an email message to the email list on a given day, the user is presented with a traffic indicator. The traffic indicator includes an updated average number of email messages sent to the email list per day and a number representing how many email messages have been sent to the email list on the given day at the time the user requests to send the email message. | 06-11-2009 |
Edward Michael Mccaffrey, West Springfield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110155024 | Collapsable travel tray - A fold-up platform, which can function as a tray table, is mounted to the back of the front seat in any transportation vehicle and is self-suspending. The portable unit is suspended by first being attached to each support post of the front seat head rest and then hooked to the bottom of the seat frame at a point above the seat adjustment tracts on both the left and the right side with hooks attached to straps which are then pulled snug on the back of a seat by using tension devices on the straps. The mounting straps are reinforced with a mounting skeleton frame along the straps with fabric stitched to the frame and straps to keep the structure from twisting. The tray platform is made in two pieces so that it can be folded and then rotated into its storage position when not in use. The platform tray is made in two pieces by using a stiff flat material that is then covered with a soft padding material and enclosed in fabric. The two pieces are then hinged and fastened together along one edge to form the tray that is stiff and strong when in use yet collapsible under strong forces. This unit is then attached to the skeleton frame and support straps along one edge so as to be able to rotate to a horizontal or vertical position. One end of flexible material is then attached to the right of the tray at a position where the two stiff pieces of the tray meet. The other end of the material is attached to the frame and strapping above the tray and on the top edge of the frame in such a manner as to suspend and support the tray in a horizontal position. The same suspension is found on the left side. The tray can then be stored by folding the front stiff portion of the tray forward and down over the back stiff portion of the tray and then rotating the folded tray to a vertical position where it is attached to the frame with a locking device. When in the this position the tray is stored out of the way for easy access to the rear seats, when unclipped and folded out and down the tray is available for platform use while the two piece design makes it easily collapsible in an emergency situation. | 06-30-2011 |
John Mccaffrey, Avon, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20120285325 | METHODS AND DEVICES FOR CIRCULATING AIR - A gas chromatography system comprising a sample introduction device, an oven coupled to the sample introduction device and a detector coupled to the oven is disclosed. In certain examples, the oven may be configured to receive a chromatography column in a space in the oven. In some examples, the oven may be constructed and arranged to provide a substantially constant temperature to the space during an analysis stage of the gas chromatography system. | 11-15-2012 |
Nathaniel Mccaffrey, Portola Valley, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110069315 | METHOD AND APPARATUS FOR WIDE-BAND IMAGING BASED ON NARROW-BAND IMAGE DATA - In one embodiment, an imaging method may include receiving an intensity value of a first spectral channel associated with a pixel location. The intensity value of the first spectral channel may be based on electromagnetic radiation reflected from an object after being emitted from a narrow-band electromagnetic radiation source. The method may further include defining an intensity value of a second spectral channel based on the intensity value of the first spectral channel. The second spectral channel may be associated with a spectral region of electromagnetic radiation different from a spectral region of electromagnetic radiation associated with the first spectral channel. The method may also include associating the intensity value of the second spectral channel with the pixel location. | 03-24-2011 |
Nathaniel J. Mccaffrey, Hampton Falls, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20090218493 | WIDE SPECTRAL RANGE HYBRID IMAGE DETECTOR - An apparatus for detecting radiation of a plurality of wavelengths of the electromagnetic spectrum may be provided. The apparatus includes a substrate, a laser irradiated layer proximal to a first side of the substrate, and a microbolometer and at least one readout circuit proximal to a second side of the substrate in electrical communication with the laser irradiated layer. The substrate, laser irradiated layer, and the microbolometer are disposed and arranged such that radiation of a first wavelength is substantially detected by the laser irradiated layer, and radiation of a second wavelength is substantially detected by the microbolometer. | 09-03-2009 |
| 20090218606 | VERTICALLY INTEGRATED LIGHT SENSOR AND ARRAYS - Embodiments hereof include a photosensing device, comprising an isolation layer; a photodetector layer comprising a plurality of pixels, wherein the photodetector layer is in contact with a first side of the isolation layer, wherein the photodetector layer comprises a laser-processed semiconductor material; and a semiconductor layer disposed on a second side of the isolation layer. | 09-03-2009 |
| 20090219403 | COMPACT PASSIVE LOW-LIGHT IMAGING APPARATUS - A passive portable imaging system for generating a viewable image of a darkened or low-light environment including a sensor made of laser-treated semiconductor material that is sensitive to low-light radiation, in some cases radiation at wavelengths longer than those of traditional visible light imager ranges. The imaging system can be incorporated into a personal electronic product such as a cellular phone or similar compact apparatus, and can provide security to a user who moves in or wishes to view a dark area and doesn't have a light source to illuminate the dark area. | 09-03-2009 |
| 20100038542 | Wideband Semiconducting Light Detector - A detector incorporating a laser-doped element that is favorably absorbing to at least a portion of the electromagnetic spectrum, for example in the infra-red range, is used in a light detector article. Readout circuits permitting a detector to operate in a substantial range of the electromagnetic spectrum, including the visual and infra-red range, enable day and night imaging in some embodiments. Configurations for making the detectors are also disclosed. | 02-18-2010 |
| 20100052088 | HIGH SENSITIVITY PHOTODETECTORS, IMAGING ARRAYS, AND HIGH EFFICIENCY PHOTOVOLTAIC DEVICES PRODUCED USING ION IMPLANTATION AND FEMTOSECOND LASER IRRADIATION - The present invention relates generally to methods for high throughput and controllable creation of high performance semiconductor substrates for use in devices such as high sensitivity photodetectors, imaging arrays, high efficiency solar cells and the like, to semiconductor substrates prepared according to the methods, and to an apparatus for performing the methods of the invention. | 03-04-2010 |
| 20100244174 | HIGHLY-DEPLETED LASER DOPED SEMICONDUCTOR VOLUME - A device with increased photo-sensitivity using laser treated semiconductor as detection material is disclosed. In some embodiments, the laser treated semiconductor may be placed between and an n-type and a p-type contact or two Schottky metals. The field within the p-n junction or the Schottky metal junction may aid in depleting the laser treated semiconductor section and may be capable of separating electron hole pairs. Multiple device configurations are presented, including lateral and vertical configurations. | 09-30-2010 |
Nathaniel Joseph Mccaffrey, Stockton, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090256942 | Simultaneous readout of CMOS APS imagers - A new method of reading an imager is achieved. The method comprises providing an imager array comprising n rows and m columns where a pair of rows can be read during a single row access time. A first image field is completed by sequentially reading and storing pixel values of pairs of adjacent rows of the imager array. The reading begins at a first row, and the reading stops when less than three rows are unread. Thereafter pixel values of the next row are read and not stored. Thereafter pixel values of the first row of the imager array are read and not stored. A second image field is completed by sequentially reading and storing pixel values of pairs of adjacent rows. The reading begins at the second row, the reading stops when less than two rows are unread. | 10-15-2009 |
Nathaniel Joseph Mccaffrey, Hampton Falls, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20120014837 | ILLUMINATION OF INTEGRATED ANALYTICAL SYSTEMS - An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed. | 01-19-2012 |
| 20120019828 | INTEGRATED ANALYTICAL SYSTEM AND METHOD - An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed. | 01-26-2012 |
| 20120021525 | OPTICS COLLECTION AND DETECTION SYSTEM AND METHOD - Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described. | 01-26-2012 |
Richard T. Mccaffrey, Scotch Plains, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20120190906 | Organic Chloride Adsorbent - Chemically combined chlorides are removed from intermediate and product streams of a hydrocarbon reforming process by contacting the streams with zeolite 13X, having a Si/Al ratio of less than 1.25. | 07-26-2012 |
Robert Mccaffrey, Hillsboro, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20080314902 | PLUG FOR CONCRETE FLOOR PENETRATIONS - A plug includes a conformable element and a structural cover or top plate for plugging a hole in a concrete floor slab. This permits a workman to plug the hole; unplug the hole; and, in some embodiments, fit a pipe through the hole. Moreover, the conformable element may be swapped-out on site, allowing a workman to adjust a diameter and outer surface of the plug to meet on-site conditions. | 12-25-2008 |
Robert J. Mccaffrey, Hillsboro, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20120089051 | Blood Glucose Meter Having Integral Lancet Device And Test Strip Storage Vial For Single Handed Use And Methods For Using Same - A blood glucose meter having a test strip port and an adjustable lancet device disposed at the same end of the device body is disclosed. The device body further includes an enclosure at the proximal end of the device body which houses a test strip storage vial and which facilitates one-handed opening and closing of the vial to simplify access to test strips contained therein. The enclosure is further provided with a window which allows the reading of the lot numbers on the label of the test strip vial therein without necessitating removal of the vial. A data connector is also provided on the device body for communication access, such as to upload data from other devices or to download data to other devices. | 04-12-2012 |
Robert John Mccaffrey, Hillsborough, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20110226772 | Child Resistant Bulk Dose Dispensing Unit - Child-resistant bulk dose dispensing packaging unit, and a method for opening the packaging unit, including a container and a lid engaged with the container. The container includes a reservoir, an aperture at a top end of the reservoir, and a protrusion extending from a surface of the container. The lid engages with the container and slides between a closed position and an open position. The lid includes a top wall, a side wall extending down from an outer edge of the top wall, and a post configured to engage the protrusion at a first position when the lid is closed so as to keep the lid closed. At least a portion of the post extends substantially parallel to the side wall at a distance from the side wall. Pressing the side wall inward places the post at a second position, wherein at the second position the post is disengaged from the protrusion. | 09-22-2011 |
Shawn Mccaffrey, Belmont, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090034935 | Methods and Apparatus for Client Aggregation of Television Programming in a Networked Personal Video Recording System - A networked personal video recording (“PVR”) system couples a plurality of clients to one or more PVR media servers over a network. One or more PVR media servers include television tuners to tune television signals. A storage medium buffers the television signals to implement PVR functionality. For example, the PVR media server records television programs for clients. Clients are assigned to television tuners, and the clients display television programs received at the assigned tuner. The network transfers the buffered television signals to the clients. | 02-05-2009 |
| 20100074600 | NETWORKED PERSONAL VIDEO RECORDING SYSTEM - A networked personal video recording (“PVR”) system couples a plurality of clients to one or more PVR media servers over a network. One or more PVR media servers include television tuners to tune television signals. A storage medium buffers the television signals to implement PVR functionality. For example, the PVR media server records television programs for clients. Clients are assigned to television tuners, and the clients display television programs received at the assigned tuner. The network transfers the buffered television signals to the clients. | 03-25-2010 |
Tim Mccaffrey, Silver Spring, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110091552 | Use of Bcl Inhibitors for the Treatment of Scarring Caused By Cutaneous Wounds, Burns and Abrasions - The present invention relates to use of Bcl inhibitors for the prevention of fibroproliferation resulting in the growth of visible or disfiguring scar tissue on human skin, including without limitation keloids and hypertrophic scars. In particular, the present invention relates to the new use of small molecule inhibitors of the Bcl-2/Bcl-XL family of anti-apoptotic proteins for the treatment of cutaneous wounds, burns and abrasions during the healing phase. | 04-21-2011 |
Timothy A. Mccaffrey, Silver Spring, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090142756 | PREDICTION OF BARE METAL STENT RESTENOSIS - Methods for predicting whether or not a patient is likely to experience restenosis after the placement of a bare metal stent are provided. The methods involve detecting and analyzing gene expression patterns of the cellular components of whole blood, where activation of selected genes has been found to be indicative of a high probability of restenosis. The method thus allows the identification, prior to placement of a stent, of patients who are i) likely to experience restenosis, and thus should receive a stent that includes anti-restenosis agents; or ii) unlikely to experience restenosis, and thus should receive a stent without anti-stenosis agents. | 06-04-2009 |
Timothy P. Mccaffrey, Swampscott, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080209728 | METHODS AND APPARATUS FOR ATTACHING SWIRLERS TO TURBINE ENGINE COMBUSTORS - A method facilitates assembling a combustor for a gas turbine engine, wherein the combustor includes a swirler assembly. The method comprises machining material to form a domeplate, positioning a sealplate including an overhanging portion against the domeplate, securing the sealplate in position relative to the domeplate with a welding process, and welding the swirler assembly to the domeplate. | 09-04-2008 |
| 20110151132 | Methods for Coating Articles Exposed to Hot and Harsh Environments - Methods for providing a coating system for reducing CMAS infiltration of substrates exposed to hot and harsh climates. Exemplary methods include optionally disposing a bond coat on a substrate, disposing an inner ceramic layer over the bond coat, or on the substrate in the absence of a bond coat, and disposing an outer alumina-containing layer including up to 50 percent by weight titania, using a high velocity oxygen fuel (HVOF) technique. Additional ceramic layers and alumina-containing layers may be provided to achieve a CMAS resistant coating. One or more suitable heat treatments may be utilized to phase-stabilize the alumina. The coating may be used for gas turbine engine components. Deposition techniques for the ceramic layer(s) may depend on the end use of the component. | 06-23-2011 |
| 20110151219 | Coating Systems for Protection of Substrates Exposed to Hot and Harsh Environments and Coated Articles - Coating system for reducing CMAS infiltration of substrates includes at least an inner ceramic layer and an outer alumina-containing layer. The outer layer includes up to 50 percent by weight titania. Additional ceramic layers and alumina-containing layers may be provided. The coating may be used for gas turbine engine components. Deposition techniques for the coating layers may depend on the end use of the component. Coated articles include a substrate, an optional bond coat on the substrate and a coating over the bond coat or on at least a portion of the substrate in the absence of a bond coat. The inner ceramic layer(s) exhibit a microstructure indicative of a deposition technique selected from thermal spray, physical vapor deposition, and suspension plasma spray, whereas the outer alumina-containing layer exhibits a microstructure indicative of suspension plasma spray, solution plasma spray, and a high velocity oxygen fuel spray. | 06-23-2011 |
William Mccaffrey, Glendale, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120122061 | ONLINE EDUCATIONAL SYSTEM WITH MULTIPLE NAVIGATIONAL MODES - A web-based educational system comprising at least one area of skill, interest, or expertise, a plurality of activities associated with each area of skill, interest, or expertise, and at least three navigational modes, wherein the navigational modes comprise a sequenced navigational mode, a guided navigational mode, and an independent navigational mode. Optionally, the learner can switch between available navigational modes. | 05-17-2012 |
| 20120122066 | ONLINE IMMERSIVE AND INTERACTIVE EDUCATIONAL SYSTEM - An immersive and interactive educational system for a child aged about 1 to about 10 years, comprising a digital processing device that is connected to the Internet and visual and audio content that creates an immersive and interactive educational environment for the child. The educational environment is characterized by comprising at least three subjects appropriate for the child, wherein each subject comprises a plurality of levels of learning; a plurality of learning activities associated with each subject; a software module for monitoring the progress of the child in each of the subjects; a software module for rewarding the child for completing an activity; and a software module for creating an avatar to represent the child. The plurality of activities associated with each subject teaches toward one or more educational objectives in a subject, is substantially free of activities not teaching toward one or more educational objectives in a subject, includes a book and at least one additional activity appropriate for the child, and includes one or more activities comprising a plurality of skill levels. | 05-17-2012 |
| 20120122067 | ONLINE EDUCATIONAL SYSTEM WITH MENTOR GUIDED LEARNING - An educational system assembling platform comprising a digital processing device connected to a computer network and a computer program, provided to said digital processing device via said network. The digital processing device comprises an operating system configured to perform executable instructions, a central processing unit, a memory device, a display, an input device, and a sound output device. The computer program includes executable instructions that create an educational environment. The educational environment comprises at least one area of skill, interest, or expertise, a plurality of learning activities associated with each area of skill, interest, or expertise, and a mentor guided learning mode. The mentor guided learning mode comprises a software module, adapted for a mentor, for selecting one or more learners, a software module, adapted for a mentor, for selecting learning activities from among said population of activities to create one or more subpopulations of activities to be completed by a learner, and a software module, adapted for a learner, for displaying and providing access to one or more subpopulations of learning activities to be completed by a learner. | 05-17-2012 |