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| 20110003343 | CONJUGATES OF BIOMOLECULES TO NANOPARTICLES - Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule:nanoparticle ratio approaches or equals 1:1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing. | 01-06-2011 |
| 20110014612 | POLYMERASE COMPOSITIONS & METHODS - Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein. | 01-20-2011 |
| 20120322057 | POLYMERASE COMPOSITIONS AND METHODS - Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein. | 12-20-2012 |
| 20130040365 | POLYMERASE COMPOSITIONS, METHODS OF MAKING AND USING SAME - The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase. | 02-14-2013 |
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| 20090037211 | SYSTEM AND METHOD OF MANAGING COMMUNITY BASED AND CONTENT BASED INFORMATION NETWORKS - A system for storing, managing, and accessing information on a network by providing an interface between a social network and a content network includes an applications platform. The system provides messaging and social networking facility incorporating enhanced instant messaging, file synchronization, network presence, interactive chat capabilities, text messaging, voice and video messaging, blogging, and email. The system includes a viewer, an indexing facility, and a storage facility. The viewer enables users to traverse content and provides services based upon context of time, place, structure, node, and observed user behavior. The viewer provides a means for users to interact with information on the network and services to manipulate information and transact activities. The indexing facility manages the structure of the network and tracks attributes and controlled vocabularies. The indexing facility supports navigation across the structure and resolves the logical index to a physical storage location. The storage facility provides physical persistence for an information component. | 02-05-2009 |
| 20090292709 | INTELLIGENT CLIENT ARCHITECTURE COMPUTER SYSTEM AND METHOD - A collision detection and data synchronization mechanism operates to expand the speed and capability of distributed applications. The execution environment employs collision detection and data synchronization to distribute data objects to appropriate network nodes to support local processing. The collision detection and data synchronization mechanism defines the set of processes and algorithms used to track distributed data objects and to manage changes to the distributed objects throughout a network of intelligent computing devices. Data and code are distributed to local computing devices necessitating tracking and synchronizing updates. The system and method ensures that data updates received during the course of a local transaction do not unwillingly affect the results of other transactions by notifying the local computing devices of changes to the data that are subject of the transaction. These conflicts are then resolved in the applications, and notification of the resolution is sent to the remaining intelligent computing devices. | 11-26-2009 |
| 20120158733 | SYSTEM AND METHOD OF MANAGING COMMUNITY-BASED AND CONTENT-BASED INFORMATION NETWORKS - A system for storing, managing, and accessing information on a network by providing an interface between a social network and a content network includes an applications platform. The system provides messaging and social networking facility incorporating enhanced instant messaging, file synchronization, network presence, interactive chat capabilities, text messaging, voice and video messaging, blogging, and email. The system includes a viewer, an indexing facility, and a storage facility. The viewer enables users to traverse content and provides services based upon context of time, place, structure, node, and observed user behavior. The viewer provides a means for users to interact with information on the network and services to manipulate information and transact activities. The indexing facility manages the structure of the network and tracks attributes and controlled vocabularies. The indexing facility supports navigation across the structure and resolves the logical index to a physical storage location. The storage facility provides physical persistence for an information component. | 06-21-2012 |
| 20120179659 | INTELLIGENT CLIENT ARCHITECTURE COMPUTER SYSTEM AND METHOD - A collision detection and data synchronization mechanism operates to expand the speed and capability of distributed applications. The execution environment employs collision detection and data synchronization to distribute data objects to appropriate network nodes to support local processing. The collision detection and data synchronization mechanism defines the set of processes and algorithms used to track distributed data objects and to manage changes to the distributed objects throughout a network of intelligent computing devices. Data and code are distributed to local computing devices necessitating tracking and synchronizing updates. The system and method ensures that data updates received during the course of a local transaction do not unwillingly affect the results of other transactions by notifying the local computing devices of changes to the data that are subject of the transaction. These conflicts are then resolved in the applications, and notification of the resolution is sent to the remaining intelligent computing devices. | 07-12-2012 |
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| 20090037211 | SYSTEM AND METHOD OF MANAGING COMMUNITY BASED AND CONTENT BASED INFORMATION NETWORKS - A system for storing, managing, and accessing information on a network by providing an interface between a social network and a content network includes an applications platform. The system provides messaging and social networking facility incorporating enhanced instant messaging, file synchronization, network presence, interactive chat capabilities, text messaging, voice and video messaging, blogging, and email. The system includes a viewer, an indexing facility, and a storage facility. The viewer enables users to traverse content and provides services based upon context of time, place, structure, node, and observed user behavior. The viewer provides a means for users to interact with information on the network and services to manipulate information and transact activities. The indexing facility manages the structure of the network and tracks attributes and controlled vocabularies. The indexing facility supports navigation across the structure and resolves the logical index to a physical storage location. The storage facility provides physical persistence for an information component. | 02-05-2009 |
| 20120158733 | SYSTEM AND METHOD OF MANAGING COMMUNITY-BASED AND CONTENT-BASED INFORMATION NETWORKS - A system for storing, managing, and accessing information on a network by providing an interface between a social network and a content network includes an applications platform. The system provides messaging and social networking facility incorporating enhanced instant messaging, file synchronization, network presence, interactive chat capabilities, text messaging, voice and video messaging, blogging, and email. The system includes a viewer, an indexing facility, and a storage facility. The viewer enables users to traverse content and provides services based upon context of time, place, structure, node, and observed user behavior. The viewer provides a means for users to interact with information on the network and services to manipulate information and transact activities. The indexing facility manages the structure of the network and tracks attributes and controlled vocabularies. The indexing facility supports navigation across the structure and resolves the logical index to a physical storage location. The storage facility provides physical persistence for an information component. | 06-21-2012 |
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| 20110099616 | Authenticating Using Cloud Authentication - An authentication mechanism in a local area network may use a cloud authentication mechanism to allow or deny authentication requests. A user may gain access within a local area network by entering a cloud identification and password, which may be verified by a cloud authentication mechanism. If the authentication is successful from the cloud authentication mechanism, the user identification and password are stored locally for subsequent authentication requests. In some embodiments, the cloud password may be periodically flushed so that subsequent requests may be passed to the cloud authentication mechanism. The authentication mechanism may be used in both domain and workgroup local area networks, and may operate in parallel with other users who may have local area network or client credentials which may not be authenticated from the cloud. | 04-28-2011 |
| 20110106919 | AUTOMATED DNS CONFIGURATION WITH LOCAL DNS SERVER - A client process may identify a local DNS server and may change a DHCP-supplied DNS setting to the local DNS server when the local DNS server is present. The client process may periodically monitor the local DNS server and, if the local DNS server is not present, the client process may revert the DNS setting to the originally supplied DHCP DNS setting. The client process may actively monitor the local DNS server by initiating communication with the local DNS server, or may passively monitor by listening for activity by the local DNS server. | 05-05-2011 |
| 20120271945 | Obtaining Server Address when Domain Name System Proxy Solution Fails - The subject disclosure is directed towards establishing communication between a client computer and a network resource on a computer network when DNS resolution has failed because of a DNS proxy solution. A user may request that the client use a tool as an alternative to DNS resolution. The client may monitor the network for a broadcast from the network resource, which contains information needed for the client to access the network resource. The network resource may broadcast the information from time to time, or it may broadcast it in response to a specific request from the client. | 10-25-2012 |
| 20130042315 | Client-Client-Server Authentication - Described is a technology by which machines of a (typically small) network have associated public key-based certificates for use in authentication with a server and validation of other machines in the network. This provides an inexpensive and straightforward mechanism to control, manage and maintain client machines, as well as to allow valid client machines to securely communicate with one another and recognize machines that are not valid on the network. Certificates are maintained on the server and checked for validity as needed. | 02-14-2013 |
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| 20080223826 | Reagent Delivery using a Membrane-Mediated Process - Methods and apparatuses for using a semi-permeable membrane to deliver a reagent to a surface in a topographically selective manner are provided. The methods and apparatuses are particularly useful for removing sulfur-containing electrocatalysts from copper surfaces using a semi-permeable membrane to deliver an oxidizing agent to a catalyst-coated surface. | 09-18-2008 |
| 20080226824 | Topographically selective oxidation - Methods for oxidizing organic compounds coated or adsorbed on a topographically patterned solid surface are provided. The methods can be used to selectively remove the organic compounds from the non-recessed areas. | 09-18-2008 |
| 20090118408 | Dielectric compositions containing coated filler and methods relating thereto - The present disclosure relates to a dielectric composition having a resin and a filler. The filler is used to raise the dielectric and has a passivating surface coating thereon. | 05-07-2009 |
| 20110094895 | Optical detection of planarization, breakthrough and end-point in membrane-mediated electropolishing of metal layers - Methods and apparatus for monitoring in situ the progress of planarization and/or removal of a thin metal layer from a substrate during membrane-mediated electropolishing processes are provided. | 04-28-2011 |
| 20110139331 | METHOD FOR INCREASING THE STRENGTH AND SOLVENT RESISTANCE OF POLYIMIDE NANOWEBS - The invention provides a method for enhancing the properties of polyimide nanowebs, the method comprising subjecting a nanoweb consisting essentially of a plurality of nanofibers of an aromatic polyimide to a temperature at least 50 C.° higher than the imidization temperature thereof for a period of time in the range of 5 seconds to 20 minutes, thereby preparing an enhanced nanoweb. Also provided is a multi-layer article comprising the enhanced nanoweb, and an electrochemical cell comprising the multi-layer article. | 06-16-2011 |
| 20110139730 | FILTRATION METHOD USING POLYIMIDE NANOWEB WITH AMIDIZED SURFACE AND APPARATUS THEREFOR - The present invention is directed to the preparation and use of aromatic polyimide nanowebs with amide-modified surfaces. Uses include as a filtration medium, and as a separator in batteries, particularly lithium-ion batteries. The invention is also directed to a method comprising the aromatic polyimide nanoweb with amide-modified surface. The invention is further directed to a multi-layer article comprising the aromatic polyimide nanoweb with amide-modified surface, and to an electrochemical cell comprising the multi-layer article. | 06-16-2011 |
| 20110143207 | MULTI-LAYER ARTICLE COMPRISING POLYIMIDE NANOWEB - This invention provides a multi-layer article comprising a first electrode material, a second electrode material, and a porous separator disposed between and in contact with the first and the second electrode materials, wherein the porous separator comprises a nanoweb consisting essentially of a plurality of nanofibers of a fully aromatic polyimide. Also provided is a method for preparing the multi-layer article, and an electrochemical cell employing the same. A multi-layer article comprising a polyimide nanoweb with enhanced properties is also provided. | 06-16-2011 |
| 20110143217 | ELECTROCHEMICAL CELL COMPRISING A SEPARATOR COMPRISING A NANOWEB CONSISTING ESSENTIALLY OF NANOFIBERS OF FULLY AROMATIC POLYIMIDE - This invention provides an electrochemical cell comprising a housing having disposed therewithin, an electrolyte, and a multi-layer article at least partially immersed in the electrolyte; the multi-layer article comprising a first metallic current collector, a first electrode material in electrically conductive contact with the first metallic current collector, a second electrode material in ionically conductive contact with the first electrode material, a porous separator disposed between and contacting the first electrode material and the second electrode material; and, a second metallic current collector in electrically conductive contact with the second electrode material, wherein the porous separator comprises a nanoweb consisting essentially of a plurality of nanofibers of a fully aromatic polyimide. Also provided is a process for preparing the multi-layer article. Further provided is an electrochemical cell wherein the separator is a polyimide nanoweb with enhanced properties. | 06-16-2011 |
| 20120148896 | MULTI-LAYER ARTICLE OF POLYIMIDE NANOWEB WITH AMIDIZED SURFACE - The present invention is directed to the preparation and use of aromatic polyimide nanowebs with amide-modified surfaces. Uses include as a filtration medium, and as a separator in batteries, particularly lithium-ion batteries. The invention is also directed to a method comprising the aromatic polyimide nanoweb with amide-modified surface. The invention is further directed to a multi-layer article comprising the aromatic polyimide nanoweb with amide-modified surface, and to an electrochemical cell comprising the multi-layer article. | 06-14-2012 |
| 20120148897 | ELECTROCHEMICAL CELL COMPRISING A MULTI-LAYER ARTICLE OF POLYIMIDE NANOWEB WITH AMIDIZED SURFACE - The present invention is directed to the preparation and use of aromatic polyimide nanowebs with amide-modified surfaces. Uses include as a filtration medium, and as a separator in batteries, particularly lithium-ion batteries. The invention is also directed to a method comprising the aromatic polyimide nanoweb with amide-modified surface. The invention is further directed to a multi-layer article comprising the aromatic polyimide nanoweb with amide-modified surface, and to an electrochemical cell comprising the multi-layer article. | 06-14-2012 |
| 20120149852 | POLYIMIDE NANOWEB WITH AMIDIZED SURFACE AND METHOD FOR PREPARING - The present invention is directed to the preparation and use of aromatic polyimide nanowebs with amide-modified surfaces. Uses include as a filtration medium, and as a separator in batteries, particularly lithium-ion batteries. The invention is also directed to a filtration apparatus comprising the aromatic polyimide nanoweb with amide-modified surface. The invention is further directed to a multi-layer article comprising the aromatic polyimide nanoweb with amide-modified surface, and to an electrochemical cell comprising the multi-layer article. | 06-14-2012 |
| 20130022858 | LITHIUM BATTERY SEPARATOR WITH SHUTDOWN FUNCTION - This invention relates to separators for batteries and other electrochemical cells, especially lithium-ion batteries, having a shutdown mechanism. The separator is a laminate that contains a nonwoven nanoweb and a porous layer composed of a plurality of thermoplastic particles having particle size smaller than the mean flow pore size of the nanoweb. The shutdown layer melts and starts to flow at a desired temperature, and restricts the ion flow path, resulting in a substantial decrease in ionic conductivity of the separator at the desired shutdown temperature, while leaving the separator intact. | 01-24-2013 |
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| 20090124793 | Corticotropin releasing factor 2 receptor agonists - Isolated corticotropin releasing factor derivatives, and nucleic acids encoding the same, are effective for treating corticotropin releasing factor 2 receptor modulated disorders such as muscular dystrophy. | 05-14-2009 |
| 20100197579 | Corticotropin Releasing Factor 2 Receptor Agonists - Isolated corticotropin releasing factor derivatives, and nucleic acids encoding the same, are effective for treating corticotropin releasing factor 2 receptor modulated disorders such as muscular dystrophy. | 08-05-2010 |
| 20100244012 | Naphthyl-substituted anthracene derivatives and their use in organic light-emitting diodes - The present invention relates to anthracene derivative compounds represented by Formula I: | 09-30-2010 |
| 20110198579 | Host material for light-emitting diodes - The present invention relates to a host material comprising a compound having two carbazole moieties which is suitable for blue-emitting OLEDs. Surprisingly, it has been found that when appropriate substituents are present in the carbazole structure, the solubility of the compounds can be improved without any adverse effect on the OLED performance. The present invention further relates to the use of the host materials and to an organic light emitting device comprising the host material. | 08-18-2011 |
| 20110260149 | N-Phenyl carbazole-based host material for light-emitting diodes - The present invention relates to a host material comprising a compound having a carbazole moiety which is suitable for blue-emitting OLEDs. Surprisingly, it has been found that when appropriate substituents are present in the carbazole structure, the solubility of the compounds can be improved without any adverse effect on the OLED performance. The present invention further relates to the use of the host materials and to an organic light emitting device comprising the host material. | 10-27-2011 |
| 20120071640 | Sulfurizing reagents and their use for oligonucleotides synthesis - An oligonucleotide which comprises at least one internucleotide linkage comprising a P—S—R bond and at least two nucleosides, wherein R corresponds to the formula (I) | 03-22-2012 |
