Patent application number | Description | Published |
20130248261 | POWERED WHEELCHAIR WITH ARTICULATING DRIVE WHEELS - A seated vehicle comprises a frame, one or more first wheels at a first position relative to the frame, one or more second wheels at a second position relative to the frame, and a wheel-positioning system. The wheel-positioning system includes one or more arms pivotally coupled to the frame, and an adjustment mechanism operatively coupled to a first position of the one or more arms. The one or more first wheels are operatively coupled to a second position of the one or more arms. The adjustment mechanism moves the one or more arms between a first position and a second position so that the one or more first wheels are in a first position relative to the one or more second wheels when the one or more arms are in the first position and are in a second position relative to the one or more second wheels when the one or more arms are in the second position. | 09-26-2013 |
20130257020 | STABILIZED RAISING WHEELCHAIR - A raising wheelchair comprises a wheeled frame and a raising system mounted to the frame and supporting a seat and a backrest. The raising system is configured to be movable between a lowered position and a raised position. The raising system includes at least one double-armed lever including a first lever member and a second lever member, a coupling member fixedly mounted to the frame, wherein the first lever member and the second lever member are pivotally coupled to the coupling member, and a coupling mechanism translationally coupled or pivotally coupled to a second end of the first lever member, pivotally coupled to a second end of the second lever member, and coupled to the backrest. The raising system maintains an orientation of the backrest relative to the ground that is substantially constant throughout substantially an entire range of movement between the lowered position and the raised position. | 10-03-2013 |
20140326522 | POWERED WHEELCHAIR WITH ARTICULATING DRIVE WHEELS - A seated vehicle comprises a frame, one or more first wheels at a first position relative to the frame, one or more second wheels at a second position relative to the frame, and a wheel-positioning system. The wheel-positioning system includes one or more arms pivotally coupled to the frame, and an adjustment mechanism operatively coupled to a first position of the one or more arms. The one or more first wheels are operatively coupled to a second position of the one or more arms. The adjustment mechanism moves the one or more arms between a first position and a second position so that the one or more first wheels are in a first position relative to the one or more second wheels when the one or more arms are in the first position and are in a second position relative to the one or more second wheels when the one or more arms are in the second position. | 11-06-2014 |
20150042077 | STABILIZED RAISING WHEELCHAIR - A raising wheelchair comprises a wheeled frame and a raising system mounted to the frame and supporting a seat and a backrest. The raising system is configured to be movable between a lowered position and a raised position. The raising system includes at least one double-armed lever including a first lever member and a second lever member, a coupling member fixedly mounted to the frame, wherein the first lever member and the second lever member are pivotally coupled to the coupling member, and a coupling mechanism translationally coupled or pivotally coupled to a second end of the first lever member, pivotally coupled to a second end of the second lever member, and coupled to the backrest. The raising system maintains an orientation of the backrest relative to the ground that is substantially constant throughout substantially an entire range of movement between the lowered position and the raised position. | 02-12-2015 |
Patent application number | Description | Published |
20080274131 | Molecular antigen arrary - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses. | 11-06-2008 |
20110305723 | Molecular Antigen Array - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses. | 12-15-2011 |
20120114674 | Molecular Antigen Array - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses. | 05-10-2012 |
20130315949 | Molecular Antigen Array - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses. | 11-28-2013 |
20150030620 | PACKAGING OF IMMUNOSTIMULATORY SUBSTANCES INTO VIRUS-LIKE PARTICLES: METHOD OF PREPARATION AND USE - The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases. | 01-29-2015 |
20150202281 | Molecular Antigen Array - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses. | 07-23-2015 |
Patent application number | Description | Published |
20090123414 | Il-15 Antigen Arrays And Uses Thereof - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-15 protein, an IL-15 mutein or an IL-15 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-15 protein, IL-15 mutein or at least one IL-15 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory and chronic autoimmune diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. | 05-14-2009 |
20100098722 | Packaging of Immunostimulatory Substances Into Virus-Like Particles: Method of Preparation and Use - The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases. | 04-22-2010 |
20100119540 | Vaccination Regimen for B-Cell Vaccines - This invention relates to the field of vaccination and treatment or prevention diseases. In particular this invention relates to the treatment or prevention of diseases by inducing hapten-specific antibody responses in a vaccinated subject. The invention further provides a method for prevention or treatment of a disease by inducing hapten-specific antibodies in a subject comprising administering into said subject a composition comprising a virus-like particle of an RNA bacteriophage and at least one hapten linked thereto. | 05-13-2010 |
20100129395 | Hapten-carrier conjugates and uses thereof - The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction. | 05-27-2010 |
20100303846 | Immunostimulatory Nucleic Acid Packaged Particles for the Treatment of Hypersensitivity - The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy. | 12-02-2010 |
20110123541 | Human Monoclonal Nicotine Specific Antibodies - The invention relates to recombinantly produced human monoclonalantibodies which are specifically binding nicotine and to nucleic acids encoding the same. The invention further relates to the use of such antibodies in the treatment of nicotine addiction. | 05-26-2011 |
20120258130 | VACCINATION REGIMEN FOR B-CELL VACCINES - This invention relates to the field of vaccination and treatment or prevention diseases. In particular this invention relates to the treatment or prevention of diseases by inducing hapten-specific antibody responses in a vaccinated subject. The invention further provides a method for prevention or treatment of a disease by inducing hapten-specific antibodies in a subject comprising administering into said subject a composition comprising a virus-like particle of an RNA bacteriophage and at least one hapten linked thereto. | 10-11-2012 |
20120301499 | Packaging of Immunostimulatory Substances into Virus-Like Particles: Method of Preparation and Use - The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases. | 11-29-2012 |
20130115189 | Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes - The present invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a virus-like particle of an RNA bacteriophage and an antigen, wherein said antigen comprises an interleukin-1 beta (IL-1β) mutein. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1β. Thus, the invention provides methods of treating, ameliorating or preventing type II diabetes by way of active immunization against IL-1β. | 05-09-2013 |
20130142821 | Hapten-Carrier Conjugates and Uses Thereof - The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction. | 06-06-2013 |
20140056933 | IMMUNOSTIMULATORY NUCLEIC ACID PACKAGED PARTICLES FOR THE TREATMENT OF HYPERSENSITIVITY - The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy. | 02-27-2014 |