Patent application number | Description | Published |
20110020925 | NEW MODULATING MOLECULES FOR AN IMPROVED REGULATED EXPRESSION SYSTEM - The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and uses thereof for treatment of disease. | 01-27-2011 |
20110275121 | Methods and Compositions for Production of Recombinant Protein in HBX-Expressing Mammalian Cells - The method of the invention provides for producing a heterologous protein in mammalian host cells having nucleic acid encoding Hepatitis B X protein and the heterologous protein, by growing mammalian host cells selected from the group consisting of HKB11, CHO, BHK21, C2C12, and HEK293 cells, by growing mammalian host cells in non-adherent suspension culture, or by growing mammalian host cells which contain nucleic acid providing exogenous X-box Binding Protein, XBP1s. The conditions should be such that HBx, exogenous XBP1s if present, and the heterologous protein are expressed by the mammalian cells. The invention includes compositions for carrying out the method. | 11-10-2011 |
20120178693 | Cofactors for Thrombin Activation of Factor VII and Uses Thereof - The invention relates to fusion proteins that bind the enzyme thrombin and enhance the activation of the substrate Factor VII to the product Factor VIIa. The invention is also directed to polynucleotides, vectors, host cells, pharmaceutical compositions, and methods of treatment. | 07-12-2012 |
20140363419 | SHORT-ACTING FACTOR VII POLYPEPTIDES - Short-acting Factor VII peptides are disclosed. A shortened half-life is desirable for treatment of acute bleeding and similar disorders. Modification of the sialylation and/or glycosylation of Factor VII and variants thereof produced peptides useful in treating conditions of acute bleeding. | 12-11-2014 |
20150044768 | METHODS AND COMPOSITIONS FOR PRODUCTION OF RECOMBINANT PROTEIN IN HBX-EXPRESSING MAMMALIAN CELLS - The method of the invention provides for producing a heterologous protein in mammalian host cells having nucleic acid encoding Hepatitis B X protein and the heterologous protein, by growing mammalian host cells selected from the group consistng of HKB11, CHO, BHK21, C2C12, and HEK293 cells, by growing mammalian host cells in non-adherent suspension culture, or by growing mammalian host cells which contain nucleic acid providing exogenous X-box Binding Protein, XBP1s. The conditions should be such that HBx, exogenous XBP1s if present, and the heterologous protein are expressed by the mammalian cells. The invention includes compositions for carrying out the method. | 02-12-2015 |
Patent application number | Description | Published |
20130254024 | Systems and Methods for Cross-Platform Software Bundling - Systems and methods are provided to enable bundling of software applications across multiple, disparate platforms, such as for example, bundling PC applications with mobile applications. The system enables mobile application developers to make offers to publishers of PC software to compensate the publishers for presenting advertisements for mobile application developers' product offerings during the installation of the publishers product offerings on user PCs. The publishers integrate an offer manager into their installation packages. When the installation packages are installed on a user's PC, the offer manager communicates with a software bundling service and identifies relevant offers, such as, for example, offers made by mobile application developers that are partnered with the software publisher supplying the installation package. Relevant offers are then presented to the user on the users PC, and if accepted, a download URL for a mobile user's application is transmitted to a user mobile device. | 09-26-2013 |
20140304071 | SYSTEMS AND METHODS FOR PRESENTING ADVERTISEMENTS WITH SOFTWARE APPLICATIONS - Exemplary embodiments of the present disclosure utilize identifiable information regarding hardware and/or software components of a client computing device to identify advertisements the end user of the client computing device is likely to find relevant and of interest. A computer-implemented method according to one exemplary embodiment of the present disclosure comprises receiving, by a computer system, information regarding a client computing device; accessing a database in communication with the computer system, the database storing a plurality of advertisements promoting a respective plurality of software applications; selecting, from the database, an advertisement from the plurality of advertisements based on the received information regarding the client device; and providing the selected advertisement to the client computing device for display using an advertising management software application operating on the client device. | 10-09-2014 |